Colorectal Cancer: A Review of Carcinogenesis, Global Epidemiology, Current Challenges, Risk Factors, Preventive and Treatment Strategies
1. Introduction. Colorectal cancer (CRC), which comprises colon and/or rectum cancer, represents a significant health problem as the world's third most commonly diagnosed and second most fatal cancer globally [].Approximately 9.4% of cancer-related deaths were due to CRC in 2020 [].However, in light of the significant increase in the number of identified cases in the older population, it is ...
Colorectal Cancer Research Articles
Researchers have identified four warning signs that they believe may help identify colorectal cancer early in younger adults. The signs or symptoms are abdominal pain, rectal bleeding, diarrhea, and iron deficiency anemia. Drug Regimen Boosts Survival of People with Advanced Colorectal Cancer. Posted: May 24, 2023.
Colorectal Cancer Screening
Abstract. Screening for colorectal cancer is widespread and successful, but screening programs across the globe differ in their recommendations. In this review article, Helsingen and colleagues review the evidence for different approaches to colorectal cancer screening and propose a framework for evaluation of screening programs going forward.
Colorectal cancer
Colorectal cancer, also known as bowel cancer, is a cancer formed by uncontrolled cell growth in the colon or rectum (parts of the large intestine), or in the appendix. Genetic analysis shows that ...
Colon cancer
Colon cancer is the disease characterized by the development of malignant cells in the lining or epithelium of the first and longest portion of the large intestine. Latest Research and Reviews
Advances in Colorectal Cancer Research
Advances in Colorectal Cancer Research. Colorectal cells grown into organoids, stem cell-derived human 'mini-organs' that are used to study human development and disease. NCI-funded researchers are working to advance our understanding of how to prevent, detect, and treat colorectal cancer. They are also looking at what factors influence ...
A Review of Colorectal Cancer in Terms of Epidemiology, Risk Factors
According to the World Cancer Research Fund/American Institute for Cancer Research , the high consumption of dairy products (in particular milk) is probably inversely associated with the risk of developing colorectal cancer. The suggested protective effect of dairy products has been largely attributed to their content of calcium.
The effect of time before diagnosis and treatment on colorectal cancer
A systematic review of methodological considerations in time to diagnosis and treatment in colorectal cancer research. Cancer Epidemiol. 2023;83:102323.
Promising Therapeutic Strategies for Colorectal Cancer Treatment Based
2.2.1. CRC Epidemiology . Colorectal cancer (CRC) is the most devastating disease identified among all malignancies [29,30]. 10% of global cancer incidence and 9.4% of all cancer deaths result from CRC, thus making it the second-most malignant and deadly cancer in the world [1,2].It is also classified as the second-leading reason for cancer-associated deaths in women and the third-highest ...
A Cell-free DNA Blood-Based Test for Colorectal Cancer Screening
A total of 89.6% of the participants without any advanced colorectal neoplasia (colorectal cancer or advanced precancerous lesions) identified on colonoscopy had a negative cfDNA blood-based test ...
Effect of Colonoscopy Screening on Risks of Colorectal Cancer and
Follow-up data were available for 84,585 participants in Poland, Norway, and Sweden — 28,220 in the invited group, 11,843 of whom (42.0%) underwent screening, and 56,365 in the usual-care group.
Recent Advances in the Treatment of Colorectal Cancer: A Review
Abstract. Colorectal cancer (CRC) is the third most common cancer worldwide, and surgical treatment remains the first-line treatment to provide a cure. In addition to the aging population, obesity, low physical activity, and smoking habits increase CRC risk. Despite advances in surgical techniques, chemotherapy, and radiotherapy, colorectal ...
Clinical Colorectal Cancer
Clinical Colorectal Cancer is devoted to manuscripts that focus on early detection/screening, diagnosis, prevention, and treatment of colorectal cancer and other GI cancers, including pancreatic, liver, gastric/gastroesophageal, biliary, and other gastrointestinal cancers. The major emphasis is on recent scientific developments and original peer-reviewed manuscripts.
Colon cancer
Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation. Chemotherapy-induced death of colon cancer cells causes ATP release triggering P2X4 to mediate an mTOR-dependent pro ...
Exploring immunotherapy in colorectal cancer
In 2020, there were 1,931,590 new cases of colorectal cancer worldwide and 935,173 deaths, accounting for 10.0% and 9.4% of the total number of cancer incidences and deaths, respectively [ 1 ]. In recent years, the research on the comprehensive treatment of colorectal cancer has continued to increase, and combination therapy with a targeted ...
Effect of multitarget faecal immunochemical testing on colorectal
We commend the study by Pieter H A Wisse and colleagues1 on advancing colorectal cancer screening with the multitarget faecal immunochemical test (mtFIT). Colorectal cancer screening is a crucial public health strategy, balancing the burden of the disease with the feasibility of acceptable screening modalities.2 This pivotal research shows mtFIT's potential to greatly improve advanced neoplasm ...
Colorectal Cancer Rising among Young Adults
Since the 1990s, the rate of colorectal cancer (which includes cancers of the colon and rectum) has been rising steadily among adults younger than 50. Not only that, but more younger people are dying from the disease. This rapid increase is especially puzzling because the rate of colorectal cancer has plummeted among older adults—largely due ...
Combo Therapy Boosts Survival for Advanced Colon Cancer
According to the American Cancer Society, an estimated 106,590 new cases of colon cancer will be diagnosed among Americans in 2024, and around 53,010 people will die of the illness. It's the third ...
Clinical trials team brings hope and dedication to colorectal cancer
They represent the power of collaboration between volunteer participants and research teams who carefully collect data. One clinical trials team at Mayo Clinic is working to test a screening tool for colorectal cancer, a leading cause of cancer deaths in the U.S. Early detection of colorectal cancer may hold the key to saving lives.
Colon Cancer
Colorectal cancer is the third most common diagnosis and cause of cancer-related death in both sexes in the United States.[1] Worldwide, the condition remains the third most common malignancy but is second only to lung cancer in its mortality rate.[2] Incidence rates have been decreasing in Western countries, mostly due to the widespread use of colonoscopy screening. However, the condition's ...
Upregulated lncRNA LINC01128 in colorectal cancer ...
Purpose Colorectal cancer (CRC) refers to high-mortality tumors arising in the colon or rectum with a high rate of recurrence. The involvement of long non-coding RNAs (lncRNAs) contributes to the treatment and prognosis evaluation of CRC, and brings a new direction for the radical cure of patients. To identify the pathological mechanism and regulation of lncRNA LINC01128 (LINC01128) on CRC ...
Younger Adults Are Missing Early Warning Signs of Colon Cancer
The Latest. Colorectal cancer rates are rapidly rising among adults in their 20s, 30s and 40s, and the most common warning sign for the disease is passing blood in the stool, according to a new ...
Optimizing immunotherapy for colorectal cancer
Important colorectal cancer (CRC) studies in 2021, including a new standard of care for first-line treatment of MSI-H-dMMR metastatic CRC, single-cell and spatial analysis of primary tumours and ...
COLORECTAL CANCER
In 2012, 614,000 women (9.2% of all new cancer cases) and 746,000 men (10.0% of new cancer cases) were diagnosed with colorectal cancer worldwide 10. Combined, in both sexes, colorectal cancer is the third-most common cancer and accounts for 9.7% of all cancers excluding non-melanoma skin cancer. More than half of the cases occur in more ...
Colon cancer rates are rising in young Americans, but insurance
Suggested screening approaches in people with an average colon cancer risk include a colonoscopy every 10 years, stool-based testing every one to three years, or CT scans every five years for ...
Colorectal cancer
The incidence of early-onset colorectal cancer (in patients <50 years old) is increasing at an alarming rate. This Review highlights potential risk factors and putative mechanisms that drive this ...
Cancers
This review article contains a concise consideration of genetic and environmental risk factors for colorectal cancer. Known risk factors associated with colorectal cancer include familial and hereditary factors and lifestyle-related and ecological factors. Lifestyle factors are significant because of the potential for improving our understanding of the disease. Physical inactivity, obesity ...
New treatment may extend survival for people with advanced colon cancer
According to the American Cancer Society, an estimated 106,590 new cases of colon cancer will be diagnosed among Americans in 2024, and around 53,010 people will die of the illness. It's the third ...
Opinion: I've seen the rise in colon cancer cases. As doctors, we must
Colorectal cancer is now the number one cause of cancer death among young men and the second leading cause among young women (defined as no older than 49). There is a common misconception that ...
Colon Cancer: A Clinician's Perspective in 2019
If the ADR increases by 1%, a patient's risk of developing colon cancer over the next year decreases by 3%. ADR is inversely associated with development of interval CRC, advanced stage interval cancer and fatal interval cancer [ 26 ]. The recommended ADR is 20% or more in females, 30% or more in males and 25% or more on an average [ 27 ].
IMAGES
COMMENTS
1. Introduction. Colorectal cancer (CRC), which comprises colon and/or rectum cancer, represents a significant health problem as the world's third most commonly diagnosed and second most fatal cancer globally [].Approximately 9.4% of cancer-related deaths were due to CRC in 2020 [].However, in light of the significant increase in the number of identified cases in the older population, it is ...
Researchers have identified four warning signs that they believe may help identify colorectal cancer early in younger adults. The signs or symptoms are abdominal pain, rectal bleeding, diarrhea, and iron deficiency anemia. Drug Regimen Boosts Survival of People with Advanced Colorectal Cancer. Posted: May 24, 2023.
Abstract. Screening for colorectal cancer is widespread and successful, but screening programs across the globe differ in their recommendations. In this review article, Helsingen and colleagues review the evidence for different approaches to colorectal cancer screening and propose a framework for evaluation of screening programs going forward.
Colorectal cancer, also known as bowel cancer, is a cancer formed by uncontrolled cell growth in the colon or rectum (parts of the large intestine), or in the appendix. Genetic analysis shows that ...
Colon cancer is the disease characterized by the development of malignant cells in the lining or epithelium of the first and longest portion of the large intestine. Latest Research and Reviews
Advances in Colorectal Cancer Research. Colorectal cells grown into organoids, stem cell-derived human 'mini-organs' that are used to study human development and disease. NCI-funded researchers are working to advance our understanding of how to prevent, detect, and treat colorectal cancer. They are also looking at what factors influence ...
According to the World Cancer Research Fund/American Institute for Cancer Research , the high consumption of dairy products (in particular milk) is probably inversely associated with the risk of developing colorectal cancer. The suggested protective effect of dairy products has been largely attributed to their content of calcium.
A systematic review of methodological considerations in time to diagnosis and treatment in colorectal cancer research. Cancer Epidemiol. 2023;83:102323.
2.2.1. CRC Epidemiology . Colorectal cancer (CRC) is the most devastating disease identified among all malignancies [29,30]. 10% of global cancer incidence and 9.4% of all cancer deaths result from CRC, thus making it the second-most malignant and deadly cancer in the world [1,2].It is also classified as the second-leading reason for cancer-associated deaths in women and the third-highest ...
A total of 89.6% of the participants without any advanced colorectal neoplasia (colorectal cancer or advanced precancerous lesions) identified on colonoscopy had a negative cfDNA blood-based test ...
Follow-up data were available for 84,585 participants in Poland, Norway, and Sweden — 28,220 in the invited group, 11,843 of whom (42.0%) underwent screening, and 56,365 in the usual-care group.
Abstract. Colorectal cancer (CRC) is the third most common cancer worldwide, and surgical treatment remains the first-line treatment to provide a cure. In addition to the aging population, obesity, low physical activity, and smoking habits increase CRC risk. Despite advances in surgical techniques, chemotherapy, and radiotherapy, colorectal ...
Clinical Colorectal Cancer is devoted to manuscripts that focus on early detection/screening, diagnosis, prevention, and treatment of colorectal cancer and other GI cancers, including pancreatic, liver, gastric/gastroesophageal, biliary, and other gastrointestinal cancers. The major emphasis is on recent scientific developments and original peer-reviewed manuscripts.
Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation. Chemotherapy-induced death of colon cancer cells causes ATP release triggering P2X4 to mediate an mTOR-dependent pro ...
In 2020, there were 1,931,590 new cases of colorectal cancer worldwide and 935,173 deaths, accounting for 10.0% and 9.4% of the total number of cancer incidences and deaths, respectively [ 1 ]. In recent years, the research on the comprehensive treatment of colorectal cancer has continued to increase, and combination therapy with a targeted ...
We commend the study by Pieter H A Wisse and colleagues1 on advancing colorectal cancer screening with the multitarget faecal immunochemical test (mtFIT). Colorectal cancer screening is a crucial public health strategy, balancing the burden of the disease with the feasibility of acceptable screening modalities.2 This pivotal research shows mtFIT's potential to greatly improve advanced neoplasm ...
Since the 1990s, the rate of colorectal cancer (which includes cancers of the colon and rectum) has been rising steadily among adults younger than 50. Not only that, but more younger people are dying from the disease. This rapid increase is especially puzzling because the rate of colorectal cancer has plummeted among older adults—largely due ...
According to the American Cancer Society, an estimated 106,590 new cases of colon cancer will be diagnosed among Americans in 2024, and around 53,010 people will die of the illness. It's the third ...
They represent the power of collaboration between volunteer participants and research teams who carefully collect data. One clinical trials team at Mayo Clinic is working to test a screening tool for colorectal cancer, a leading cause of cancer deaths in the U.S. Early detection of colorectal cancer may hold the key to saving lives.
Colorectal cancer is the third most common diagnosis and cause of cancer-related death in both sexes in the United States.[1] Worldwide, the condition remains the third most common malignancy but is second only to lung cancer in its mortality rate.[2] Incidence rates have been decreasing in Western countries, mostly due to the widespread use of colonoscopy screening. However, the condition's ...
Purpose Colorectal cancer (CRC) refers to high-mortality tumors arising in the colon or rectum with a high rate of recurrence. The involvement of long non-coding RNAs (lncRNAs) contributes to the treatment and prognosis evaluation of CRC, and brings a new direction for the radical cure of patients. To identify the pathological mechanism and regulation of lncRNA LINC01128 (LINC01128) on CRC ...
The Latest. Colorectal cancer rates are rapidly rising among adults in their 20s, 30s and 40s, and the most common warning sign for the disease is passing blood in the stool, according to a new ...
Important colorectal cancer (CRC) studies in 2021, including a new standard of care for first-line treatment of MSI-H-dMMR metastatic CRC, single-cell and spatial analysis of primary tumours and ...
In 2012, 614,000 women (9.2% of all new cancer cases) and 746,000 men (10.0% of new cancer cases) were diagnosed with colorectal cancer worldwide 10. Combined, in both sexes, colorectal cancer is the third-most common cancer and accounts for 9.7% of all cancers excluding non-melanoma skin cancer. More than half of the cases occur in more ...
Suggested screening approaches in people with an average colon cancer risk include a colonoscopy every 10 years, stool-based testing every one to three years, or CT scans every five years for ...
The incidence of early-onset colorectal cancer (in patients <50 years old) is increasing at an alarming rate. This Review highlights potential risk factors and putative mechanisms that drive this ...
This review article contains a concise consideration of genetic and environmental risk factors for colorectal cancer. Known risk factors associated with colorectal cancer include familial and hereditary factors and lifestyle-related and ecological factors. Lifestyle factors are significant because of the potential for improving our understanding of the disease. Physical inactivity, obesity ...
According to the American Cancer Society, an estimated 106,590 new cases of colon cancer will be diagnosed among Americans in 2024, and around 53,010 people will die of the illness. It's the third ...
Colorectal cancer is now the number one cause of cancer death among young men and the second leading cause among young women (defined as no older than 49). There is a common misconception that ...
If the ADR increases by 1%, a patient's risk of developing colon cancer over the next year decreases by 3%. ADR is inversely associated with development of interval CRC, advanced stage interval cancer and fatal interval cancer [ 26 ]. The recommended ADR is 20% or more in females, 30% or more in males and 25% or more on an average [ 27 ].