how to discuss the statement of the problem in research

• Research Process

What is a Problem Statement? [with examples]

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Table of Contents

The statement of the problem is one of the first things that a colleague or potential client will read. With the vastness of the information available at one’s fingertips in the online9 world, your work may have just a few seconds to draw in a reader to take a deeper look at your proposal before moving on to the next option. It explains quickly to the reader, the problem at hand, the need for research, and how you intend to do it.

A strong, clear description of the problem that drew you to your research has to be straightforward, easy to read and, most important, relevant. Why do you care about this problem? How can solving this problem impact the world? The problem statement is your opportunity to explain why you care and what you propose to do in the way of researching the problem.

A problem statement is an explanation in research that describes the issue that is in need of study . What problem is the research attempting to address? Having a Problem Statement allows the reader to quickly understand the purpose and intent of the research. The importance of writing your research proposal cannot be stressed enough. Check for more information on Writing a Scientific Research Project Proposal .

It is expected to be brief and concise , and should not include the findings of the research or detailed data . The average length of a research statement is generally about one page . It is going to define the problem, which can be thought of as a gap in the information base. There may be several solutions to this gap or lack of information, but that is not the concern of the problem statement. Its purpose is to summarize the current information and where a lack of knowledge may be presenting a problem that needs to be investigated .

The purpose of the problem statement is to identify the issue that is a concern and focus it in a way that allows it to be studied in a systematic way . It defines the problem and proposes a way to research a solution, or demonstrates why further information is needed in order for a solution to become possible.

What is Included in a Problem Statement?

Besides identifying the gap of understanding or the weakness of necessary data, it is important to explain the significance of this lack.

-How will your research contribute to the existing knowledge base in your field of study?

-How is it significant?

-Why does it matter?

Not all problems have only one solution so demonstrating the need for additional research can also be included in your problem statement. Once you identify the problem and the need for a solution, or for further study, then you can show how you intend to collect the needed data and present it.

How to Write a Statement of Problem in Research Proposal

It is helpful to begin with your goal. What do you see as the achievable goal if the problem you outline is solved? How will the proposed research theoretically change anything? What are the potential outcomes?

Then you can discuss how the problem prevents the ability to reach your realistic and achievable solution. It is what stands in the way of changing an issue for the better. Talk about the present state of affairs and how the problem impacts a person’s life, for example.

It’s helpful at this point to generally layout the present knowledge and understanding of the subject at hand, before then describing the gaps of knowledge that are currently in need of study. Your problem statement is a proposed solution to address one of these gaps.

A good problem statement will also layout the repercussions of leaving the problem as it currently stands. What is the significance of not addressing this problem? What are the possible future outcomes?

Example of Problem Statement in Research Proposal

If, for example , you intended to research the effect of vitamin D supplementation on the immune system , you would begin with a review of the current knowledge of vitamin D’s known function in relation to the immune system and how a deficiency of it impacts a person’s defenses.

You would describe the ideal environment in the body when there is a sufficient level of vitamin D. Then, begin to identify the problems associated with vitamin D deficiency and the difficulty of raising the level through supplementation, along with the consequences of that deficiency. Here you are beginning to identify the problem of a common deficiency and the current difficulty of increasing the level of vitamin D in the blood.

At this stage, you may begin to identify the problem and narrow it down in a way that is practical to a research project. Perhaps you are proposing a novel way of introducing Vitamin D in a way that allows for better absorption by the gut, or in a combination with another product that increases its level in the blood.

Describe the way your research in this area will contribute to the knowledge base on how to increase levels of vitamin D in a specific group of subjects, perhaps menopausal women with breast cancer. The research proposal is then described in practical terms.

How to write a problem statement in research?

Problem statements differ depending on the type and topic of research and vary between a few sentences to a few paragraphs.

However, the problem statement should not drag on needlessly. Despite the absence of a fixed format, a good research problem statement usually consists of three main parts:

Context: This section explains the background for your research. It identifies the problem and describes an ideal scenario that could exist in the absence of the problem. It also includes any past attempts and shortcomings at solving the problem.

Significance: This section defines how the problem prevents the ideal scenario from being achieved, including its negative impacts on the society or field of research. It should include who will be the most affected by a solution to the problem, the relevance of the study that you are proposing, and how it can contribute to the existing body of research.

Solution: This section describes the aim and objectives of your research, and your solution to overcome the problem. Finally, it need not focus on the perfect solution, but rather on addressing a realistic goal to move closer to the ideal scenario.

Here is a cheat sheet to help you with formulating a good problem statement.

1. Begin with a clear indication that the problem statement is going to be discussed next. You can start with a generic sentence like, “The problem that this study addresses…” This will inform your readers of what to expect next.

2. Next, mention the consequences of not solving the problem . You can touch upon who is or will be affected if the problem continues, and how.

3. Conclude with indicating the type of research /information that is needed to solve the problem. Be sure to reference authors who may have suggested the necessity of such research.

This will then directly lead to your proposed research objective and workplan and how that is expected to solve the problem i.e., close the research gap.

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Research Problem Statement — Find out how to write an impactful one!

Table of Contents

What Is a Research Problem Statement?

A research problem statement is a clear, concise, and specific statement that describes the issue or problem that the research project addresses. It should be written in a way that is easily understandable to both experts and non-experts in the field.

To write a research problem statement, you should:

• Identify the general area of interest: Start by identifying the general area of research that interests you.
• Define the specific problem: Narrow down the general area of interest to a specific problem or issue.
• Explain the significance of the problem: Provide context for the problem by explaining why it is important to study and what gap in current knowledge or understanding it fills.
• Provide a clear and concise statement: State the problem in a clear and concise manner, making sure to use language that is easily understood by your intended audience.
• Use a scientific and objective tone: The problem statement should be written in a neutral and objective tone, avoiding any subjective language and personal bias .

An Example of a Research Problem Statement

“The increasing prevalence of obesity in children is a growing public health concern. Despite the availability of information on healthy eating and physical activity, many children are still not engaging in healthy lifestyle behaviors. The problem this study addresses is the lack of understanding of the barriers and facilitators to healthy lifestyle behaviors in children.”

When to Write a Problem Statement in Research?

A research problem statement should be written at the beginning of the research process, before any data collection or analysis takes place. This is because the statement sets the foundation for the entire research project by clearly defining the problem that the research is trying to address.

Writing a problem statement early in the research process helps to guide the research design and methodology , and ensures that the research is focused on addressing the specific problem at hand. It also helps to ensure that the research is relevant and addresses a gap in current knowledge or understanding.

In addition, a well-written problem statement effectively communicates the purpose and significance of the research to potential funders, collaborators, and other stakeholders. It also generates interest and support for the research project.

It’s also important to note that, during the research process, the statement can be refined or updated as new information is discovered or as the research progresses. This is normal and it’s a good idea to revise the statement as needed to ensure that it remains clear and concise and that it accurately reflects the current focus of the research project.

What Does a Research Problem Statement Include?

A research problem statement typically includes the following elements:

1. The research topic:

The general area of interest or field of study that the research project addresses.

2. The specific problem or issue:

A clear and concise statement of the problem or issue that the research project aims to address.

3. The significance of the problem:

A discussion of why the problem is important and what gap in current knowledge or understanding it fills.

4. The research questions:

A set of questions that the research project aims to answer, in order to address the problem or issue.

5. The research objectives:

A set of specific and measurable objectives that the research project aims to achieve.

6. The scope of the research:

A description of the specific population, setting, or context that the research project will focus on.

7. The theoretical framework:

A discussion of the theoretical concepts and principles that inform the research project.

8. The research design:

A description of the research methodologies that will be used to collect and analyze data in order to address the research questions and objectives.

It’s important to note that the problem statement is usually brief and concise, typically a few sentences or a short paragraph. But it should provide enough information to convey the main idea of the research project.

Important Features of Research Problem Statement

The problem statement should be clear and easy to understand. Write it in a way that is accessible to both experts and non-experts in the field.

2. Specificity

The statement should be specific and clearly define the problem or issue that the research project aims to address. It should be narrow enough to be manageable, but broad enough to be of interest to others in the field.

3. Significance

The statement should explain why the problem is important and what gap in current knowledge or understanding it fills. It should provide context for the research project and help to justify its importance.

4. Relevance

The statement should be relevant to the field of study and address an issue that is currently of concern to researchers.

5. Research questions

The statement should include a set of research questions that the research project aims to answer in order to address the problem or issue.

6. Research objectives

The statement should include a set of specific and measurable objectives that the research project aims to achieve.

The statement should define the specific population, setting, or context that the research project will focus on.

8. Theoretical framework

The statement should provide an overview of the theoretical concepts and principles that inform the research project.

9. Research design

The statement should provide an overview of the research methodologies. This will be useful collect and analyze data in order to address the research questions and objectives.

Difference Between a Thesis Statement and a Problem Statement

A thesis statement and a problem statement are related but distinct elements of a research project.

A thesis statement is a statement that summarizes the central argument or claim of a research paper or essay. It presents the main idea of the paper and sets the direction for the rest of the content. It’s usually located at the end of the introduction, and it’s often one sentence.

A problem statement, on the other hand, is a statement that describes a specific problem or issue that the research project aims to address. It sets the foundation for the entire research project by clearly defining the research problem. It is usually located at the beginning of a research paper or proposal, and is of one or a few paragraphs.

In summary, a thesis statement is a summary of the main point or key argument of the research paper. A problem statement describes the specific issue that the research project aims to address. A thesis statement is more focused on the final outcome of the research. While a problem statement is focused on the current state of knowledge and the gap in understanding that the research project aims to fill.

In Conclusion

A problem statement is a critical component of the research project, as it provides a clear and concise roadmap for the research, and helps to ensure that the research is well-designed and addresses a significant and relevant issue.

We hope this blog has clarified your doubts and confusion associated with research problem statement and helps you write an effective statement for your research project!

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How to Write a Statement of a Problem in Research with Steps

Published by Grace Graffin at August 11th, 2021 , Revised On October 3, 2023

Research is a systematic investigation to find new techniques, products or processes to solve problems. Apart from being systematic, research is empirical in nature: it’s based on observations and measurement of those observations.

It’s what comes before the development. Impacts and policies that are born in society are borne out of the research.

The most important step to perform any research is to identify a problem that needs to be solved. Therefore, it is necessary to define a research problem before starting the actual research process. Once a research problem has been identified, the next step is to write a problem statement.

Philosopher Kaoru Ishikawa said: “You will have a problem half-solved by defining it correctly on the first day.”

This quote perfectly reflects the importance of a problem statement in research. Before writing a problem statement, it is essential to pinpoint a specific problem, the difficulties you can expect to face as you try to solve it and the research gaps you aim to fill with your research.

The last part—how your research aims to fill a gap in the existing literature—will act as a springboard to the solution(s) that policy makers, for instance, might eventually take to solve that problem.

Filling a gap, therefore, is very important towards solving an existing problem.

What is a Problem Statement?

A problem statement is a clear and concise description of an issue or challenge that needs to be addressed. It typically outlines the existing gap between the current state (what currently is) and the desired state (what should be). Crafting a well-defined problem statement is critical for problem-solving, research, or project planning, as it serves as a guidepost and sets the direction for the subsequent steps.

Research Problem and Research Method – A Cyclical Process

The type of research strategy used in research determines whether you will be analysing theoretical problems to add value to existing knowledge, discussing practical issues to become an agent of change for an organisation or industry or looking at both aspects in relation to any given problem.

However, the kind of problem you aim to tackle with your research, to begin with, will also help you narrow down which research design , method or strategy to opt for.

This is therefore a cyclical process. Your research aim guides your research design can help you focus on a specific kind of research gap/problem.

However, generally, your research will focus on one or the other.

Here is all you need to know about how to write a statement of the problem in research, also called problem statement by some research writers .

Why do you Need a Statement of the Problem, to Begin with?

You need a statement of the problem to transform a generalised problem into a well-defined, brief, targeted statement to perform research in the decision-making process. The problem statement helps the researcher to identify the purpose of the ongoing research.

The problem statement in the dissertation is the pillar of the introduction chapter through which the reader can understand the research questions and scope of the project. If you do not define the problem statement properly, the results might become unmanageable.

Writing Problem Statement for a Business or Organisation

In the business world, problem statements provide the basis for the enhancement and refinement of projects. Without identifying and understanding the problem, it will be hard to find and effectively implement solutions.

A stand-alone document that solely provides an in-depth and detailed problem statement is usually the answer for organisations and businesses when it becomes imperative to find the solution to a problem.

Writing Problem Statement for Academic Research

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Problem Statement – How to Write it

Ask yourself the following questions before writing the problem statement:

• What is wrong in the research area/subarea XYZ?
• Where did it happen?
• When did it happen?
• To what extent (how much)?
• I know that because…(evidence)

‘What’ always defines the defect of the problem at hand and explains why it matters? ‘Where’ defines the geological location of the problem. ‘When’ defines the history and the pattern of the problem, the goal of the stated problem and the scope of research.

‘How much’ defines the trend of the problem as to how many objects are facing the same defect and to what extent. The last part, ‘I know this because…’, will help the researcher identify the standard(s) that he must meet.

Step 1: Understanding the Problem

The problem statement should provide a clear and concise background to the research problem you are investigating. Before starting your research , review the literature about the specific problem and find a gap to fill with your own research.

Practical Research Problem Statement

If you are doing experimental research , you can identify problems by talking to people working in a relevant field, studying research reports, and reviewing previous research. Here are some examples of practical research problems:

• A problem that hinders the efficiency of a company
• An institutional process that needs interventions
• An area of concern in your field/sub-field of interest
• Members of a society facing a specific difficulty

The problem statement should focus on the details related to the problem, such as:

• When and where was the problem observed?
• Who is/are affected by it?
• What research has been conducted and what practical steps have been taken to resolve the problem?

Example of Practical Research Problem Statement

The production of a company is low for the months of July and August every year. Initial research has been conducted by the company, which revealed poor production in July and August is due to the unavailability of local raw material.

The company has made some effective attempts at engaging the local suppliers to ensure an uninterrupted supply of the raw material, but these efforts are yet to have any significant impact on the production levels.

Theoretical Research Problem Statement

According to USC Libraries, “A theoretical framework consists of concepts and, together with their definitions and reference to relevant scholarly literature, existing theory that is used for your particular study…theoretical framework must demonstrate an understanding of theories and concepts…relevant to the topic of your research paper and that relate to the broader areas of knowledge being considered.”

The theoretical research indirectly contributes to the change by identifying the problem, expanding knowledge and improving understanding. The researcher can find a specific problem by brainstorming the topic and reviewing already published theories and research.

When writing a problem statement based on a theoretical research problem , it is important to recognise the historical, geographical, social and scientific background. Here are the elements of the theoretical problem statement framework that you should consider:

• What are the facts about the problem?
• Does the problem relate to a certain geographical area or time period?
• How is the problem discussed and explained in the existing literature?

Example of Theoretical Research Problem Statement

The production of a company is low for July and August every year. Initial research has been conducted by the company, which revealed poor production in July and August is due to the unavailability of local raw material. The company has made some effective attempts to engage the local suppliers to ensure an uninterrupted raw material supply. Still, these efforts are yet to have any significant impact on the production levels.

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Step 2 – Show why it’s Important and Relevant

By discussing the importance of the problem under investigation, you are demonstrating the relevance of your research. However, this does not mean that you will end up discovering something unimaginable or extraordinary.

The objective here is to clearly state how and why your research problem is relevant in your chosen area of study and why it requires further research.

As indicated previously, practical research deals with a problem affecting society, social group, firm or organisation on a broader scale. To elaborate on why it is important to solve this problem and why your research is significant, you could consider the following questions:

• What will be the consequences if the problem remains unsolved?
• Who do these consequences have the most implications for?
• What is the wider relevance of the problem being investigated?

Low production in July and August negatively affects the company’s marketing capital, thereby becoming an area of deep concern for the directors and stakeholders. The marketing budget cut in July and August is hindering its ability to promote its products uninterruptedly.

Addressing this problem will have practical benefits for the company and help establish the reasons for disruption in raw material supply.

The relevance of all theoretical issues may not be too obvious, even though most theoretical problems do have practical implications. Here are some questions for you to ponder to establish the importance of your research problem:

• Will your research help to advance understanding of the topic under investigation?
• Are there any benefits of you resolving the problem for other researchers who wish to explore this topic further in the future?
• What are the direct or indirect implications (s) of the problem you are trying to solving?

The new forms of employment such as freelance, contract-based work and zero-hour work arrangements are recognised as either a manipulative last option or a flexible active choice. It is necessary to conduct comprehensive qualitative research to uncover why fresh graduates take up these types of employment in the gig economy. There is a need to advance more vigorous concepts relating to instability and flexibility in modern forms of employment from employees’ perspectives, which will also help shape future policies.

Also see: How to Write the Abstract for Dissertation

Step 3 – Declaring the Problem

Before you jump on to state your research’s problem statements, it’s important to devote a sentence or two to let your readers know the precise, narrowed-down research problem you will be discussing about.

For language clarity purposes, here are some strong opening statements to achieve this step:

• Recently, there has been growing interest in …
• The possibility of…has generated wide interest in …
• The development of…is a classic problem in…
• The development of…has led to the hope that …
• The…has become a favourite topic for analysis …
• Knowledge of…has great importance for …
• The study of…has become an important aspect of …
• A central issue in…is…
• The…has been extensively studied in recent years.
• Many investigators have recently turned to …
• The relationship between…has been investigated by many researchers.
• Many recent studies have found out…

Step 4 – Establishing Aim and Objectives

The last step in writing a problem statement is to provide a framework for solving the problem. This will help you, the researcher, stay focused on your research aims and not stray; it will also help you readers keep in mind the reason as to why you conducted this study, to begin with.

A good problem statement does not provide the exact solution to any problem. Rather, it focuses more on how to effectively understand or tackle a problem by establishing the possible causes.

The aim of a research study is its end goal or overall purpose. Following are some examples of how you can craft your research aim statements:

• This research study aims to investigate…
• This paper is aimed at exploring…
• This research aims to identify…

On the other hand, objectives are the smaller steps that a researcher must take to address the aim of the research. Once you have laid out the research problem your research will deal with, it’s important to next mention the how behind that. Objectives are mostly imperative statements, often beginning with transitive verbs like ‘to analyse,’ ‘to investigate,’ etc.

Some more examples are:

• Statistical analysis will be conducted to determine…
• Both quantitative and qualitative research methods will be employed to probe…
• Face-to-face interviews will be carried out with the participants to establish…

Practical Research Aim and Objectives

This project aims to identify the causes of disturbed supply of raw material in the region, which resulted in low production for the company in July and August. This will be achieved by conducting interviews and surveys with the suppliers to understand why the supply is unpredictable in those two months and what can be done to ensure orderliness. Practical experiments will also be conducted to observe the effectiveness of proposed solutions.

Theoretical Research Aim and Objectives

This study aims to understand and unearth the experiences of fresh graduates in the modern economy. The sample population will participate in this study through qualitative research methods, which are expected to provide a deeper insight into the perceptions and motives of these fresh graduates working as freelancers and contract-based employees. The data collected from this exercise and the existing literature on the topic will be analysed in statistical analysis software.

TIP: Search the common themes of the problem statement in your field of research before writing a problem statement.

Also see: Argumentative Essay Writing Service

Problem Statement versus Significance of the Study

Even though both may sound similar, the statement of the problem and the significance of your study are going to be different. The latter does develop upon and from the former, though.

The problem statement tells your readers what’s wrong, whereas the significance of the study will tell them how your research contributed to that problem. You can’t have a significance of a study without mentioning the problem statement first.

Furthermore, signifying your study implies mentioning 4 key points related to it:

• How your study will further develop the theory behind the existing problem
• Practical solutions that might be implemented to solve the problem (especially in field research work)
• Whether your study or research will pave way for innovative methods to solve the existing problem.
• How your study can help in policy making and implementation, impact studies, etc.

Problem statement in research is the description of an existing issue that needs to be addressed. The problem statement is a focal point of any research and a bridge between the  literature review  and the  research methodology .

Problem statement often has three elements; the problem itself, the method of solving the problem, and the purpose. There are five aspects of every problem: What, Where, When, to what extent, and what defects you know about the topic. Here is an  example of a problem statement in a research proposal  for your better understanding.

If you wish to know more about how to start your research process, then you might want to take a look at the “ Starting the Research Process ” section on our website, which has several articles relating to a  research problem , problem statement, research aim and objectives, and  research proposal .

ResearchProspect is a UK-registered business that offers academic support and assistance to students across the globe. Our writers can help you with individual chapters of your dissertation or the full dissertation writing service , no matter how urgent or complex your requirements might be.

Frequently Asked Questions

Is it necessary to write a problem statement.

Yes, the most important step to perform any research is to identify a problem that needs to be solved. Therefore, it is necessary to define a research problem before starting the actual research process .

How is a problem statement different from a problem statement written for an organisation?

In the business world, problem statements provide the basis for the enhancement and refinement of projects. Whereas, in academic research, A problem statement helps researchers understand and realise organised the significance of a research problem .

What is a practical research problem?

Doing experimental research can identify problems by talking to people working in a relevant field, studying research reports, and reviewing previous research. 

What is a theoretical research problem?

A theoretical research problem is when the researcher finds a specific problem by brainstorming and reviewing already published theories and research.

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The Research Problem & Statement

What they are & how to write them (with examples)

By: Derek Jansen (MBA) | Expert Reviewed By: Eunice Rautenbach (DTech) | March 2023

If you’re new to academic research, you’re bound to encounter the concept of a “ research problem ” or “ problem statement ” fairly early in your learning journey. Having a good research problem is essential, as it provides a foundation for developing high-quality research, from relatively small research papers to a full-length PhD dissertations and theses.

In this post, we’ll unpack what a research problem is and how it’s related to a problem statement . We’ll also share some examples and provide a step-by-step process you can follow to identify and evaluate study-worthy research problems for your own project.

Overview: Research Problem 101

What is a research problem.

• What is a problem statement?

Where do research problems come from?

• How to find a suitable research problem
• Key takeaways

A research problem is, at the simplest level, the core issue that a study will try to solve or (at least) examine. In other words, it’s an explicit declaration about the problem that your dissertation, thesis or research paper will address. More technically, it identifies the research gap that the study will attempt to fill (more on that later).

Let’s look at an example to make the research problem a little more tangible.

To justify a hypothetical study, you might argue that there’s currently a lack of research regarding the challenges experienced by first-generation college students when writing their dissertations [ PROBLEM ] . As a result, these students struggle to successfully complete their dissertations, leading to higher-than-average dropout rates [ CONSEQUENCE ]. Therefore, your study will aim to address this lack of research – i.e., this research problem [ SOLUTION ].

A research problem can be theoretical in nature, focusing on an area of academic research that is lacking in some way. Alternatively, a research problem can be more applied in nature, focused on finding a practical solution to an established problem within an industry or an organisation. In other words, theoretical research problems are motivated by the desire to grow the overall body of knowledge , while applied research problems are motivated by the need to find practical solutions to current real-world problems (such as the one in the example above).

As you can probably see, the research problem acts as the driving force behind any study , as it directly shapes the research aims, objectives and research questions , as well as the research approach. Therefore, it’s really important to develop a very clearly articulated research problem before you even start your research proposal . A vague research problem will lead to unfocused, potentially conflicting research aims, objectives and research questions .

What is a research problem statement?

As the name suggests, a problem statement (within a research context, at least) is an explicit statement that clearly and concisely articulates the specific research problem your study will address. While your research problem can span over multiple paragraphs, your problem statement should be brief , ideally no longer than one paragraph . Importantly, it must clearly state what the problem is (whether theoretical or practical in nature) and how the study will address it.

Here’s an example of a statement of the problem in a research context:

Rural communities across Ghana lack access to clean water, leading to high rates of waterborne illnesses and infant mortality. Despite this, there is little research investigating the effectiveness of community-led water supply projects within the Ghanaian context. Therefore, this study aims to investigate the effectiveness of such projects in improving access to clean water and reducing rates of waterborne illnesses in these communities.

As you can see, this problem statement clearly and concisely identifies the issue that needs to be addressed (i.e., a lack of research regarding the effectiveness of community-led water supply projects) and the research question that the study aims to answer (i.e., are community-led water supply projects effective in reducing waterborne illnesses?), all within one short paragraph.

Need a helping hand?

Wherever there is a lack of well-established and agreed-upon academic literature , there is an opportunity for research problems to arise, since there is a paucity of (credible) knowledge. In other words, research problems are derived from research gaps . These gaps can arise from various sources, including the emergence of new frontiers or new contexts, as well as disagreements within the existing research.

Let’s look at each of these scenarios:

New frontiers – new technologies, discoveries or breakthroughs can open up entirely new frontiers where there is very little existing research, thereby creating fresh research gaps. For example, as generative AI technology became accessible to the general public in 2023, the full implications and knock-on effects of this were (or perhaps, still are) largely unknown and therefore present multiple avenues for researchers to explore.

New contexts – very often, existing research tends to be concentrated on specific contexts and geographies. Therefore, even within well-studied fields, there is often a lack of research within niche contexts. For example, just because a study finds certain results within a western context doesn’t mean that it would necessarily find the same within an eastern context. If there’s reason to believe that results may vary across these geographies, a potential research gap emerges.

Disagreements – within many areas of existing research, there are (quite naturally) conflicting views between researchers, where each side presents strong points that pull in opposing directions. In such cases, it’s still somewhat uncertain as to which viewpoint (if any) is more accurate. As a result, there is room for further research in an attempt to “settle” the debate.

Of course, many other potential scenarios can give rise to research gaps, and consequently, research problems, but these common ones are a useful starting point. If you’re interested in research gaps, you can learn more here .

How to find a research problem

Given that research problems flow from research gaps , finding a strong research problem for your research project means that you’ll need to first identify a clear research gap. Below, we’ll present a four-step process to help you find and evaluate potential research problems.

If you’ve read our other articles about finding a research topic , you’ll find the process below very familiar as the research problem is the foundation of any study . In other words, finding a research problem is much the same as finding a research topic.

Step 1 – Identify your area of interest

Naturally, the starting point is to first identify a general area of interest . Chances are you already have something in mind, but if not, have a look at past dissertations and theses within your institution to get some inspiration. These present a goldmine of information as they’ll not only give you ideas for your own research, but they’ll also help you see exactly what the norms and expectations are for these types of projects.

At this stage, you don’t need to get super specific. The objective is simply to identify a couple of potential research areas that interest you. For example, if you’re undertaking research as part of a business degree, you may be interested in social media marketing strategies for small businesses, leadership strategies for multinational companies, etc.

Depending on the type of project you’re undertaking, there may also be restrictions or requirements regarding what topic areas you’re allowed to investigate, what type of methodology you can utilise, etc. So, be sure to first familiarise yourself with your institution’s specific requirements and keep these front of mind as you explore potential research ideas.

Step 2 – Review the literature and develop a shortlist

Once you’ve decided on an area that interests you, it’s time to sink your teeth into the literature . In other words, you’ll need to familiarise yourself with the existing research regarding your interest area. Google Scholar is a good starting point for this, as you can simply enter a few keywords and quickly get a feel for what’s out there. Keep an eye out for recent literature reviews and systematic review-type journal articles, as these will provide a good overview of the current state of research.

At this stage, you don’t need to read every journal article from start to finish . A good strategy is to pay attention to the abstract, intro and conclusion , as together these provide a snapshot of the key takeaways. As you work your way through the literature, keep an eye out for what’s missing – in other words, what questions does the current research not answer adequately (or at all)? Importantly, pay attention to the section titled “ further research is needed ”, typically found towards the very end of each journal article. This section will specifically outline potential research gaps that you can explore, based on the current state of knowledge (provided the article you’re looking at is recent).

Take the time to engage with the literature and develop a big-picture understanding of the current state of knowledge. Reviewing the literature takes time and is an iterative process , but it’s an essential part of the research process, so don’t cut corners at this stage.

As you work through the review process, take note of any potential research gaps that are of interest to you. From there, develop a shortlist of potential research gaps (and resultant research problems) – ideally 3 – 5 options that interest you.

Step 3 – Evaluate your potential options

Once you’ve developed your shortlist, you’ll need to evaluate your options to identify a winner. There are many potential evaluation criteria that you can use, but we’ll outline three common ones here: value, practicality and personal appeal.

Value – a good research problem needs to create value when successfully addressed. Ask yourself:

• Who will this study benefit (e.g., practitioners, researchers, academia)?
• How will it benefit them specifically?
• How much will it benefit them?

Practicality – a good research problem needs to be manageable in light of your resources. Ask yourself:

• What data will I need access to?
• What knowledge and skills will I need to undertake the analysis?
• What equipment or software will I need to process and/or analyse the data?
• How much time will I need?
• What costs might I incur?

Personal appeal – a research project is a commitment, so the research problem that you choose needs to be genuinely attractive and interesting to you. Ask yourself:

• How appealing is the prospect of solving this research problem (on a scale of 1 – 10)?
• Why, specifically, is it attractive (or unattractive) to me?
• Does the research align with my longer-term goals (e.g., career goals, educational path, etc)?

Depending on how many potential options you have, you may want to consider creating a spreadsheet where you numerically rate each of the options in terms of these criteria. Remember to also include any criteria specified by your institution . From there, tally up the numbers and pick a winner.

Step 4 – Craft your problem statement

Once you’ve selected your research problem, the final step is to craft a problem statement. Remember, your problem statement needs to be a concise outline of what the core issue is and how your study will address it. Aim to fit this within one paragraph – don’t waffle on. Have a look at the problem statement example we mentioned earlier if you need some inspiration.

Key Takeaways

We’ve covered a lot of ground. Let’s do a quick recap of the key takeaways:

• A research problem is an explanation of the issue that your study will try to solve. This explanation needs to highlight the problem , the consequence and the solution or response.
• A problem statement is a clear and concise summary of the research problem , typically contained within one paragraph.
• Research problems emerge from research gaps , which themselves can emerge from multiple potential sources, including new frontiers, new contexts or disagreements within the existing literature.
• To find a research problem, you need to first identify your area of interest , then review the literature and develop a shortlist, after which you’ll evaluate your options, select a winner and craft a problem statement .

Psst... there’s more!

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How to Write a Statement of the Problem for Your Research Proposal

Defining your research problem is essential when conducting an experiment. In this article, you will learn how to write a statement of the problem for your research proposal. Learn about the characteristics of a good statement of the problem and examples of research questions.

Updated on May 17, 2022

You are a great researcher. You are full of ideas and questions as to where to go next with your work. You would not be in this position if you were not good at coming up with interesting questions within your area.

One problem, though, is knowing where to spend your time, energy, and money. Which ideas, questions, and problems are worthwhile?

You need to be able to define a good research problem. A research problem addresses an existing gap in knowledge in your field and leads to further investigations by you and other researchers. Inspiring others with your research problem will lead to citations, enhancing your and your institution's impact.

In order to write a clear and useful problem statement, you need to describe a question and its consequences.

One key way to assess the ‘usefulness' of your research ideas is to learn how to express them as clear problems.

In this article, we will talk about how to write a statement of the problem for your next research proposal. This is important not just for assessing the ‘usefulness' of research ideas, but also for formulating a grant application or proposal. We'll talk about how to explain your research ideas to others in the form of a problem statement in your proposal.

What is a statement of the problem in research?

All research projects should start with a clear problem statement. A problem statement is a formulation of an issue which is usually a ‘gap' within your area. A research gap is an unanswered question, an issue, controversy, or untested hypothesis that has not yet been addressed.

The trick with research problems is working out whether they are actually worth investing the time, energy, and money to figure out. This comes with experience, or you could just read on!

Since a clear problem statement is going to form the basis of your next research project, the question is: How can I write one?

How is this done? The first step is to become familiar with the basic elements of a problem statement in effective research.

Characteristics of a problem statement

A research problem statement has two key attributes:

• The problem must be challenging and original, but also potentially achievable by your team.
• The problem must not be incremental. In other words, don't try to address a small change or advance on an existing study that leads to no new scientific insight. This could be damaging to your and your team's reputation, and will likely not lead to a meaningful publication.

Developing a ‘good' research problem statement, therefore, involves systematic planning and setting time-based, realistic objectives. Your problem has to be achievable.

You'll also need to apply feasible research methods based on an approach that best suits the research question. Your methods have to make sense. They must be usable. In other words, you must be able to acquire statistically sufficient and relevant data that is reproducible.

Finally, the problem you define means you'll need to train team members in this particular research area and methods.

Writing a statement of the problem

Stating a research problem is done by defining it within the general area of your research. This depends on your previous work and experience. It may be an area you want to move into or a topic related to what you have already worked on as a researcher. Examples could include a question in astrophysics within physics, robotics within engineering, nutrition within medicine, or marine biology within ocean and Earth science.

Once you've determined your overall area (and you'll know this already of course), it's time to drill down, decide, and define a research problem within that field.

First , your statement should identify a problem that needs to be addressed within your selected sub-area.

This will almost certainly require literature work, but the idea may arise from:

• Discussions you've had with colleagues;
• Discussions at a conference;
• A paper you've read.

Second , your problem statement should be a “good research problem.” This will require further investigation and reading as you consider “what has been done?” and “what needs to be done?”

Third , search for more information, perhaps by:

• Locating relevant books, papers and other materials;
• Evaluating the quality and authority of the information collected;
• Maintaining a regular literature review throughout the project;
• Making regular notes on background material;
• Deciding how this literature search will be carried out within the research group;
• Deciding how information gained will be disseminated to the group (e.g., via each researcher carrying out a regular literature review in their sub-area and information disseminated at group meetings or via email at regular intervals).

This process may well change or modify how your research problem is stated or formulated.

Once your research problem has been identified, research questions within the problem need to be specified.

How long should your statement of the problem be?

Not too long. One page is more than enough for a clear and effective problem statement.

Research questions within your problem

The first stage of writing your research problem statement involves formulating your questions in a meaningful way. In the context of important questions, we are looking for things that many readers across different disciplines find to be interesting. But at the same time, set your question within your field.

Thus, once a research problem has been established, several questions can be written down. These questions should specify exactly what needs to be determined to address the problem.

These questions should also be specific enough that they can be answered using appropriate available research methods - or methods that could be made available to the research group (e.g. by buying or borrowing equipment).

These questions should require complex in-depth investigation, analysis, and argument. They should not be simple enough that they can be answered easily with well-established facts or yes/no answers.

All research questions should be focused, specific, appropriately complex, and relevant to the overall aims of the project.

Examples of questions and next steps

• How do government regulations prevent companies from polluting water systems?
• What factors have influenced population growth in the fastest growing countries?
• How can a bespoke thermal desorption unit be designed and built for use in detection of trace particulate matter in a polluted environment (e.g., a busy city street)?
• What methods and procedures can be used to understand, and hence control, fundamental chemical processes that occur in flames?
• How can measurement protocols used in mass spectrometry in a university research laboratory be developed and standardized to enable direct comparison with related measurements in a government laboratory?

Once the problem and questions have been identified, the resources required to carry out the research will need to be assessed. This will involve:

• Identifying the equipment needed. Find out what is available and what needs to be purchased.
• Assessing which consumables (e.g., chemicals) are needed for the project, and determining if they can be obtained on a regular basis (i.e., in the right quantities at the appropriate times).
• Identifying the software, data-analyses and other computer support needed. Assess what needs to be purchased.
• Assessing what laboratory and office space is needed. And if more is required, discuss this with the relevant laboratory manager.
• Identifying what support for travel is needed for the group, as well as what resources are required for the group to attend relevant conferences and training of group personnel.

Final thoughts

Defining and writing a clear statement of a problem as the basis of a project is the first - and most important - step in any research. The tips and ideas in this article will help you clearly identify the purpose of the research you are developing.

A clear research problem statement will likely form the skeleton of the Introduction of your final article. If you are able to clearly direct your reader (the most important person in the publishing process) to an important and interesting question, they will likely stay engaged, and use and cite your article in the future.

The AJE Team

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• How to Write a Problem Statement for your Research

Every research starts with identifying a problem which is usually an existing gap in your field of study. Once you do this, the next step is to craft a statement of the problem that captures this issue and how you plan to resolve it. A statement of problem forms the basis of every systematic investigation. 

Seeing as a problem statement forms the core of your research, it makes sense to know how to write an effective one. So how do you go about this? First, you need to get acquainted with the features of a good problem statement plus its elements and structure. 

Use this guide to know how to write an effective statement of the problem for your systematic investigation. 

What is the Statement of the Problem in Research?

A statement of problem refers to the critical issue that your research seeks to address. In other words, it captures the existing knowledge gap that your study aims to bridge using reliable results or outcomes. A problem statement can be as little as a few sentences or go all the way to several paragraphs—what matters is it communicates the central focus of your study. 

As your study bridges this gap, it also leaves room for future investigations. The implication is that your problem statement should not be too broad; instead, it should address one specific issue and contribute to the knowledge pool for further research. 

Use for Free: Research Form Templates

What are the Features of a Good Problem Statement?  

A good problem statement captures the core purpose of your study in simple, clear, and direct terms. Some other tell-tale signs of a well-written research statement of problem include: 

• A good problem statement is concrete and concise. It doesn’t capture ideas vaguely or ambiguously.
• It allows you to contextualize the research problem.
• A good problem statement helps you to set the aims and objectives of your systematic investigation. 
• It justifies your research and draws attention to the study’s significance. 

Why is a Problem Statement Important in Research Writing?

Writing a good problem statement serves both the researcher and the readers. For the researcher, the problem statement helps you visualize the scope of your project and outline it accordingly. Also, it allows you to map out specific aims and objectives for your study. 

On the flip side, the problem statement helps the reader identify the core reason for your research and see how your work fits into the existing body of knowledge. It helps them get on the same page as you regarding the importance and significance of your systematic investigation. 

If you require funding for your research, a problem statement can help potential financiers to see why investing in your project is the right move to make. It gives them an overview of the existing problem, your solution, and the impact of your solution on the field of study. 

Elements and Structure of a Problem Statement

In its most basic form, a problem statement comprises three(3) elements which are: 

• The research problem
• The claim or working thesis
• The significance of the study

In other words, it tells the reader what you’re trying to solve, how you plan to solve it, and why you want to solve it. 

1. The Research Problem

Your research problem is the reason for your systematic investigation. It is the gap you identified and planned to fill based on the results of your study. You can also think of this as the primary research question. 

A few questions you should ask yourself here include: 

• Is it clear what’s being described in this problem statement?
• Do I understand the main problem being described here?
• Do I have a good grasp of what the main issue is here?

2. The Claim or Working Thesis 

Your working thesis is the first attempt at asserting your position, and it spells out your stance on the matter at a specific point in time. It’s called a “working” thesis because it is subject to change as your study progresses. In your working thesis, you have the chance to justify your position by providing primary and secondary claims that support your position. 

3. The Significance of the Study 

This is the point where you communicate the value of your research and show readers why it is necessary in the first place. Here, you can discuss the impact of your work and its relevance to your field of study. Don’t forget to highlight the contributions of your work to existing knowledge and how others will benefit from it. 

Read: Research Report: Definition, Types + [Writing Guide]

What is the Difference Between a Thesis Statement and a Problem Statement? 

A problem statement focuses on the specific issue you’ve identified and hope to resolve with your research. It comprises the research problem, claim, or working statement and the significance of your research. On the other hand, a thesis statement makes a specific claim or assertion open for debate. 

For example, the statement “writing is more of a science than an art” is an excellent example of a thesis statement because it proposes an idea that may be true or false. Once you establish the thesis statement for your research, you are expected to provide evidence and build a strong argument that supports this claim.

What are the Steps for Writing a Problem Statement? 

• Define Your Research Context 
• State Why The Problem Matters 
• State the Financial Cost
• Back Up Your Claims
• Propose A Solution
• Conclude By Summarizing the Problem and Solution

1. Define Your Research Context 

The first thing you need to do is build a solid context that makes it easier for readers to understand the problem. A hack for this is to describe an ideal world where the problem doesn’t exist. In other words, help your readers to visualize how different things would be if they didn’t have to deal with this problem in the first place. 

For example, if you’re researching the rise in the number of train accidents in London, start by describing how the process would function if the current problem didn’t exist. When you’ve done this, you can refer to the research problem at the end of your explanation. 

2. State Why the Problem Matters

You should let readers in on why the problem matters and why you must address it at this point. In other words, answer the question, “why is it important that we fix this particular problem?” What difference would it make? 

Your job here is to show the reader why your research problem is the biggest elephant in the room. You may also consider including what attempts have already been made to solve the problem and why they didn’t work out. 

3. State the Financial Cost

If there’s a financial implication of not fixing the problem, then it’s a good idea to state it here. This is more useful if you’re pitching for funding for your research. 

4. Back Up Your Claims

It’s not enough to say that the problem has some negative impact on other people or your organization; you must back up all of these claims with well-researched data. This is the point where you pull up information from relevant secondary data sources and reference them in your work. 

5. Proffer a Solution

Now that we know the problem, the next question is, “what can be done about it”? To answer this, you need to propose a practical solution to the research problem. Take time to demonstrate why this is the most pragmatic solution and why it will work. More importantly, focus on the impact of your solution and hint at its benefits. 

6. Conclude By Summarizing the Problem and Solution

Your conclusion should consist of the problem, why it needs to be fixed, and a summarized argument of why your solution is the best answer to the problem.

Sample Problem Statement 

Problem : The use of hard drugs amongst teenagers in the District of Columbia has increased significantly over the past decade. 

Background : According to the Drug Abuse Statistics Organization data, 50% of teenagers have misused a drug at least once. Teenagers in the District of Columbia are 11.94% more likely to have used drugs in the last month than the average American teen. Existing data shows that this is a significant problem but fails to address the root causes of rising teenage drug abuse in the state. Therefore, more research is required to identify why teenagers in Colombia abuse drugs and proffer solutions to this menace. 

Relevance : Young people who abuse drugs expose themselves to many risks, including life-threatening conditions and mental health-related problems. Drug abuse can impact the brain’s ability to function in the short term and prevent proper growth and development in the long term. Data shows that teenagers who use hard drugs are more likely to be disillusioned. Addressing this problem will give concerned parties the much-needed insights to help them curtail drug abuse. 

Objectives : This research aims to identify the root causes of teenage drug abuse and map out actionable solutions to address this. 

Mistakes to Avoid when Writing Problem Statements  

A good problem statement sets the tone for the rest of your dissertation, so you want to get it right. That said, here are some things you should have at the back of your mind as you craft a problem statement for your research paper. 

1. Make sure your problem statement is straight to the point. Every sentence should reinforce the importance of your study. 

2. Narrow the scope of your problem statement.

3. Avoid unnecessary jargon and highly technical language.

4. Build a logical argument that will convince the reader

5. Emphasize the “why” of the problem 

FAQ About Writing a Statement of the Problem

How do you identify a research problem?

The best way to identify a research problem is to read through existing studies to discover any gaps in knowledge. You can also discover research problems by observing your environment and identifying any contradictions that exist among perspectives. 

Conclusion 

Whether you’re seeking funding for your research or approval from your professor, you need to write a well-defined statement of the problem. A problem statement allows you to pitch the core idea of your study and show others why it is worth being addressed. It should draw attention to the core idea of your research, and convince others to invest in your systematic investigation. 

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Home » Problem Statement – Writing Guide, Examples and Types

Problem Statement – Writing Guide, Examples and Types

Table of Contents

Problem Statement

Definition:

Problem statement is a clear, concise, and well-defined statement that outlines the issue or challenge that needs to be addressed. It is a crucial element in any project or research as it provides a clear understanding of the problem, its context, and its potential impact.

Types of Problem Statements

There are various types of problem statements, and the type of problem statement used depends on the context and purpose of the project or research. Some common types of problem statements are:

Business Problem Statement

Business Problem Statement identifies a problem or challenge within an organization that needs to be solved. It typically includes the impact of the problem on the organization and its stakeholders, such as customers, employees, or shareholders.

Research Problem Statement

Research Problem Statement outlines the research question or problem that the study aims to address. It describes the research objectives, the significance of the research, and the potential impact of the research findings.

Design Problem Statement

Design Problem Statement defines the problem or challenge that a design project aims to solve. It includes the user’s needs, the design constraints, and the desired outcomes of the design project.

Social Problem Statement

Social Problem Statement describes a problem or challenge in society that needs to be addressed. It typically includes the social, economic, or political impact of the problem and its effect on individuals or communities.

Technical Problem Statement

Technical Problem Statement defines a problem or challenge related to technology or engineering. It includes the technical requirements, constraints, and potential solutions to the problem.

Components of Problem Statement

The components of a problem statement may vary depending on the context and purpose of the project or research, but some common components include:

• Problem description : This component provides a clear and concise description of the problem, its context, and its impact. It should explain what the problem is, who is affected by it, and why it needs to be addressed.
• Background information : This component provides context for the problem by describing the current state of knowledge or practice related to the problem. It may include a review of relevant literature, data, or other sources of information.
• Objectives : This component outlines the specific objectives that the project or research aims to achieve. It should explain what the project or research team hopes to accomplish by addressing the problem.
• Scope : This component defines the boundaries of the problem by specifying what is included and excluded from the problem statement. It should clarify the limits of the project or research and ensure that the team remains focused on the core problem.
• Methodology : This component outlines the approach or methodology that the project or research team will use to address the problem. It may include details about data collection, analysis, or other methods used to achieve the objectives.
• Expected outcomes : This component describes the potential impact or outcomes that the project or research aims to achieve. It should explain how the solution or findings will address the problem and benefit the stakeholders.

How to write Problem Statement

Here are some general steps to follow when writing a problem statement:

• Identify the problem : Clearly identify the problem that needs to be addressed. Consider the context, stakeholders, and potential consequences of the problem.
• Research the problem: Conduct research to gather data and information about the problem. This may involve reviewing literature, analyzing data, or consulting with experts.
• Define the problem: Define the problem clearly and concisely, using specific language and avoiding vague or ambiguous terms. Be sure to include the impact of the problem and the context in which it occurs.
• State the objectives : Clearly state the objectives that the project or research aims to achieve. This should be specific and measurable, with clear outcomes that can be evaluated.
• Identify the scope: Identify the boundaries of the problem, including what is included and excluded from the problem statement. This helps to ensure that the team remains focused on the core problem.
• Outline the methodology : Outline the approach or methodology that the project or research team will use to address the problem. This should be based on research and best practices, and should be feasible and realistic.
• Describe the expected outcomes : Describe the potential impact or outcomes that the project or research aims to achieve. Be specific about how the solution or findings will address the problem and benefit the stakeholders.
• Revise and refine : Review the problem statement and revise it as needed to ensure clarity, accuracy, and completeness.

Applications of Problem Statement

Here are some of the applications of problem statements:

• Research : In academic research, problem statements are used to clearly define the research problem, identify the research question, and justify the need for the study. A well-crafted problem statement is essential for the success of any research project.
• Project management: In project management, problem statements are used to identify the issues or challenges that a project team needs to address. Problem statements help project managers to define project scope, set project goals, and develop project plans.
• Business strategy: In business strategy, problem statements are used to identify business challenges and opportunities. Problem statements help businesses to define their strategic objectives, develop action plans, and allocate resources.
• Product development : In product development, problem statements are used to identify customer needs and develop new products that address those needs. Problem statements help product developers to define product requirements, develop product features, and test product prototypes.
• Policy-making: In public policy-making, problem statements are used to identify social, economic, and environmental issues that require government intervention. Problem statements help policymakers to define policy objectives, develop policy options, and evaluate policy outcomes.

Examples of Problem Statements

Examples of Problem Statements are as follows:

• High student-to-teacher ratios are leading to decreased individualized attention and lower academic achievement.
• Limited funding for extracurricular activities is limiting opportunities for student development and engagement.
• The lack of diversity and inclusion in curriculum is limiting cultural understanding and perpetuating inequalities.
• The need for continuous professional development for teachers is crucial to improving teaching quality and student outcomes.
• Unequal access to education due to socio-economic status, geographical location, or other factors is contributing to disparities in academic achievement.
• The shortage of healthcare professionals is leading to increased patient wait times and decreased quality of care.
• Limited access to mental health services is contributing to the high prevalence of mental health issues and suicides.
• The over-prescription of opioids is contributing to the current opioid epidemic and increasing rates of addiction and overdose.
• Limited access to affordable and nutritious food is leading to poor nutrition and increased rates of chronic diseases.
• The lack of standardized electronic health record systems is limiting coordination of care and leading to medical errors.

Environmental Science

• Pollution from industrial and agricultural practices is contributing to climate change and increased health risks.
• The overexploitation of natural resources is leading to decreased biodiversity and ecological imbalance.
• Limited access to clean water is leading to health issues and affecting agriculture and economic development.
• The destruction of natural habitats is leading to the extinction of many species and disrupting ecosystems.
• Climate change is leading to more frequent and severe natural disasters, causing significant damage to infrastructure and displacement of populations.

Engineering

• The inadequate design and maintenance of bridges and roads is leading to increased accidents and fatalities.
• The lack of reliable and sustainable energy sources is contributing to environmental degradation and limiting economic growth.
• The lack of cybersecurity measures in critical infrastructure is making it vulnerable to cyber attacks and compromising public safety.
• The lack of efficient waste management systems is contributing to pollution and environmental degradation.
• The need for developing technologies that are environmentally friendly and sustainable is crucial to addressing climate change.

Social Work

• The lack of resources for mental health and social services is contributing to homelessness and the need for emergency assistance.
• The high prevalence of child abuse and neglect is leading to long-term physical and emotional harm to children.
• The lack of affordable and accessible childcare is limiting the opportunities for working parents, especially mothers.
• The stigmatization of mental health issues is limiting access to mental health services and perpetuating discrimination.
• The limited access to education, employment, and housing opportunities is contributing to poverty and social inequality.
• The increasing use of ad-blocking software is limiting the effectiveness of traditional digital advertising.
• The lack of transparency in digital advertising is leading to ad fraud and decreased trust in online marketing.
• The need to adapt marketing strategies to changing consumer behaviors and preferences is crucial to reaching target audiences effectively.
• The high competition in the marketplace is making it challenging for small businesses to compete with larger corporations.
• The need to balance marketing goals with ethical considerations is crucial to maintaining consumer trust and avoiding negative publicity.
• The high prevalence of anxiety and depression is leading to decreased productivity and increased healthcare costs.
• The limited access to mental health services in certain geographic areas is limiting access to care and contributing to disparities in mental health outcomes.
• The need for effective prevention and intervention programs for substance abuse and addiction is crucial to reducing rates of addiction and overdose.
• The lack of awareness and understanding of mental health issues is perpetuating stigma and limiting access to care.
• The need for culturally sensitive mental health services that are tailored to the needs of diverse populations is crucial to improving mental health outcomes.

Purpose of Problem Statement

The purpose of a problem statement is to clearly and concisely describe a specific problem or issue that needs to be addressed. It serves as a clear and succinct explanation of the problem, its context, and its importance, providing the necessary information to understand why the problem is worth solving. A well-crafted problem statement also helps to define the scope of the problem, which in turn helps to guide the research or problem-solving process. In essence, a problem statement sets the stage for identifying potential solutions and determining the best approach to solve the problem.

Characteristics of Problem Statement

The characteristics of a good problem statement include:

• Clear and concise : A problem statement should be written in clear and concise language, free of technical jargon, and easily understandable to the intended audience.
• Specific : The statement should clearly define the problem and its scope. It should identify the who, what, where, when, and why of the problem.
• Measurable : A problem statement should be measurable in some way, whether through quantitative or qualitative methods. This allows for objective assessment of progress towards solving the problem.
• Relevant : The problem statement should be relevant to the context in which it is presented. It should relate to the needs and concerns of stakeholders and the broader community.
• Feasible : The problem statement should be realistic and achievable, given the available resources and constraints.
• Innovative: A good problem statement should inspire creative and innovative solutions.
• Actionable : The problem statement should lead to actionable steps that can be taken to address the problem. It should provide a roadmap for moving forward.

Advantages of Problem Statement

Advantages of Problem Statement are as follows:

• Focus : A problem statement helps to clearly define the problem at hand and provides focus to the problem-solving process. It helps to avoid wasting time and resources on issues that are not relevant.
• Alignment : A well-written problem statement ensures that everyone involved in the problem-solving process is on the same page and understands the issue at hand. This alignment helps to ensure that efforts are focused in the right direction and that everyone is working towards the same goal.
• Clarity : A problem statement provides clarity about the nature of the problem and its impact. This clarity helps to facilitate communication and decision-making, making it easier to develop effective solutions.
• Innovation : A well-crafted problem statement can inspire creativity and encourage innovative thinking. By clearly defining the problem, it can help to identify new approaches and solutions that may not have been considered before.
• Measurability : A problem statement that is clear and specific can be used to measure progress and success. It helps to ensure that efforts are focused on addressing the root cause of the problem and that progress towards a solution can be tracked and evaluated.

Limitations of Problem Statement

While problem statements have many advantages, they also have some limitations, such as:

• Limited Scope: A problem statement is usually focused on a specific issue or challenge. As a result, it may not capture the full complexity of a larger problem, which can limit the effectiveness of the solutions developed.
• Lack of Detail : In some cases, problem statements may be too broad or lack sufficient detail, which can make it difficult to develop effective solutions. It’s important to ensure that the problem statement is specific enough to guide the problem-solving process.
• Bias : The way in which a problem statement is written can sometimes reflect the biases or assumptions of the person or group writing it. This can lead to a narrow or incomplete understanding of the problem and limit the effectiveness of the solutions developed.
• Inflexibility : A problem statement may be too rigid or inflexible, which can limit the exploration of alternative solutions. It’s important to keep an open mind and be willing to adapt the problem statement as new information or perspectives emerge.

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The first step in research is to outline the research problem – this might be an area of concern, a gap in the existing knowledge or a deviation in something that has been previously established, which warrants further investigation. 

Importance of the problem statement

The statement of a problem defines and describes the research hypothesis or question(s), along with the broad method that will be used to solve the problem . The statement of the problem serves as the basis for the introductory section of your project proposal. A well-formulated statement of the problem sets the stage for the rest of your study , including how you will address the problem and any anticipated outcomes or answers. Once you have very clearly laid out the core issue, problem or question that you’re investigating, you’ll have a much sharper focus for conducting and writing up the rest of your study. A clear and straightforward statement will also inform and impress your reader in grasping the issues that your proposed project will address.

Defining the ‘problem’

The research question should be compelling and must have an underlying basis. While formulating the problem statement, as a keen researcher, you should consider the current state of the topic in question, along with any other observations or educated guesses. 

As you are defining the ‘problem’ that you are addressing in your research, consider the following questions: 

• What is the problem?
• Why is it a problem, and why does it need to be resolved? 
• What are the likely benefits of solving the problem? 
• Besides the central question, what are smaller, specific questions that need to be asked and answered?

Clarifying and refining the problem statement

In the initial stages of writing, the problem statement might be a bit rough around the edges. A final and more refined form will emerge as you reflect more deeply over the topic and delve into the literature. The current status of the topic , including what is known and what is not , will help you refine your original problem statement to a clearer and more specific one.

Wrapping it up

To conclude the section, briefly summarise the problem and emphasise the need to fix it. All potential advantages and anticipated outcomes and implications should be mentioned here. Contextualising the problem in a broad sense will also strengthen your case.

Sample problem statement

In a detailed project proposal, the statement of the problem could be nearly a page long, over several paragraphs . In a report or paper, the problem is typically expressed in a few sentences in the Introduction . Here is an example based on a fictional study.

Early and targeted warning of dengue outbreaks is critical for vector control. Current studies have primarily focused on the role of weather conditions in dengue forecasting. Environmental and microenvironmental suitability for mosquito breeding has been sorely neglected as a crucial factor, particularly in the urban setting. The surge in dengue and other mosquito-borne infections in India metropolitan cities in 2020–2021 highlights the urgent need to identify conducive features to better track and predict outbreaks. This study proposes a framework for implementing intra-urban dengue forecasting by… Through this investigation, we aim to develop a set of early predictors for improved surveillance of dengue in large urban swathes in Indian metropolitan cities. 

Dos and don’ts of writing a problem statement

• Write the actual problem statement as a declarative statement or as a question .
• Explain in the statement how previous studies have not addressed the issue or have fallen short due to certain limitations.
• Outline in your statement how you plan to overcome or circumvent previous roadblocks to fill these deficiencies.
• Ensure the statement is lucid and to the point, without any distracting information.
• Cite credible sources where needed.

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Importance of Broadening the Research Topic

It is important to adopt a flexible approach when choosing a topic to investigate. The goal when writing any paper is to choose a research problem that is focused and time-limited. However, your starting point should not be so narrowly defined that you unnecessarily constrict your opportunity to investigate the topic thoroughly. A research problem that is too narrowly defined leads to any of the following problems :

• You can't find enough information and what you do find is tangential or irrelevant.
• You find information that is so specific that it can't lead to any significant conclusions.
• Your sources cover so few ideas that you can't expand them into a significant paper.
• The research problem is so case specific that it limits opportunities to generalize or apply the results to other contexts.
• The significance of the research problem is limited to only a very small, unique population.

Ravitch, Sharon M. and Matthew Riggan. Reason and Rigor: How Conceptual Frameworks Guide Research . Los Angeles, CA: SAGE, 2017.

Strategies for Broadening the Research Topic

In general, an indication that a research problem is too narrowly defined is that you can't find any relevant or meaningful information about it. If this happens, don't immediately abandon your efforts to investigate the problem because it could very well be an excellent topic of study. A good way to begin is to look for parallels and opportunities for broader associations that apply to the initial research problem. A strategy for doing this is to ask yourself the basic six questions of who, what, where, when, how, and why.

Here is an example of how to apply the six questions strategy to broadening your topic. Let's use the research topic of how to investigate ways to improve trade relations between Peru and Bolivia as an example. Ask yourself:

• Who? -- are there other countries involved in the relations between these two countries that might want to challenge or encourage this relationship? Are there particular individuals or special interest groups [e.g., politicians, union leaders, etc.] promoting trade relations or trying to inhibit it? [remember to ask either the individual who question, the collective who question, or the institutional who question].
• What? -- what are the specific trading commodities you are examining? Are there commodities not currently traded between Peru and Bolivia that could be? What commodities are being traded but should be traded in greater volume? What barriers exist that may help or hinder the import-exports of specific commodities?
• Where? -- where are examples of other bi-lateral trade agreements that could model the potential for closer trade relations between Peru and Bolivia? Where are the benefits most likely to be felt within each country? Note that the question of where can also relate to specific spatial and geographical issues, such as, are there any areas impeding transportation of goods in the region?
• When? -- how long have these countries had or not had trade relations? How far into the future might a trade relationship last given other factors? The question of when can apply to either past issues or future areas of interest.
• How? -- how might Peru and Bolivia forge these ties in relation to, for example, long-standing internal conflicts within each country? Note that the how question can also be framed as, "In what way might...." [e.g., In what way might improved trade relations lead to other forms of economic exchanges between the two countries?].
• Why? -- what advantages can each country gain by pursuing active trade relations? Why might other countries be concerned about closer ties between these two countries? Asking why can illuminate the " So What? " question applied to your topic and, thus, provide a means of assessing significance.

Reflecting upon these six questions during your initial review of the literature can help you formulate ways to expand the parameters of your initial research problem, providing an opportunity to identify new avenues of investigation and centering your study around gaps in the literature when answers to questions cannot be found. Once you've identified additional directions in which to proceed with your topic, you can try narrowing it down again, if needed.

NOTE:   Do not determine on your own that a research problem is too narrowly defined . Always consult with a librarian before making this assumption because librarians are experts in finding information and interpreting it in relation to a research problem. As such, they can help guide you to undiscovered research or suggest ways to design a broader analysis of your research problem using resources you did not even know existed.

Booth, Wayne C. The Craft of Research . Fourth edition. Chicago, IL: The University of Chicago Press, 2016; Coming Up With Your Topic. Institute for Writing Rhetoric. Dartmouth College; Getting Started With Your Research: A Self-Help Guide to Quality Information, Jean and Alexander Heard Library. Vanderbilt University; Strategies for Broadening a Topic. University Libraries. Information Skills Modules. Virginia Tech University.

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The self-driving car revolution reached a momentous milestone with the U.S. Department of Transportation’s release in September 2016 of its first handbook of rules on autonomous vehicles .

Many members of the Stanford community are debating ethical issues that will arise when humans turn over the wheel to algorithms. (Image credit: AlealL / Getty Images)

Discussions about how the world will change with driverless cars on the roads and how to make that future as ethical and responsible as possible are intensifying.

Some of these conversations are taking place at Stanford. The topic of ethics and autonomous cars will be discussed during a free live taping of an episode of Philosophy Talk , a nationally syndicated radio show co-hosted by professors Ken Taylor and John Perry , on Wednesday, May 24, at the Cubberley Auditorium.

Stanford News Service talked to several Stanford scholars for their insights on the most significant ethical questions and concerns when it comes to letting algorithms take the wheel.

Trolley problem debated

A common argument on behalf of autonomous cars is that they will decrease traffic accidents and thereby increase human welfare. Even if true, deep questions remain about how car companies or public policy will engineer for safety.

“Everyone is saying how driverless cars will take the problematic human out of the equation,” said Taylor, a professor of philosophy. “But we think of humans as moral decision-makers. Can artificial intelligence actually replace our capacities as moral agents?”

That question leads to the “trolley problem,” a popular thought experiment ethicists have mulled over for about 50 years, which can be applied to driverless cars and morality.

In the experiment, one imagines a runaway trolley speeding down a track which has five people tied to it. You can pull a lever to switch the trolley to another track, which has only one person tied to it. Would you sacrifice the one person to save the other five, or would you do nothing and let the trolley kill the five people?

Engineers of autonomous cars will now have to tackle this question and other, more complicated scenarios, said Taylor and Rob Reich , the director of Stanford’s McCoy Family Center for Ethics in Society .

“It won’t be just the choice between killing one or killing five,” said Reich, who is also a professor of political science. “Will these cars optimize for overall human welfare, or will the algorithms prioritize passenger safety or those on the road? Or imagine if automakers decide to put this decision into the consumers’ hands, and have them choose whose safety to prioritize. Things get a lot trickier.”

Minimizing risk

But Stephen Zoepf , executive director of the Center for Automotive Research at Stanford (CARS) , along with several other Stanford scholars, including mechanical engineering Professor Chris Gerdes , argue that agonizing over the trolley problem isn’t helpful.

“It’s not productive,” Zoepf said. “People make all sorts of bad decisions. If there is a way to improve on that with driverless cars, why wouldn’t we?”

Zoepf said the more important ethical question is what is the level of risk society would be willing to incur with self-driving cars on the road. For the past several months, Zoepf and his CARS colleagues have been working on a project on ethical programming of automotive vehicles.

“We say, ‘let’s look at the tradeoffs inherent in safety and mobility,’” Zoepf said. “Should there be a designated right of way for automated vehicles, for example, or how fast should we permit automated vehicles to travel?”

Loss of jobs

Another ethical concern is the number of jobs that will be lost if self-driving vehicles become the norm, Taylor and Reich said.

More than 3.5 million truck drivers haul cargo on U.S. roads, according to the latest statistics by the American Trucking Associations , a trade association for the U.S. trucking industry.

“You can’t outsource driving,” Taylor said. “Technology has always destroyed jobs but created other jobs. But with the current technology revolution, things may look differently.”

Technological developments can cause the loss of jobs. But tech companies and governments can and must take steps to prepare for those losses, said Margaret Levi , professor of political science and the director of the Center for Advanced Study in the Behavioral Sciences .

“We have to be prepared for this job loss and know how to deal with it,” Levi said. “That’s part of the ethical responsibility of society. What do we do with people who are displaced? But it is not only the transformation in labor. It is also the transformation in transport, private and public. We must plan for that, too.”

Transparency and collaboration

Some scholars have also pointed out the need for greater transparency in the design of driverless cars.

“Should it be transparent how the algorithms of these cars are made?” Reich said. “The public interest is at stake, and transparency is an important consideration to inform public debate.”

But no matter their stance on a particular issue with self-driving cars, the scholars agree that there needs to be greater collaboration among disciplines in the development stage of this and other revolutionary technology.

“We need social scientists and ethicists on the design teams from the get-go,” Levi said. “That won’t resolve all the questions, but it would at least be a start to dealing with some of them.”

At Stanford, some of these collaborations are already taking place.

Jason Millar, an engineer and postdoctoral research fellow with the Center of Ethics in Society, is also working on the CARS ethical programming project. He is tackling how to translate knowledge developed in academic and philosophical circles into the daily design work of technology and artificial intelligence products.

“The idea is to address the concerns upfront, designing good technology that fits into people’s social worlds,” Millar said.

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• Published: 21 May 2024

The pig as an optimal animal model for cardiovascular research

• Hao Jia   ORCID: orcid.org/0000-0002-4736-0957 1   na1 ,
• Yuan Chang   ORCID: orcid.org/0000-0002-0966-7966 1   na1 &
• Jiangping Song   ORCID: orcid.org/0000-0002-9782-3323 1 , 2  

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Cardiovascular disease is a worldwide health problem and a leading cause of morbidity and mortality. Preclinical cardiovascular research using animals is needed to explore potential targets and therapeutic options. Compared with rodents, pigs have many advantages, with their anatomy, physiology, metabolism and immune system being more similar to humans. Here we present an overview of the available pig models for cardiovascular diseases, discuss their advantages over other models and propose the concept of standardized models to improve translation to the clinical setting and control research costs.

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GBD 2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet 396 , 1204–1222 (2020).

Article   Google Scholar  

Tsao, C. W. et al. Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association. Circulation 147 , e93–e621 (2023).

Article   PubMed   Google Scholar  

Suzuki, Y., Yeung, A. C. & Ikeno, F. The pre-clinical animal model in the translational research of interventional cardiology. JACC Cardiovasc. Interv. 2 , 373–383 (2009).

Robinson, N. B. et al. The current state of animal models in research: a review. Int. J. Surg. 72 , 9–13 (2019).

Pound, P. & Ritskes-Hoitinga, M. Is it possible to overcome issues of external validity in preclinical animal research? Why most animal models are bound to fail. J. Transl. Med. 16 , 304 (2018).

Article   PubMed   PubMed Central   Google Scholar  

Crisóstomo, V. et al. Common swine models of cardiovascular disease for research and training. Lab Anim. 45 , 67–74 (2016).

Silva, K. A. S. & Emter, C. A. Large animal models of heart failure: a translational bridge to clinical success. JACC Basic Transl. Sci. 5 , 840–856 (2020).

Shu, S., Ren, J. & Song, J. Cardiac xenotransplantation: a promising way to treat advanced heart failure. Heart Fail. Rev. 27 , 71–91 (2022).

Lelovas, P. P., Kostomitsopoulos, N. G. & Xanthos, T. T. A comparative anatomic and physiologic overview of the porcine heart. J. Am. Assoc. Lab Anim. Sci. 53 , 432–438 (2014).

CAS   PubMed   PubMed Central   Google Scholar  

Swindle, M. M., Makin, A., Herron, A. J., Clubb, F. J. Jr. & Frazier, K. S. Swine as models in biomedical research and toxicology testing. Vet. Pathol. 49 , 344–356 (2012).

Article   CAS   PubMed   Google Scholar  

Lunney, J. K. et al. Importance of the pig as a human biomedical model. Sci. Transl. Med. 13 , eabd5758 (2021).

Mathern, N., Yousefian, E., Ridwan, H., Nikoubashman, O. & Wiesmann, M. Comparison of porcine and human vascular diameters for the optimization of interventional stroke training and research. PLoS ONE 17 , e0268005 (2022).

Article   CAS   PubMed   PubMed Central   Google Scholar  

Elmadhun, N. Y. et al. The pig as a valuable model for testing the effect of resveratrol to prevent cardiovascular disease. Ann. NY Acad. Sci. 1290 , 130–135 (2013).

Kuwahara, M. et al. Effects of pair housing on diurnal rhythms of heart rate and heart rate variability in miniature swine. Exp. Anim. 53 , 303–309 (2004).

Zuo, K. et al. Measurement of the luminal diameter of peripheral arterial vasculature in Yorkshire×Landrace swine by using ultrasonography and angiography. J. Am. Assoc. Lab Anim. Sci. 59 , 438–444 (2020).

PubMed   PubMed Central   Google Scholar  

Kassab, G. S. & Fung, Y. C. Topology and dimensions of pig coronary capillary network. Am. J. Physiol. 267 , H319–H325 (1994).

CAS   PubMed   Google Scholar  

Kumar, D. et al. Distinct mouse coronary anatomy and myocardial infarction consequent to ligation. Coron. Artery Dis. 16 , 41–44 (2005).

Gallet, R. et al. Exosomes secreted by cardiosphere-derived cells reduce scarring, attenuate adverse remodelling, and improve function in acute and chronic porcine myocardial infarction. Eur. Heart J. 38 , 201–211 (2017).

Huang, P. et al. Atorvastatin enhances the therapeutic efficacy of mesenchymal stem cells-derived exosomes in acute myocardial infarction via up-regulating long non-coding RNA H19. Cardiovasc. Res. 116 , 353–367 (2020).

Thirugnanasambandam, M. et al. Effect of collateral flow on catheter-based assessment of cardiac microvascular obstruction. Ann. Biomed. Eng. 50 , 1090–1102 (2022).

Genain, M. A. et al. Comparative anatomy and angiography of the cardiac coronary venous system in four species: human, ovine, porcine, and canine. J. Vet. Cardiol. 20 , 33–44 (2018).

Siepe, M. et al. Anatomical study on the surgical technique used for xenotransplantation: porcine hearts into humans. J. Surg. Res. 143 , 211–215 (2007).

Wessels, A. & Sedmera, D. Developmental anatomy of the heart: a tale of mice and man. Physiol. Genomics 15 , 165–176 (2003).

Crick, S. J., Sheppard, M. N., Ho, S. Y., Gebstein, L. & Anderson, R. H. Anatomy of the pig heart: comparisons with normal human cardiac structure. J. Anat. 193 , 105–119 (1998).

Oglesby, M. et al. Trabecular cutting: a novel surgical therapy to increase diastolic compliance. J. Appl. Physiol. 127 , 457–463 (2019).

Yamauchi, H. et al. Creation of nonischemic functional mitral regurgitation by annular dilatation and nonplanar modification in a chronic in vivo swine model. Circulation 128 , S263–S270 (2013).

Wylensek, D. et al. A collection of bacterial isolates from the pig intestine reveals functional and taxonomic diversity. Nat. Commun. 11 , 6389 (2020).

Lim, M. Y., Song, E. J., Kang, K. S. & Nam, Y. D. Age-related compositional and functional changes in micro-pig gut microbiome. Geroscience 41 , 935–944 (2019).

Heinritz, S. N., Mosenthin, R. & Weiss, E. Use of pigs as a potential model for research into dietary modulation of the human gut microbiota. Nutr. Res. Rev. 26 , 191–209 (2013).

Li, X. et al. Establishment of a Macaca fascicularis gut microbiome gene catalog and comparison with the human, pig, and mouse gut microbiomes. Gigascience 7 , giy100 (2018).

Schelstraete, W., Devreese, M. & Croubels, S. Comparative toxicokinetics of Fusarium mycotoxins in pigs and humans. Food Chem. Toxicol. 137 , 111140 (2020).

Dawson, H. D. et al. Structural and functional annotation of the porcine immunome. BMC Genomics 14 , 332 (2013).

Mestas, J. & Hughes, C. C. Of mice and not men: differences between mouse and human immunology. J. Immunol. 172 , 2731–2738 (2004).

Clapperton, M., Glass, E. J. & Bishop, S. C. Pig peripheral blood mononuclear leucocyte subsets are heritable and genetically correlated with performance. Animal 2 , 1575–1584 (2008).

Groenen, M. A. et al. Analyses of pig genomes provide insight into porcine demography and evolution. Nature 491 , 393–398 (2012).

Warr, A. et al. An improved pig reference genome sequence to enable pig genetics and genomics research. Gigascience 9 , giaa051 (2020).

Kooij, V. et al. Sizing up models of heart failure: proteomics from flies to humans. Proteomics Clin. Appl. 8 , 653–664 (2014).

Elnakish, M. T., Hassanain, H. H. & Janssen, P. M. Vascular remodeling-associated hypertension leads to left ventricular hypertrophy and contractile dysfunction in profilin-1 transgenic mice. J. Cardiovasc. Pharmacol. 60 , 544–552 (2012).

Rafael-Fortney, J. A. et al. Early treatment with lisinopril and spironolactone preserves cardiac and skeletal muscle in Duchenne muscular dystrophy mice. Circulation 124 , 582–588 (2011).

Müller, O. J. et al. Improved cardiac gene transfer by transcriptional and transductional targeting of adeno-associated viral vectors. Cardiovasc. Res. 70 , 70–78 (2006).

Su, H. et al. AAV serotype 1 mediates more efficient gene transfer to pig myocardium than AAV serotype 2 and plasmid. J. Gene Med. 10 , 33–41 (2008).

Liu, S. et al. Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction. Sci. Transl. Med. 13 , eabd6892 (2021).

Costa, F. M. et al. Impact of ESC/ACCF/AHA/WHF universal definition of myocardial infarction on mortality at 10 years. Eur. Heart J. 33 , 2544–2550 (2012).

Samsky, M. D. et al. Cardiogenic shock after acute myocardial infarction: a review. JAMA 326 , 1840–1850 (2021).

Wang, X. et al. Stem cells for myocardial repair with use of a transarterial catheter. Circulation 120 , S238–S246 (2009).

Inagaki, K. et al. Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo. Circulation 108 , 2304–2307 (2003).

Traxler, D. et al. Early elevation of systemic plasma clusterin after reperfused acute myocardial infarction in a preclinical porcine model of ischemic heart disease. Int. J. Mol. Sci. 21 , 4591 (2020).

Vilahur, G. et al. Protective effects of ticagrelor on myocardial injury after infarction. Circulation 134 , 1708–1719 (2016).

Crisostomo, V. et al. Dose-dependent improvement of cardiac function in a swine model of acute myocardial infarction after intracoronary administration of allogeneic heart-derived cells. Stem Cell Res. Ther. 10 , 152 (2019).

Fernández-Jiménez, R. et al. Myocardial edema after ischemia/reperfusion is not stable and follows a bimodal pattern: imaging and histological tissue characterization. J. Am. Coll. Cardiol. 65 , 315–323 (2015).

Malliaras, K. et al. Validation of contrast-enhanced magnetic resonance imaging to monitor regenerative efficacy after cell therapy in a porcine model of convalescent myocardial infarction. Circulation 128 , 2764–2775 (2013).

Pulido, M. et al. Transcriptome profile reveals differences between remote and ischemic myocardium after acute myocardial infarction in a swine model. Biology 12 , 340 (2023).

Trivella, M. G. et al. Percutaneous cardiac support during myocardial infarction drastically reduces mortality: perspectives from a swine model. Int. J. Artif. Organs 40 , 338–344 (2017).

Delgado-Montero, A. et al. Blood stasis imaging predicts cerebral microembolism during acute myocardial infarction. J. Am. Soc. Echocardiogr. 33 , 389–398 (2020).

Lim, M. et al. Intravenous injection of allogeneic umbilical cord-derived multipotent mesenchymal stromal cells reduces the infarct area and ameliorates cardiac function in a porcine model of acute myocardial infarction. Stem Cell Res. Ther. 9 , 129 (2018).

Lubberding, A. F., Sattler, S. M., Flethøj, M., Tfelt-Hansen, J. & Jespersen, T. Comparison of hemodynamics, cardiac electrophysiology, and ventricular arrhythmia in an open- and a closed-chest porcine model of acute myocardial infarction. Am. J. Physiol. Heart Circ. Physiol. 318 , H391–h400 (2020).

Malyar, N. M., Lerman, L. O., Gössl, M., Beighley, P. E. & Ritman, E. L. Relation of nonperfused myocardial volume and surface area to left ventricular performance in coronary microembolization. Circulation 110 , 1946–1952 (2004).

Carlsson, M., Wilson, M., Martin, A. J. & Saeed, M. Myocardial microinfarction after coronary microembolization in swine: MR imaging characterization. Radiology 250 , 703–713 (2009).

Kleinbongard, P. & Heusch, G. A fresh look at coronary microembolization. Nat. Rev. Cardiol. 19 , 265–280 (2022).

Pascual Izco, M. et al. Ivabradine in acute heart failure: effects on heart rate and hemodynamic parameters in a randomized and controlled swine trial. Cardiol. J. 27 , 62–71 (2020).

Rønning, L. et al. Opposite diastolic effects of omecamtiv mecarbil versus dobutamine and ivabradine co-treatment in pigs with acute ischemic heart failure. Physiol. Rep. 6 , e13879 (2018).

Olivari, D. et al. Searching for preclinical models of acute decompensated heart failure: a concise narrative overview and a novel swine model. Cardiovasc. Drugs Ther. 36 , 727–738 (2022).

Poss, K. D., Wilson, L. G. & Keating, M. T. Heart regeneration in zebrafish. Science 298 , 2188–2190 (2002).

Porrello, E. R. et al. Transient regenerative potential of the neonatal mouse heart. Science 331 , 1078–1080 (2011).

Bergmann, O. et al. Evidence for cardiomyocyte renewal in humans. Science 324 , 98–102 (2009).

Cahill, T. J., Choudhury, R. P. & Riley, P. R. Heart regeneration and repair after myocardial infarction: translational opportunities for novel therapeutics. Nat. Rev. Drug. Discov. 16 , 699–717 (2017).

Senyo, S. E. et al. Mammalian heart renewal by pre-existing cardiomyocytes. Nature 493 , 433–436 (2013).

Zhu, W. et al. Regenerative potential of neonatal porcine hearts. Circulation 138 , 2809–2816 (2018).

Panchal, A. R. et al. 2019 American Heart Association focused update on advanced cardiovascular life support: use of advanced airways, vasopressors, and extracorporeal cardiopulmonary resuscitation during cardiac arrest: an update to the American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 140 , e881–e894 (2019).

PubMed   Google Scholar  

Hoogendoorn, A. et al. Variation in coronary atherosclerosis severity related to a distinct LDL (low-density lipoprotein) profile: findings from a familial hypercholesterolemia pig model. Arterioscler. Thromb. Vasc. Biol. 39 , 2338–2352 (2019).

Denolin, H., Kuhn, H., Krayenbuehl, H. P., Loogen, F. & Reale, A. The definition of heart failure. Eur. Heart J. 4 , 445–448 (1983).

McDonagh, T. A. et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur. Heart J. 42 , 3599–3726 (2021).

Heidenreich, P. A. et al. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation 145 , e895–e1032 (2022).

Savarese, G., Stolfo, D., Sinagra, G. & Lund, L. H. Heart failure with mid-range or mildly reduced ejection fraction. Nat. Rev. Cardiol. 19 , 100–116 (2022).

Borlaug, B. A. Evaluation and management of heart failure with preserved ejection fraction. Nat. Rev. Cardiol. 17 , 559–573 (2020).

Harjola, V. P. et al. Organ dysfunction, injury and failure in acute heart failure: from pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur. J. Heart Fail. 19 , 821–836 (2017).

Naar, J. et al. Acute severe heart failure reduces heart rate variability: an experimental study in a porcine model. Int. J. Mol. Sci. 24 , 493 (2022).

Lacko, S. et al. Severe acute heart failure - experimental model with very low mortality. Physiol. Res. 67 , 555–562 (2018).

Roche, E. T. et al. Soft robotic sleeve supports heart function. Sci. Transl. Med. 9 , eaaf3925 (2017).

Tsao, C. W. et al. Heart Disease and Stroke Statistics-2022 Update: a report from the American Heart Association. Circulation 145 , e153–e639 (2022).

Packer, M. et al. Cardiovascular and renal outcomes with empagliflozin in heart failure. N. Engl. J. Med. 383 , 1413–1424 (2020).

Anker, S. D. et al. Empagliflozin in heart failure with a preserved ejection fraction. N. Engl. J. Med. 385 , 1451–1461 (2021).

Khatibzadeh, S., Farzadfar, F., Oliver, J., Ezzati, M. & Moran, A. Worldwide risk factors for heart failure: a systematic review and pooled analysis. Int. J. Cardiol. 168 , 1186–1194 (2013).

Sharp, T. E. 3rd et al. Renal denervation prevents heart failure progression via inhibition of the renin-angiotensin system. J. Am. Coll. Cardiol. 72 , 2609–2621 (2018).

Schuleri, K. H. et al. The adult Göttingen minipig as a model for chronic heart failure after myocardial infarction: focus on cardiovascular imaging and regenerative therapies. Comp. Med. 58 , 568–579 (2008).

Sassoon, D. J. et al. Glucagon-like peptide 1 receptor activation augments cardiac output and improves cardiac efficiency in obese swine after myocardial infarction. Diabetes 66 , 2230–2240 (2017).

Martínez-Milla, J. et al. Translational large animal model of hibernating myocardium: characterization by serial multimodal imaging. Basic Res. Cardiol. 115 , 33 (2020).

Onohara, D. et al. Image-guided targeted mitral valve tethering with chordal encircling snares as a preclinical model of secondary mitral regurgitation. J. Cardiovasc. Transl. Res. 15 , 653–665 (2022).

Watanabe, S., Bikou, O., Hajjar, R. J. & Ishikawa, K. Swine model of mitral regurgitation induced heart failure. Methods Mol. Biol. 1816 , 327–335 (2018).

Möllmann, H. et al. Desynchronization: a novel model to induce heart failure. Thorac. Cardiovasc. Surg. 57 , 441–448 (2009).

Pfeffer, M. A., Shah, A. M. & Borlaug, B. A. Heart failure with preserved ejection fraction in perspective. Circ. Res. 124 , 1598–1617 (2019).

Olver, T. D. et al. Western diet-fed, aortic-banded Ossabaw swine: a preclinical model of cardio-metabolic heart failure. JACC Basic Transl. Sci. 4 , 404–421 (2019).

Sharp, T. E. 3rd et al. Novel Göttingen miniswine model of heart failure with preserved ejection fraction integrating multiple comorbidities. JACC Basic Transl. Sci. 6 , 154–170 (2021).

Charles, C. J. et al. A porcine model of heart failure with preserved ejection fraction: magnetic resonance imaging and metabolic energetics. ESC Heart Fail. 7 , 92–102 (2020).

Elliott, P. et al. Classification of the cardiomyopathies: a position statement from the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur. Heart J. 29 , 270–276 (2008).

Maron, B. J. et al. Contemporary definitions and classification of the cardiomyopathies: an American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation 113 , 1807–1816 (2006).

Olivotto, I. et al. Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet 396 , 759–769 (2020).

Jefferies, J. L. & Towbin, J. A. Dilated cardiomyopathy. Lancet 375 , 752–762 (2010).

Argulian, E., Sherrid, M. V. & Messerli, F. H. Misconceptions and facts about hypertrophic cardiomyopathy. Am. J. Med. 129 , 148–152 (2016).

Marian, A. J. & Braunwald, E. Hypertrophic cardiomyopathy: genetics, pathogenesis, clinical manifestations, diagnosis, and therapy. Circ. Res. 121 , 749–770 (2017).

Maron, B. J. & Maron, M. S. Hypertrophic cardiomyopathy. Lancet 381 , 242–255 (2013).

del Rio, C. L. et al. Abstract 20770: a novel mini-pig genetic model of hypertrophic cardiomyopathy: altered myofilament dynamics, hyper-contractility, and impaired systolic/diastolic functional reserve in vivo. Circulation 136 , A20770 (2017).

Google Scholar  

Geisterfer-Lowrance, A. A. et al. A molecular basis for familial hypertrophic cardiomyopathy: a beta cardiac myosin heavy chain gene missense mutation. Cell 62 , 999–1006 (1990).

von der Ecken, J., Heissler, S. M., Pathan-Chhatbar, S., Manstein, D. J. & Raunser, S. Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution. Nature 534 , 724–728 (2016).

Sewanan, L. R. et al. Extracellular matrix from hypertrophic myocardium provokes impaired twitch dynamics in healthy cardiomyocytes. JACC Basic Transl. Sci. 4 , 495–505 (2019).

Montag, J. et al. Successful knock-in of hypertrophic cardiomyopathy-mutation R723G into the MYH7 gene mimics HCM pathology in pigs. Sci. Rep. 8 , 4786 (2018).

Kraft, T. et al. Familial hypertrophic cardiomyopathy: functional effects of myosin mutation R723G in cardiomyocytes. J. Mol. Cell. Cardiol. 57 , 13–22 (2013).

McKenna, W. J. & Judge, D. P. Epidemiology of the inherited cardiomyopathies. Nat. Rev. Cardiol. 18 , 22–36 (2021).

Marsman, E. M. J., Postema, P. G. & Remme, C. A. Brugada syndrome: update and future perspectives. Heart 108 , 668–675 (2022).

Park, D. S. et al. Genetically engineered SCN5A mutant pig hearts exhibit conduction defects and arrhythmias. J. Clin. Invest. 125 , 403–412 (2015).

Schneider, J. W. et al. Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs. Nat. Med. 26 , 1788–1800 (2020).

Brauch, K. M. et al. Mutations in ribonucleic acid binding protein gene cause familial dilated cardiomyopathy. J. Am. Coll. Cardiol. 54 , 930–941 (2009).

Farrar, D. J., Chow, E. & Brown, C. D. Isolated systolic and diastolic ventricular interactions in pacing-induced dilated cardiomyopathy and effects of volume loading and pericardium. Circulation 92 , 1284–1290 (1995).

Schroeder, M. A. et al. Hyperpolarized 13 C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart. Eur. J. Heart Fail. 15 , 130–140 (2013).

Saito, Y. et al. Direct epicardial assist device using artificial rubber muscle in a swine model of pediatric dilated cardiomyopathy. Int. J. Artif. Organs 38 , 588–594 (2015).

Tanaka, Y. et al. Diffuse fibrosis leads to a decrease in unipolar voltage: validation in a swine model of premature ventricular contraction-induced cardiomyopathy. Heart Rhythm 13 , 547–554 (2016).

Hirai, K. et al. Cardiosphere-derived exosomal microRNAs for myocardial repair in pediatric dilated cardiomyopathy. Sci. Transl. Med. 12 , eabb3336 (2020).

Crespo-Leiro, M. G. et al. Heart transplantation: focus on donor recovery strategies, left ventricular assist devices, and novel therapies. Eur. Heart J. 43 , 2237–2246 (2022).

Russo, M. J. et al. The effect of ischemic time on survival after heart transplantation varies by donor age: an analysis of the United Network for Organ Sharing database. J. Thorac. Cardiovasc. Surg. 133 , 554–559 (2007).

Thomas, S. S. & D’Alessandro, D. A. Traumatic brains and broken hearts: mending the donor shortage in cardiac transplantation. J. Am. Coll. Cardiol. 70 , 1259–1261 (2017).

Pahuja, M., Case, B. C., Molina, E. J. & Waksman, R. Overview of the FDA’s Circulatory System Devices Panel virtual meeting on the TransMedics Organ Care System (OCS) Heart—portable extracorporeal heart perfusion and monitoring system. Am. Heart J. 247 , 90–99 (2022).

Ardehali, A. et al. Ex-vivo perfusion of donor hearts for human heart transplantation (PROCEED II): a prospective, open-label, multicentre, randomised non-inferiority trial. Lancet 385 , 2577–2584 (2015).

García Sáez, D. et al. Ex vivo heart perfusion after cardiocirculatory death; a porcine model. J. Surg. Res. 195 , 311–314 (2015).

Mohiuddin, M. M., Reichart, B., Byrne, G. W. & McGregor, C. G. A. Current status of pig heart xenotransplantation. Int. J. Surg. 23 , 234–239 (2015).

Zhu, Y. et al. The Stanford experience of heart transplantation over five decades. Eur. Heart J. 42 , 4934–4943 (2021).

Pepper, J. R., Khagani, A. & Yacoub, M. Heart transplantation. J. Antimicrob. Chemother. 36 , 23–38 (1995).

Singh, T. P. et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-fourth pediatric heart transplantation report - 2021; focus on recipient characteristics. J. Heart Lung Transplant. 40 , 1050–1059 (2021).

Stehlik, J. et al. The Registry of the International Society for Heart and Lung Transplantation: 29th official adult heart transplant report—2012. J. Heart Lung Transplant. 31 , 1052–1064 (2012).

Messer, S. et al. Human heart transplantation from donation after circulatory-determined death donors using normothermic regional perfusion and cold storage. J. Heart Lung Transplant. 37 , 865–869 (2018).

Gao, S. Z. et al. Prevalence of accelerated coronary artery disease in heart transplant survivors. Comparison of cyclosporine and azathioprine regimens. Circulation 80 , Iii100–Iii105 (1989).

Madariaga, M. L. et al. Induction of cardiac allograft tolerance across a full MHC barrier in miniature swine by donor kidney cotransplantation. Am. J. Transplant. 13 , 2558–2566 (2013).

Yamada, K. et al. The effect of thymectomy on tolerance induction and cardiac allograft vasculopathy in a miniature swine heart/kidney transplantation model. Transplantation 68 , 485–491 (1999).

Schwarze, M. L. et al. Effects of mycophenolate mofetil on cardiac allograft survival and cardiac allograft vasculopathy in miniature swine. Ann. Thorac. Surg. 80 , 1787–1793 (2005).

Madsen, J. C., Sachs, D. H., Fallon, J. T. & Weissman, N. J. Cardiac allograft vasculopathy in partially inbred miniature swine. I. Time course, pathology, and dependence on immune mechanisms. J. Thorac. Cardiovasc. Surg. 111 , 1230–1239 (1996).

Sachs, D. H. et al. Transplantation in miniature swine. I. Fixation of the major histocompatibility complex. Transplantation 22 , 559–567 (1976).

Badiwala, M. V. et al. Donor pretreatment with hypertonic saline attenuates primary allograft dysfunction: a pilot study in a porcine model. Circulation 120 , S206–S214 (2009).

Ribeiro, R. V. P., Badiwala, M. V., Ramzy, D., Tumiati, L. C. & Rao, V. Recipient hypertonic saline infusion prevents cardiac allograft dysfunction. J. Thorac. Cardiovasc. Surg. 157 , 615–625.e1 (2019).

Watson, A. J. et al. Enhanced preservation of pig cardiac allografts by combining erythropoietin with glyceryl trinitrate and zoniporide. Am. J. Transplant. 13 , 1676–1687 (2013).

Grant, A. A. et al. In vivo resuscitation, perfusion, and transplantation of a porcine cardiac allograft donated after circulatory death. J. Card. Surg. 35 , 300–303 (2020).

Cooper, D. K. C. & Pierson, R. N. 3rd The future of cardiac xenotransplantation. Nat. Rev. Cardiol. 19 , 281–282 (2022).

Griffith, B. P. et al. Genetically modified porcine-to-human cardiac xenotransplantation. N. Engl. J. Med. 387 , 35–44 (2022).

Singh, A. K. et al. Cardiac xenotransplantation: progress in preclinical models and prospects for clinical translation. Transpl. Int. 35 , 10171 (2022).

Phelps, C. J. et al. Production of alpha 1,3-galactosyltransferase-deficient pigs. Science 299 , 411–414 (2003).

Kuwaki, K. et al. Heart transplantation in baboons using α1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat. Med. 11 , 29–31 (2005).

Tector, A. J., Mosser, M., Tector, M. & Bach, J. M. The possible role of anti-Neu5Gc as an obstacle in xenotransplantation. Front. Immunol. 11 , 622 (2020).

Byrne, G., Ahmad-Villiers, S., Du, Z. & McGregor, C. B4GALNT2 and xenotransplantation: a newly appreciated xenogeneic antigen. Xenotransplantation 25 , e12394 (2018).

Lutz, A. J. et al. Double knockout pigs deficient in N -glycolylneuraminic acid and galactose α-1,3-galactose reduce the humoral barrier to xenotransplantation. Xenotransplantation 20 , 27–35 (2013).

McGregor, C. G. et al. Human CD55 expression blocks hyperacute rejection and restricts complement activation in Gal knockout cardiac xenografts. Transplantation 93 , 686–692 (2012).

Iwase, H. et al. Pig-to-baboon heterotopic heart transplantation–exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens. Xenotransplantation 22 , 211–220 (2015).

Mohiuddin, M. M. et al. Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft. Nat. Commun. 7 , 11138 (2016).

Abicht, J. M. et al. Multiple genetically modified GTKO/hCD46/HLA-E/hβ2-mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood. Xenotransplantation 25 , e12390 (2018).

Chan, J. L. et al. Encouraging experience using multi-transgenic xenografts in a pig-to-baboon cardiac xenotransplantation model. Xenotransplantation 24 , e12330 (2017).

Khush, K. K. et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: 37th adult heart transplantation report-2020; focus on deceased donor characteristics. J. Heart Lung Transplant. 39 , 1003–1015 (2020).

Salter, B. S. et al. Temporary mechanical circulatory support devices: practical considerations for all stakeholders. Nat. Rev. Cardiol. 20 , 263–277 (2023).

Vincent, F. et al. Arterial pulsatility and circulating von Willebrand factor in patients on mechanical circulatory support. J. Am. Coll. Cardiol. 71 , 2106–2118 (2018).

Sonntag, S. J. et al. Virtual implantations to transition from porcine to bovine animal models for a total artificial heart. Artif. Organs 44 , 384–393 (2020).

Lawton, J. S. et al. 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: Executive Summary: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation 145 , e4–e17 (2022).

Hocum Stone, L. L. et al. Magnetic resonance imaging assessment of cardiac function in a swine model of hibernating myocardium 3 months following bypass surgery. J. Thorac. Cardiovasc. Surg. 153 , 582–590 (2017).

Itoda, Y. et al. Novel anastomotic device for distal coronary anastomosis: preclinical results from swine off-pump coronary artery bypass model. Ann. Thorac. Surg. 101 , 736–741 (2016).

Hocum Stone, L. et al. Cardiac strain in a swine model of regional hibernating myocardium: effects of CoQ10 on contractile reserve following bypass surgery. J. Cardiovasc. Transl. Res. 9 , 368–373 (2016).

Hocum Stone, L. L. et al. Recovery of hibernating myocardium using stem cell patch with coronary bypass surgery. J. Thorac. Cardiovasc. Surg. 162 , e3–e16 (2021).

Veres, G. et al. Is internal thoracic artery resistant to reperfusion injury? Evaluation of the storage of free internal thoracic artery grafts. J. Thorac. Cardiovasc. Surg. 156 , 1460–1469 (2018).

Tomášek, P. et al. Histological mapping of porcine carotid arteries—an animal model for the assessment of artificial conduits suitable for coronary bypass grafting in humans. Ann. Anat. 228 , 151434 (2020).

Grajciarová, M. et al. Are ovine and porcine carotid arteries equivalent animal models for experimental cardiac surgery: a quantitative histological comparison. Ann. Anat. 242 , 151910 (2022).

Garoffolo, G. et al. Coronary artery mechanics induces human saphenous vein remodelling via recruitment of adventitial myofibroblast-like cells mediated by Thrombospondin-1. Theranostics 10 , 2597–2611 (2020).

Dahan, N. et al. Dynamic autologous reendothelialization of small-caliber arterial extracellular matrix: a preclinical large animal study. Tissue Eng. Part A 23 , 69–79 (2017).

Fukushima, S. et al. A reproducible swine model of a surgically created saccular thoracic aortic aneurysm. Exp. Anim. 70 , 257–263 (2021).

Takano, T., Katada, Y., Komaki, N., Onozawa, S. & Yokoyama, H. A technique for creating an experimental type Ia endoleak model in the thoracic aorta of swine. Jpn. J. Radiol. 39 , 1127–1132 (2021).

Argenta, R., Perini, S. C. & Pereira, A. H. Thoracic aortic aneurysm. An experimental model in pigs. Acta Cir. Bras. 36 , e360602 (2021).

Boufi, M. et al. Endovascular creation and validation of acute in vivo animal model for type A aortic dissection. J. Surg. Res. 225 , 21–28 (2018).

Lugenbiel, P. et al. Atrial myofibroblast activation and connective tissue formation in a porcine model of atrial fibrillation and reduced left ventricular function. Life Sci. 181 , 1–8 (2017).

Boulate, D. et al. Induction and phenotyping of acute right heart failure in a large animal model of chronic thromboembolic pulmonary hypertension. J. Vis. Exp. 181 , e58057 (2022).

Christiansen, J. G. et al. Systemic inflammatory response and local cytokine expression in porcine models of endocarditis. Apmis 122 , 292–300 (2014).

Cruz, F. M. et al. Exercise triggers ARVC phenotype in mice expressing a disease-causing mutated version of human plakophilin-2. J. Am. Coll. Cardiol. 65 , 1438–1450 (2015).

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Acknowledgements

This work was supported by the National Natural Science Fund for Distinguished Young Scholars of China (82125004; to J.S.) and the Frontier Biotechnology Key Project of National Key R & D Program of the Ministry of Science and Technology of China (2023YFC3404300; to J.S.).

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These authors contributed equally: Hao Jia, Yuan Chang.

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Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovascular Implant Materials, Animal Experimental Centre, National Centre for Cardiovascular Disease, Department of Cardiac Surgery, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Hao Jia, Yuan Chang & Jiangping Song

Sanya Institute of China Agricultural University, Sanya, China

Jiangping Song

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J.S. contributed to the article’s conceptualization. H.J. was instrumental in drafting and revising the manuscript. Y.C. was responsible for drafting the manuscript and designing the figure.

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Jia, H., Chang, Y. & Song, J. The pig as an optimal animal model for cardiovascular research. Lab Anim (2024). https://doi.org/10.1038/s41684-024-01377-4

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CERN Accelerating science

CERN and the US sign joint statement of intent

Joint Statement of Intent between the US and CERN concerns future planning for large research infrastructures, advanced scientific computing and open science

24 May, 2024

By Matthew Chalmers

CERN and the US government have released a joint statement concerning future planning for large research infrastructures, advanced scientific computing and open science. The Joint Statement of Intent was signed in Washington DC in April by CERN Director-General, Fabiola Gianotti, and Principal Deputy US Chief Technology Officer, Deirdre Mulligan, of the White House Office of Science and Technology (pictured).

Acknowledging their longstanding partnership in nuclear and particle physics, CERN and the US intend to enhance collaboration in planning activities for large-scale, resource-intensive facilities with the goal of providing a sustainable and responsible pathway for the peaceful use of future accelerator technologies.

Concerning the proposed Future Circular Collider, FCC-ee, which would collide electrons and positrons to produce copious quantities of Higgs bosons, the text states: “Should the CERN Member States determine the FCC-ee is likely to be CERN’s next world-leading research facility following the high-luminosity Large Hadron Collider, the United States intends to collaborate on its construction and physics exploitation, subject to appropriate domestic approvals.” A technical and financial feasibility study for the proposed FCC is due to be completed in March 2025.

CERN and the US also intend to discuss potential collaboration on pilot projects to incorporate new analytics techniques and tools such as AI into particle physics research at scale and affirm their collective mission “to take swift strategic action that leads to accelerating widespread adoption of equitable open research, science, and scholarship throughout the world”.

In December 2023, the high-energy physics advisory panel to the US Department of Energy and the National Science Foundation released a 10-year strategic plan for US particle physics. Meanwhile, the next update of the European Strategy for Particle Physics , which is formed through a broad consultation of the particle physics community in Europe and beyond, is about to get under way. The CERN Council has set the deadline for submitting written input for the next Strategy update at 31 March 2025, with a view to concluding the process in June 2026. The final report of the FCC Feasibility Study will be a key component of that input.

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More military veterans and active duty service members are dying by suicide than in battle – understanding why can help with prevention

Associate Professor of Psychological Sciences, Auburn University

Disclosure statement

This work was in part supported by the Military Suicide Research Consortium (MSRC), an effort supported by the Office of the Assistant Secretary of Defense for Health Affairs under Award No. (W81XWH-16-2-0003; ARS). Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the MSRC or the Department of Defense.

Auburn University provides funding as a member of The Conversation US.

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Although service members know they may lose their lives in combat in service of their country, they may not expect to lose their lives – or those they love – to suicide. A 2021 study estimated that four times as many active duty service members and veterans died by suicide as died in battle since 9/11.

Despite recent calls to action to improve suicide prevention within the military, suicide rates remain elevated among service members. In particular, active duty Army suicide rates were nearly two times higher than other active duty military services and more than two and a half times higher than the general population . Suicide rates are even more elevated in veterans, with an estimated 17 or more dying by suicide each day in 2021.

My research is aimed at identifying what drives high rates of suicide among certain groups. Better understanding what causes active duty service members and veterans to think about and plan suicide is imperative for efforts to prevent it.

Risk factors for suicide within the military

There are many reasons why service members and veterans may have elevated rates of thoughts of suicide and death. Notably, risk factors for active duty service members can be different from those of veterans.

Some factors linked to suicide in active duty service members include loneliness, relationship issues, workplace difficulties, trauma, disrupted schedules, increased stress, poor sleep, injury and chronic pain. On top of these same factors, veterans may also experience difficulties transitioning to civilian life .

Additionally, service members may have an elevated capability for suicide, meaning a decreased fear of death, high pain tolerance and familiarity with using highly lethal means like firearms.

Rethinking suicide research in the military

Increasing rates of suicide suggest that researchers need to study suicide differently in order to save more lives. Fortunately, several research advances are helping scientists rethink the way people study suicide within and outside the military.

In my lab’s recent study, we harnessed some of these innovations to study what drives thoughts of suicide among service members. We asked 92 participants to download an app on their phones and take short surveys assessing suicide risk factors four times per day for one month. Using a newer type of statistical method called network analysis , we were able to pinpoint which symptoms related to suicide risk had the greatest influence on other symptoms at one moment in time as well as over time.

Overall, we found that feeling ineffective or like a burden to others, a sense of low belonging or feeling disconnected from others, and agitation are important drivers of moment-to-moment and longer-term risk for thoughts of suicide among service members and veterans.

Increasing effectiveness and belonging

Based on our study results, considering how the military both fosters and hinders a sense of belonging and effectiveness could help address suicide risk factors. This may become even more important as demands created by technology, such as drone pilots operating in siloed facilities, may lead active duty service members to be less connected to one another.

Additionally, some active duty service members report task saturation – feeling like they have too much to do without enough time, resources or tools to get tasks done. They also report working an unbalanced amount of hours that precludes rest and reflection . Allowing soldiers more time to do their work and reflect on it could renew their sense of effectiveness and improve their understanding of how they contribute to overall goals.

Additionally, military leadership could find ways to prioritize and reward group-level achievements over individual accomplishments. This could lead to both increased belonging and reduced feelings of ineffectiveness, in turn reducing thoughts of suicide.

Finally, relaxation techniques , including progressive muscle relaxation, massage and gentle movement, could be beneficial in reducing agitation.

There is still much work to do to turn the tides in the fight against suicide and help those who serve and protect us. If you or someone you love is thinking about suicide, know that you are not alone and there is help. For military-specific resources, you can call 988 and then press 1, or text 838255. You can also visit www.veteranscrisisline.net .

• Mental health
• US military
• US veterans
• Suicidal ideation

Data Manager

Director, Social Policy

Coordinator, Academic Advising

Head, School of Psychology

Senior Research Fellow - Women's Health Services

Opinion The problem with diversity statements — and what to do about them

DEI statements have too often led to self-censorship and ideological policing.

As the United States reckoned with racial inequality during and after the 2020 Black Lives Matter protests, many saw Diversity, Equity and Inclusion (DEI) programs as a way to address the issues in higher education. As part of the trend, many schools began requiring candidates for teaching positions to submit DEI statements. In these statements, potential hires explain how they would advance diversity, equity and inclusion in their teaching and research activities. One 2021 study found that about one-third of job postings at elite universities required them.

Now, however, some in academia are starting to express second thoughts about this practice. In April, Harvard Law School professor Randall L. Kennedy urged abolition of DEI statements, arguing that they amount to “compulsion” and “ideological litmus tests.” Not long after Mr. Kennedy’s article appeared, the Massachusetts Institute of Technology became the first top university to voluntarily end their use. The decision came after extensive consultations among all six of the school’s academic deans. MIT’s president, Sally Kornbluth, explained : “We can build an inclusive environment in many ways, but compelled statements impinge on freedom of expression, and they don’t work.”

In doing away with DEI statements, MIT was not abandoning the goals of greater diversity, equity and inclusion, which remain not only valid but also vital. DEI programs can have an important place. They should not be abolished or undermined — as red states such as Florida and Texas have done, by forbidding the use of state funds for DEI in public universities. Reshaping universities via such a heavy-handed use of state power could set a dangerous precedent for academic freedom more generally.

And yet as a specific policy, DEI statements advance their declared objectives at too high a cost. In fact, they stoke what Mr. Kennedy, a self-described “scholar on the left,” who formerly served as a law clerk for Justice Thurgood Marshall, called “intense and growing resentment” among academics. Not surprisingly, 90 percent of self-described conservative faculty view the statements as political litmus tests, but so do more than 50 percent of moderates and even one-quarter of liberals, according to a survey by the Foundation for Individual Rights and Expression, a nonpartisan watchdog group specializing in campus free speech issues.

Because the criteria for acceptable DEI statements are often vague, jobseekers must do the work of anticipating the ideological and political preferences of university administrators and faculty, who are disproportionately left-leaning . The MIT Communication Lab, for instance, explained that a diversity statement is an “opportunity to show that you care about the inclusion of many forms of identity in academia and in your field, including but not limited to gender, race/ethnicity, age, nationality, sexual orientation, religion, and ability status” and notes “it may be appropriate to acknowledge aspects of your own marginalized identity and/or your own privilege.” Harvard University’s Bok Center for Teaching and Learning included a list of guiding questions including, “Do you seek to identify and mitigate how inequitable and colonial social systems are reinforced in the academy by attending to and adjusting the power dynamics in your courses?”

Yet jobseekers who disagree with the ideological premises of such inquiries have an overwhelming incentive to suppress their true beliefs, or pretend to have the “right” ones, lest they be eliminated from consideration. It’s a dilemma, especially given the high stakes: As the University of California at Davis’s vice chancellor for DEI explained, “In these searches, it is the candidate’s diversity statement that is considered first; only those who submit persuasive and inspiring statements can advance for complete consideration.” In one faculty search at University of California at Berkeley, around 75 percent of applicants were screened out of consideration — irrespective of criteria such as teaching ability and research skills. Small wonder that many applicants engage in what Daniel Sargent, a history professor at UC Berkeley, calls “ performative dishonesty .”

The last thing academia — or the country — needs is another incentive for people to be insincere or dishonest. The very purpose of the university is to encourage a free exchange of ideas, seek the truth wherever it may lead, and to elevate intellectual curiosity and openness among both faculty and students. Whatever their original intent, the use of DEI statements has too often resulted in self-censorship and ideological policing. Fundamentally reconsidering them could actually strengthen DEI, by placing it on a more sustainable basis — intellectually and politically. MIT is one of the first to tackle the issue; here’s hoping it won’t be the last.

The Post’s View | About the Editorial Board

Editorials represent the views of The Post as an institution, as determined through discussion among members of the Editorial Board , based in the Opinions section and separate from the newsroom.

Members of the Editorial Board: Opinion Editor David Shipley , Deputy Opinion Editor Charles Lane and Deputy Opinion Editor Stephen Stromberg , as well as writers Mary Duenwald, Shadi Hamid , David E. Hoffman , James Hohmann , Heather Long , Mili Mitra , Eduardo Porter , Keith B. Richburg and Molly Roberts .

• Directories

Climate & Health: The effect of heat in the housing of Indigenous peoples

Presented by ANU College of Health & Medicine

Substandard housing combines with energy insecurity to produce dangerously hot and often overcrowded living conditions in remote Northern Territory communities. Climate change is set to amplify this problem unless we act now.

Join us for a welcome address and discussion as our panel members share their lived experience and expertise on the health effects of climate change. They'll discuss the impact that housing has on driving health and social inequality, and how we can protect human health through the design and build of homes, resilient to climate shock.

Panel members:

• Professor Russell Gruen , Dean ANU College of Health and Medicine.
• Associate Professor Heather Logie , Head of the Battery Storage and Grid Integration Program, ANU School of Engineering.
• Brad Riley , Research Fellow and PhD Candidate, ANU Centre for Indigenous Policy Research.
• Dr Simon Quilty,  PhD, ANU College of Health and Medicine.
• Norman Frank Jupurrurla , Warumungu Elder and Culture Man from the Burudu Clan.
• Patricia Frank Nururrurla , Warumungu Elder and strong woman of culture.
• Jimmy Frank Jupurrurla , Warumungu Leader.

Date and Times

• Wed 29 May 2024, 3:30 pm - Wed 29 May 2024, 5:00 pm
• Professor Russell Gruen, Dean ANU College of Health and Medicine
• Associate Professor Heather Logie, Head of the Battery Storage and Grid Integration Program, ANU School of Engineering
• Brad Riley, Research Fellow and PhD Candidate, ANU Centre for Indigenous Policy Research
• Dr Simon Quilty, PhD, ANU College of Health and Medicine
• Norman Frank Jupurrurla, Warumungu Elder and Culture Man from the Burudu Clan
• Patricia Frank Nururrurla, Warumungu Elder and strong woman of culture
• Jimmy Frank Jupurrurla, Warumungu Leader
•   Kierra-Jade Maciver   Send email

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