phd chemistry hkust

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PhD in Chemistry

The hong kong university of science and technology ( ).

The PhD in Chemistry at The Hong Kong University of Science and Technology (HKUST) is a 3 years long program for international students, taught in English.

📖 Introduction

The Hong Kong University of Science and Technology is a public research university in Clear Water Bay, Hong Kong. Founded in 1991 by the British Hong Kong Government, it was the territory's third institution to be granted university status.

HKUST is commonly regarded as one of the fastest-growing universities in the world. As of 2019, the university was ranked seventh in Asia by QS and third by Times, and around the top 40 internationally. It also ranked first in Times Higher Education Young University Rankings in 2019 and second by QS world's under-50 universities in 2020.

Today, the university consists of four main academic schools, offering programs in science, engineering, business and management, humanities and social science, along with the Interdisciplinary Programs Office, HKUST Fok Ying Tung Graduate School / Guangzhou HKUST Fok Ying Tung Research Institute, HKUST Jockey Club Institute for Advanced Study and HKUST Institute for Public Policy.

🏫 About The Hong Kong University of Science and Technology (HKUST)

The university is largely a campus university, occupying a 60-hectare site at the northern part of the Clear Water Bay Peninsula in Sai Kung District, New Territories, Hong Kong, overlooking Port Shelter in Tai Po Tsai. The campus layout and architecture is based on a master plan submitted jointly by Simon Kwan & Associates and Percy Thomas Partnership, the runner-up entry in an architectural competition held before the university was founded.

As the campus has a sloped terrain, buildings and facilities are built on separate terraces carved out of the hillside, with the academic facilities occupying the top-level terraces, and undergraduate halls of residence and sporting facilities at the seafront. The terraces are connected by motor roads as well as a network of footbridges and elevators known as Bridge Link.

The countryside setting of the university contributed to the fact that HKUST was once the only public university in Hong Kong not being directly served by an MTR station, prior to the re-titling of the Education University of Hong Kong. The university is connected to the metro network through public bus routes including 91, 91M, 91P, 291P and 792M, complemented by a handful of minibus services, with Choi Hung and Hang Hau stations being the major feeder points.

About Hong Kong

Hong Kong is a Special Administrative Region of the People’s Republic of China. It is a place with multiple personalities as a result of being both Cantonese Chinese and having been under British colonization. Today, the former British colony is a major tourism destination for China’s increasingly affluent mainland population. It is an important hub in East Asia with global connections to many of the world’s cities. It is a unique destination that has absorbed people and cultural influences from places as diverse as Vietnam and Vancouver and proudly proclaims itself to be Asia’s World City.

Living on Campus

Life in undergraduate halls

Leaving home and arriving at the university for the first time is both exciting and challenging! Luckily we offer a rich network of mentors including Hall Education Teams, Residence Masters, Learning Community Fellows, Residential Life Officers, Tutors, and Learning Community Coordinators.   Not only will you be supported every step of the way, but you will have the chance to join activities, events, and discussions and get to know everybody in the community. Pretty soon you'll be qualified to be the mentor for incoming students!   As the residential year begins, you'll have a Hall Orientation to help you get to know everybody, be introduced to the "dos and don'ts" of hall life, and understand the role and responsibilities expected of you. Most importantly, the orientation will be tremendous fun! You will meet plenty of people in no time at all, and feel at home.

Life in postgraduate halls – SKCC Hall and University Apartments

Enriching your educational life is what the postgraduate experience is all about. On-campus you will have convenient access to academic and research facilities, the opportunity to interact with peers, and meet the people who will not only help you learn but will become lifelong friends and maybe even professional associates in the future. Living with people from a variety of cultures and backgrounds is a wonderful way to enrich yourself and enjoy an immersive experience in diversity.

Lee Shau Kee Library

The HKUST Lee Shau Kee Library, part of the Hong Kong Academic Library Link (HKALL), occupies a central location of the campus. Connected to the Academic Building, it is accessible directly from the Hong Kong Jockey Club Atrium. It spans five floors with over 12,350 sq m of floor space, providing more than 3,674 seats as well as computing facilities. It offers a wide array of information resources, both local and remote. In addition to over 720,000 print and electronic volumes and a large collection of media resources, it provides access to more than 47,000 periodical titles, a large number of e-books, databases, and other digital information resources. The library also includes 24-hour-capable Learning Commons which provides a technology-rich environment for active learning and education.

The library owns a collection of old maps of China and the rest of Asia, produced by Chinese and Western cartographers over the last 500 years. A selection of these maps, providing an insight into the history of international geographic knowledge, was published by the library in a limited-edition (1000 copies) volume in 2003.

Student Amenities

The Amenities Service Counter is located in Room LG3005 inside the Indoor Sports Complex. It provides services and assistance to users of the student amenities. These services include:

• student lockers
• loan of equipment for activities organized by student societies and teams
• information and advice on all matters related to amenities

Sports Facilities

The University provides a variety of sports and recreation facilities for the enhancement and promotion of your total well-being. All Full-time and Part-time students, staff and family members, long-serving retirees/leavers and Sports Facilities User Cardholders are welcome to use the facilities.  

The demand for sports facilities is quite keen. Sports skill classes, sports team practices and organized sports events including the intervarsity and intramural sports competitions are held in various facilities throughout the year.

🏠 Accommodation

Did you know? The Hong Kong University of Science and Technology on-campus residential halls provide a total of:

4,544 places for undergraduate students in UG Halls

120 places in single rooms for MBA students

900 places in single or double rooms for Research Postgraduate Students

They also have off-campus accommodation, and the university has also 21 apartments in Tai Po Tsai and Sam Long to provide accommodation for full-time postgraduate students on taught programs. You can apply to these at your school or program office.

• You will need to book the accommodation after you have been accepted.
• You can choose to live on campus or off campus in private accommodation.
• We have an article about how to find accommodation off campus here .

Application Fee:

Tuition fee:

42,100 CNY per year

126,300 CNY in total

Insurance is 358 CNY .

❓ ✅ ❌ Entry Requirements

The minimum age is 18 and the maximum age is 65.

Minimum education level: Master's

All students from all countries are eligible to apply to this program.

📬 Admissions Process

3 steps to apply to a chinese university.

Choose Programs

Apply Online

Enroll in China

Please choose the programs here , "You are advised to select 2-3 programs to increase your chances of getting accepted.

Required Documents:

• Academic Study Plan or Project Proposal
• Second Recommendation Letter
• First Recommendation Letter
• English Language Certificate
• Your Highest Academic Transcript (In English)
• Your Graduation Certificate (in English)
• Your Photograph
• Your Passport Copy

Preparing documents:

You can start your application now and send the application documents during your application. Some documents you can send later if you don’t have them right away. Some more info about preparing application documents is here

Application process:

Applying Online is simple in just a few steps. More information is available here .

The first steps are to choose the programs, pay the application fee and upload the application documents.

Once submitted to China Admissions, we will review your application within 2-3 days and proceed to the university or ask you for further clarification

After it has been processed to the university you will receive your unique application ID from each university.

The university may contact you directly for further questions.

We will then follow up each week with the university for updates. As soon as there is any update we will let you know. If you have made other plans, decide to withdraw / change address at any time please let us know.

After you have been accepted you will receive your admissions letter electronically and asked to pay the non-refundable deposit to the university.

Once you have paid the deposit the university will issue you the admissions letter and visa form to your home country.

❓ Have a Question?

There are no similar questions. Please send us your question below

📝 The Hong Kong University of Science and Technology (HKUST) Reviews

🛏️ Accommodation

🏓 Facilities

💲 Value for money

👨‍🏫 Classes

🕺 Student experience

🗣️ Recommend a friend?

Why Apply on China Admissions?

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PHD in Chemistry - Methods for Selective Construction of Carbon–Carbon and Carbon–Heteroatom Bonds & Studies on the Total Synthesis of Pre-schisanartanin-F

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The University is now inviting applications for 2024/25 Fall Term. Click to apply now!  

2024/25 Fall Term Admissions  (commencing in September 2024)

The application for 2023/24 Spring Term admissions is now closed. To check the application status, please click here .

For the following programs, please apply via the links as below:

• MBA Programs
• HKUST-NYU Stern MSc in Global Finance
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• HKUST Executive MBA
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PhD in Physical Chemistry The University of Hong Kong, 2015

• (852) 3469 2627
• [email protected]
• Personal Web

Research Interest

• Single molecule manipulation
• Raman spectroscopy
• Protein folding
• Biophysical chemistry

Publications

Additional label-free chemical resolution to single-molecule force spectroscopy Biophysical Journal, v. 123, (3), February 2024, p. 448a-449a, Supplement 1 Huang, Jinqing Article

Dynamic conformational changes of a tardigrade group-3 late embryogenesis abundant protein modulate membrane biophysical properties PNAS Nexus, v. 3, (1), January 2024, article number pgae006 Li, Xiao-Han; Yu, Conny W.H.; Gomez-Navarro, Natalia; Stancheva, Viktoriya; Zhu, Hongni; Murthy, Andal; Wozny, Michael; Malhotra, Ketan; Johnson, Christopher M.; Blackledge, Martin; Santhanam, Balaji; Liu, Wei; Huang, Jinqing; Freund, Stefan M. V.; Miller, Elizabeth A.; Babu, M Madan Article

Metastable biological matter in liquid phase separation Applied Research, v. 3, (2), April 2024, article number e202300071 Liu, Jianhui; Liu, Xiaolin; Zhang, Tianfu; Huang, Jinqing; Tang, Benzhong; Chau, Ying Article

Novel solution and solid-state emissive long-wavelength carbon dots for water sensing and white LED applications Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, v. 304, January 2024, article number 123328 Zhou, Weiying; Sun, Zishan; Fan, Jiaqi; Huang, Wenjing; Zhang, Jiahui; Song, Hongji; Zhou, Liya; Huang, Jinqing; Wu, Zhan-chao; Zhang, Xinguo Article

Additional label-free chemical resolution to single-molecule force spectroscopy Huang, Jinqing Conference paper

Construction of Multiphasic Membraneless Organelles towards Spontaneous Spatial Segregation and Directional Flow of Biochemical Reactions Chemical Science, v. 14, (4), January 2023, p. 801-811 Zhorabek, Fariza; Abesekara, Manisha Sandupama; Liu, Jianhui; Dai, Xin; Huang, Jinqing; Chau, Ying Article

Efficient optical plasmonic tweezer-controlled single-molecule SERS characterization of pH-dependent amylin species in aqueous milieus Nature Communications, v. 14, (1), November 2023, article number 6996 Fu, Wenhao; Chi, Huanyu; Dai, Xin; Zhu, Hongni; Mesias, Vince St. Dollente; Liu, Wei; Huang, Jinqing Article

Flexible Hf 6 Ta 2 O 17 @ acidified carbon nanotube composite films with enhanced interfacial interaction for high-performance supercapacitors Ceramics International, v. 49, (13), July 2023, p. 22089-22099 Xue, Yufeng; Ruan, Piao; Zhu, Li; Cao, Yi; Fu, Wenhao; Huang, Jinqing; Qiu, Wenfeng Article

Single-molecule force manipulation facilitated multiple rereads of a drug-bound DNA at specified sites by surface-enhanced Raman spectroscopy Biophysical Journal, v. 122, (3, Supplement 1), February 2023, p. 429a Huang, Jinqing Article

Synthesis and luminescent properties of ZnWO 4 : Cr 3+ nanoparticles for NIR-II fluorescence imaging Ceramics International, v. 49, (15), August 2023, p. 25682-25688 Xiao, Qiang; Zhou, Weiying; Fan, Jiaqi; Zhou, Liya; Chen, Peican; Mo, Fowang; Huang, Jinqing; Liu, Xiang; Zhang, Xinguo Article

Tunable lipid-coated nanoporous silver sheet for characterization of protein-membrane interactions by surface-enhanced Raman scattering (SERS) Analytical and Bioanalytical Chemistry, v. 415, (16), April 2023, p. 3243-3253 Zhu, Hongni; Zhang, Jianing; Dai, Xin; Mesias, Vince St. Dollente; Chi, Huanyu; Wang, Congcheng; Yeung, Chi Shun; Chen, Qing; Liu, Wei; Huang, Jinqing Article

Single-molecule force manipulation facilitated multiple rereads of a drug-bound DNA at specified sites by surface-enhanced Raman spectroscopy Huang, Jinqing Conference paper

A SURF4-to-Proteoglycan Relay Mechanism that Mediates the Sorting and Secretion of a Tagged Variant of Sonic Hedgehog Proceedings of the National Academy of Sciences of the United States of America, v. 119, (11), March 2022, article number e2113991119 Tang, Xiao; Chen, Rong; Mesias, Vince St. Dollente; Wang, Tingxuan; Wang, Ying; Poljak, Kristina; Fan, Xinyu; Miao, Hanchi; Hu, Junjie; Zhang, Liang; Huang, Jinqing; Yao, Shuhuai; Miller, Elizabeth A.; Guo, Yusong Article

Bright Red-Emitting P, Br Co-Doped Carbon Dots as “OFF-ON” Fluorescent Probe for Cu 2+ and L-cysteine Detection Journal of Alloys and Compounds, v. 897, March 2022, article number 162731 Zhou, Weiying; Mo, Fuwang; Sun, Zishan; Luo, Jiabao; Fan, Jiaqi; Zhu, Hongni; Zhu, Zhenpeng; Huang, Jinqing; Zhang, Xinguo Article

Combing force manipulation and Raman spectroscopy characterization to study protein structures Biophysical Journal, v. 121, (3), February 2022, p. 3a, Supplement 1 Huang, Jinqing Article

Controlling synthetic membraneless organelles by a red-light-dependent singlet oxygen-generating protein Nature Communications, v. 13, (1), June 2022, article number 3197 Li, Manjia; Park, Byung Min; Dai, Xin; Xu, Yingjie; Huang, Jinqing; Sun, Fei Article

Directed assembly of genetically engineered eukaryotic cells into living functional materials via ultrahigh-affinity protein interactions Science Advances, v. 8, (44), 4 November 2022, article number eade0073 Yi, Qikun; Dai, Xin; Park, Byung Min; Gu, Junhao; Luo, Jiren; Wang, Ri; Yu, Cong; Kou, Songzi; Huang, Jinqing; Lakerveld, Richard; Sun, Fei Article

High-efficient and pH-sensitive orange luminescence from silicon-doped carbon dots for information encryption and bio-imaging Journal of Colloid and Interface Science, v. 607, (Part 1), February 2022, p. 16-23 Sun, Zishan; Zhou, Weiying; Luo, Jiabao; Fan, Jiaqi; Wu, Zhan-chao; Zhu, Hongni; Huang, Jinqing; Zhang, Xinguo Article

Minimalist Design of an Intrinsically Disordered Protein-Mimicking Scaffold for an Artificial Membraneless Organelle ACS Central Science, v. 8, (4), April 2022, p. 493-500 Liu, Jianhui; Zhorabek, Fariza; Dai, Xin; Huang, Jinqing; Chau, Ying Article

Moderate Binding between Two SARS-CoV-2 Protein Segments and α-Synuclein Alters Its Toxic Oligomerization Propensity Differently The Journal of Physical Chemistry Letters, v. 13, (45), November 2022, p. 10642-10648 Mesias, Vince St. Dollente; Zhu, Hongni; Tang, Xiao; Dai, Xin; Liu, Wei; Guo, Yusong; Huang, Jinqing Article

Optical Trapping of Plasmonic Nanoparticles for In Situ Surface-Enhanced Raman Spectroscopy Characterizations Journal of Visualized Experiments, v. 2022, (184), June 2022, article number e63862 Dai, Xin; Qiu, Wenting; Huang, Jinqing Article

Protein purification, crystallization, and structure determination of human DEAD-box RNA helicase DDX21 in different unwinding states STAR Protocols, v. 3, (3), 16 September 2022, article number 101642 Chen, Zijun; Huang, Jinqing; Li, Jixi Article

Red-emitting carbon dots as luminescent agent in wide-range water detection in organic solvents and polarity-selective zebrafish imaging Journal of Alloys and Compounds, v. 920, 5 November 2022, article number 165963 Zhou, Weiying; Liu, Chuang; Fan, Jiaqi; Luo, Jiabao; Liu, Lihong; Huang, Jinqing; Liu, Ruiyuan; Zhang, Xinguo Article

Combing force manipulation and Raman spectroscopy characterization to study protein structures Huang, Jinqing Conference paper

Efficient separation and characterization of biomolecules by optical tweezers-controlled surface-enhanced Raman spectroscopy Huang, Jinqing Conference paper

Manipulation and characterization of biomolecule-metal complex interaction at the single-molecule level Huang, Jinqing Conference paper

Effective ACE2 peptide-nanoparticle conjugation and its binding with the SARS-Cov-2 RBD quantified by dynamic light scattering Chemical Communications, v. 57, (57), July 2021, p. 6979-6982 Mesias, Vince St. Dollente; Zhu, Hongni; Tang, Xiao; Dai, Xin; Guo, Yusong; Liu, Wei; Huang, Jinqing Article

Insights into unexpected photoisomerization from photooxidation of tribromoacetic acid in aqueous environment using ultrafast spectroscopy Journal of Hazardous Materials, v. 418, September 2021, article number 126214 Yeung, Chi Shun; Tse, Ho Yin; Lau, Chun Yin; Guan, Jianyu; Huang, Jinqing; Phillips, David Lee; Leu, Shao-Yuan Article

Optical tweezers-controlled hotspot for sensitive and reproducible surface-enhanced Raman spectroscopy characterization of native protein structures Nature Communications, v. 12, (1), February 2021, article number 1292 Dai, Xin; Fu, Wenhao; Chi, Huanyu; Mesias, Vince St. Dollente; Zhu, Hongni; Leung, Cheuk Wai; Liu, Wei; Huang, Jinqing Article

Combining optical tweezers microscopy and surface-enhanced Raman spectroscopy (SERS) to characterize protein structures Huang, Jinqing Conference paper

Truncated Angiotensin-Converting Enzyme-2 peptide conjugated nanoparticles as an efficient, specific, and long-lasting antiviral platform for SARS-CoV-2 Mesias, Vince St. Dollente; Zhu, Hongni; Tang, Xiao; Dai, Xin; Guo, Yusong; Liu, Wei; Huang, Jinqing Conference paper

Highly reusable nanoporous silver sheet for sensitive SERS detection of pesticides Analyst, v. 145, (15), August 2020, p. 5158-5165 Chi, Huanyu; Wang, Congcheng; Wang, Zhien; Zhu, Hongni; Mesias, Vince St. Dollente; Dai, Xin; Chen, Qing; Liu, Wei; Huang, Jinqing Article

Single-Molecule Mechanical Unfolding of AT-Rich Chromosomal Fragile Site DNA Hairpins: Resolving the Thermodynamic and Kinetic Effects of a Single G-T Mismatch The Journal of Physical Chemistry. B, v. 124, (42), 22 October 2020, p. 9365-9370 Li, Xiong; Pei, Yufeng; Zhang, Yashuo; Liu, Yajun; Fu, Wenhao; Li, Jixi; You, Huijuan; Huang, Jinqing Article

Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation Advanced Science, 2020 Huang, Jinqing Article

DNA‑Pt complex interactions investigated by single‑molecule force spectroscopy and surface‑enhanced Raman spectroscopy Dai, Xin; Li, Xiong; Leung, Cheuk Wai; Zhu, Hongni; Huang, Jinqing Conference paper

Octave-spanning mid-infrared pulses for ultrafast temporal resolution in single-molecule manipulations and characterizations Huang, Jinqing Conference paper

A spectroscopic study of the excited state proton transfer processes of (8-bromo-7-hydroxyquinolin-2-yl)methyl-protected phenol in aqueous solutions Photochemical and Photobiological Sciences, v. 16, (4), April 2017, p. 575-584 Huang, Jinqing; Muliawan, Adna P.; Ma, Jiani; Li, Mingde; Chiu, Hoikei; Lan, Xin; Deodato, Davide; Phillips, David Lee; Dore, Timothy M. Article

Octave-spanning mid-infrared pulses by plasma generation in air pumped with an Yb:KGW source Optics Letters, v. 41, (21), November 2016, p. 4855-4858 Huang, Jinqing; Alexander Parobek; Ziad Ganim Article

Substituent Effects on the Photodeprotection Reactions of Selected Ketoprofen Derivatives in Phosphate Buffered Aqueous Solutions Scientific Reports, v. 6, February 2016, article number 21606 Liu, Mingyue; Li, Mingde; Huang, Jinqing; Li, Tianlu; Liu, Han; Li, Xuechen; Phillips, David Lee Article

How Does the C–Halogen Bond Break in the Photosubstitution Reaction of 3-Fluorobenzophenone in Acidic Aqueous Solutions? Journal of Organic Chemistry, v. 80, (19), October 2015, p. 9425-9436 Huang, Jinqing; Ma, Jiani; Li, Mingde; Liu, Mingyue; Zhang, Xiting; Phillips, David Lee Article

Investigation of the Role of Protonation of Benzophenone and Its Derivatives in Acidic Aqueous Solutions Using Time-Resolved Resonance Raman Spectroscopy: How Are Ketyl Radicals Formed in Aqueous Solutions? Journal of Physical Chemistry B, v. 119, (6), February 2015, p. 2241-2252 Li, Mingde; Huang, Jinqing; Liu, Mingyue; Li, Songbo; Ma, Jiani; Phillips, David Lee Article

A Computational Chemistry Investigation of the Mechanism of the Water-Assisted Decomposition of Trichloroethylene Oxide Journal of Physical Chemistry A, v. 118, (9), March 2014, p. 1557-1567 Huang, Jinqing; Yeung, Chishun; Ma, Jiani; Gayner, Emma R.; Phillips, David Lee Article

Direct Time-Resolved Spectroscopic Observation of Arylnitrenium Ion Reactions with Guanine-Containing DNA Oligomers Journal of Organic Chemistry, v. 79, (8), April 2014, p. 3610-3614 Xue, Jiadan; Du, Lili; Zhu, Ruixue; Huang, Jinqing; Phillips, David Lee Article

Meta Versus Para Substitution: How Does C–H Activation in a Methyl Group Occur in 3-Methylbenzophenone but Does Not Take Place in 4-Methylbenzophenone? Journal of Organic Chemistry, v. 78, (10), May 2013, p. 4867-4878 Ma, Jiani; Su, Tao; Li, Mingde; Zhang, Xiting; Huang, Jinqing; Phillips, David Lee Article

How and When Does an Unusual and Efficient Photoredox Reaction of 2-(1-Hydroxyethyl) 9,10-Anthraquinone Occur? A Combined Time-Resolved Spectroscopic and DFT Study Journal of the American Chemical Society, v. 134, (36), September 2012, p. 14858-14868 Ma, Jiani; Su, Tao; Li, Mingde; Du, Wei; Huang, Jinqing; Guan, Xiangguo; Phillips, David Lee Article

Synthesis and luminescence of Eu 2+ -doped alkaline-earth apatites for application in white LED Journal of Luminescence, v. 130, (4), April 2010, p. 554-559 Zhang, Xinguo; Zhang, Jilin; Huang, Jinqing; Tang, Xueping; Gong, Menglian Article

Near UV-based LED fabricated with Ba 5 SiO 4 (F,Cl) 6 :Eu 2+ as blue- and green-emitting phosphor Optical Materials, v. 32, (1), November 2009, p. 75-78 Zhang, Xinguo; Wang, Xiaoxiao; Huang, Jinqing; Shi, Jinxin; Gong, Menglian Article

Additional label-free chemical resolution to single-molecule force spectroscopy Biophysical Journal, v. 123, (3), February 2024, p. 448a-449a, Supplement 1 Huang, Jinqing

Dynamic conformational changes of a tardigrade group-3 late embryogenesis abundant protein modulate membrane biophysical properties PNAS Nexus, v. 3, (1), January 2024, article number pgae006 Li, Xiao-Han; Yu, Conny W.H.; Gomez-Navarro, Natalia; Stancheva, Viktoriya; Zhu, Hongni; Murthy, Andal; Wozny, Michael; Malhotra, Ketan; Johnson, Christopher M.; Blackledge, Martin; Santhanam, Balaji; Liu, Wei; Huang, Jinqing; Freund, Stefan M. V.; Miller, Elizabeth A.; Babu, M Madan

Metastable biological matter in liquid phase separation Applied Research, v. 3, (2), April 2024, article number e202300071 Liu, Jianhui; Liu, Xiaolin; Zhang, Tianfu; Huang, Jinqing; Tang, Benzhong; Chau, Ying

Novel solution and solid-state emissive long-wavelength carbon dots for water sensing and white LED applications Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, v. 304, January 2024, article number 123328 Zhou, Weiying; Sun, Zishan; Fan, Jiaqi; Huang, Wenjing; Zhang, Jiahui; Song, Hongji; Zhou, Liya; Huang, Jinqing; Wu, Zhan-chao; Zhang, Xinguo

Conference paper 1

Additional label-free chemical resolution to single-molecule force spectroscopy Huang, Jinqing

Construction of Multiphasic Membraneless Organelles towards Spontaneous Spatial Segregation and Directional Flow of Biochemical Reactions Chemical Science, v. 14, (4), January 2023, p. 801-811 Zhorabek, Fariza; Abesekara, Manisha Sandupama; Liu, Jianhui; Dai, Xin; Huang, Jinqing; Chau, Ying

Efficient optical plasmonic tweezer-controlled single-molecule SERS characterization of pH-dependent amylin species in aqueous milieus Nature Communications, v. 14, (1), November 2023, article number 6996 Fu, Wenhao; Chi, Huanyu; Dai, Xin; Zhu, Hongni; Mesias, Vince St. Dollente; Liu, Wei; Huang, Jinqing

Flexible Hf 6 Ta 2 O 17 @ acidified carbon nanotube composite films with enhanced interfacial interaction for high-performance supercapacitors Ceramics International, v. 49, (13), July 2023, p. 22089-22099 Xue, Yufeng; Ruan, Piao; Zhu, Li; Cao, Yi; Fu, Wenhao; Huang, Jinqing; Qiu, Wenfeng

Single-molecule force manipulation facilitated multiple rereads of a drug-bound DNA at specified sites by surface-enhanced Raman spectroscopy Biophysical Journal, v. 122, (3, Supplement 1), February 2023, p. 429a Huang, Jinqing

Synthesis and luminescent properties of ZnWO 4 : Cr 3+ nanoparticles for NIR-II fluorescence imaging Ceramics International, v. 49, (15), August 2023, p. 25682-25688 Xiao, Qiang; Zhou, Weiying; Fan, Jiaqi; Zhou, Liya; Chen, Peican; Mo, Fowang; Huang, Jinqing; Liu, Xiang; Zhang, Xinguo

Tunable lipid-coated nanoporous silver sheet for characterization of protein-membrane interactions by surface-enhanced Raman scattering (SERS) Analytical and Bioanalytical Chemistry, v. 415, (16), April 2023, p. 3243-3253 Zhu, Hongni; Zhang, Jianing; Dai, Xin; Mesias, Vince St. Dollente; Chi, Huanyu; Wang, Congcheng; Yeung, Chi Shun; Chen, Qing; Liu, Wei; Huang, Jinqing

Single-molecule force manipulation facilitated multiple rereads of a drug-bound DNA at specified sites by surface-enhanced Raman spectroscopy Huang, Jinqing

A SURF4-to-Proteoglycan Relay Mechanism that Mediates the Sorting and Secretion of a Tagged Variant of Sonic Hedgehog Proceedings of the National Academy of Sciences of the United States of America, v. 119, (11), March 2022, article number e2113991119 Tang, Xiao; Chen, Rong; Mesias, Vince St. Dollente; Wang, Tingxuan; Wang, Ying; Poljak, Kristina; Fan, Xinyu; Miao, Hanchi; Hu, Junjie; Zhang, Liang; Huang, Jinqing; Yao, Shuhuai; Miller, Elizabeth A.; Guo, Yusong

Bright Red-Emitting P, Br Co-Doped Carbon Dots as “OFF-ON” Fluorescent Probe for Cu 2+ and L-cysteine Detection Journal of Alloys and Compounds, v. 897, March 2022, article number 162731 Zhou, Weiying; Mo, Fuwang; Sun, Zishan; Luo, Jiabao; Fan, Jiaqi; Zhu, Hongni; Zhu, Zhenpeng; Huang, Jinqing; Zhang, Xinguo

Combing force manipulation and Raman spectroscopy characterization to study protein structures Biophysical Journal, v. 121, (3), February 2022, p. 3a, Supplement 1 Huang, Jinqing

Controlling synthetic membraneless organelles by a red-light-dependent singlet oxygen-generating protein Nature Communications, v. 13, (1), June 2022, article number 3197 Li, Manjia; Park, Byung Min; Dai, Xin; Xu, Yingjie; Huang, Jinqing; Sun, Fei

Directed assembly of genetically engineered eukaryotic cells into living functional materials via ultrahigh-affinity protein interactions Science Advances, v. 8, (44), 4 November 2022, article number eade0073 Yi, Qikun; Dai, Xin; Park, Byung Min; Gu, Junhao; Luo, Jiren; Wang, Ri; Yu, Cong; Kou, Songzi; Huang, Jinqing; Lakerveld, Richard; Sun, Fei

High-efficient and pH-sensitive orange luminescence from silicon-doped carbon dots for information encryption and bio-imaging Journal of Colloid and Interface Science, v. 607, (Part 1), February 2022, p. 16-23 Sun, Zishan; Zhou, Weiying; Luo, Jiabao; Fan, Jiaqi; Wu, Zhan-chao; Zhu, Hongni; Huang, Jinqing; Zhang, Xinguo

Minimalist Design of an Intrinsically Disordered Protein-Mimicking Scaffold for an Artificial Membraneless Organelle ACS Central Science, v. 8, (4), April 2022, p. 493-500 Liu, Jianhui; Zhorabek, Fariza; Dai, Xin; Huang, Jinqing; Chau, Ying

Moderate Binding between Two SARS-CoV-2 Protein Segments and α-Synuclein Alters Its Toxic Oligomerization Propensity Differently The Journal of Physical Chemistry Letters, v. 13, (45), November 2022, p. 10642-10648 Mesias, Vince St. Dollente; Zhu, Hongni; Tang, Xiao; Dai, Xin; Liu, Wei; Guo, Yusong; Huang, Jinqing

Optical Trapping of Plasmonic Nanoparticles for In Situ Surface-Enhanced Raman Spectroscopy Characterizations Journal of Visualized Experiments, v. 2022, (184), June 2022, article number e63862 Dai, Xin; Qiu, Wenting; Huang, Jinqing

Protein purification, crystallization, and structure determination of human DEAD-box RNA helicase DDX21 in different unwinding states STAR Protocols, v. 3, (3), 16 September 2022, article number 101642 Chen, Zijun; Huang, Jinqing; Li, Jixi

Red-emitting carbon dots as luminescent agent in wide-range water detection in organic solvents and polarity-selective zebrafish imaging Journal of Alloys and Compounds, v. 920, 5 November 2022, article number 165963 Zhou, Weiying; Liu, Chuang; Fan, Jiaqi; Luo, Jiabao; Liu, Lihong; Huang, Jinqing; Liu, Ruiyuan; Zhang, Xinguo

Conference paper 3

Combing force manipulation and Raman spectroscopy characterization to study protein structures Huang, Jinqing

Efficient separation and characterization of biomolecules by optical tweezers-controlled surface-enhanced Raman spectroscopy Huang, Jinqing

Manipulation and characterization of biomolecule-metal complex interaction at the single-molecule level Huang, Jinqing

Effective ACE2 peptide-nanoparticle conjugation and its binding with the SARS-Cov-2 RBD quantified by dynamic light scattering Chemical Communications, v. 57, (57), July 2021, p. 6979-6982 Mesias, Vince St. Dollente; Zhu, Hongni; Tang, Xiao; Dai, Xin; Guo, Yusong; Liu, Wei; Huang, Jinqing

Insights into unexpected photoisomerization from photooxidation of tribromoacetic acid in aqueous environment using ultrafast spectroscopy Journal of Hazardous Materials, v. 418, September 2021, article number 126214 Yeung, Chi Shun; Tse, Ho Yin; Lau, Chun Yin; Guan, Jianyu; Huang, Jinqing; Phillips, David Lee; Leu, Shao-Yuan

Optical tweezers-controlled hotspot for sensitive and reproducible surface-enhanced Raman spectroscopy characterization of native protein structures Nature Communications, v. 12, (1), February 2021, article number 1292 Dai, Xin; Fu, Wenhao; Chi, Huanyu; Mesias, Vince St. Dollente; Zhu, Hongni; Leung, Cheuk Wai; Liu, Wei; Huang, Jinqing

Conference paper 2

Combining optical tweezers microscopy and surface-enhanced Raman spectroscopy (SERS) to characterize protein structures Huang, Jinqing

Truncated Angiotensin-Converting Enzyme-2 peptide conjugated nanoparticles as an efficient, specific, and long-lasting antiviral platform for SARS-CoV-2 Mesias, Vince St. Dollente; Zhu, Hongni; Tang, Xiao; Dai, Xin; Guo, Yusong; Liu, Wei; Huang, Jinqing

Highly reusable nanoporous silver sheet for sensitive SERS detection of pesticides Analyst, v. 145, (15), August 2020, p. 5158-5165 Chi, Huanyu; Wang, Congcheng; Wang, Zhien; Zhu, Hongni; Mesias, Vince St. Dollente; Dai, Xin; Chen, Qing; Liu, Wei; Huang, Jinqing

Single-Molecule Mechanical Unfolding of AT-Rich Chromosomal Fragile Site DNA Hairpins: Resolving the Thermodynamic and Kinetic Effects of a Single G-T Mismatch The Journal of Physical Chemistry. B, v. 124, (42), 22 October 2020, p. 9365-9370 Li, Xiong; Pei, Yufeng; Zhang, Yashuo; Liu, Yajun; Fu, Wenhao; Li, Jixi; You, Huijuan; Huang, Jinqing

Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation Advanced Science, 2020 Huang, Jinqing

DNA‑Pt complex interactions investigated by single‑molecule force spectroscopy and surface‑enhanced Raman spectroscopy Dai, Xin; Li, Xiong; Leung, Cheuk Wai; Zhu, Hongni; Huang, Jinqing

Octave-spanning mid-infrared pulses for ultrafast temporal resolution in single-molecule manipulations and characterizations Huang, Jinqing

A spectroscopic study of the excited state proton transfer processes of (8-bromo-7-hydroxyquinolin-2-yl)methyl-protected phenol in aqueous solutions Photochemical and Photobiological Sciences, v. 16, (4), April 2017, p. 575-584 Huang, Jinqing; Muliawan, Adna P.; Ma, Jiani; Li, Mingde; Chiu, Hoikei; Lan, Xin; Deodato, Davide; Phillips, David Lee; Dore, Timothy M.

Octave-spanning mid-infrared pulses by plasma generation in air pumped with an Yb:KGW source Optics Letters, v. 41, (21), November 2016, p. 4855-4858 Huang, Jinqing; Alexander Parobek; Ziad Ganim

Substituent Effects on the Photodeprotection Reactions of Selected Ketoprofen Derivatives in Phosphate Buffered Aqueous Solutions Scientific Reports, v. 6, February 2016, article number 21606 Liu, Mingyue; Li, Mingde; Huang, Jinqing; Li, Tianlu; Liu, Han; Li, Xuechen; Phillips, David Lee

How Does the C–Halogen Bond Break in the Photosubstitution Reaction of 3-Fluorobenzophenone in Acidic Aqueous Solutions? Journal of Organic Chemistry, v. 80, (19), October 2015, p. 9425-9436 Huang, Jinqing; Ma, Jiani; Li, Mingde; Liu, Mingyue; Zhang, Xiting; Phillips, David Lee

Investigation of the Role of Protonation of Benzophenone and Its Derivatives in Acidic Aqueous Solutions Using Time-Resolved Resonance Raman Spectroscopy: How Are Ketyl Radicals Formed in Aqueous Solutions? Journal of Physical Chemistry B, v. 119, (6), February 2015, p. 2241-2252 Li, Mingde; Huang, Jinqing; Liu, Mingyue; Li, Songbo; Ma, Jiani; Phillips, David Lee

A Computational Chemistry Investigation of the Mechanism of the Water-Assisted Decomposition of Trichloroethylene Oxide Journal of Physical Chemistry A, v. 118, (9), March 2014, p. 1557-1567 Huang, Jinqing; Yeung, Chishun; Ma, Jiani; Gayner, Emma R.; Phillips, David Lee

Direct Time-Resolved Spectroscopic Observation of Arylnitrenium Ion Reactions with Guanine-Containing DNA Oligomers Journal of Organic Chemistry, v. 79, (8), April 2014, p. 3610-3614 Xue, Jiadan; Du, Lili; Zhu, Ruixue; Huang, Jinqing; Phillips, David Lee

Meta Versus Para Substitution: How Does C–H Activation in a Methyl Group Occur in 3-Methylbenzophenone but Does Not Take Place in 4-Methylbenzophenone? Journal of Organic Chemistry, v. 78, (10), May 2013, p. 4867-4878 Ma, Jiani; Su, Tao; Li, Mingde; Zhang, Xiting; Huang, Jinqing; Phillips, David Lee

How and When Does an Unusual and Efficient Photoredox Reaction of 2-(1-Hydroxyethyl) 9,10-Anthraquinone Occur? A Combined Time-Resolved Spectroscopic and DFT Study Journal of the American Chemical Society, v. 134, (36), September 2012, p. 14858-14868 Ma, Jiani; Su, Tao; Li, Mingde; Du, Wei; Huang, Jinqing; Guan, Xiangguo; Phillips, David Lee

Synthesis and luminescence of Eu 2+ -doped alkaline-earth apatites for application in white LED Journal of Luminescence, v. 130, (4), April 2010, p. 554-559 Zhang, Xinguo; Zhang, Jilin; Huang, Jinqing; Tang, Xueping; Gong, Menglian

Near UV-based LED fabricated with Ba 5 SiO 4 (F,Cl) 6 :Eu 2+ as blue- and green-emitting phosphor Optical Materials, v. 32, (1), November 2009, p. 75-78 Zhang, Xinguo; Wang, Xiaoxiao; Huang, Jinqing; Shi, Jinxin; Gong, Menglian

Teaching Assignment

Research postgraduate (rpg) supervision, from january 2021 to december 2024 (as of 23 may 2024), current rpgs.

ZHANG, Jianing Chemistry

LIU, Shijia Chemistry

Graduated RPGs

FU, Wenhao Chemistry ( Completed in 2023 )

MESIAS, Vince St. Dollente Chemistry ( Completed in 2023 )

ZHU, Hongni Chemistry ( Completed in 2021 )

CHIU, King Wai Chemistry ( Completed in 2023 )

From January 2022 to December 2024

• HUANG Jinqing (Lead)
• CHAU Ying (Lead)
• HUANG Jinqing

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Program requirements and who should take it .

The M.Sc. in Analytical Chemistry is a taught 1 year (Full-time) or 2-year (Part-time) degree.  Applications will be considered from graduates with B.Sc. Second Class Degree (or equivalent) in Chemistry or other related subjects, with some prior knowledge of Chemistry.  The language of instruction is English and students must also meet the university requirements for admission.

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Department of Chemistry

To graduate from this undergraduate degree program, students are required to fulfill the following requirements: • University Common Core Requirements • University English Language Requirement

• University Legal Education Requirement • School Requirements: School of Science • Major Requirements: BSc in Chemistry • At least 120 credits (where the requirements of a student’s programs of study fall short of 120 credits, additional elective credits must be earned. These elective credits may include those which are used to earn a minor program or additional major.)

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(This article was originally published on  EurekAlert!  on May 10, 2024)

A research team led by the Hong Kong University of Science and Technology (HKUST) has discovered how carboxysomes, carbon-fixing structures found in some bacteria and algae, work. The breakthrough could help scientists redesign and repurpose the structures to enable plants to convert sunlight into more energy, paving the way for improved photosynthesis efficiency, potentially increasing the global food supply and mitigating global warming. 

Carboxysomes are tiny compartments in certain bacteria and algae that encase particular enzymes in a shell made of proteins. They perform carbon fixation, which is the process of converting carbon dioxide from the atmosphere into organic compounds that can be used by the cell for growth and energy. Scientists have been trying to figure out how these compartments put themselves together.

In their latest research, the team led by Prof. ZENG Qinglu, Associated Professor at HKUST’s Department of Ocean Science showed the overall architecture of carboxysomes purified from a type of bacteria called  Prochlorococcus . In collaboration with Prof. ZHOU Cong-Zhao of the School of Life Sciences in the University of Science & Technology of China, the team overcame one of the biggest technical difficulties in cell breakage and contamination, which would prevent the proper purification of carboxysomes. The team also proposes a complete assembly model of α-carboxysome, which has not been observed in previous studies.

In specific, the team utilized the single-particle cryo-electron microscopy to determine the structure of α-carboxysome and characterize the assembly pattern of the protein shell, which looks like a 20-sided shape with specific proteins arranged on its surface. To obtain the structure of the minimal α-carboxysome with a diameter of 86 nm, they collected over 23,400 images taken from the microscope at the HKUST Biological Cryo-EM Center and manually picked about 32,000 intact α-carboxysome particles for analysis. Inside, the RuBisCO enzymes are arranged in three concentric layers, and the research team also discovered that a protein called CsoS2 helps to hold everything together inside the shell. Finally, the findings suggest that carboxysomes are put together from the outside in. This means that the inside surface of the shell is strengthened by certain parts of the CsoS2 protein, while other parts of the protein attract the RuBisCO enzymes and organize them into layers.

One of the most promising application of carboxysome is in plant synthetic biology, whereby the introduction of carboxysome into plant chloroplasts as the CO2-concentrating mechanism can improve photosynthetic efficiency and crop yield. “Our study unveils the mystery of α-carboxysome assembly from  Prochlorococcus , thus providing novel insights into global carbon cycling,” says Prof. Zeng. The findings will also be important to slow down global warming, he says, as marine cyanobacteria fix 25% of global CO2. “Our understanding of the CO2 fixation mechanism of marine cyanobacteria will enable us to improve their CO2 fixation rate so that more CO2 can be removed from the atmosphere,” he says.

Following this study, the team plans to introduce  Prochlorococcus  α-carboxysome into plant chloroplasts and investigate whether the minimal α-carboxysome can improve the photosynthetic efficiency in plants. They also plan to modify the carboxysome genes and make genetically modified super cyanobacteria that are able to fix carbon dioxide at very high rates, which may be able to slow down global warming. 

The study was recently published in the scientific journal  Nature Plants .

Prof. ZENG Qinglu(right) and one of the research paper author Mr LI Haofu (left), PhD student in Department of Ocean Science, showing the sample of  Prochlorococcus  MED4 culture.

With the support of the HKUST Biological Cryo-EM Center, the team utilized the single-particle cryo-electron microscopy to determine the structure of the intact shell and characterize the  overall architecture of the four-layered assembly pattern of  Prochlorococcus  α-carboxysome.

The self-assembly model of Prochlorococcus α-carboxysome.

An HKUST-led international research collaboration has achieved a significant milestone in Alzheimer’s disease (AD) diagnosis and management. The team, spearheaded by Prof. Nancy IP, President and the Morningside Professor of Life Science at the Hong Kong University of Science and Technology (HKUST), and Director of the Hong Kong Center for Neurodegenerative Diseases (HKCeND), has developed a cutting-edge blood test for the early detection of AD and mild cognitive impairment (MCI), surpassing remarkable accuracy rates of over 96% and 87% respectively. Notably, this blood test is applicable across ethnic populations, providing a global solution to the diagnosis and management of AD.

An international research team led by the Hong Kong University of Science and Technology (HKUST) has achieved a significant breakthrough by developing an artificial intelligence (AI) model that can help mitigate global ammonia (NH3) emission from agriculture.