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Distinct properties of putative trophoblast stem cells established from somatic cell nuclear-transferred pig blastocysts

Genetically modified pigs are considered ideal models for studying human diseases and potential sources for xenotransplantation research. However, the somatic cell nuclear transfer (SCNT) technique utilized to...

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Electroacupuncture attenuates neuropathic pain via suppressing BIP-IRE-1α-mediated endoplasmic reticulum stress in the anterior cingulate cortex

Studies have suggested that endoplasmic reticulum stress (ERS) is involved in neurological dysfunction and that electroacupuncture (EA) attenuates neuropathic pain (NP) via undefined pathways. However, the rol...

Effect of Cannabis sativa L. extracts, phytocannabinoids and their acetylated derivates on the SHSY-5Y neuroblastoma cells’ viability and caspases 3/7 activation

There is a need for novel treatments for neuroblastoma, despite the emergence of new biological and immune treatments, since refractory pediatric neuroblastoma is still a medical challenge. Phyto cannabinoids ...

The hepatoprotective effect of 4-phenyltetrahydroquinolines on carbon tetrachloride induced hepatotoxicity in rats through autophagy inhibition

The liver serves as a metabolic hub within the human body, playing a crucial role in various essential functions, such as detoxification, nutrient metabolism, and hormone regulation. Therefore, protecting the ...

Connexin channels and hemichannels are modulated differently by charge reversal at residues forming the intracellular pocket

Members of the β-subfamily of connexins contain an intracellular pocket surrounded by amino acid residues from the four transmembrane helices. The presence of this pocket has not previously been investigated i...

IDH1 mutation produces R-2-hydroxyglutarate (R-2HG) and induces mir-182-5p expression to regulate cell cycle and tumor formation in glioma

Mutations in isocitrate dehydrogenase 1 and 2 ( IDH1 and IDH2 ), are present in most gliomas. IDH1 mutation is an important prognostic marker in glioma. However, its regulatory mechanism in glioma remains incomplet...

Therapeutic potential of oleic acid supplementation in myotonic dystrophy muscle cell models

We recently reported that upregulation of Musashi 2 (MSI2) protein in the rare neuromuscular disease myotonic dystrophy type 1 contributes to the hyperactivation of the muscle catabolic processes autophagy and...

Dorsal root ganglion-derived exosomes deteriorate neuropathic pain by activating microglia via the microRNA-16-5p/HECTD1/HSP90 axis

The activated microglia have been reported as pillar factors in neuropathic pain (NP) pathology, but the molecules driving pain-inducible microglial activation require further exploration. In this study, we in...

MicroRNA-721 regulates gluconeogenesis via KDM2A-mediated epigenetic modulation in diet-induced insulin resistance in C57BL/6J mice

Aberrant gluconeogenesis is considered among primary drivers of hyperglycemia under insulin resistant conditions, with multiple studies pointing towards epigenetic dysregulation. Here we examine the role of mi...

Combined transcriptomics and proteomics unveil the impact of vitamin C in modulating specific protein abundance in the mouse liver

Vitamin C (ascorbate) is a water-soluble antioxidant and an important cofactor for various biosynthetic and regulatory enzymes. Mice can synthesize vitamin C thanks to the key enzyme gulonolactone oxidase (Gul...

Novel role of LLGL2 silencing in autophagy: reversing epithelial-mesenchymal transition in prostate cancer

Prostate cancer (PCa) is a major urological disease that is associated with significant morbidity and mortality in men. LLGL2 is the mammalian homolog of Lgl. It acts as a tumor suppressor in breast and hepati...

Rapid development and mass production of SARS-CoV-2 neutralizing chicken egg yolk antibodies with protective efficacy in hamsters

Despite the record speed of developing vaccines and therapeutics against the SARS-CoV-2 virus, it is not a given that such success can be secured in future pandemics. In addition, COVID-19 vaccination and appl...

High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats

Obesity, associated with the intake of a high-fat diet (HFD), and anxiety are common among those living in modern urban societies. Recent studies suggest a role of microbiome-gut-brain axis signaling, includin...

General regulatory factors exert differential effects on nucleosome sliding activity of the ISW1a complex

Chromatin dynamics is deeply involved in processes that require access to DNA, such as transcriptional regulation. Among the factors involved in chromatin dynamics at gene regulatory regions are general regula...

Establishment of primary prostate epithelial and tumorigenic cell lines using a non-viral immortalization approach

Research on prostate cancer is mostly performed using cell lines derived from metastatic disease, not reflecting stages of tumor initiation or early progression. Establishment of cancer cell lines derived from...

The effect of diabetes mellitus on differentiation of mesenchymal stem cells into insulin-producing cells

Diabetes mellitus (DM) is a global epidemic with increasing incidences. DM is a metabolic disease associated with chronic hyperglycemia. Aside from conventional treatments, there is no clinically approved cure...

Control of astrocytic Ca 2+ signaling by nitric oxide-dependent S-nitrosylation of Ca 2+ homeostasis modulator 1 channels

Astrocytes Ca 2+ signaling play a central role in the modulation of neuronal function. Activation of metabotropic glutamate receptors (mGluR) by glutamate released during an increase in synaptic activity triggers ...

Increased levels and activation of the IL-17 receptor in microglia contribute to enhanced neuroinflammation in cerebellum of hyperammonemic rats

Patients with liver cirrhosis may show minimal hepatic encephalopathy (MHE) with mild cognitive impairment and motor incoordination. Rats with chronic hyperammonemia reproduce these alterations. Motor incoordi...

Identification and expression analysis of two steamer-like retrotransposons in the Chilean blue mussel ( Mytilus chilensis )

Disseminated neoplasia (DN) is a proliferative cell disorder of the circulatory system of bivalve mollusks. The disease is transmitted between individuals and can also be induced by external chemical agents su...

Noncoding RNAs in skeletal development and disorders

Protein-encoding genes only constitute less than 2% of total human genomic sequences, and 98% of genetic information was previously referred to as “junk DNA”. Meanwhile, non-coding RNAs (ncRNAs) consist of app...

Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage

Alcohol, a widely abused drug, significantly diminishes life quality, causing chronic diseases and psychiatric issues, with severe health, societal, and economic repercussions. Previously, we demonstrated that...

Galectins in epithelial-mesenchymal transition: roles and mechanisms contributing to tissue repair, fibrosis and cancer metastasis

Galectins are soluble glycan-binding proteins that interact with a wide range of glycoproteins and glycolipids and modulate a broad spectrum of physiological and pathological processes. The expression and subc...

Glutaminolysis regulates endometrial fibrosis in intrauterine adhesion via modulating mitochondrial function

Endometrial fibrosis, a significant characteristic of intrauterine adhesion (IUA), is caused by the excessive differentiation and activation of endometrial stromal cells (ESCs). Glutaminolysis is the metabolic...

The long-chain flavodoxin FldX1 improves the biodegradation of 4-hydroxyphenylacetate and 3-hydroxyphenylacetate and counteracts the oxidative stress associated to aromatic catabolism in Paraburkholderia xenovorans

Bacterial aromatic degradation may cause oxidative stress. The long-chain flavodoxin FldX1 of Paraburkholderia xenovorans LB400 counteracts reactive oxygen species (ROS). The aim of this study was to evaluate the...

MicroRNA-148b secreted by bovine oviductal extracellular vesicles enhance embryo quality through BPM/TGF-beta pathway

Extracellular vesicles (EVs) and their cargoes, including MicroRNAs (miRNAs) play a crucial role in cell-to-cell communication. We previously demonstrated the upregulation of bta-mir-148b in EVs from oviductal...

YME1L-mediated mitophagy protects renal tubular cells against cellular senescence under diabetic conditions

The senescence of renal tubular epithelial cells (RTECs) is crucial in the progression of diabetic kidney disease (DKD). Accumulating evidence suggests a close association between insufficient mitophagy and RT...

Effects of latroeggtoxin-VI on dopamine and α-synuclein in PC12 cells and the implications for Parkinson’s disease

Parkinson’s disease (PD) is characterized by death of dopaminergic neurons leading to dopamine deficiency, excessive α-synuclein facilitating Lewy body formation, etc. Latroeggtoxin-VI (LETX-VI), a proteinaceo...

Glial-restricted progenitor cells: a cure for diseased brain?

The central nervous system (CNS) is home to neuronal and glial cells. Traditionally, glia was disregarded as just the structural support across the brain and spinal cord, in striking contrast to neurons, alway...

Carbapenem-resistant hypervirulent ST23 Klebsiella pneumoniae with a highly transmissible dual-carbapenemase plasmid in Chile

The convergence of hypervirulence and carbapenem resistance in the bacterial pathogen Klebsiella pneumoniae represents a critical global health concern. Hypervirulent K. pneumoniae (hvKp) strains, frequently from...

Endometrial mesenchymal stromal/stem cells improve regeneration of injured endometrium in mice

The monthly regeneration of human endometrial tissue is maintained by the presence of human endometrial mesenchymal stromal/stem cells (eMSC), a cell population co-expressing the perivascular markers CD140b an...

Embryo development is impaired by sperm mitochondrial-derived ROS

Basal energetic metabolism in sperm, particularly oxidative phosphorylation, is known to condition not only their oocyte fertilising ability, but also the subsequent embryo development. While the molecular pat...

Fibroblasts inhibit osteogenesis by regulating nuclear-cytoplasmic shuttling of YAP in mesenchymal stem cells and secreting DKK1

Fibrous scars frequently form at the sites of bone nonunion when attempts to repair bone fractures have failed. However, the detailed mechanism by which fibroblasts, which are the main components of fibrous sc...

MSC-derived exosomes protect auditory hair cells from neomycin-induced damage via autophagy regulation

Sensorineural hearing loss (SNHL) poses a major threat to both physical and mental health; however, there is still a lack of effective drugs to treat the disease. Recently, novel biological therapies, such as ...

Alpha-synuclein dynamics bridge Type-I Interferon response and SARS-CoV-2 replication in peripheral cells

Increasing evidence suggests a double-faceted role of alpha-synuclein (α-syn) following infection by a variety of viruses, including SARS-CoV-2. Although α-syn accumulation is known to contribute to cell toxic...

Lactadherin immunoblockade in small extracellular vesicles inhibits sEV-mediated increase of pro-metastatic capacities

Tumor-derived small extracellular vesicles (sEVs) can promote tumorigenic and metastatic capacities in less aggressive recipient cells mainly through the biomolecules in their cargo. However, despite recent ad...

Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndrome

Growing evidence has suggested that Type I Interferon (I-IFN) plays a potential role in the pathogenesis of Down Syndrome (DS). This work investigates the underlying function of MX1, an effector gene of I-IFN,...

The novel roles of YULINK in the migration, proliferation and glycolysis of pulmonary arterial smooth muscle cells: implications for pulmonary arterial hypertension

Abnormal remodeling of the pulmonary vasculature, characterized by the proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs) along with dysregulated glycolysis, is a pathognomonic feat...

Electroacupuncture promotes neurogenesis in the dentate gyrus and improves pattern separation in an early Alzheimer's disease mouse model

Impaired pattern separation occurs in the early stage of Alzheimer’s disease (AD), and hippocampal dentate gyrus (DG) neurogenesis participates in pattern separation. Here, we investigated whether spatial memo...

Role of SYVN1 in the control of airway remodeling in asthma protection by promoting SIRT2 ubiquitination and degradation

Asthma is a heterogenous disease that characterized by airway remodeling. SYVN1 (Synoviolin 1) acts as an E3 ligase to mediate the suppression of endoplasmic reticulum (ER) stress through ubiquitination and de...

Advances towards the use of gastrointestinal tumor patient-derived organoids as a therapeutic decision-making tool

In December 2022 the US Food and Drug Administration (FDA) removed the requirement that drugs in development must undergo animal testing before clinical evaluation, a declaration that now demands the establish...

Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression

Atherosclerosis (AS), a significant contributor to cardiovascular disease (CVD), is steadily rising with the aging of the global population. Pyroptosis and apoptosis, both caspase-mediated cell death mechanism...

Prenatal ethanol exposure and changes in fetal neuroendocrine metabolic programming

Prenatal ethanol exposure (PEE) (mainly through maternal alcohol consumption) has become widespread. However, studies suggest that it can cause intrauterine growth retardation (IUGR) and multi-organ developmen...

Autologous non-invasively derived stem cells mitochondria transfer shows therapeutic advantages in human embryo quality rescue

The decline in the quantity and quality of mitochondria are closely associated with infertility, particularly in advanced maternal age. Transferring autologous mitochondria into the oocytes of infertile female...

Development of synthetic modulator enabling long-term propagation and neurogenesis of human embryonic stem cell-derived neural progenitor cells

Neural progenitor cells (NPCs) are essential for in vitro drug screening and cell-based therapies for brain-related disorders, necessitating well-defined and reproducible culture systems. Current strategies em...

Heat-responsive microRNAs participate in regulating the pollen fertility stability of CMS-D2 restorer line under high-temperature stress

Anther development and pollen fertility of cytoplasmic male sterility (CMS) conditioned by Gossypium harknessii cytoplasm (CMS-D2) restorer lines are susceptible to continuous high-temperature (HT) stress in sum...

Chemogenetic inhibition of NTS astrocytes normalizes cardiac autonomic control and ameliorate hypertension during chronic intermittent hypoxia

Obstructive sleep apnea (OSA) is characterized by recurrent episodes of chronic intermittent hypoxia (CIH), which has been linked to the development of sympathoexcitation and hypertension. Furthermore, it has ...

SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca 2+ dynamics

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the ongoing coronavirus disease 2019 (COVID-19). An aspect of high uncertainty is whether the SARS-CoV-2 per se or the systemic inflammation ...

The effect of zofenopril on the cardiovascular system of spontaneously hypertensive rats treated with the ACE2 inhibitor MLN-4760

Angiotensin converting enzyme 2 (ACE2) plays a crucial role in the infection cycle of SARS-CoV-2 responsible for formation of COVID-19 pandemic. In the cardiovascular system, the virus enters the cells by bind...

Two murine models of sepsis: immunopathological differences between the sexes—possible role of TGFβ1 in female resistance to endotoxemia

Endotoxic shock (ExSh) and cecal ligature and puncture (CLP) are models that induce sepsis. In this work, we investigated early immunologic and histopathologic changes induced by ExSh or CLP models in female a...

An intracellular, non-oxidative factor activates in vitro chromatin fragmentation in pig sperm

In vitro incubation of epididymal and vas deferens sperm with Mn 2+ induces Sperm Chromatin Fragmentation (SCF), a mechanism that causes double-stranded breaks in toroid-linker regions (TLRs). Whether this mechani...

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Collection  12 March 2020

Top 50 Life and Biological Sciences Articles

We are pleased to share with you the 50 most read Nature Communications  articles* in life and biological sciences published in 2019. Featuring authors from around the world, these papers highlight valuable research from an international community.

Browse all Top 50 subject area collections here .

*Based on data from Google Analytics, covering January-December 2019 (data has been normalised to account for articles published later in the year)

Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income

Household income is used as a marker of socioeconomic position, a trait that is associated with better physical and mental health. Here, Hill et al. report a genome-wide association study for household income in the UK and explore its relationship with intelligence in post-GWAS analyses including Mendelian randomization.

• W. David Hill
• Neil M. Davies
• Ian J. Deary

A 5700 year-old human genome and oral microbiome from chewed birch pitch

Birch pitch is thought to have been used in prehistoric times as hafting material or antiseptic and tooth imprints suggest that it was chewed. Here, the authors report a 5,700 year-old piece of chewed birch pitch from Denmark from which they successfully recovered a complete ancient human genome and oral microbiome DNA.

• Theis Z. T. Jensen
• Jonas Niemann
• Hannes Schroeder

A short translational ramp determines the efficiency of protein synthesis

Several factors contribute to the efficiency of protein expression. Here the authors show that the identity of amino acids encoded by codons at position 3–5 significantly impact translation efficiency and protein expression levels.

• Manasvi Verma
• Junhong Choi
• Sergej Djuranovic

Early coauthorship with top scientists predicts success in academic careers

By examining publication records of scientists from four disciplines, the authors show that coauthoring a paper with a top-cited scientist early in one's career predicts lasting increases in career success, especially for researchers affiliated with less prestigious institutions.

• Tomaso Aste
• Giacomo Livan

Ancient DNA from the skeletons of Roopkund Lake reveals Mediterranean migrants in India

Remains of several hundred humans are scattered around Roopkund Lake, situated over 5,000 meters above sea level in the Himalayan Mountains. Here the authors analyze genome-wide data from 38 skeletons and find 3 clusters with different ancestries and dates, showing the people were desposited in multiple catastrophic events.

• Éadaoin Harney
• Ayushi Nayak

Ketamine can reduce harmful drinking by pharmacologically rewriting drinking memories

Memories linking environmental cues to alcohol reward are involved in the development and maintenance of heavy drinking. Here, the authors show that a single dose of ketamine, given after retrieval of alcohol-reward memories, disrupts the reconsolidation of these memories and reduces drinking in humans.

• Ravi K. Das
• Sunjeev K. Kamboj

Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

Here, the authors show that sequential treatment with long-acting slow-effective release ART and AAV9- based delivery of CRISPR-Cas9 results in undetectable levels of virus and integrated DNA in a subset of humanized HIV-1 infected mice. This proof-of-concept study suggests that HIV-1 elimination is possible.

• Prasanta K. Dash
• Rafal Kaminski
• Howard E. Gendelman

XX sex chromosome complement promotes atherosclerosis in mice

Men and women differ in their risk of developing coronary artery disease, in part due to differences in their levels of sex hormones. Here, AlSiraj et al. show that the XX sex genotype regulates lipid metabolism and promotes atherosclerosis independently of sex hormones in mice.

• Yasir AlSiraj
• Lisa A. Cassis

Early-career setback and future career impact

Little is known about the long-term effects of early-career setback. Here, the authors compare junior scientists who were awarded a NIH grant to those with similar track records, who were not, and find that individuals with the early setback systematically performed better in the longer term.

• Benjamin F. Jones
• Dashun Wang

Ideological differences in the expanse of the moral circle

How do liberals and conservatives differ in their expression of compassion and moral concern? The authors show that conservatives tend to express concern toward smaller, more well-defined, and less permeable social circles, while liberals express concern toward larger, less well-defined, and more permeable social circles.

• Jesse Graham

A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

Biomarkers that predict mortality are of interest for clinical as well as research applications. Here, the authors analyze metabolomics data from 44,168 individuals and identify key metabolites independently associated with all-cause mortality risk.

• Joris Deelen
• Johannes Kettunen
• P. Eline Slagboom

New insects feeding on dinosaur feathers in mid-Cretaceous amber

Numerous feathered dinosaurs and early birds have been discovered from the Jurassic and Cretaceous, but the early evolution of feather-feeding insects is not clear. Here, Gao et al. describe a new family of ectoparasitic insects from 10 specimens found associated with feathers in mid-Cretaceous amber.

• Taiping Gao
• Xiangchu Yin

Acoustic enrichment can enhance fish community development on degraded coral reef habitat

Healthy coral reefs have an acoustic signature known to be attractive to coral and fish larvae during settlement. Here the authors use playback experiments in the field to show that healthy reef sounds can increase recruitment of juvenile fishes to degraded coral reef habitat, suggesting that acoustic playback could be used as a reef management strategy.

• Timothy A. C. Gordon
• Andrew N. Radford
• Stephen D. Simpson

Phagocytosis-like cell engulfment by a planctomycete bacterium

Phagocytosis is a typically eukaryotic feature that could be behind the origin of eukaryotic cells. Here, the authors describe a bacterium that can engulf other bacteria and small eukaryotic cells through a phagocytosis-like mechanism.

• Takashi Shiratori
• Shigekatsu Suzuki
• Ken-ichiro Ishida

Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation

The neural mechanisms that lead to a relative deficit in memory retrieval in the afternoon are unclear. Here, the authors show that the circadian - dependent transcription factor BMAL1 regulates retrieval through dopamine and glutamate receptor phosphorylation.

• Shunsuke Hasegawa
• Hotaka Fukushima
• Satoshi Kida

Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets

Integrating independent large-scale pharmacogenomic screens can enable unprecedented characterization of genetic vulnerabilities in cancers. Here, the authors show that the two largest independent CRISPR-Cas9 gene-dependency screens are concordant, paving the way for joint analysis of the data sets.

• Joshua M. Dempster
• Clare Pacini
• Francesco Iorio

Phylogenomics of 10,575 genomes reveals evolutionary proximity between domains Bacteria and Archaea

The authors build a reference phylogeny of 10,575 evenly-sampled bacterial and archaeal genomes, based on 381 markers. The results indicate a remarkably closer evolutionary proximity between Archaea and Bacteria than previous estimates that used fewer “core” genes, such as the ribosomal proteins.

Pan-cancer molecular subtypes revealed by mass-spectrometry-based proteomic characterization of more than 500 human cancers

Mass-spectrometry-based profiling can be used to stratify tumours into molecular subtypes. Here, by classifying over 500 tumours, the authors show that this approach reveals proteomic subgroups which cut across tumour types.

• Fengju Chen
• Darshan S. Chandrashekar
• Chad J. Creighton

CRISPR-Switch regulates sgRNA activity by Cre recombination for sequential editing of two loci

Inducible genome editing systems often suffer from leakiness or reduced activity. Here the authors develop CRISPR-Switch, a Cre recombinase ON/OFF-controlled sgRNA cassette that allows consecutive editing of two loci.

• Krzysztof Chylinski
• Maria Hubmann
• Ulrich Elling

CRISPR-Cas3 induces broad and unidirectional genome editing in human cells

Class 1 CRISPR systems are not as developed for genome editing as Class 2 systems are. Here the authors show that Cas3 can be used to generate functional knockouts and knock-ins, as well as Cas3-mediated exon-skipping in DMD cells.

• Hiroyuki Morisaka
• Kazuto Yoshimi
• Tomoji Mashimo

Genetic evidence for assortative mating on alcohol consumption in the UK Biobank

From observational studies, alcohol consumption behaviours are known to be correlated in spouses. Here, Howe et al. use partners’ genotypic information in a Mendelian randomization framework and show that a SNP in the ADH1B gene associates with partner’s alcohol consumption, suggesting that alcohol consumption affects mate choice.

• Laurence J. Howe
• Daniel J. Lawson
• Gibran Hemani

The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy

While the cellular recycling process autophagy has been linked to aging, the impact of selective autophagy on lifespan remains unclear. Here Kumsta et al. show that the autophagy receptor p62/SQSTM1 is required for hormetic benefits and p62/SQSTM1 overexpression is sufficient to extend C. elegans lifespan and improve proteostasis.

• Caroline Kumsta
• Jessica T. Chang
• Malene Hansen

The coincidence of ecological opportunity with hybridization explains rapid adaptive radiation in Lake Mweru cichlid fishes

Recent studies have suggested that hybridization can facilitate adaptive radiations. Here, the authors show that opportunity for hybridization differentiates Lake Mweru, where cichlids radiated, and Lake Bangweulu, where cichlids did not radiate despite ecological opportunity in both lakes.

• Joana I. Meier
• Rike B. Stelkens
• Ole Seehausen

Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases

Gut microbiota alterations, including enrichment of flagellated bacteria, are associated with metabolic syndrome and chronic inflammatory diseases. Here, Tran et al. show, in mice, that elicitation of mucosal anti-flagellin antibodies protects against experimental colitis and ameliorates diet-induced obesity.

• Hao Q. Tran
• Ruth E. Ley
• Benoit Chassaing

Possible role of L-form switching in recurrent urinary tract infection

The reservoir for recurrent urinary tract infection in humans is unclear. Here, Mickiewicz et al. detect cell-wall deficient (L-form) E. coli in fresh urine from patients, and show that the isolated bacteria readily switch between walled and L-form states.

• Katarzyna M. Mickiewicz
• Yoshikazu Kawai
• Jeff Errington

Dual microglia effects on blood brain barrier permeability induced by systemic inflammation

Although it is known that microglia respond to injury and systemic disease in the brain, it is unclear if they modulate blood–brain barrier (BBB) integrity, which is critical for regulating neuroinflammatory responses. Here authors demonstrate that microglia respond to inflammation by migrating towards and accumulating around cerebral vessels, where they initially maintain BBB integrity via expression of the tight-junction protein Claudin-5 before switching, during sustained inflammation, to phagocytically remove astrocytic end-feet resulting in impaired BBB function

• Koichiro Haruwaka
• Ako Ikegami
• Hiroaki Wake

Mice with hyper-long telomeres show less metabolic aging and longer lifespans

Telomere shortening is associated with aging. Here the authors analyze mice with hyperlong telomeres and demonstrate that longer telomeres than normal have beneficial effects such as delayed metabolic aging, increased longevity and less incidence of cancer.

• Miguel A. Muñoz-Lorente
• Alba C. Cano-Martin
• Maria A. Blasco

Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture

Organoid cultures have been developed from multiple tissues, opening new possibilities for regenerative medicine. Here the authors demonstrate the derivation of GMP-compliant hydrogels from decellularized porcine small intestine which support formation and growth of human gastric, liver, pancreatic and small intestinal organoids.

• Giovanni Giuseppe Giobbe
• Claire Crowley
• Paolo De Coppi

Engineered E. coli Nissle 1917 for the delivery of matrix-tethered therapeutic domains to the gut

Anti-inflammatory treatments for gastrointestinal diseases can often have detrimental side effects. Here the authors engineer E. coli Nissle 1917 to create a fibrous matrix that has a protective effect in DSS-induced colitis mice.

• Pichet Praveschotinunt
• Anna M. Duraj-Thatte
• Neel S. Joshi

Ambient black carbon particles reach the fetal side of human placenta

Exposure to air pollution during pregnancy has been associated with impaired birth outcomes. Here, Bové et al. report evidence of black carbon particle deposition on the fetal side of human placentae, including at early stages of pregnancy, suggesting air pollution could affect birth outcome through direct effects on the fetus.

• Hannelore Bové
• Eva Bongaerts
• Tim S. Nawrot

Real-time decoding of question-and-answer speech dialogue using human cortical activity

Speech neuroprosthetic devices should be capable of restoring a patient’s ability to participate in interactive dialogue. Here, the authors demonstrate that the context of a verbal exchange can be used to enhance neural decoder performance in real time.

• David A. Moses
• Matthew K. Leonard
• Edward F. Chang

In-cell identification and measurement of RNA-protein interactions

RNA-interacting proteome can be identified by RNA affinity purification followed by mass spectrometry. Here the authors developed a different RNA-centric technology that combines high-throughput immunoprecipitation of RNA binding proteins and luciferase-based detection of their interaction with the RNA.

• Antoine Graindorge
• Inês Pinheiro
• Alena Shkumatava

A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus

Genedrives bias the inheritance of alleles in diploid organisms. Here, the authors develop a gene-drive analogous system for bacteria, selectively editing and clearing plasmids.

• J. Andrés Valderrama
• Surashree S. Kulkarni

Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort

The studies showing health benefits of flavonoids and their impact on cancer mortality are incomplete. Here, the authors perform a prospective cohort study in Danish participants and demonstrate an inverse association between regular flavonoid intake and both cardiovascular and cancer related mortality.

• Nicola P. Bondonno
• Frederik Dalgaard
• Jonathan M. Hodgson

Senescent cell turnover slows with age providing an explanation for the Gompertz law

One of the underlying causes of aging is the accumulation of senescent cells, but their turnover rates and dynamics during ageing are unknown. Here the authors measure and model senescent cell production and removal and explore implications for mortality.

• Amit Agrawal

Optimizing agent behavior over long time scales by transporting value

People are able to mentally time travel to distant memories and reflect on the consequences of those past events. Here, the authors show how a mechanism that connects learning from delayed rewards with memory retrieval can enable AI agents to discover links between past events to help decide better courses of action in the future.

• Chia-Chun Hung
• Timothy Lillicrap

Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway

Ageing is associated with clonal hematopoiesis of indeterminate potential (CHIP), which is linked to increased risks of hematological malignancies. Here the authors uncover an epigenetic mechanism through which mutant p53 drives clonal hematopoiesis through interaction with EZH2.

A systematic evaluation of single cell RNA-seq analysis pipelines

There has been a rapid rise in single cell RNA-seq methods and associated pipelines. Here the authors use simulated data to systematically evaluate the performance of 3000 possible pipelines to derive recommendations for data processing and analysis of different types of scRNA-seq experiments.

• Beate Vieth
• Swati Parekh
• Ines Hellmann

Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue

Alzheimer’s disease is characterised by the deposition of Aβ amyloid fibrils and tau protein neurofibrillary tangles. Here the authors use cryo-EM to structurally characterise brain derived Aβ amyloid fibrils and find that they are polymorphic and right-hand twisted, which differs from in vitro generated Aβ fibrils.

• Marius Kollmer
• William Close
• Marcus Fändrich

Droplet Tn-Seq combines microfluidics with Tn-Seq for identifying complex single-cell phenotypes

Culturing transposon-mutant libraries in pools can mask complex phenotypes. Here the authors present microfluidics mediated droplet Tn-Seq, which encapsulates individual mutants, promotes isolated growth and enables cell-cell interaction analyses.

• Derek Thibault
• Paul A. Jensen
• Tim van Opijnen

An artificial metalloenzyme biosensor can detect ethylene gas in fruits and Arabidopsis leaves

Existing methods to detect ethylene in plant tissue typically require gas chromatography or use ethylene-dependent gene expression as a proxy. Here Vong et al . show that an artificial metalloenzyme-based ethylene probe can be used to detect ethylene in plants with improved spatiotemporal resolution.

• Kenward Vong
• Katsunori Tanaka

Artificially cloaked viral nanovaccine for cancer immunotherapy

Cancer therapy using oncolytic virus has shown pre-clinical and clinical efficacy. Here, the authors report ExtraCRAd, an oncolytic virus cloaked with tumour cell membrane and report its therapeutic effects in vitro and in vivo in multiple mouse tumour models.

• Manlio Fusciello
• Flavia Fontana
• Vincenzo Cerullo

A transposable element insertion is associated with an alternative life history strategy

Tradeoffs are central to life history theory and evolutionary biology, yet almost nothing is known about their mechanistic basis. Here the authors characterize one such mechanism and find a transposable element insertion is associated with the switch between alternative life history strategies.

• Alyssa Woronik
• Kalle Tunström
• Christopher W. Wheat

Patterns of genetic differentiation and the footprints of historical migrations in the Iberian Peninsula

The Iberian Peninsula has a complex history. Here, the authors analyse the genetic structure of the modern Iberian population at fine scale, revealing historical population movements associated with the time of Muslim rule.

• Clare Bycroft
• Ceres Fernandez-Rozadilla
• Simon Myers

Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease

Immune cells are shaped by the tissue environment, yet the states of healthy human T cells are mainly studied in the blood. Here, the authors perform single cell RNA-seq of T cells from tissues and blood of healthy donors and show its utility as a reference map for comparison of human T cell states in disease.

• Peter A. Szabo
• Hanna Mendes Levitin
• Peter A. Sims

Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke

Stroke risk is influenced by genetic and lifestyle factors and previously a genomic risk score (GRS) for stroke was proposed, albeit with limited predictive power. Here, Abraham et al. develop a metaGRS that is composed of several stroke-related GRSs and demonstrate improved predictive power compared with individual GRS or classic risk factors.

• Gad Abraham
• Rainer Malik
• Martin Dichgans

Mitochondrial oxidative capacity and NAD + biosynthesis are reduced in human sarcopenia across ethnicities

Sarcopenia is the loss of muscle mass and strength associated with physical disability during ageing. Here, the authors analyse muscle biopsies from 119 patients with sarcopenia and age-matched controls of different ethnic groups and find transcriptional signatures indicating mitochondrial dysfunction, associated with reduced mitochondria numbers and lower NAD +  levels in older individuals with sarcopenia.

• Eugenia Migliavacca
• Stacey K. H. Tay
• Jerome N. Feige

NAD + augmentation restores mitophagy and limits accelerated aging in Werner syndrome

The molecular mechanisms of mitochondrial dysfunction in the premature ageing Werner syndrome were elusive. Here the authors show that NAD + depletion-induced impaired mitophagy contributes to this phenomenon, shedding light on potential therapeutics.

• Evandro F. Fang
• Vilhelm A. Bohr

Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells

Single strand breaks represent the most common form of DNA damage yet no methods to map them in a genome-wide fashion at single nucleotide resolution exist. Here the authors develop such a method and apply to uncover patterns of single-strand DNA “breakome” in different biological conditions.

• Lorena Salazar-García
• Philipp Kapranov

Evaluation of 16S rRNA gene sequencing for species and strain-level microbiome analysis

Here, the authors explore the potential of the 16S gene for discriminating bacterial taxa and show that full-length sequencing combined with appropriate clustering of intragenomic sequence variation can provide accurate representation of bacterial species in microbiome datasets.

• Jethro S. Johnson
• Daniel J. Spakowicz
• George M. Weinstock

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May 21, 2024

Can plague be transmitted by louse bite?

Yersinia pestis , the causative agent of plague, uses fleas and rodents as vectors for transmission. David Bland, Joseph Hinnebusch and colleagues report a new vector for Y. pestis , showing that it can infect the Pawlowsky glands of human body lice and be transmitted by louse bite.

Image credit: David M Bland

PLOS Biologue

Community blog for plos biology, plos genetics and plos computational biology..

Research Article

Ejaculation, mating effort and life history trade-offs

Theory assumes that allocation to pre- and post-copulatory sexual traits draws from a common pool of resources, creating equivalent life-history trade-offs. However, Meng-Han Joseph Chung, Rebecca Fox and Michael Jennions use a novel experiment with mosquitofish to reveal independent costs of mating effort and sperm allocation on subsequent male performance.

Image credit: Andrew Kahn

Recently Published Articles

• Assessing the evolution of research topics in a biological field using plant science as an example
• Leveraging interindividual variability in threat conditioning of inbred mice to model trait anxiety
• Integrating phylogenies into single-cell RNA sequencing analysis allows comparisons across species, genes, and cells

Current Issue April 2024

Meta-Research Article

Evolution of research topics in plant science

Our ability to understand the progress of science through the evolution of research topics is limited by the need for specialist knowledge and the exponential growth of the literature. Shin-Han Shiu and Melissa Lehti-Shiu use artificial intelligence and machine learning approaches to demonstrate how a biological field (plant science) has evolved, how the model systems have changed, and how countries differ in terms of research focus and impact.

Image credit: pbio.3002612

Novel PROTAC moiety for CRL4 DCAF11 E3 ligase

Targeted protein degradation strategies are promising avenues for drug development, but it is important to broaden the toolbox of E3 ligases that can be engaged. Ying Wang, Tianzi Wei, Man Zhao, Liang Hong, Rui Wang, Ruilin Tian, Guofeng Li and co-workers shows that alkenyl oxindole compounds act as novel E3 ligase ligands and recruit the CRL4-DCAF11 E3 ubiquitin ligase complex for substrate degradation.

Image credit: pbio.3002550

Driving action observation and execution

Neuronal activity during action execution and action observation is ubiquitous in the primate brain but what minimal visual features drive this activity? Sofie De Schrijver, Thomas Decramer and Peter Janssen show that neurons active during action observation and action execution respond to surprisingly simple visual stimuli which do not contain any meaningful action.

Image credit: pbio.3002358

Robust genetic codes boost evolution

Does the robustness of the standard genetic code accelerate or impede adaptive evolution? Hana Rozhoňová, Joshua Payne and colleagues use experimental data from six massively parallel sequence-to-function assays for four proteins to show that robust genetic codes enhance protein evolvability by producing smooth adaptive landscapes with few peaks. Don’t miss the related Primer .

Image credit: pbio.3002594

Help or punish?

In third-party interventions, people tend to get involved in others’ injustices by either punishing the transgressor or helping the victim. Huagen Wang, Shaozheng Qin, Chao Liu and co-workers show that acute stress decreases the third party’s willingness to punish the violator and increases their willingness to help the victim. Read more details in the associated Primer.

Image credit: pbio.3002195

Integrating phylogenies into single-cell RNA data

Samuel Church, Jasmine Mah and Casey Dunn argue that, by integrating phylogenetic approaches into scRNA-seq analyses, hypotheses about gene and cell evolution can be robustly tested.

Image credit: pbio.3002633

"Nature's Strongholds" and the 30x30 target

The 2022 GBF set out to conserve a global area of 30% by 2030. This Essay provides a framework for area-based conservation that prioritizes "Nature's Strongholds", arguing that these are disproportionately important for biodiversity conservation.

Image credit: Omar Torrico

Synteny in phylogenomics

Reconstructing the tree of life is a central goal in biology. Jacob Steenwyk and Nicole King discuss the use of synteny for reconstructing the tree of life and propose a roadmap for conducting rigorous and accurate synteny-based phylogenomic analysis.

Image credit: pbio.3002632

Unsolved Mystery

How do endosymbionts work with so few genes?

This Unsolved Mystery article explores how genome reduction alters endosymbiont biology and highlights a ‘tipping point’ where the loss of the ability to build a cell envelope coincides with a marked erosion of translation-related genes.

Image credit: pbio.3002577

Symbiosis across the tree of life

Symbiosis research has become a holistic and pervasive field with a mature theoretical basis. This collection showcases symbiotic relationships across the tree of life, exploring their evolutionary basis and underlying mechanisms.

PLOS Biology 20th Anniversary

PLOS Biology is 20 and we are celebrating with a collection that contains articles that look back at landmark studies that we published, others that look past and future, and others discussing how publishing and open science have evolved and what is to come.

Engineering plants for a changing climate

This collection explores engineering strategies to help us adapt plants to a changing climate, including breeding techniques, genome engineering, synthetic biology and microbiome engineering.

Going for green

The green collection explores biological solutions that could be applied to reduce CO2 emissions, get rid of non-degradable plastics, produce food in a sustainable manner or generate energy.

Ocean solutions for a sustainable, healthy and inclusive future

This collection explores potential solutions to mitigate the impacts of human activity on ocean ecosystems to minimize or reverse degradation.

CSHL: Brain Body Physiology

May 29 - Jun 2

Meet Senior Editor Luke Smith ([email protected])

GRC: Plant Communication: Understanding Signal Creation, Transmission, and Perception in Plant Systems

June 9 - 14

Meet Senior Editor Ines Alvarez-Garcia ([email protected])

AMS Microbe 2024

June 13 - 17

Meet Editor in Chief Nonia Pariente ([email protected])

EMBL: Innate immunity in host-pathogens interactions

June 18 - 21

Meet Associate Editor Melissa Vazquez Hernandez ([email protected])

FENS Forum 2024

June 24 - 29

Meet Senior Editor Christian Schnell ([email protected])

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Page 1 of 6

Endothelial adherens junctions and the actin cytoskeleton: an 'infinity net'?

A recent paper in BMC Biology reports that actin stress fibers in adjacent cultured endothelial cells are linked through adherens junctions. This organization might provide a super-cellular network that could ena...

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Robust and specific inhibition of microRNAs in Caenorhabditis elegans

MicroRNAs (miRNAs) are small non-coding RNAs that regulate the expression of numerous target genes. Yet, while hundreds of miRNAs have been identified, little is known about their functions. In a recent report...

Genome of a songbird unveiled

An international collaborative effort has recently uncovered the genome of the zebra finch, a songbird model that has provided unique insights into an array of biological phenomena.

The mathematics of sexual attraction

Pollen tubes follow attractants secreted by the ovules. In a recent paper in BMC Plant Biology , Stewman and colleagues have quantified the parameters of this attraction and used them to calibrate a mathematical m...

Diversity lost: are all Holarctic large mammal species just relict populations?

Population genetic analyses of Eurasian wolves published recently in BMC Evolutionary Biology suggest that a major genetic turnover took place in Eurasian wolves after the Pleistocene. These results add to the gr...

Hybridization and speciation in angiosperms: arole for pollinator shifts?

The majority of convincingly documented cases of hybridization in angiosperms has involved genetic introgression between the parental species or formation of a hybrid species with increased ploidy; however, ho...

Evolution underground: shedding light on the diversification of subterranean insects

A recent study in BMC Evolutionary Biology has reconstructed the molecular phylogeny of a large Mediterranean cave-dwelling beetle clade, revealing an ancient origin and strong geographic structuring. It seems li...

A modern circadian clock in the common angiosperm ancestor of monocots and eudicots

The circadian clock enhances fitness through temporal organization of plant gene expression, metabolism and physiology. Two recent studies, one in BMC Evolutionary Biology , demonstrate through phylogenetic analys...

Scale-eating cichlids: from hand(ed) to mouth

Two recent studies in BMC Biology and Evolution raise important questions about a textbook case of frequency-dependent selection in scale-eating cichlid fishes. They also suggest a fascinating new line of researc...

Top dogs: wolf domestication and wealth

A phylogeographic analysis of gene sequences important in determining body size in dogs, recently published in BMC Biology , traces the appearance of small body size to the Neolithic Middle East. This finding stre...

No better time to FRET: shedding light on host pathogen interactions

Understanding the spatio-temporal subversion of host cell signaling by bacterial virulence factors is key to combating infectious diseases. Following a recent study by Buntru and co-workers published in BMC Biolo...

Making progress in genetic kin recognition among vertebrates

A recent study in BMC Evolutionary Biology has shown that genetically similar individual ring-tailed lemurs are also more similar in their scent composition, suggesting a possible mechanism of kin recognition. Th...

Regeneration review reprise

There have been notable advances in the scientific understanding of regeneration within the past year alone, including two recently published in BMC Biology . Increasingly, progress in the regeneration field is be...

Acoel and platyhelminth models for stem-cell research

Acoel and platyhelminth worms are particularly attractive invertebrate models for stem-cell research because their bodies are continually renewed from large pools of somatic stem cells. Several recent studies,...

Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila

The TSC-22 domain family (TSC22DF) consists of putative transcription factors harboring a DNA-binding TSC-box and an adjacent leucine zipper at their carboxyl termini. Both short and long TSC22DF isoforms are ...

Bunched and Madm: a novel growth-regulatory complex?

By combining Drosophila genetics and proteomics Gluderer et al. report in this issue of Journal of Biology the isolation of a novel growth-regulatory complex consisting of Bunched and Madm. Future study of this c...

Q&A: What can microfluidics do for stem-cell research?

Regulation of metabolism in caenorhabditis elegans longevity.

The nematode Caenorhabditis elegans is a favorite model for the study of aging. A wealth of genetic and genomic studies show that metabolic regulation is a hallmark of life-span modulation. A recent study in BMC ...

Reprogramming of the non-coding transcriptome during brain development

A recent global analysis of gene expression during the differentiation of neuronal stem cells to neurons and oligodendrocytes indicates a complex pattern of changes in the expression of both protein-coding tra...

The THO complex as a key mRNP biogenesis factor in development and cell differentiation

The THO complex is a key component in the co-transcriptional formation of messenger ribonucleoparticles that are competent to be exported from the nucleus, yet its precise function is unknown. A recent study in B...

SnoPatrol: how many snoRNA genes are there?

Small nucleolar RNAs (snoRNAs) are among the most evolutionarily ancient classes of small RNA. Two experimental screens published in BMC Genomics expand the eukaryotic snoRNA catalog, but many more snoRNAs remain...

Sometimes one just isn't enough: do vertebrates contain an H2A.Z hyper-variant?

How much functional specialization can one component histone confer on a single nucleosome? The histone variant H2A.Z seems to be an extreme example. Genome-wide distribution maps show non-random (and evolutio...

Apical polarity in three-dimensional culture systems: where to now?

Delineation of the mechanisms that establish and maintain the polarity of epithelial tissues is essential to understanding morphogenesis, tissue specificity and cancer. Three-dimensional culture assays provide...

The water flea Daphnia - a 'new' model system for ecology and evolution?

Daphnia pulex is the first crustacean to have its genome sequenced. Availability of the genome sequence will have implications for research in aquatic ecology and evolution in particular, as addressed by a series...

Top ten in Journal of Biology in 2009: stem cells, influenza, pit bulls, Darwin, and more

The bacterial pathogen listeria monocytogenes : an emerging model in prokaryotic transcriptomics.

A major challenge in bacterial pathogenesis is understanding the molecular basis of the switch from saprophytism to virulence. Following a recent whole-genome transcriptomic analysis using tiling arrays, an ar...

Forward genetics in Tribolium castaneum : opening new avenues of research in arthropod biology

A recent paper in BMC Biology reports the first large-scale insertional mutagenesis screen in a non-drosophilid insect, the red flour beetle Tribolium castaneum . This screen marks the beginning of a non-biased, '...

Mapping the protistan 'rare biosphere'

The use of cultivation-independent approaches to map microbial diversity, including recent work published in BMC Biology , has now shown that protists, like bacteria/archaea, are much more diverse than had been re...

Scribble at the crossroads

Although proteins involved in determining apical-basal cell polarity have been directly linked to tumorigenesis, their precise roles in this process remain unclear. A recent report in BMC Biology clarifies the si...

Q&A: Quantitative approaches to planar polarity and tissue organization

Gene regulation, evolvability and the limits of genomics, the transcriptome of human monocyte subsets begins to emerge.

Human monocytes can be divided into subsets according to their expression or lack of the cell-surface antigen CD16. In papers published recently in the Journal of Proteome Research and in BMC Genomics , two groups...

Chromatin 'programming' by sequence - is there more to the nucleosome code than %GC?

The role of genomic sequence in directing the packaging of eukaryotic genomes into chromatin has been the subject of considerable recent debate. A new paper from Tillo and Hughes shows that the intrinsic therm...

Fishing for the signals that pattern the face

Zebrafish are a powerful system for studying the early embryonic events that form the skull and face, as a model for human craniofacial birth defects such as cleft palate. Signaling pathways that pattern the p...

Coordinated gene expression by post-transcriptional regulons in African trypanosomes

The regulation of gene expression in trypanosomes is unique. In the absence of transcriptional control at the level of initiation, a subset of Trypanosoma brucei genes form post-transcriptional regulons in which ...

Promoter architecture and the evolvability of gene expression

Evolutionary changes in gene expression are a main driver of phenotypic evolution. In yeast, genes that have rapidly diverged in expression are associated with particular promoter features, including the prese...

Adaptations of proteins to cellular and subcellular pH

Bioinformatics-based searches for correlations between subcellular localization and pI or charge distribution of proteins have failed to detect meaningful correlations. Recent work published in BMC Biology finds ...

TBP2 is a general transcription factor specialized for female germ cells

The complexity of the core promoter transcription machinery has emerged as an additional level of transcription regulation that is used during vertebrate development. Recent studies, including one published in BM...

Generalized immune activation as a direct result of activated CD4 + T cell killing

In addition to progressive CD4 + T cell immune deficiency, HIV infection is characterized by generalized immune activation, thought to arise from increased microbial exposure resulting from diminishing immunity.

Life and death as a T lymphocyte: from immune protection to HIV pathogenesis

Detailed analysis of T cell dynamics in humans is challenging and mouse models can be important tools for characterizing T cell dynamic processes. In a paper just published in Journal of Biology , Marques et al . s...

What we still don't know about AIDS

The gene complement of the ancestral bilaterian - was urbilateria a monster.

Expressed sequence tag analyses of the annelid Pomatoceros lamarckii , recently published in BMC Evolutionary Biology , are consistent with less extensive gene loss in the Lophotrochozoa than in the Ecdysozoa, but ...

The nature of cell-cycle checkpoints: facts and fallacies

The concept of checkpoint controls revolutionized our understanding of the cell cycle. Here we revisit the defining features of checkpoints and argue that failure to properly appreciate the concept is leading ...

An expanded evolutionary role for flower symmetry genes

CYCLOIDEA (CYC) -like TCP genes are critical for flower developmental patterning. Exciting recent breakthroughs, including a study by Song et al. published in BMC Evolutionary Biology , demonstrate that CYC -like ge...

Mechanisms of ubiquitin transfer by the anaphase-promoting complex

The anaphase-promoting complex (APC) is a ubiquitin-protein ligase required for the completion of mitosis in all eukaryotes. Recent mechanistic studies reveal how this remarkable enzyme combines specificity in...

Targeting TNF-α for cancer therapy

As the tumor vasculature is a key element of the tumor stroma, angiogenesis is the target of many cancer therapies. Recent work published in BMC Cell Biology describes a fusion protein that combines a peptide pre...

TEs or not TEs? That is the evolutionary question

Transposable elements (TEs) have contributed a wide range of functional sequences to their host genomes. A recent paper in BMC Molecular Biology discusses the creation of new transcripts by transposable element i...

Molecular machines or pleiomorphic ensembles: signaling complexes revisited

Signaling complexes typically consist of highly dynamic molecular ensembles that are challenging to study and to describe accurately. Conventional mechanical descriptions misrepresent this reality and can be a...

Ockham's broom: A new series

Adaptation by introgression.

Both selective and random processes can affect the outcome of natural hybridization. A recent analysis in BMC Evolutionary Biology of natural hybridization between an introduced and a native salamander reveals th...

Journal of Biology

ISSN: 1475-4924

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Page 1 of 24

Upregulated dual oxidase 1-induced oxidative stress and caspase-1-dependent pyroptosis reflect the etiologies of heart failure

Oxidative stress is implicated in the pathogenesis of heart failure. Dual oxidase 1 (DUOX1) might be important in heart failure development through its mediating role in oxidative stress. This study was design...

• View Full Text

Comparing chemical transfection, electroporation, and lentiviral vector transduction to achieve optimal transfection conditions in the Vero cell line

Transfection is an important analytical method for studying gene expression in the cellular environment. There are some barriers to efficient DNA transfection in host cells, including circumventing the plasma ...

High-fat diet enhances cell proliferation and compromises intestinal permeability in a translational canine intestinal organoid model

Emerging evidence underscores the responsiveness of the mammalian intestine to dietary cues, notably through the involvement of LGR5 + intestinal stem cells in orchestrating responses to diet-driven signals. H...

mTOR signaling pathway regulation HIF-1 α effects on LPS induced intestinal mucosal epithelial model damage

Sepsis-induced small-intestinal injury is associated with increased morbidity and mortality. Our previous study and other papers have shown that HIF-1α has a protective effect on intestinal mucosal injury in s...

Long non-coding RNA SOX2OT in tamoxifen-resistant breast cancer

Hormone receptor (HR)-positive breast cancer can become aggressive after developing hormone-treatment resistance. This study elucidated the role of long non-coding RNA (lncRNA) SOX2OT in tamoxifen-resistant (T...

Mice lacking DIO3 exhibit sex-specific alterations in circadian patterns of corticosterone and gene expression in metabolic tissues

Disruption of circadian rhythms is associated with neurological, endocrine and metabolic pathologies. We have recently shown that mice lacking functional type 3 deiodinase (DIO3), the enzyme that clears thyroi...

Optimization of seeding density of OP9 cells to improve hematopoietic differentiation efficiency

OP9 mouse stromal cell line has been widely used to induce differentiation of human embryonic stem cells (hESCs) into hematopoietic stem/progenitor cells (HSPCs). However, the whole co-culture procedure usuall...

Development of an in vitro human alveolar epithelial air-liquid interface model using a small molecule inhibitor cocktail

The alveolar epithelium is exposed to numerous stimuli, such as chemicals, viruses, and bacteria that cause a variety of pulmonary diseases through inhalation. Alveolar epithelial cells (AECs) cultured in vitr...

Mechanical stretch leads to increased caveolin-1 content and mineralization potential in extracellular vesicles from vascular smooth muscle cells

Hypertension-induced mechanical stress on vascular smooth muscle cells (VSMCs) is a known risk factor for vascular remodeling, including vascular calcification. Caveolin-1 (Cav-1), an integral structural compo...

Melatonin reduces lung injury in type 1 diabetic mice by the modulation of autophagy

In recent years, the role of autophagy has been highlighted in the pathogenesis of diabetes and inflammatory lung diseases. In this study, using a diabetic model of mice, we investigated the expression of auto...

TonEBP/NFAT5 expression is associated with cisplatin resistance and migration in macrophage-induced A549 cells

Macrophages promote angiogenesis, metastasis, and drug resistance in several cancers. Similarly, TonEBP/NFAT5 induces metastasis in renal carcinoma and colon cancer cells. However, the role of this transcripti...

Optimizing combination therapy in prostate cancer: mechanistic insights into the synergistic effects of Paclitaxel and Sulforaphane-induced apoptosis

Combination therapies in cancer treatment have demonstrated synergistic or additive outcomes while also reducing the development of drug resistance compared to monotherapy. This study explores the potential of...

CTC together with Shh and Nrf2 are prospective diagnostic markers for HNSCC

The lack of appropriate prognostic biomarkers remains a significant obstacle in the early detection of Head and Neck Squamous Cell Carcinoma (HNSCC), a cancer type with a high mortality rate. Despite considera...

Prioritization of Trypanosoma brucei editosome protein interactions interfaces at residue resolution through proteome-scale network analysis

Trypanosoma brucei is the causative agent for trypanosomiasis in humans and livestock, which presents a growing challenge due to drug resistance. While identifying novel drug targets is vital, the process is dela...

Sumoylation of SAP130 regulates its interaction with FAF1 as well as its protein stability and transcriptional repressor function

Fas-associated factor 1 (FAF1) is a multidomain protein that interacts with diverse partners to affect numerous cellular processes. Previously, we discovered two Small Ubiquitin-like Modifier (SUMO)-interactin...

Loss of Dec1 inhibits alcohol-induced hepatic lipid accumulation and circadian rhythm disorder

Chronic alcohol exposure increases liver damage such as lipid accumulation and hepatitis, resulting in hepatic cirrhosis. Chronic alcohol intake is known to disturb circadian rhythms in humans and animals. DEC...

Association between plasma L-carnitine levels and mitochondrial DNA copy number

Mitochondria are key cytoplasmic organelles in eukaryotic cells that generate adenosine triphosphate (ATP) through the electron transport chain and oxidative phosphorylation. Mitochondrial DNA (mtDNA) copy num...

Effect of Emi1 gene silencing on the proliferation and invasion of human breast cancer cells

Breast cancer is the most common malignant tumour in women. The early silk-splitting inhibitor protein 1 Emi1 is responsible for mediating ubiquitin protein degradation. The present study investigated the effe...

TNFα induces Caspase-3 activity in hematopoietic progenitor cells CD34+, CD33+, and CD41 + of myelodysplastic syndromes

Cytopenia is the primary feature of Myelodysplastic Syndrome, even in the presence of hypercellular bone marrow. TNFα is recognized as both a proinflammatory, and proapoptotic cytokine with a well established ...

From network analysis to experimental validation: identification of regulators of non-muscle myosin II contractility using the folded-gastrulation signaling pathway

The morphogenetic process of apical constriction, which relies on non-muscle myosin II (NMII) generated constriction of apical domains of epithelial cells, is key to the development of complex cellular pattern...

Simple, low-cost, and well-performing method, the outgrowth technique, for the isolation of cells from nasal polyps

Epithelial cells are an important part of the pathomechanism in chronic rhinosinusitis with nasal polyps. It is therefore essential to establish a robust method for the isolation and culture of epithelial cell...

Comprehensive brain tissue metabolomics and biological network technology to decipher the mechanism of hydrogen-rich water on Radiation-induced cognitive impairment in rats

Hydrogen-rich water (HRW) has been shown to prevent cognitive impairment caused by ionizing radiation. This study aimed to investigate the pharmacological effects and mechanisms of HRW on ionizing radiation by...

Mineral elements and adiposity-related consequences in adolescents with intellectual disabilities

Patients with intellectual disabilities are shown to have a limited capacity for cooperation, communication,and other biological consequences, which significantly require a specialized interest in healthcare p...

Glycyrrhizin inhibits LPS-induced inflammatory responses in goat ruminal epithelial cells in vitro

Inflammation plays a crucial role in the progression of Subacute Ruminal Acidosis (SARA). The experiment was designed to investigate anti-inflammatory effects of glycyrrhizin on goats ruminal epithelial cells ...

D-galactose-induced mitochondrial oxidative damage and apoptosis in the cochlear stria vascularis of mice

Age-related hearing loss, known as presbycusis, is the result of auditory system degeneration. Numerous studies have suggested that reactive oxygen species (ROS) and mitochondrial oxidative damage play importa...

Keratin 19 binds and regulates cytoplasmic HNRNPK mRNA targets in triple-negative breast cancer

Heterogeneous nuclear ribonucleoprotein K (HNRNPK) regulates pre-mRNA processing and long non-coding RNA localization in the nucleus. It was previously shown that shuttling of HNRNPK to the cytoplasm promotes ...

A computational peptide model induces cancer cells’ apoptosis by docking Kringle 5 to GRP78

Cells can die through a process called apoptosis in both pathological and healthy conditions. Cancer development and progression may result from abnormal apoptosis. The 78-kDa glucose-regulated protein (GRP78)...

BMP9 maintains the phenotype of HTR-8/Svneo trophoblast cells by activating the SDF1/CXCR4 pathway

Bone morphogenetic protein 9 (BMP9) has been shown to regulate processes such as angiogenesis, endothelial dysfunction, and tumorigenesis. However, the role of BMP9 in preeclampsia (PE) is unclear. The purpose...

Emodin and aloe-emodin, two potential molecules in regulating cell migration of skin cells through the MAP kinase pathway and affecting Caenorhabditis elegans thermotolerance

Emodin and aloe-emodin are two anthraquinones having positive effects in wound healing. However, their mechanism of action of wound healing is not fully understood. The MAP kinase family, which plays an active...

Knockdown of ELF4 aggravates renal injury in ischemia/reperfusion mice through promotion of pyroptosis, inflammation, oxidative stress, and endoplasmic reticulum stress

Renal ischemia/reperfusion (I/R) injury is a major cause of acute kidney injury (AKI). Dysfunction of E74-like ETS transcription factor 4 (ELF4) leads to inflammation. This research intended to look into the f...

Janus Kinase 3 phosphorylation and the JAK/STAT pathway are positively modulated by follicle-stimulating hormone (FSH) in bovine granulosa cells

Janus kinase 3 (JAK3) is a member of the JAK family of tyrosine kinase proteins involved in cytokine receptor-mediated intracellular signal transduction through the JAK/STAT signaling pathway. JAK3 was previou...

Genetic and protein interaction studies between the ciliary dyslexia candidate genes DYX1C1 and DCDC2

DYX1C1 (DNAAF4) and DCDC2 are two of the most replicated dyslexia candidate genes in genetic studies. They both have demonstrated roles in neuronal migration, in cilia growth and function and they both are cytosk...

SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation

The platelet-derived growth factor (PDGF) family of ligands exerts their cellular effects by binding to α- and β-tyrosine kinase receptors (PDGFRα and PDGFRβ, respectively). SUMOylation is an important posttra...

Myogenic differentiation of human myoblasts and Mesenchymal stromal cells under GDF11 on Poly-ɛ-caprolactone-collagen I-Polyethylene-nanofibers

For the purpose of skeletal muscle engineering, primary myoblasts (Mb) and adipogenic mesenchymal stem cells (ADSC) can be co-cultured and myogenically differentiated. Electrospun composite nanofiber scaffolds...

Computational analysis of missense variant CYP4F2*3 (V433M) in association with human CYP4F2 dysfunction: a functional and structural impact

Cytochrome P450 4F2 (CYP4F2) enzyme is a member of the CYP4 family responsible for the metabolism of fatty acids, therapeutic drugs, and signaling molecules such as arachidonic acid, tocopherols, and vitamin K...

Using RNA-seq to identify suitable housekeeping genes for hypoxia studies in human adipose-derived stem cells

Hypoxic culture conditions have been used to study the impact of oxygen deprivation has on gene expression in a number of disease models. However, hypoxia response elements present in the promoter regions of s...

SCAT8/miR-125b-5p axis triggers malignant progression of nasopharyngeal carcinoma through SCARB1

Nasopharyngeal carcinoma is a tumor with high malignancy and poor prognosis, which severely affects the health of the patients. LncRNAs and microRNAs are crucial for the occurrence and development of nasophary...

ARNTL2 upregulation of ACOT7 promotes NSCLC cell proliferation through inhibition of apoptosis and ferroptosis

Recent studies have reported that the circadian transcription factor aryl hydrocarbon receptor nuclear translocator like 2 (ARNTL2) promotes the metastatic progression of lung adenocarcinoma. However, the mole...

Evolutionary relevance of single nucleotide variants within the forebrain exclusive human accelerated enhancer regions

Human accelerated regions (HARs) are short conserved genomic sequences that have acquired significantly more nucleotide substitutions than expected in the human lineage after divergence from chimpanzees. The f...

The DNA demethylation-regulated SFRP2 dictates the progression of endometriosis via activation of the Wnt/β-catenin signaling pathway

Endometriosis cause decreases in life quality and pelvic pain in reproductive-age women. Methylation abnormalities played a functional role in the progression of endometriosis, this study aimed to explore the ...

Pre-treatment with IL-6 potentiates β-cell death induced by pro-inflammatory cytokines

Type I Diabetes mellitus (T1D) is characterized by a specific destruction of β-cells by the immune system. During this process pro-inflammatory cytokines are released in the pancreatic islets and contribute for β...

Role of the human solute carrier family 14 member 1 gene in hypoxia-induced renal cell carcinoma occurrence and its enlightenment to cancer nursing

Hypoxia is considered a critical contributor to renal cell carcinoma progression, including invasion and metastasis. However, the potential mechanisms by which it promotes invasion and metastasis have not yet ...

Cyclic tensile force modifies calvarial osteoblast function via the interplay between ERK1/2 and STAT3

Mechanical therapies, such as distraction osteogenesis, are widely used in dental clinics. During this process, the mechanisms by which tensile force triggers bone formation remain of interest. Herein, we inve...

Urine-derived mesenchymal stem cells-derived exosomes enhances survival and proliferation of aging retinal ganglion cells

This study was designed to investigate to test the effect of exosomes from urine-derived mesenchymal stem cells (USCs) on the survival and viability of aging retinal ganglion cells (RGCs), and explored the pre...

RPL11 promotes non-small cell lung cancer cell proliferation by regulating endoplasmic reticulum stress and cell autophagy

Abnormal biogenesis and ribosome free function of ribosomal proteins (RPs) is important for tumorgenesis and development. Ribosomal protein L11 (RPL11) is a component of ribosomal 60 S large subunit with diffe...

Sperm capacitation and transcripts levels are altered by in vitro THC exposure

Delta-9-tetrahydrocannabinol (THC) is the primary phytocannabinoid responsible for the psychoactive properties of cannabis and is known to interact with the endocannabinoid system, which is functionally presen...

The dual role of Nrf2 in melanoma: a systematic review

Melanoma is the most lethal type of skin cancer that originates from the malignant transformation of melanocytes. Although novel treatments have improved patient survival in melanoma, the overall prognosis rem...

Hyperoxia exposure upregulates Dvl-1 and activates Wnt/β-catenin signaling pathway in newborn rat lung

Bronchopulmonary dysplasia is a serious and lifelong pulmonary disease in premature neonates that influences around one-quarter of premature newborns. The wingless-related integration site /β-catenin signaling...

Circ-ATL1 silencing reverses the activation effects of SIRT5 on smooth muscle cellular proliferation, migration and contractility in intracranial aneurysm by adsorbing miR-455

Alterations in vascular smooth muscle cells (VSMCs) contribute to the pathogenesis of intracranial aneurysms (IAs). However, molecular mechanisms underlying these changes remain unknown. The present study aime...

HMGB1 mediates lipopolysaccharide-induced macrophage autophagy and pyroptosis

Autophagy and pyroptosis of macrophages play important protective or detrimental roles in sepsis. However, the underlying mechanisms remain unclear. High mobility group box protein 1 (HMGB1) is associated with...

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Digital Commons @ USF > College of Arts and Sciences > Molecular Biosciences > Theses and Dissertations

Molecular Biosciences Theses and Dissertations

Theses/dissertations from 2023 2023.

Exploring strain variation and bacteriophage predation in the gut microbiome of Ciona robusta , Celine Grace F. Atkinson

Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression , Janine M. DeBlasi

Thermodynamic frustration of TAD2 and PRR contribute to autoinhibition of p53 , Emily Gregory

Utilization of Detonation Nanodiamonds: Nanocarrier for Gene Therapy in Non-Small Cell Lung Cancer , Allan E. Gutierrez

Role of HLA-DRB1 Fucosylation in Anti-Melanoma Immunity , Daniel K. Lester

Targeting BET Proteins Downregulates miR-33a To Promote Synergy with PIM Inhibitors in CMML , Christopher T. Letson

Regulated Intramembrane Proteolysis by M82 Peptidases: The Role of PrsS in the Staphylococcus aureus Stress Response , Baylie M. Schott

Histone Deacetylase 8 is a Novel Therapeutic Target for Mantle Cell Lymphoma and Preserves Natural Killer Cell Cytotoxic Function , January M. Watters

Theses/Dissertations from 2022 2022

Regulation of the Heat Shock Response via Lysine Acetyltransferase CBP-1 and in Neurodegenerative Disease in Caenorhabditis elegans , Lindsey N. Barrett

Determining the Role of Dendritic Cells During Response to Treatment with Paclitaxel/Anti-TIM-3 , Alycia Gardner

Cell-free DNA Methylation Signatures in Cancer Detection and Classification , Jinyong Huang

The Role Of Eicosanoid Metabolism in Mammalian Wound Healing and Inflammation , Kenneth D. Maus

A Holistic Investigation of Acidosis in Breast Cancer , Bryce Ordway

Characterizing the Impact of Postharvest Temperature Stress on Polyphenol Profiles of Red and White-Fruited Strawberry Cultivars , Alyssa N. Smith

Theses/Dissertations from 2021 2021

Multifaceted Approach to Understanding Acinetobacter baumannii Biofilm Formation and Drug Resistance , Jessie L. Allen

Cellular And Molecular Alterations Associated with Ovarian and Renal Cancer Pathophysiology , Ravneet Kaur Chhabra

Ecology and diversity of boletes of the southeastern United States , Arian Farid

CircREV1 Expression in Triple-Negative Breast Cancer , Meagan P. Horton

Microbial Dark Matter: Culturing the Uncultured in Search of Novel Chemotaxonomy , Sarah J. Kennedy

The Multifaceted Role of CCAR-1 in the Alternative Splicing and Germline Regulation in Caenorhabditis elegans , Doreen Ikhuva Lugano

Unraveling the Role of Novel G5 Peptidase Family Proteins in Virulence and Cell Envelope Biogenesis of Staphylococcus aureus , Stephanie M. Marroquin

Cytoplasmic Polyadenylation Element Binding Protein 2 Alternative Splicing Regulates HIF1α During Chronic Hypoxia , Emily M. Mayo

Transcriptomic and Functional Investigation of Bacterial Biofilm Formation , Brooke R. Nemec

A Functional Characterization of the Omega (ω) subunit of RNA Polymerase in Staphylococcus aureus , Shrushti B. Patil

The Role Of Cpeb2 Alternative Splicing In TNBC Metastasis , Shaun C. Stevens

Screening Next-generation Fluorine-19 Probe and Preparation of Yeast-derived G Proteins for GPCR Conformation and Dynamics Study , Wenjie Zhao

Theses/Dissertations from 2020 2020

Understanding the Role of Cereblon in Hematopoiesis Through Structural and Functional Analyses , Afua Adutwumwa Akuffo

To Mid-cell and Beyond: Characterizing the Roles of GpsB and YpsA in Cell Division Regulation in Gram-positive Bacteria , Robert S. Brzozowski

Spatiotemporal Changes of Microbial Community Assemblages and Functions in the Subsurface , Madison C. Davis

New Mechanisms That Regulate DNA Double-Strand Break-Induced Gene Silencing and Genome Integrity , Dante Francis DeAscanis

Regulation of the Heat Shock Response and HSF-1 Nuclear Stress Bodies in C. elegans , Andrew Deonarine

New Mechanisms that Control FACT Histone Chaperone and Transcription-mediated Genome Stability , Angelo Vincenzo de Vivo Diaz

Targeting the ESKAPE Pathogens by Botanical and Microbial Approaches , Emily Dilandro

Succession in native groundwater microbial communities in response to effluent wastewater , Chelsea M. Dinon

Role of ceramide-1 phosphate in regulation of sphingolipid and eicosanoid metabolism in lung epithelial cells , Brittany A. Dudley

Allosteric Control of Proteins: New Methods and Mechanisms , Nalvi Duro

Microbial Community Structures in Three Bahamian Blue Holes , Meghan J. Gordon

A Novel Intramolecular Interaction in P53 , Fan He

The Impact of Myeloid-Mediated Co-Stimulation and Immunosuppression on the Anti-Tumor Efficacy of Adoptive T cell Therapy , Pasquale Patrick Innamarato

Investigating Mechanisms of Immune Suppression Secondary to an Inflammatory Microenvironment , Wendy Michelle Kandell

Posttranslational Modification and Protein Disorder Regulate Protein-Protein Interactions and DNA Binding Specificity of p53 , Robin Levy

Mechanistic and Translational Studies on Skeletal Malignancies , Jeremy McGuire

Novel Long Non-Coding RNA CDLINC Promotes NSCLC Progression , Christina J. Moss

Genome Maintenance Roles of Polycomb Transcriptional Repressors BMI1 and RNF2 , Anthony Richard Sanchez IV

The Ecology and Conservation of an Urban Karst Subterranean Estuary , Robert J. Scharping

Biological and Proteomic Characterization of Cornus officinalis on Human 1.1B4 Pancreatic β Cells: Exploring Use for T1D Interventional Application , Arielle E. Tawfik

Evaluation of Aging and Genetic Mutation Variants on Tauopathy , Amber M. Tetlow

Theses/Dissertations from 2019 2019

Investigating the Proteinaceous Regulome of the Acinetobacter baumannii , Leila G. Casella

Functional Characterization of the Ovarian Tumor Domain Deubiquitinating Enzyme 6B , Jasmin M. D'Andrea

Integrated Molecular Characterization of Lung Adenocarcinoma with Implications for Immunotherapy , Nicholas T. Gimbrone

The Role of Secreted Proteases in Regulating Disease Progression in Staphylococcus aureus , Brittney D. Gimza

Advanced Proteomic and Epigenetic Characterization of Ethanol-Induced Microglial Activation , Jennifer Guergues Guergues

Understanding immunometabolic and suppressive factors that impact cancer development , Rebecca Swearingen Hesterberg

Biochemical and Proteomic Approaches to Determine the Impact Level of Each Step of the Supply Chain on Tomato Fruit Quality , Robert T. Madden

Enhancing Immunotherapeutic Interventions for Treatment of Chronic Lymphocytic Leukemia , Kamira K. Maharaj

Characterization of the Autophagic-Iron Axis in the Pathophysiology of Endometriosis and Epithelial Ovarian Cancers , Stephanie Rockfield

Understanding the Influence of the Cancer Microenvironment on Metabolism and Metastasis , Shonagh Russell

Modeling of Interaction of Ions with Ether- and Ester-linked Phospholipids , Matthew W. Saunders

Novel Insights into the Multifaceted Roles of BLM in the Maintenance of Genome Stability , Vivek M. Shastri

Conserved glycine residues control transient helicity and disorder in the cold regulated protein, Cor15a , Oluwakemi Sowemimo

A Novel Cytokine Response Modulatory Function of MEK Inhibitors Mediates Therapeutic Efficacy , Mengyu Xie

Novel Strategies on Characterizing Biologically Specific Protein-protein Interaction Networks , Bi Zhao

Theses/Dissertations from 2018 2018

Characterization of the Transcriptional Elongation Factor ELL3 in B cells and Its Role in B-cell Lymphoma Proliferation and Survival , Lou-Ella M.m. Alexander

Identification of Regulatory miRNAs Associated with Ethanol-Induced Microglial Activation Using Integrated Proteomic and Transcriptomic Approaches , Brandi Jo Cook

Molecular Phylogenetics of Floridian Boletes , Arian Farid

MYC Distant Enhancers Underlie Ovarian Cancer Susceptibility at the 8q24.21 Locus , Anxhela Gjyshi Gustafson

Quantitative Proteomics to Support Translational Cancer Research , Melissa Hoffman

A Systems Chemical Biology Approach for Dissecting Differential Molecular Mechanisms of Action of Clinical Kinase Inhibitors in Lung Cancer , Natalia Junqueira Sumi

Investigating the Roles of Fucosylation and Calcium Signaling in Melanoma Invasion , Tyler S. Keeley

Synthesis, Oxidation, and Distribution of Polyphenols in Strawberry Fruit During Cold Storage , Katrina E. Kelly

Investigation of Alcohol-Induced Changes in Hepatic Histone Modifications Using Mass Spectrometry Based Proteomics , Crystina Leah Kriss

Off-Target Based Drug Repurposing Using Systems Pharmacology , Brent M. Kuenzi

Investigation of Anemarrhena asphodeloides and its Constituent Timosaponin-AIII as Novel, Naturally Derived Adjunctive Therapeutics for the Treatment of Advanced Pancreatic Cancer , Catherine B. MarElia

The Role of Phosphohistidine Phosphatase 1 in Ethanol-induced Liver Injury , Daniel Richard Martin

Theses/Dissertations from 2017 2017

Changing the Pathobiological Paradigm in Myelodysplastic Syndromes: The NLRP3 Inflammasome Drives the MDS Phenotype , Ashley Basiorka

Modeling of Dynamic Allostery in Proteins Enabled by Machine Learning , Mohsen Botlani-Esfahani

Uncovering Transcriptional Activators and Targets of HSF-1 in Caenorhabditis elegans , Jessica Brunquell

The Role of Sgs1 and Exo1 in the Maintenance of Genome Stability. , Lillian Campos-Doerfler

Mechanisms of IKBKE Activation in Cancer , Sridevi Challa

Discovering Antibacterial and Anti-Resistance Agents Targeting Multi-Drug Resistant ESKAPE Pathogens , Renee Fleeman

Functional Roles of Matrix Metalloproteinases in Bone Metastatic Prostate Cancer , Jeremy S. Frieling

Disorder Levels of c-Myb Transactivation Domain Regulate its Binding Affinity to the KIX Domain of CREB Binding Protein , Anusha Poosapati

Role of Heat Shock Transcription Factor 1 in Ovarian Cancer Epithelial-Mesenchymal Transition and Drug Sensitivity , Chase David Powell

Cell Division Regulation in Staphylococcus aureus , Catherine M. Spanoudis

A Novel Approach to the Discovery of Natural Products From Actinobacteria , Rahmy Tawfik

Non-classical regulators in Staphylococcus aureus , Andy Weiss

Theses/Dissertations from 2016 2016

In Vitro and In Vivo Antioxidant Capacity of Synthetic and Natural Polyphenolic Compounds Identified from Strawberry and Fruit Juices , Marvin Abountiolas

Quantitative Proteomic Investigation of Disease Models of Type 2 Diabetes , Mark Gabriel Athanason

CMG Helicase Assembly and Activation: Regulation by c-Myc through Chromatin Decondensation and Novel Therapeutic Avenues for Cancer Treatment , Victoria Bryant

Computational Modeling of Allosteric Stimulation of Nipah Virus Host Binding Protein , Priyanka Dutta

Cell Cycle Arrest by TGFß1 is Dependent on the Inhibition of CMG Helicase Assembly and Activation , Brook Samuel Nepon-Sixt

Gene Expression Profiling and the Role of HSF1 in Ovarian Cancer in 3D Spheroid Models , Trillitye Paullin

VDR-RIPK1 Interaction and its Implications in Cell Death and Cancer Intervention , Waise Quarni

Regulation of nAChRs and Stemness by Nicotine and E-cigarettes in NSCLC , Courtney Schaal

Targeting Histone Deacetylases in Melanoma and T-cells to Improve Cancer Immunotherapy , Andressa Sodre De Castro Laino

Nonreplicative DNA Helicases Involved in Maintaining Genome Stability , Salahuddin Syed

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Investigative School Research Projects in Biology: Effects on Students

2024, In: Shaping the Future of Biological Education Research: Selected Papers from the ERIDOB 2022 Conference, Korfiatis, K., Grace, M. & Hammann, M. (Eds), Springer, Cham, pp. 107-117.

School biology often entails undertaking practical work, which is generally intended to help students gain conceptual understanding, practical and wider skills, and understanding of how biologist work (Kampourakis & Reiss, 2018). However, the literature on practical work in school science indicates that it often achieves less than its proponents intend (Abrahams & Millar, 2008; Gatsby Charitable Foundation, 2017). Investigative school research projects are relatively uncommon, relative to other types of practical work, such as confirmatory practical activities (intended to produce the same result for all students every time), but it has been argued that they can give students a better understanding of what it is like to undertake authentic science. A systematic review found that investigative student science research projects could have a number of benefits for students including the learning of science ideas, affective responses to science, intentions to pursue careers involving science, and development of a range of skills, some specific to practical work and others, such as collaborative teamwork, more general (Bennett et al., 2018). Nevertheless, this same review concluded that further work is needed to enhance the quality of the available evidence and to explore more fully the potential longer-term benefits of participation in such projects at secondary school level.

Related Papers

Kevin Markwell

Cypriot Journal of Educational Sciences

CJES Journal

The study aims to develop theoretical foundations, methods of forming research skills of pupils in biological education, and experimental substantiation of its effectiveness. The following methods were used: analysis of psychological and pedagogical, biological, scientific, and methodological literature, the definition of the theory, the innovative methods of biological education, practical work, pedagogical practice, control, questionnaires, interviews, statistical analysis, identification, and implementation of training experiments. It is proposed to develop methods and determine the content of the formation of research competence through project activities, conduct and introduce them into the educational process. It is necessary to analyze the psychological, pedagogical, biological, scientific, and methodological literature to determine the theory, innovative methods of biological education, the organization of practical work, pedagogical practice, using a statistical method, which will lead to the creation of a methodology for the formation of research skills of pupils.

International Journal of Science Education

Michael J Reiss

Practical independent research projects (IRPs) are a feature of school science in a number of countries. To assess the impact of IRPs on students, a systematic review of the literature was undertaken. Thirty-nine papers met the review inclusion criteria, reporting on work from twelve countries. The review indicates that IRPs are often associated with wider initiatives such as authentic science, problem-based learning, and project-based learning. There is considerable variability in the nature of IRP work in relation to focus, models of provision, assessment, the involvement of external partners such as universities and employers, and funding, and this diversity affects whether judgements on the quality of the evidence base on impact. The majority of the research reviewed explored areas such as conceptual understanding, motivation to study science once it is no longer compulsory and attitudes to science, and the development of practical skills. Benefits were identified in relation to the learning of science ideas, affective responses to science, views of pursuing careers involving science, and development of a range of skills. Studies focusing on traditionally under-represented groups indicated that such students felt more positive about science as a result of undertaking IRPs. The review findings indicate that further work is needed to enhance the quality of the available evidence, to consider the ways in which IRPs can be validly assessed, to explore more fully the potential benefits for traditionally under-represented groups, and to explore more fully the potential longer-term benefits of participation in IRPs at high school level.

Tamara Ledley

Peter Farrell

The author, a teaching-principal working in a multi-grade classroom in rural Victoria, Australia, describes his justification and process for teaching ‘big science’ to primary school children. The author avoids the trivialised cookbook approach to science implemented by his colleagues, instead involving his students in the rich learning possibilities brought about by long-term experimentation. These possibilities include question generating, background research, choosing, designing and conducting the experiment, analysing the results using graphical literacy techniques, and finishing with a discussion and conclusion. The author suggests scientific drawing as a worthwhile educational pursuit while waiting for results. The author shares how he shrinks and expands his expectations of his students and how he scaffolds his support to them. Finally, as part of his professional development, the author shares his reflective process, in which he includes a review of the literature after the event.

Dina Tsybulsky

This qualitative, phenomenological study presents the experiences of high-school biology students (n = 233) in an outreach programme titled Students Meet Authentic Science. The core of the programme consists of students’ visits to life-science university research laboratories (from here on referred to as labs). The programme was designed according to the science-as-inquiry approach, which emphasises learning about science, as well as the important feature of conducting dialogues with scientists on issues pertaining to the nature of science. Data were collected through interviews, reflective journals, and questionnaires (which included both open-ended questions and Likert-like responses to given statements). The qualitative data were analysed using open content analysis, whereas quantitative data were analysed using descriptive statistics. Findings indicate that students had a wide range of significant cognitive, introspective, social, and object-related experiences. The majority of the students’ experiences were positive. The theoretical and practical implications of these findings are discussed within.

Cultural Studies of Science Education

Deniz Peker

As student-teacher-scientist partnerships become more widespread, there is a need for research to understand the roles assumed by scientists and teachers as they interact with students in general and in inquiry learning environments in particular. Although teacher roles during inquiry learning have been studied, there is a paucity of research about the roles that scientists assume in their interactions with students. Socio-cultural perspectives on learning emphasize social interaction as a means for students to make meaning of scientific ideas. Thus, this naturalistic study of classroom discourse aims to explore the ways scientists and teachers help high school students make meaning during authentic inquiry investigations. Conversational analysis is conducted of video recordings of discussions between students and teachers and students and scientists from two instances of a student-teacher-scientist partnership program. A social semiotic analytic framework is used to interpret the a...

Frontiers for Young Minds

CBE—Life Sciences Education

esin kandemir

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150 Actual Biology Research Paper Topics

Table of contents

• 1 What Is Biology? What Topics Might Biologists Study?
• 2 How to Choose a Topic for Biology Research Paper?
• 3.1 15 Developmental Biology Topics For Research
• 3.2 15 Immune System Biology Research Topics
• 3.3 15 Cell Biology Research Topics
• 3.4 15 DNA Research Topics
• 3.5 15 Molecular Biology Research Topics
• 3.6 15 Neurobiology Research Topics
• 3.7 15 Abortion, Human cloning, and Genetic Researches Topics
• 3.8 15 Environmental and Ecology Topics for Your Research
• 3.9 15 Plant Pathology Biology Research Topics
• 3.10 15 Animals Biology Research Topics
• 3.11 15 Marine Biology Research Topics
• 3.12 15 Zoology Research Topics
• 3.13 15 Genetics Research Topics
• 3.14 15 Biotechnology Research Topics
• 3.15 15 Evolutionary Biology Research Topics

Biology is one of the most magnetic fields of study these days. If you want to be a biologist or scientist in the future, there is no better time to start than right now. Biology research topics covered in this article will keep you busy and interested. Writing a research paper is one of the best ways to dip your toes into the field. Before doing that, you need to know some good topics for the research paper . They should be suitable for biology students rather than cutting-edge researchers. On Papersowl.com , we provide as many biology research paper examples as possible so that you have a huge choice.

What Is Biology? What Topics Might Biologists Study?

Biology is simply the study of everything that has a form of life. It includes investigations on plants, animals, and everything found in the environment. It is about studying how life forms grow, develop, and interact with each other. Biology essay topics for research encompass all these and more.

This science uncovers many fields where various life forms are studied. It makes sense to look through these fields to help you decide which suits you the best.

Plant Biology research topics are about studying the plants around us. They disclose information about their existence as a part of the ecosystem, their life cycle, resources they can give us, their ability to preserve them from climate changes, and so on. There are many ideas to choose from, but you must focus on a specific one.

Human Biology research topics are all about us. These topics focus on different body parts, such as the human brain, the human immunological system, the nervous system, etc. In addition, you can discuss DNA modifications in humans and explain why genetic disorders occur in your research projects. Various cell research is also common today.

Biology research topics on the environment are in great demand too. For example, climate change is becoming a more significant threat every day. By studying environmental topics in biology for projects and research, we can come up with ways to combat them and preserve ecosystems.

Microbiology research topics delve into things we can’t see. There are trillions of microbes and bacteria all around us. Knowing about them is essential to understanding what makes us sick and how to fight against them. All microbiology research paper topics are pretty complicated yet very engaging to include in your paper research.

Molecular biology topics dive even deeper into the level of atoms and molecules. The various medicines and drugs we take were all created through molecular-biology research. It is one of the areas full of ideas, but there is yet to be much evidence. Science is advancing in this realm but still needs a lot of time. Topics of molecular biology will need days for research only.

Keep in mind that there are more ideas and variations of this science. We offer more examples in further sections of the article about developmental biology, marine biology, evolutionary biology, etc. Explore them and make your writing appealing and meaningful in the eyes of a professor.

How to Choose a Topic for Biology Research Paper?

When choosing a biology project topic, you must be aware of one or more fields of science. Biology research is critical to the present world. By doing research, we can learn more about genetic disorders, immune disorders, mental health, natural disease resistance, etc. Knowing about each of these could save lives in the future.

For those who may not have the time or resources to do their own research, there are research paper writing services that can provide assistance with the project. And we are always here to help you find your own topic among interesting biology research topics. Here we prepared some useful tips to follow.

• Tip 1: The level of interest matters Pay attention to one that interests you, and you might have ideas on how to develop the topic. Passion is fundamental in research, after all.
• Tip 2: Explore the topic Try to narrow things down a bit. If the topic is too broad, you may not be able to cover all aspects of it in one research paper. If it is too narrow, the paper could end up too short. Analyze the topic and the ways to approach it. By doing so, you can strike a balance between the two.
• Tip 3: Discover the recent developments To make your research paper touchable with the present day, you must explore the latest developments in the field. You can find out what kind of research has been done recently by looking at journals. Check out research papers, topics, research articles, and other sources.
• Tip 4: Ensure to get enough resources When choosing a topic, make sure it has plenty of resources available. For example, a research paper on xenobiology or cutting-edge nanobiology might sound attractive. Still, you might have difficulties getting data and resources for those unless you are a researcher at a government lab. Data, resources, complex numbers, and statistics are all invaluable to writing a paper about these topics.

That is why we have selected a range of biological topics. The topics on this list are all hopefully exciting topics for research you could write an excellent paper on. We should also add that easy biology topics to research are rare, and a writer usually needs days to prepare and start writing. Yes, biology research topics for high school students are a bit easier, but still, they need time to explore them.

On the other hand, biology research topics for college students are far more complex and detailed. Some people prefer evolutionary biology research paper topics, and we can agree with this claim. These research areas do have a lot of potential and a lot of data to support the claims. Others prefer cell biology research topics that are a bit specific and fun. Anyway, with this article’s list of easy biology research topics, you will surely find the one matching your interest.

For those who may not have the time or resources to do their own research, there are provide assistance with the project.

Top Research Biology Paper Topics

This section contains a large selection of research biology paper topics. You will be able to find one that will suit you the best. The only thing left is to decide what variation of science you prefer. Whether you’re interested in microbiology, genetics, or any other type of science, you’ll find a topic to get you started. If you’re ever stuck or need some extra help, you can always pay someone to write your paper for you. So, take a look, and choose the perfect topic for your project!

15 Developmental Biology Topics For Research

Exploring the processes of how cells grow and develop is exciting. The human body contains millions of cells, and it’s interesting to research their behavior under different conditions. If you feel like writing about it, you can find some interesting biology topics below.

• How do stem cells form different tissues?
• How are tumors formed?
• Duplication of genomes
• Plasticity of development
• Different birth defects
• Interactions between genes and the environment
• Anticancer drugs mixtures
• Developmental diseases: Origin
• Drosophila Oogenesis
• Most deadly viruses
• Most deadly bacteria in the world
• How do germs affect cells?
• How does leukemia start?
• Development of the cardiovascular system in children
• How do autoimmune diseases start and affect the human body?

15 Immune System Biology Research Topics

For decades, many scientists and immunologists have studied the human immune system and tried to explain its reaction to various pathogens. This area allows you to deepen into it and reveal how a body protects itself from harmful impact. Look over the biology research questions below and find your match-up.

• How does the human body’s immune system work?
• The human immune system: How to strengthen it?
• What makes the immunological system weaker?
• The notion of auto-immune diseases and their effect on the body’s immune system
• The global HIV/aids epidemic
• What methods are used to prevent the spread of hives?
• Living with auto-immune diseases
• Genetics and the immune system: effects and consequences
• How do immune disorders affect the body, and what causes them?
• Are allergies signs of worrying about an immune disorder?
• DNA modification in solving immune disorders
• Stress as the biggest ruiner of the immunological system
• Vaccines as strong supporters of the immunological system
• The perception of vaccines in society
• Why do some people refuse vaccines and put others around them in danger?

15 Cell Biology Research Topics

Cell study might seem challenging yet very engaging. It will be a good idea to compare various types of cells and compare them in animals and plants. Make your choice from the list of cell biology research topics below.

• The structure of an animal cell
• Mitochondria and its meaning in cell development
• Cells classification and their functions
• Red blood cells and their function in transporting oxygen
• White blood cells and their responsibility to fight diseases
• How are plant cells different from animal cells?
• What would it be if animals had a function to photosynthesize?
• Single-celled organisms: What is it, and how do they work?
• What processes do cells go through in division?
• Invasion of bacteria into the body
• Viruses – alive or not?
• Fungi: their reproduction and distribution
• Cancer cells: Why are they so dangerous?
• What methods are used to kill cancer cells?
• The role of stem cells and their potential in a body

15 DNA Research Topics

The variety of biology research topics for college students might impress you a lot. This is a science with a large field of investigation, disclosing much scientific information to use in your project. The notion of DNA and its gist are also excellent options to write about.

• The structure of the human DNA
• The main components of a DNA chain
• Why does DNA have a double-helix spiral structure?
• The purpose of chromosomes
• MRNA and its relation to DNA
• Do single-celled organisms have DNA?
• Do viruses have DNA?
• What happens if you have too many or too few chromosomes?
• Analyzing the structure of DNA using computers
• Uses for the DNA of extinct organisms like mammoths and dinosaurs
• Storing non-genetic information in DNA
• Can you write a computer program into human DNA?
• How does radiation affect DNA?
• Modifying DNA to treat aids
• Can we fight cancer through DNA modification?

15 Molecular Biology Research Topics

Do you prefer to research molecules’ chemical and physical composition? We gathered some molecular biology research topics to make your choice easier.

• The structure and components of a gene
• How do molecules move in and out of a cell?
• The basic building blocks of life
• How are drugs designed for humans?
• How is a vaccine designed to target a specific disease?
• Dominant genes vs. recessive genes
• Prion disease – why is it so dangerous?
• Hormones and their function in the body
• Developing artificial hormones from other animals
• How to carry out a western blot?
• Testing and analyzing DNA using PCR
• The three-dimensional structure of a molecule
• What is DNA transcription, and how is it used?
• The structure of a prion
• What is the central dogma of molecular biology?

15 Neurobiology Research Topics

The more you dive into science, the more exciting things you find. That’s about biology. Here, you can choose biology research topics for high school and try to reveal more simply.

• Nervous system: its structure and function
• Neurons as unique cells playing a central role in the nervous system
• What is the maximum reaction speed in a human?
• Reaction speed: how to improve it?
• Research on Organic Farming
• What are the symptoms of Alzheimer’s disease?
• Why do we feel happy or sad?
• Headaches in terms of Neurobiology
• What are the reasons for neurobiological degeneration?
• Myths and reality of Amnesia
• What causes Alzheimer’s Disease, and what are the consequences of the disease?
• What is the treatment for Spinal Cord Injury?
• Studies on Narcolepsy and Insomnia: What are the causes?
• Is there a connection between Mental Health and Neurobiology?
• Emotions in terms of their reflection in the brain

15 Abortion, Human cloning, and Genetic Researches Topics

There are so many scientific researches and theories that society accepts or neglects. You can operate different notions and try to explain them, reflecting their advantages and downsides for a human being. We gathered some enticing life science research topics for high school students that might interest you.

• The controversy around abortion: legal or not?
• Can abortion be safe?
• Human cloning – reality vs. science-fiction
• The goals of cloning humans
• Are human cloning and transplantation ethical?
• Having a “perfect child” through gene therapy: Is it a myth?
• How far has gene therapy gone in genetic research?
• Advantages and disadvantages of gene therapy
• How gene therapy can help beat cancer
• How gene therapy can eliminate diabetes
• The opportunity to edit genes by CRISPR
• DNA modifications in humans to enhance our abilities – an ethical dilemma
• Will expensive gene therapy widen the gap between the rich and the poor?
• Cloning: the good and the Bad for a Generation
• The disadvantages of cloning
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15 Environmental and Ecology Topics for Your Research

The nature around us is so enormous and includes many branches to investigate. If you are keen on the environment and how ecology affects it, the list of follow-up biology paper topics might be helpful to you.

• The theory of evolution
• How does natural selection work?
• How do living organisms adapt to their environment?
• The concept of divergent and convergent evolution
• Building a sustainable environment
• Development of environment-friendly cities
• How to control population growth?
• Why have recycling resources become so essential in the modern world?
• The effect of plastic on the environment
• What are the global consequences of deforestation?
• What can we expect when losing biodiversity?
• Ecological damage: How to prevent it?
• How can GMO products affect ecology?
• Cloning endangered or extinct species: Is it a good idea?
• Is climate change the main reason for disrupting ecology?

15 Plant Pathology Biology Research Topics

Many factors impact human health and the quality of food products matters. These easy biology research topics will be useful if you want to describe the connection between those two concepts.

• How do plants protect themselves from diseases?
• How to increase the plant’s resistance to diseases?
• Diseases distribution among plants
• The banana pandemic
• How do herbicides influence plants?
• Corn blight
• Can any plant diseases affect humans?
• The issue of stem rust and its impact on wheat
• What approaches are used to struggle against invasive plants and affected weeds?
• Fertilizers: their pros and cons on plants
• Plant disease genetics: its system and structure
• What is the connection between ecological changes and plant diseases?
• Modifications on food production because of plant diseases
• How do fungal and viral diseases appear in plants?
• The sweet potato virus

15 Animals Biology Research Topics

It’s hard to find someone who doesn’t like animals. If you are curious about animals scientifically, here you are with biology research paper topics in this field.

• Classification of animals
• Land-based life: its evolution history
• Controversies about keeping animals as pets
• Is it ethical to test drugs and products on animals?
• Why do nature reserves against zoos?
• Evidence on prehistoric aquatic animals growing giant
• What species of animals are vegan?
• Animals and their social behavior
• Primate behavior
• How intelligent can other primates be?
• Are wolves and dogs intelligent?
• Domesticating animals
• Hibernation in animals
• Why animals migrate
• Should we bring back extinct animals?

15 Marine Biology Research Topics

The marine theme is engaging as it reveals so many interesting facts about life forms dwelling under the water. You can make your paper look captivating using biology topics in marine below.

• How acidification affects aquatic environments
• Evolution in the deep sea
• What’s the meaning of camouflage mechanism in sea life?
• Consequences of oil spills on marine life
• Oldest marine species
• How do whales communicate with each other?
• How blind fish navigate
• Are marine shows and aquariums ethical?
• The biology and life cycle of seabirds
• How jellyfish are immortal
• Plankton ecology
• Difference between freshwater and seawater marine life
• Coral reefs: their importance and evolution
• Saving and restoring coral reefs
• Life in the deep-sea ocean trenches

15 Zoology Research Topics

Zoology can be an excellent choice to write about if you are close to animal studies. Look at biology topics to research and choose the one that fits your interest most.

• Asian elephants and human speech patterns
• Oyster genomes and adaptation
• Darwin’s work in the Galápagos Islands
• Asian carp: Invasive species analysis
• Giant squids: Fact vs. fiction
• Coyote and wolf hybrid species in the United States
• Parasites and disease
• Migration patterns of killer bees
• The treatment of species in Melville’s Moby Dick
• Biodiversity and plankton
• The role of camels and the development of Africa and the Middle East
• Muskellunge and adaptive creek mechanisms to small water
• Ants and cooperative behavior among species
• Animal communication and the origin of language
• Speech in African Gray Parrots

15 Genetics Research Topics

Writing about modifications caused on the gene level is pretty challenging but very fascinating. You can select one among the biological questions for research and bring up a meaningful paper.

• Genetics and its role in cancer studies
• Can genetic code be confidential?
• Is it possible to choose the sex of a person before birth?
• Genetics as a ray of hope for children with an intellectual disability
• What factors in human genetics affect behavior?
• Is it somehow possible to improve human personality through genetics?
• Are there any living cells in the gene?
• Fighting HIV with gene mutations
• Genetic mutations
• How addictive substances affect genes
• Genetic testing: is it necessary?
• Cloning: positive or negative outcome for future generations
• Pros and cons of genetic engineering
• Is the world ready for the bioethics revolution?
• The linkage between genetics and obesity

15 Biotechnology Research Topics

The way scientists conduct research today is magnificent. Implementing high-tech innovations in biology research brings new opportunities to study the world. What are these opportunities? Explore biotechnology research topics for college students and disclose the best options for you.

• Biotechnology used in plant research
• What is the contribution of biotechnology to food?
• Pharmacogenetics: What is it, and how it works?
• How are anti-cancer drugs produced to be effective?
• Nanotechnology in DNA: How to isolate it?
• Recent nanotechnology used in HIV treatment
• What biotech apps are used to detect foodborne pathogens in food systems?
• Genotypes research: Why are they tolerant and sensitive to heavy metal?
• High-tech solutions in diagnosing cancer
• Forensic DNA and its latest developments
• Metabolic changes at the level of cells
• Nanotechnology in improving treatments for respiratory viruses
• The latest biotech discoveries
• Digital evolution: bioresearch and its transformation
• The concept of vaccine development

15 Evolutionary Biology Research Topics

Knowing how life forms started their existence is fundamental. And more interesting is to look through the evolution of many processes. If you find this trend of research more engaging, we outlined evolutionary biology research paper topics to diversify your choice.

• Darwin’s concept’s impact on science
• The evolution concept by Lamarck
• Origins of the evolutionary theory
• Evolution acceptance: a belief vs. a theory?
• Evolutionary in microbiology
• Development of robotics
• Revealing differences: human brain & animal brain
• Preservation of biological resources
• Transformations in aging
• Adaptive genetic system
• Morphometrics’ history
• Developmental theory and population genomics
• Bacteria ecology’s evolution
• Biological changes: impact and evolution
• Infectious diseases and their profession

The world of science and biology is vast, making research tedious. Use our list of interesting biology research topics to choose the best issue to write your own paper.

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