Four types: single holistic, single embedded, multiple holistic, multiple embedded
The post-positive paradigm postulates there is one reality that can be objectively described and understood by “bracketing” oneself from the research to remove prejudice or bias. 27 Yin focuses on general explanation and prediction, emphasizing the formulation of propositions, akin to hypothesis testing. This approach is best suited for structured and objective data collection 9 , 11 and is often used for mixed-method studies.
Constructivism assumes that the phenomenon of interest is constructed and influenced by local contexts, including the interaction between researchers, individuals, and their environment. 27 It acknowledges multiple interpretations of reality 24 constructed within the context by the researcher and participants which are unlikely to be replicated, should either change. 5 , 20 Stake and Merriam’s constructivist approaches emphasize a story-like rendering of a problem and an iterative process of constructing the case study. 7 This stance values researcher reflexivity and transparency, 28 acknowledging how researchers’ experiences and disciplinary lenses influence their assumptions and beliefs about the nature of the phenomenon and development of the findings.
A key tenet of case study methodology often underemphasized in literature is the importance of defining the case and phenomenon. Researches should clearly describe the case with sufficient detail to allow readers to fully understand the setting and context and determine applicability. Trying to answer a question that is too broad often leads to an unclear definition of the case and phenomenon. 20 Cases should therefore be bound by time and place to ensure rigor and feasibility. 6
Yin 22 defines a case as “a contemporary phenomenon within its real-life context,” (p13) which may contain a single unit of analysis, including individuals, programs, corporations, or clinics 29 (holistic), or be broken into sub-units of analysis, such as projects, meetings, roles, or locations within the case (embedded). 30 Merriam 24 and Stake 5 similarly define a case as a single unit studied within a bounded system. Stake 5 , 23 suggests bounding cases by contexts and experiences where the phenomenon of interest can be a program, process, or experience. However, the line between the case and phenomenon can become muddy. For guidance, Stake 5 , 23 describes the case as the noun or entity and the phenomenon of interest as the verb, functioning, or activity of the case.
Yin’s approach to a case study is rooted in a formal proposition or theory which guides the case and is used to test the outcome. 1 Stake 5 advocates for a flexible design and explicitly states that data collection and analysis may commence at any point. Merriam’s 24 approach blends both Yin and Stake’s, allowing the necessary flexibility in data collection and analysis to meet the needs.
Yin 30 proposed three types of case study approaches—descriptive, explanatory, and exploratory. Each can be designed around single or multiple cases, creating six basic case study methodologies. Descriptive studies provide a rich description of the phenomenon within its context, which can be helpful in developing theories. To test a theory or determine cause and effect relationships, researchers can use an explanatory design. An exploratory model is typically used in the pilot-test phase to develop propositions (eg, Sibbald et al. 31 used this approach to explore interprofessional network complexity). Despite having distinct characteristics, the boundaries between case study types are flexible with significant overlap. 30 Each has five key components: (1) research question; (2) proposition; (3) unit of analysis; (4) logical linking that connects the theory with proposition; and (5) criteria for analyzing findings.
Contrary to Yin, Stake 5 believes the research process cannot be planned in its entirety because research evolves as it is performed. Consequently, researchers can adjust the design of their methods even after data collection has begun. Stake 5 classifies case studies into three categories: intrinsic, instrumental, and collective/multiple. Intrinsic case studies focus on gaining a better understanding of the case. These are often undertaken when the researcher has an interest in a specific case. Instrumental case study is used when the case itself is not of the utmost importance, and the issue or phenomenon (ie, the research question) being explored becomes the focus instead (eg, Paciocco 32 used an instrumental case study to evaluate the implementation of a chronic disease management program). 5 Collective designs are rooted in an instrumental case study and include multiple cases to gain an in-depth understanding of the complexity and particularity of a phenomenon across diverse contexts. 5 , 23 In collective designs, studying similarities and differences between the cases allows the phenomenon to be understood more intimately (for examples of this in the field, see van Zelm et al. 33 and Burrows et al. 34 In addition, Sibbald et al. 35 present an example where a cross-case analysis method is used to compare instrumental cases).
Merriam’s approach is flexible (similar to Stake) as well as stepwise and linear (similar to Yin). She advocates for conducting a literature review before designing the study to better understand the theoretical underpinnings. 24 , 25 Unlike Stake or Yin, Merriam proposes a step-by-step guide for researchers to design a case study. These steps include performing a literature review, creating a theoretical framework, identifying the problem, creating and refining the research question(s), and selecting a study sample that fits the question(s). 24 , 25 , 36
Using multiple data collection methods is a key characteristic of all case study methodology; it enhances the credibility of the findings by allowing different facets and views of the phenomenon to be explored. 23 Common methods include interviews, focus groups, observation, and document analysis. 5 , 37 By seeking patterns within and across data sources, a thick description of the case can be generated to support a greater understanding and interpretation of the whole phenomenon. 5 , 17 , 20 , 23 This technique is called triangulation and is used to explore cases with greater accuracy. 5 Although Stake 5 maintains case study is most often used in qualitative research, Yin 17 supports a mix of both quantitative and qualitative methods to triangulate data. This deliberate convergence of data sources (or mixed methods) allows researchers to find greater depth in their analysis and develop converging lines of inquiry. For example, case studies evaluating interventions commonly use qualitative interviews to describe the implementation process, barriers, and facilitators paired with a quantitative survey of comparative outcomes and effectiveness. 33 , 38 , 39
Yin 30 describes analysis as dependent on the chosen approach, whether it be (1) deductive and rely on theoretical propositions; (2) inductive and analyze data from the “ground up”; (3) organized to create a case description; or (4) used to examine plausible rival explanations. According to Yin’s 40 approach to descriptive case studies, carefully considering theory development is an important part of study design. “Theory” refers to field-relevant propositions, commonly agreed upon assumptions, or fully developed theories. 40 Stake 5 advocates for using the researcher’s intuition and impression to guide analysis through a categorical aggregation and direct interpretation. Merriam 24 uses six different methods to guide the “process of making meaning” (p178) : (1) ethnographic analysis; (2) narrative analysis; (3) phenomenological analysis; (4) constant comparative method; (5) content analysis; and (6) analytic induction.
Drawing upon a theoretical or conceptual framework to inform analysis improves the quality of case study and avoids the risk of description without meaning. 18 Using Stake’s 5 approach, researchers rely on protocols and previous knowledge to help make sense of new ideas; theory can guide the research and assist researchers in understanding how new information fits into existing knowledge.
Columbia University has recently demonstrated how case studies can help train future health leaders. 41 Case studies encompass components of systems thinking—considering connections and interactions between components of a system, alongside the implications and consequences of those relationships—to equip health leaders with tools to tackle global health issues. 41 Greenwood 42 evaluated Indigenous peoples’ relationship with the healthcare system in British Columbia and used a case study to challenge and educate health leaders across the country to enhance culturally sensitive health service environments.
An important but often omitted step in case study research is an assessment of quality and rigour. We recommend using a framework or set of criteria to assess the rigour of the qualitative research. Suitable resources include Caelli et al., 43 Houghten et al., 44 Ravenek and Rudman, 45 and Tracy. 46
Although “pragmatic” case studies (ie, utilizing practical and applicable methods) have existed within psychotherapy for some time, 47 , 48 only recently has the applicability of pragmatism as an underlying paradigmatic perspective been considered in HSR. 49 This is marked by uptake of pragmatism in Randomized Control Trials, recognizing that “gold standard” testing conditions do not reflect the reality of clinical settings 50 , 51 nor do a handful of epistemologically guided methodologies suit every research inquiry.
Pragmatism positions the research question as the basis for methodological choices, rather than a theory or epistemology, allowing researchers to pursue the most practical approach to understanding a problem or discovering an actionable solution. 52 Mixed methods are commonly used to create a deeper understanding of the case through converging qualitative and quantitative data. 52 Pragmatic case study is suited to HSR because its flexibility throughout the research process accommodates complexity, ever-changing systems, and disruptions to research plans. 49 , 50 Much like case study, pragmatism has been criticized for its flexibility and use when other approaches are seemingly ill-fit. 53 , 54 Similarly, authors argue that this results from a lack of investigation and proper application rather than a reflection of validity, legitimizing the need for more exploration and conversation among researchers and practitioners. 55
Although occasionally misunderstood as a less rigourous research methodology, 8 case study research is highly flexible and allows for contextual nuances. 5 , 6 Its use is valuable when the researcher desires a thorough understanding of a phenomenon or case bound by context. 11 If needed, multiple similar cases can be studied simultaneously, or one case within another. 16 , 17 There are currently three main approaches to case study, 5 , 17 , 24 each with their own definitions of a case, ontological and epistemological paradigms, methodologies, and data collection and analysis procedures. 37
Individuals’ experiences within health systems are influenced heavily by contextual factors, participant experience, and intricate relationships between different organizations and actors. 55 Case study research is well suited for HSR because it can track and examine these complex relationships and systems as they evolve over time. 6 , 7 It is important that researchers and health leaders using this methodology understand its key tenets and how to conduct a proper case study. Although there are many examples of case study in action, they are often under-reported and, when reported, not rigorously conducted. 9 Thus, decision-makers and health leaders should use these examples with caution. The proper reporting of case studies is necessary to bolster their credibility in HSR literature and provide readers sufficient information to critically assess the methodology. We also call on health leaders who frequently use case studies 56 – 58 to report them in the primary research literature.
The purpose of this article is to advocate for the continued and advanced use of case study in HSR and to provide literature-based guidance for decision-makers, policy-makers, and health leaders on how to engage in, read, and interpret findings from case study research. As health systems progress and evolve, the application of case study research will continue to increase as researchers and health leaders aim to capture the inherent complexities, nuances, and contextual factors. 7
This article has been written by Badal Singh.
Table of Contents
“There is nothing more foreign to a civilized and democratic system than to preventive detention.”
– Robert Bourassa
The Constitution of India carries the conscience of the Constitution-makers and the common people, reflects the form of society that needs to be adopted, the rules to be followed, the obligations to be performed and the rights to be enjoyed without any sort of interference and disruptions. Among the rights granted by the supreme authority of the nation, the fundamental rights are the basic and prime ones that can be enjoyed by each citizen of the state and any infringement of these rights are subject to judicial review. There are exceptions to these wherein the state can suspend any of them in matters of state security, the sovereignty of the nation or for the maintenance of the public order. The problem arises when the private and basic human rights of the individual are infringed and a very serious question as to what extent the state can interfere in the life and rights granted to the individual arises.
India being the largest democracy grants liberty to its individual through Article 21 and 22 in the form of personal liberty and preventive detention. The rights granted in Article 21 and 22 of the Constitution are the ones that face the maximum heat of being infringed. The right to life and personal liberty granted by Article 21 of the Constitution goes hand in hand with Article 22 as both talks about the liberties provided to the citizen and some of the exceptional circumstances under which these rights are unavailable or restricted.
Liberty is itself the gift of the law and may by law (be) forfeited or abridged. This statement by Justice A.N Ray sums up the meaning and scope of liberty provided to an individual in India. When required, the state can restrict liberty up to any extent as it may deem valid, but only through the correct and ethical interpretation of the law. Whether the interpretation is fit or not, whether appropriate scrutiny has been done over the impediment of such rights, or whether the restriction is arbitrary in nature is a matter of great apprehension.
Article 22 of the Indian constitution deals with the Protection from Arrest and Detention. The first part of this article confers certain rights to the individual such as the knowledge of ground of arrest, right to consult and to be defended by a legal practitioner, right to be produced before the magistrate within 24 hours of arrest (excluding the journey time) and right to be released after 24 hours unless the magistrate authorizes further detention. These rights aren’t granted to an alien or a person detained under the preventive detention laws. The second part deals with such preventive detention laws and is mentioned in the sub-clause 3 of Article 22 .
This article acts as a boon for the stakeholders to prohibit activities that could disturb the peace of the nation or would be dangerous for the sovereignty of the nation. At the same time, the stakeholders can use the same laws to oppress the voices and wrongdoings, thus curbing the freedom of speech and expression granted by the constitution. Thus, this article of the Constitution being so significant can also be paradoxical and a matter of debate.
After 300 years of the devastating and dismal British era, India gained independence on 15 August 1947 and nearly after 3 years of independence, with the deeds of the constituent assembly, the constitution of India was framed and adopted by the people of India. The Constitution of India, the largest written text of its kind, is the supreme law of land and consists of all the provisions through which law and order is maintained within the state and in state affairs. The Constitution also envisages six different types of fundamental rights within itself. Among those fundamental rights, the right to preventive arrest and detention is given in Article 22 of the Indian Constitution. The crux of the given Article is that no person shall be denied the ground of his arrest and his right to consult a legal practitioner isn’t exhausted as well.
The Article also stipulates a time period of 24 hours (excluding the travel period) within which the arrested individual needs to be presented before the magistrate and no person should be kept in custody beyond the said period without the authority from the magistrate. But there are certain exceptions given in the article and under such circumstances, individuals can’t avail the existing rights under the first and second section of the article. Section 3 of the article says that these rights can’t be availed by enemy aliens or the individuals detained under the preventive detention laws.
Also, Section 151 of the Criminal Procedure Code, 1971 grants a police officer the right to a police officer without the order of a magistrate or even without a warrant letter, merely on a suspicion that an individual is in a position or condition to commit a crime. Now, we need to focus on what preventive detention laws are, and what are the significances and consequences of such laws.
Preventive detention laws are the set of rules and statutes that allow the state and its authorities to detain an individual or a group of them under suspicion that the individual would commit any cognizable offence under the law and would be a threat to the sovereignty of the state, instability of the society or dismantling of the public order.
The arrest under such provisions of the preventive detention laws is known as “preventive arrest”. Preventive detention laws are generally designed to grant the state swift decisions during times of emergency and dire need. The importance of these laws was understood and upheld by the constituent assembly as they considered these laws proficient enough to be included in the ambit of fundamental rights.
But the authorities granted to the state and its agencies isn’t absolute and is subject to certain conditions and speculations. Section 4 of the article states that no person under the provision of preventive detention laws can be detained for more than 3 months unless it is so prescribed by an advisory board consisting of persons eligible of being a judge of high courts, provided that nothing in this sub-clause shall authorize the detention of any person beyond the maximum period prescribed by any law made by Parliament under sub-clause (b) of clause (7); or if such person is detained in accordance with the provisions of any law made by Parliament under subclauses (a) and (b) of clause (7).
Also, the authority detaining an individual has the duty to inform and make available a legal representative available as per clause 5.
The law seems quite a crystal clear and transparent in nature. But it is not what it looks like and there arises a lot of debates on the provisions envisaged in clause 7 of article 22. It provides the powers to the parliament to make the laws in case the detention is more than the prescribed period of three months and the absence of a recommendation by the advisory committee.
According to the same, it is the parliament that decides the extent of time that an individual can be detained, under the preventive detention laws and also the procedure followed by the advisory committee is to be decided by the parliament. This gives absolute power to the parliament. Sometimes, it can take arbitrary decisions that can be against the consensus of the public at large. It can infringe with the right to speech and expression and right to life and personal liberty of individuals, even without committing any offence and only if he/she goes against the will or expectation of the ruling party in the state.
In this way, a single clause of Article 22 can lead to the dismantling of the golden trilogy , i.e., the rights granted to an individual under Article 14,19 and 21 of the Indian constitution. The authorities can even deny the grounds of an arrest taking an excuse as the fact being against the public order as per clause 5 of Article 22. Democracy as said by Lincoln is a form of government of the people, by the people and for the people. The whole crux of democracy lies within the people living in the state and the rights they enjoy without any kind of interference or infringement.
The arbitrary laws which infringe such rights without any reasonableness or rational nexus between the act committed by the individual and the sanctions faced by him, act as a blot on democracy and degrades the notion as to why democracy is practised.
The constitution provides the framework through the help of which the rule of law within a state is followed and made to follow. Apart from the constitution, there are certainly other sources of legislation such as the IPC, CrPC and CPC which deal with the criminal and civil justice system of the country. Laws vary according to their nature. Some of them are enabling whereas the remaining are restrictive.
Preventive detention laws are generally restrictive in nature and curb the rights to freedom of speech, movement, expression and liberty. These laws authorize the state with the power to detain an individual without filing a case by anyone or without any offence being committed by that specific individual.
These detentions are protective in nature and allow the state and the concerned authorities to prevent the crime from being committed. If the state has a presumption that an individual could be a threat to the peace and stability of the society and there exists no other applicable means to prevent such mishap, the state as per the law made and envisaged by the parliament in consensus with the concerned articles of the constitution, can arrest and detain an individual without a trial for a reasonable time limit as discussed above.
The history of preventive detention in India dates back to the colonial era. During the regime of the East India Company in India, laws such as the Rowlett Act (1919), Bengal Criminal Amendment Ordinance and Defense of India Act, 1939, envisaged the provisions of preventive detention. These acts allowed the authorities to detain anyone on just a mere suspicion and no reasonable nexus needed to be established between the arrest and reasoning behind the arrest.
The British regime used these provisions to oppress the protestors and the revolutionaries to a much greater extent. These laws provided a pathway for dictatorship in prevention of maintaining the rule of law. Whenever things went opposite to that of what the Britishers expected, they would take the support of such stringent and arbitrary legislations to hide behind and contravene the rights of the common individuals. Primarily designed to have strict control over the unruly elements of the society, these laws during the British regime created a legal escape for the contemporary authorities, for all the wrong deeds and violations of basic rights.
After independence, the drafters of the constitution had many discussions and debates about whether the preventive detention laws would be included or not. The assembly with a common consensus agreed to include provisions related to preventive detention in the fundamental rights of the constitution as they deemed its inclusion necessary for the protection of the sovereignty of the nation and avoid any kind of hostility or mishap.
The first preventive detention law in India was passed in February 1950 by the parliament of India. This law lasted for a time period of 21 years, i.e., till 1971, and then was abolished. Before being abolished, the applicability of this case was observed in the A.K Gopalan v. State of Madras.
In the end, the validity of this case was upheld by the supreme court, with the exclusion of some of the provision. Afterwards, the country formulated a lot of preventive detention laws in different stages of post-development but the provisions that were provided in such rules were almost similar.
The Unlawful Activities Prevention Act (UAPA) was another preventive detention law implemented in 1967. This act provides for provisions that help in dealing with the terror activities and curb the actions that pose a threat to the sovereignty of the state. The act has been amended multiple times as per the need of reinforcement in relation with the situation of the society.
The last amendment which took place recently in the year 2019, gave the government to declare an individual a terrorist on mere suspicion by the officials believing it to be so. Initially, the provision was only for the groups and organizations which came under the ambit of terrorism. Also, after the Prevention of Terror Activities Act (POTA) and Terror and Disruptive Activities Act (TADA) was repealed, their provisions were included in the UAPA through an amendment done in the year 2004. This made UAPA an act with stringent regulations that the authority could use in cases such as the terror attack that occurred on 26th November 2007. But the same act can be used by the state to impose arbitrary restrictions on individuals without much scope of justice and judicial trials.
Another preventive detention law that has been in the public eye in recent times is the Public Safety Act of Jammu and Kashmir. Designed for action against the timber smugglers within Jammu and Kashmir, this Act was introduced by Sheikh Abdullah in the year 1978. And in the contemporary situation, after the abrogation of Article 370 from the Constitution, it was his son Farookh Abdullah who had to face the heat of this provision.
He was detained by the NDA government under suspense that letting him free would initiate riots and conflicts in the state of Kashmir, leading to chaos in the society and internal disturbance within the nation. But was his and Mehbooba Mufti’s detention ethical? Rather than ethical, the question that needs to be raised and scrutinized is whether the detention was valid as per the doctrine of justice and was the detention not in violation of the basic fundamental rights that are needed to be abided by. These questions arise in the context of all the existing preventive detention laws different parties portray differently, sometimes conflicting opinions.
No subject matter is universally accepted with the same reasoning. The facts and point of views differ from person to person. Each of them carries definite reasoning and connects it with a reasonable nexus to support their point of view. The thing that has to be paid attention to is whether the reasoning that has been provided is valid and feasible with respect to the present scenario of the society.
Also, the counter-arguments provided by the party against, should also be considered and the prominent should be implemented in the behaviour and in the working mechanism of the society. The same is the situation regarding the preventive detention laws’ inclusion amongst the governing statutes.
The virtuous and the intellects of society don’t have the same opinion regarding such laws. Some think that these laws are just a few arbitrary provisions that the state and its authorities use to curb the rise of any expressive thoughts that could be derogatory for the existing sovereigns or to halt the exercise of basic fundamental rights of an individual if he does anything in contrary of what is just and beneficial for the existing rulers and democrats.
These people just believe that these laws are against the basic doctrine of the Constitution. Laws are from and for people, and not the people are from laws. And such stringency that disallows and disdains such freedom of life, liberty, expression and equality of citizens shouldn’t be declared valid.
The absence and flout of such laws in the advanced foreign nations like England and other European nations provides advocacy to the views of the individuals who are against the preventive detention laws. Since these provisions provide for arrest and sanctions against individuals without even the commencement of crime, they are not in correspondence with the norms of the Constitution.
This is not how justice ought to be delivered and is against the public policy and norms of humanity. Mihir Desai , a senior advocate says that these preventive detention laws allow the state to carve out exceptions for its lawlessness.
The state can to curb any existing dissent or dissenters, charge individuals under such laws, which otherwise they wouldn’t have been able to, through any other source. Therefore, some people believe that such laws don’t stand any chance of existence and are outdated and against the terms of democracy.
Amidst such dissenting opinions regarding the preventive detention laws, there are a considerable number of people who think preventive detention laws are a very vital set of legislations that help in preserving and protecting the sovereignty of the nation and its people. India, being a multi-religious, multi-ethnic and multi-cultural country, consists of people of different faiths, carrying diverse identity and following varieties of norms and traditions. And when any contradiction arises, it gives rise to conflict amongst the groups.
Therefore, Indian society is always vulnerable to riots and religious conflicts. To avoid such mishaps, it is vital for the state to have stringent provisions to control and prohibit the commencement of any sort of disservice. Also, terrorism is one of the major areas of concern for India and the government spends a huge part of the annual part in safeguarding the country from terrorists and terror activities.
Preventive detention laws provide a helping hand to prevent such activities before occurrence and thus maintain the peace and stability within the state.
The supreme court in the case of AlijanMian v. District Magistrate, Dhanbad set forward a difference between criminal proceedings and crime. It stated that criminal proceedings refer to punishing a person who has committed a crime, but preventive detention in itself isn’t a crime.
In Anil Dey v. State of West Bengal , the Supreme Court held that “the veil of subjective satisfaction of the detaining authority cannot be lifted by the courts with a view to appreciate its objective sufficiency”. Although the courts “cannot substitute their own opinion for that of the detaining authority by applying an objective test to decide the necessity of detention for a specified purpose, they do review whether the satisfaction is “honest and real, and not fanciful and imaginary”. It is thus advised by the court to the judicial authorities to use its virtue while detaining anyone under any law and such detainment can always be the subject of review and objectivity tests of the court.
Article 22, although not perfect and ideal, was included in the Constitution after tons of debates and arguments among the members of the constituent assembly. The Constitution provides for basic freedoms to each of its citizens and they are provided with the rights to enjoy those freedoms without any infringement. But these rights are to be enjoyed to an extent only up to which the rights of others aren’t infringed.
Therefore, one must have mutual respect for the rights granted to others as well. Similarly, the state must also portray respect to the rights which have been granted by the rule of law to the citizens.
But sometimes for the sake of preservation of rights of a huge mass, the state should also have the rights to curb some of the rights granted to some of the individuals, specifically those individuals who have the capacity to disturb the mechanism of the society. Preventive detention is equally important for the nation as the other essential laws. It is a wicked sine non qua.
It is like a medicine with some side effects, but if the body has to be maintained in proper working condition, then it must be accepted with its side effects. The provisions of these laws are held up by the supreme court and it has found it justifiable on each and every ground. The only ground that creates controversies is the unjust and irrational use of such provisions by the state for personal benefits.
But what about a country where thousands of individuals each year are detained without a just justification by the authorities and an effective trial? The role of the judiciary comes into the picture under such scenarios. Also, the effectiveness and transparency of the advisory committee that decides on the further detention of the individual is equally important. Any kind of corruption would lead to the monopoly of the state. As said earlier, preventive detention is a hard pill to swallow. And it is actually a way to protect the rights of the public at large, even if the rights of some individuals have to be infringed.
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Article 22 of the Indian constitution talks about the protection of life and personal liberty .
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Two cases about Hertz claimed top spots in 2021's Top 40 Most Popular Case Studies
Two cases on the uses of debt and equity at Hertz claimed top spots in the CRDT’s (Case Research and Development Team) 2021 top 40 review of cases.
Hertz (A) took the top spot. The case details the financial structure of the rental car company through the end of 2019. Hertz (B), which ranked third in CRDT’s list, describes the company’s struggles during the early part of the COVID pandemic and its eventual need to enter Chapter 11 bankruptcy.
The success of the Hertz cases was unprecedented for the top 40 list. Usually, cases take a number of years to gain popularity, but the Hertz cases claimed top spots in their first year of release. Hertz (A) also became the first ‘cooked’ case to top the annual review, as all of the other winners had been web-based ‘raw’ cases.
Besides introducing students to the complicated financing required to maintain an enormous fleet of cars, the Hertz cases also expanded the diversity of case protagonists. Kathyrn Marinello was the CEO of Hertz during this period and the CFO, Jamere Jackson is black.
Sandwiched between the two Hertz cases, Coffee 2016, a perennial best seller, finished second. “Glory, Glory, Man United!” a case about an English football team’s IPO made a surprise move to number four. Cases on search fund boards, the future of malls, Norway’s Sovereign Wealth fund, Prodigy Finance, the Mayo Clinic, and Cadbury rounded out the top ten.
Other year-end data for 2021 showed:
CRDT compiled the Top 40 list by combining data from its case store, Google Analytics, and other measures of interest and adoption.
All of this year’s Top 40 cases are available for purchase from the Yale Management Media store .
And the Top 40 cases studies of 2021 are:
1. Hertz Global Holdings (A): Uses of Debt and Equity
2. Coffee 2016
3. Hertz Global Holdings (B): Uses of Debt and Equity 2020
4. Glory, Glory Man United!
5. Search Fund Company Boards: How CEOs Can Build Boards to Help Them Thrive
6. The Future of Malls: Was Decline Inevitable?
7. Strategy for Norway's Pension Fund Global
8. Prodigy Finance
9. Design at Mayo
10. Cadbury
11. City Hospital Emergency Room
13. Volkswagen
14. Marina Bay Sands
15. Shake Shack IPO
16. Mastercard
17. Netflix
18. Ant Financial
19. AXA: Creating the New CR Metrics
20. IBM Corporate Service Corps
21. Business Leadership in South Africa's 1994 Reforms
22. Alternative Meat Industry
23. Children's Premier
24. Khalil Tawil and Umi (A)
25. Palm Oil 2016
26. Teach For All: Designing a Global Network
27. What's Next? Search Fund Entrepreneurs Reflect on Life After Exit
28. Searching for a Search Fund Structure: A Student Takes a Tour of Various Options
30. Project Sammaan
31. Commonfund ESG
32. Polaroid
33. Connecticut Green Bank 2018: After the Raid
34. FieldFresh Foods
35. The Alibaba Group
36. 360 State Street: Real Options
37. Herman Miller
38. AgBiome
39. Nathan Cummings Foundation
40. Toyota 2010
Landmark judgements on article 20 of the indian constitution.
State of Rajasthan v. Mohan Lal |
Article 20 of the Constitution of India constitutes a pivotal fundamental right, safeguarding the rights of accused individuals and convicts. This post contains summary of landmark judgements on Article 20.
Article 20 encompasses three crucial provisions:
Article 20(1) pertains to ex-post facto laws, preventing retroactive legal consequences for past actions, and distinguishing between the prospective and retrospective nature of laws;
Article 20(2) establishes the principle of double jeopardy, safeguarding against multiple prosecutions or penalties for the same offense; and
Article 20(3) ensures the right against self-incrimination, empowering individuals to abstain from providing potentially self-damaging testimony. Collectively, these principles fortify a just legal framework, preserving individual rights and equitable treatment within the Indian legal system.
Here is a summary of landmark judgements on Article 20 of the Indian Constitution :
Section 5(3) of the Prevention of Corruption Act, addressing disproportionate income cases, necessitates individuals to substantiate the legitimacy of assets that appear exceedingly disproportionate to their earnings.
In this context, the pivotal concern emerges regarding the compliance of such a provision with the safeguards enshrined in Article 20 of the Constitution. In a legal challenge posed by Sajjan Singh, who cited the law’s enactment in 1947 subsequent to a 1948 search operation, while asserting the accumulation of disproportionate assets since 1920, the core contention centers on the prospect of retrospective imposition of liability.
However, the Court’s ruling pivoted on Article 20(1)’s principle, which guards against retroactively intensifying penalties or liabilities. The Court discerned the distinction between altering the burden of proof, as outlined in Section 5(3), and augmenting legal ramifications.
Conclusively, the Court determined that the obligation to provide pre-1947 asset receipts did not constitute a retrospective imposition of liability, as it pertained solely to the evidentiary aspect and did not enhance punitive consequences, aligning with the interpretation that such evidentiary shifts lay outside the scope of Article 20(1).
In a case involving a sixteen-year-old boy who trespassed on private property and committed a molestation offense, he was initially found guilty, resulting in imprisonment and a fine.
The subsequent enactment of the Prohibition of Offenders Act, specifying that those under twenty-one be sent to juvenile facilities, raised a Supreme Court question on retroactivity. The Government cited Article 20, barring harsher retroactive punishment.
The Court, led by Justice Subba Rao, emphasized the law’s benevolent intent and extended it ex-post-facto, mitigating punishment. Therefore, article 20(2) was invoked, clarifying “double jeopardy” concerns.
The Hon’ble Supreme Court of India emphasized that legislative acts characterizing actions as criminal offenses along with their corresponding penalties inherently operate on a prospective basis.
Applying such laws retrospectively, as cautioned by the Court, would run counter to the safeguards enshrined in Article 20 (1) of the Indian Constitution. This principle serves to protect individuals from facing punitive measures for actions committed prior to the establishment of the relevant legal provisions, thereby upholding the fundamental principles of justice and fairness integral to the constitutional framework.
The Court’s discerning observation pertained to the encompassing scope of Article 20 (1), elucidating that it encompasses a pivotal tenet preventing the imposition of penalties more severe than those in force at the commencement of an offence.
This principle safeguards individuals from facing heightened retrospective punishments, underscoring the imperative of maintaining consistency between the legal consequences applicable at the time of the offense and any subsequent alterations to the penalty framework.
By adhering to this principle, the Court reinforces the foundational elements of fairness, proportionality, and legal certainty within the Indian legal system.
In this specific case, an individual was found in possession of a certain quantity of gold, which was in violation of the prevailing local law. The customs authority seized the gold, and subsequently, the person faced prosecution in a criminal court.
The central issue before the court revolved around the concept of Double Jeopardy, wherein it had to determine whether this sequence of events constituted a violation of the principle. The court was tasked with evaluating whether the individual could be subjected to multiple legal actions and penalties for the same offence of possessing illicit gold, given that both the confiscation by customs and the subsequent criminal prosecution were implicated.
The Supreme Court ruled that the mandatory application of certain scientific techniques—namely, narcoanalysis, polygraph examination, and the Brain Electrical Activation Profile (BEAP)—possesses a ‘testimonial’ nature, thereby invoking the safeguards of Article 20(3) of the Constitution.
The techniques involved include polygraph tests for lie detection, narcoanalysis which administers truth serum to elicit responses while in a semi-conscious state, and brain mapping which analyzes brain signals during recollection.
The primary defense against their challenge was that these measures don’t entail voluntary statements but rather scientific procedures akin to blood tests. However, Selvi’s judgment rejected this analogy, deeming the techniques not comparable to neutral blood tests.
Instead, they were likened to oral testimonies as answers are elicited via devices, directly involving the accused, in contrast to blood tests which remain impartial and detached.
The Narcotics, Drugs and Psychotropic Substances Act held relevance in the present case, where a contention arose that Article 20 of the Constitution exclusively prohibits the imposition of penalties or convictions based on ex post facto legislation, but does not extend to restraining the trial or prosecution process itself.
Furthermore, it was contended that a trial conducted utilizing a distinct procedural framework from the one in force at the time of the offense does not necessarily adhere to the same limitations, and thus cannot be deemed constitutionally invalid.
This perspective underscores the nuanced interpretation of Article 20 within the context of the mentioned Act, highlighting the balance between safeguarding individual rights against retrospective punishment and maintaining the constitutional integrity of trial procedures that may evolve over time.
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The case of anna o. showed that psychoanalysis worked. did freud tamper with it.
There is perhaps no one more devoted to the cause than a convert, and there is no one more violent toward it than a person who has lost their faith. The faithful turned faithless take up the act of crusade, but in reverse: new atheists confronting the world with secular eyes, children who learn that their parents aren’t omnipotent. They have suffered the loss of an organizing principle, the very thing they built their life around. Now, they may seek revenge on the object that caused an earlier delusion. The commitment doesn’t end—it just takes on new guises.
Beyond the reactions of former lovers and former zealots, we see this in the history of psychoanalysis, perhaps because the practice attracts and demands those same qualities of immersion and devotion. Many have justly loved psychoanalysis, and many have justly despaired of it. This includes the very founders of rational emotive behavioral therapy and cognitive behavioral therapy, who brought about a sea change in mental health care, and the critics Frederick Crews, Jeffrey Masson, and Philip Rieff, who turned against Freud even after he had been unthroned as king of the twentieth century. This hatred can feel quasi-personal, aimed at the originator, their father figure, Sigmund Freud.
This loss of faith looms over Gabriel Brownstein’s book, The Secret Mind of Bertha Pappenheim: The Woman Who Invented Freud’s Talking Cure . On its face, the book is a study of the first analytic patient (although she didn’t exactly receive psychoanalytic treatment), Bertha Pappenheim. Pappenheim, who was treated by Freud’s mentor Josef Breuer in Vienna, was the subject of one of Breuer’s case studies and was much discussed by Freud throughout his own career. The book’s stated aim is to offer a full portrait of someone flattened and circulated as a specimen. For Pappenheim is best known by another name—Anna O.—and is best known not as her full person, who left a legacy of feminist and activist patronage, but as the world’s most famous hysteric.
But quietly, this is also a book about the birth and death of psychoanalysis—which is to say that the narrative of Freud’s ascendance and betrayal is the engine that drives the book. Brownstein argues, sometimes contradictorily, that Freud’s brilliance and his drive to make his way as a medical doctor propelled him to tamper with Bertha’s story.
Given that Pappenheim’s stunning cure is the origin story of psychoanalysis, Brownstein seeks to denigrate the whole endeavor on these grounds. If the Anna O. case was a fraud, so, too, would the cure be that she discovered.
Hysteria, much like psychoanalysis, has a storied past, one with a powerful crescendo followed by a caesura. Though the term “hysteric” is now assumed in common speech to be either a pejorative epithet, synonymous with performative hyper-emotionality ( he was hysterical ), or a historical diagnosis made up by misogynistic doctors (like, some argue, Breuer and Freud), the condition was once quite common. For the uninitiated, hysteria is an illness where the body speaks, where neurotic symptoms appear in and on it. It was treated by an array of cures, from gynecological massage (prescribed orgasm), hypnotism, rest, and drugging, to change of scenery, and, yes, for a very few patients, starting in the late nineteenth century, Breuer and Freud’s cathartic method. This eventually became psychoanalysis. This was, it must be said, a treatment that seems preferable to the other options.
Bertha Pappenheim was in many ways a typical hysterical patient, and an extraordinary woman. When she went to see Breuer in 1880, she presented with the typical hysterical complaints: partial paralysis, disturbances of appetite and language, pain. She couldn’t recall her native German and only spoke in English. She wouldn’t drink water. She had fallen ill while nursing her father, and her condition deteriorated upon his death. She was treated both in her home and in an asylum, often with high doses of drugs. What marks her case as special is that Pappenheim was the first person on Earth to be treated by the cathartic method, in large part because she invented it. Anytime you hear someone say “talking cure,” they’re using the very term Pappenheim ascribed to the yearslong experiment she undertook, morning and night, with her doctor. As she chattered on, as she engaged in the “chimney sweeping” of her mind—so the story goes—she felt better.
Freud and Breuer went on to co-write the groundbreaking Studies on Hysteria , published in 1895. The two doctors, one senior and one junior, open the book with a co-written introduction and end it with a pair of stand-alone essays (Freud’s undermining Breuer’s) in which the nascent theories of repression, defense, catharsis, and abreaction first appear. Each supplied case material of hysteric women treated by this nascent cathartic method. Freud wrote up four cases, and Breuer only contributed the case of Pappenheim, now disguised and named “Anna O.” The two detailed the symptoms of their patients and how each was aided, if not outright cured, by this new talking protocol.
In Breuer’s write-up of Anna O., which only runs about 25 pages, he elaborates on the case study, telling his readers how ill Anna was, when, and why. He then goes on to describe his therapeutic practice of sitting with her at night, and how, while Anna O. was under hypnosis, the two came to “develop a therapeutic technique” of linking each of her symptoms to the moment it appeared. The water she will not drink, for instance, is linked to a moment she saw her English ladies’ companion let a little dog drink from her glass. After the connection is revealed under hypnosis, Breuer tells us, Anna O. drinks water once more. The process repeated until there were no symptoms left, and Anna O.’s mental state presumably returned to normal.
The problem is—and basically all historians of psychoanalysis agree on this point—that even though Breuer and Freud reported a miracle cure, Anna O. didn’t get better. In fact, she got worse and was put in a sanatorium. The question is why. Brownstein, following the anti-Freud tradition, attributes this failure to the treatment. Freud, of course, attributed this failure to the person who offered the treatment—Breuer—not because he couldn’t cure her, but because he didn’t finish doing so.
Like all origin myths, the case has been subject to endless interpretation and reinterpretation. Even the original case study is retrospective: Breuer didn’t write up the Anna O. case at the time of treatment. He did so at Freud’s urging, so that the two might document this new technique of psychotherapy. Anna O. thus became the first patient of psychoanalysis only after the fact, and even though her treatment has just about nothing in common with psychoanalysis today, she is celebrated as such. Freud then revised the case multiple times across his life (in private letters, then in publications in 1910 and 1914), often to diminish Breuer’s role in the origin of psychoanalysis. This is in part due to what Freud thought of privately as Breuer’s failure: When Anna O. showed Breuer she had transferred onto him—by fantasizing about having his baby—Breuer ran away. Breuer could have invented psychoanalysis had he stayed in the room—but he didn’t dare. And thus Anna remained ill, but, in Freud’s understanding, psychoanalysis was not at fault.
Once Freud died, others revised the case in their own ways. Stacks of books can be called up in any research library by those who either defend or revile Freud—and nearly all of them, at one point, turn to Anna O. These studies often seek to collate and correlate Breuer’s flattened write-up of the case with historical reality, trying to reconstruct both Anna O.’s illness and her medical treatment. Some are feminist rereadings of the case, arguing that Anna O. was sick with patriarchy; others center squarely on Freud’s obsession with the case, excavating his letters about Anna O. to various ends.
What’s plain as day: Pappenheim has become the Rorschach test for the field. What we see in her case tends to be run through our feelings about psychoanalysis. The great historian of psychoanalysis John Forrester has argued that the baby that Anna O. spoke of wanting to have with Breuer was psychoanalysis—something she conceived with Breuer, even though he wouldn’t stick around and take responsibility for it. Anti-Freudian Mikkel Borch-Jacobsen sees Anna O.’s case as entirely fabricated, a young woman taken in by her handsome doctor and given huge quantities of drugs; if she invented psychoanalysis, she was the first to be duped by it. As the late Peter Gay observed, “There are contradictions and obscurities in successive versions of the case, but this much is more or less beyond dispute: In 1880, when Anna O. fell ill, she was twenty-one.”
But because very little besides Breuer’s documents is known of her life at the time of treatment, we project what we want onto her, and we can, for her history is a mere fragment. That we continue to do so makes exquisite sense: Psychoanalysis teaches us we must go back to our origins to go forward. And the treatment of Anna O. by Breuer is one way—a decent way—to conceptualize the start of Freud’s theory of mind.
Brownstein’s main critique of Freud’s use of Anna O. is this: that he took her case for his own material ends (though, by the same token, we might ask after Brownstein’s book advance). Freud was a broke young doctor; he needed to get married, and, to do so, he needed to press Breuer into writing Studies on Hysteria so that he could practice this new treatment with a kind of paternal authorization, styling himself as a doctor of “the cathartic method of J. Breuer.”
Brownstein agrees with anti-Freudians like Borch-Jacobsen and Crews that Anna O.’s treatment was a dismal failure. And even though that would make the lie—that Anna O. was cured—Breuer’s, Brownstein argues it was Freud who metaphorically had a gun to his mentor’s head and forced him to write it. More softly, Brownstein argues that Anna O. obscures Bertha Pappenheim, whom Brownstein now promises to deliver to us. Here’s the problem: Brownstein wants to make Freud the (very) bad guy of a story that had little to do with him, even if he had a great deal to do with the case becoming a story. So much so that Brownstein treats the possibility of Freud seeing Bertha Pappenheim at a party years after the treatment as corroborating evidence for some kind of misdeed.
Brownstein thus rewrites up the notorious case, with his chatty, negative asides and interpretations taking center stage. His first close reading from the book is, appropriately, from the first page. He argues that, though Studies purports to be “about the sex lives and sex drives of young bourgeois women,” it “begins by announcing that, for the purposes of propriety, any discussion of their actual intimate lives will be avoided.” Brownstein argues that this is a cover—that Breuer and Freud are maliciously withholding evidence for their theory because there isn’t any and because the doctors wanted to appear respectable. But if we read the first page of Studies , here’s what Breuer and Freud actually wrote: “It would be a grave breach of confidence to publish material of this kind, with the risk of patients being recognized and their acquaintances becoming informed of facts which were confided only to the physician.” There is a deep truth to what Freud and Breuer argue: They were working in a small coterie of largely wealthy Viennese Jewish patients. Everyone knew one another (hence, the great possibility of Freud running into Pappenheim). If you circulated reports of the ills of a young woman’s “marriage bed” or lack thereof, it would have meant no father would refer his daughter to Breuer or Freud, let alone the greater ethical considerations Brownstein says are gestured to half-heartedly.
Elsewhere, Brownstein accuses Freud of having a faulty memory and disguising the patient (despite the authors’ own opening warning to the reader not to go looking for biographical information of Pappenheim). To cover over the lack of details about her, Brownstein freely narrativizes the case, turning it into a historical fiction. At other times, Brownstein seems furious that Freud tends to write beautifully—Brownstein takes this as a sign of fudging the facts—while he then turns to close reading it like a literary critic.
By the end, we know from Brownstein that we’re supposed to find Breuer largely unobjectionable, but in the grips of a young Freud. The cardinal sin for Brownstein, though, is that Anna O. wasn’t made better. (Brownstein believes that she was in fact suffering from a functional neurological disorder, a contemporary diagnosis that overlaps with hysteria.) She was transported back to the asylum, so ill that Breuer reportedly told Freud his beloved patient might be better off dead, so that she might be free of suffering. Yet we might pause and say something did indeed happen in that treatment: Pappenheim was ultimately able to recover enough. By 1889, at 29 years of age, she was able not only to get out of bed, to talk, but to work in a soup kitchen. From this year on, she published—first anonymously and then pseudonymously, under the name Paul Berthold. Soon, Pappenheim was finally known not as Anna O., not as Berthold, but as herself. She also became famous as herself, a powerful, feminist leader, founding the Jewish Women’s Association and centralizing Jewish women’s organizing toward both employment and charity.
Why a book about Bertha Pappenheim now? One answer: With its claim that it will deliver readers Pappenheim in full, Brownstein’s book sits on that ever-expanding shelf of nonfiction books that seek to tell the stories of women who have been relegated to the margins of history, returning them to their larger, unobfuscated import. The book, too, in trying to bring Pappenheim’s story up to the present by rediagnosing her with functional neurological disorder, joins the book market for explorations of contested illness. Yet this book isn’t exactly proper to either of these subgenres. Instead, we might make sense of it as a work of backlash: Just as a range of analysts and writers have turned once more to Freud (as The New York Times proclaimed in an article not quite aptly titled “Not Your Daddy’s Freud”), so have others returned to maligning him. Brownstein has offered us, perhaps, the first book of the Freud Wars 2.0.
Brownstein, in fact, inherits the role of Freud skeptic from an earlier generation. His father, Dr. Shale Brownstein, was a prominent New York psychiatrist and psychoanalyst with a Rolodex of famous patients. Sometime in the 1980s, Dr. Brownstein became disillusioned with psychoanalysis and became an anti-Freudian—though we are never quite told why. One night, when Brownstein went to visit his father, he found him in his underwear, speaking wildly. The subject: Bertha Pappenheim. His father held a thick envelope filled with scientific and historic papers, newspaper clippings, reviews of books, and his own essay on the subject.
His father gave him the manila envelope. The younger Brownstein went home to Brooklyn, and the next day his father was dead. As if in a novel, Brownstein then becomes fixated on the envelope and its contents only to discover he has misplaced it. His own book is as much an attempt to decipher his father’s theory about Bertha Pappenheim as to understand his father’s turn against Freud. Brownstein makes clear that his father was a devoted doctor, and treated queer luminaries in downtown New York, including Peter Hujar and Richard Serra. Dr. Brownstein tended to babies with HIV in the 1980s who languished otherwise in their cots, when others wouldn’t dare go near. Dr. Brownstein gave everything to psychoanalysis, but then something changed. We don’t quite know what, but his father became so disillusioned that he burned all 24 volumes of Freud’s Standard Edition .
Was it the homophobia of mainstream psychoanalysis that rightfully made him repudiate his training? Was it indeed the legacy of Anna O.? I wish we knew what Brownstein felt as he wrestled with Freud via his father. As author and son, Brownstein is overwhelmed by the research subject he must now try to understand and, more importantly, terribly overwhelmed by the pain of being alive when life is most brutal. Shortly after his father’s death, his wife is diagnosed with terminal pancreatic cancer, and when the global pandemic arrives, Brownstein must weather it without them.
While Brownstein seemingly hates Freud, he, like many others, can’t escape him. Early in the book, he disparages two Freudian terms: “secondary gain,” which can be described as the unconscious advantage patients acquire through their illness (stereotyped here as attention), and “ la belle indifférence ,” a calm character in the face of crisis. But toward the book’s close, Brownstein suddenly tips his hand: He comes to a form of self-understanding through these concepts. In not getting treated for a heart problem, he says he has a case of la belle indifférence . In writing the book, he self-analyzes, he can be understood as having a case of secondary gain—after all, Brownstein was quite literally paid for producing it.
But Brownstein uses these concepts defensively—to show his reader he is in on the joke. The book itself, more movingly, is a testament to yet another set of Freudian concepts: the return of the repressed, as evidenced by his return to the use of Freud; working through (here, loss of his father, his wife); and, indeed, sublimation. Writing the book then might be an act of Freudian sublimation; it is also an act of devotion.
Hannah Zeavin is an assistant professor of history at UC Berkeley. She is the author of The Distance Cure: A History of Teletherapy .
Powerful qtl mapping and favorable allele mining in an all-in-one population: a case study of heading date.
These authors equally contributed to this work
Pengfei Wang, Ying Yang, Daoyang Li, Zhichao Yu, Bo zhang, Xiangchun Zhou, Lizhong Xiong, Jianwei Zhang, Yongzhong Xing, Powerful QTL mapping and favorable allele mining in an all-in-one population: a case study of heading date, National Science Review , 2024;, nwae222, https://doi.org/10.1093/nsr/nwae222
The multiparent advanced generation intercross (MAGIC) population is characterized with great potentials in power and resolution of QTL mapping, but SNP-based GWAS does not fully play its potential. In this study, a MAGIC population of 1021 lines was developed from four Xian and four Geng varieties from 5 subgroups of rice. A total of 44,000 genes showed functional polymorphisms among eight parents, including frameshift variations or premature stop codon variations, which provides the potential to map almost all genes of the MAGIC population. Principal component analysis results showed that the MAGIC population had a weak population structure. A high-density bin map of 24,414 bins was constructed. Segregation distortion occurred in the regions possessing the genes underlying genetic incompatibility and gamete development. SNP-based association analysis and bin-based linkage analysis identified 25 significant loci and 47 QTLs for heading date, including 14 known heading date genes. The mapping resolution of genes is dependent on genetic effects with offset distances of less than 55 kb for major effect genes and less than 123 kb for moderate effect genes. Four causal variants and noncoding structure variants were identified to be associated with heading date. Three to four types of alleles with strong, intermediate, weak, and no genetic effects were identified from eight parents, providing flexibility for the improvement of rice heading date. In most cases, japonica rice carries weak alleles, and indica rice carries strong alleles and nonfunctional alleles. These results confirmed that the MAGIC population provides the exceptional opportunity to detect QTLs, and its use is encouraged for mapping genes and mining favorable alleles for breeding.
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ADHD indicates attention-deficit/hyperactivity disorder; CVD, cardiovascular disease.
a Controls were derived from the same base cohort as the cases; thus, a case with a later date of CVD diagnosis could potentially serve as a control for another case in the study.
Crude odds ratios (ORs) were based on cases and controls matched on age, sex, and calendar time. Adjusted ORs (AORs) were based on cases and controls matched on age, sex, and calendar time and adjusted for country of birth, educational level, somatic comorbidities (type 2 diabetes, obesity, dyslipidemia, and sleep disorders), and psychiatric comorbidities (anxiety disorders, autism spectrum disorder, bipolar disorder, conduct disorder, depressive disorder, eating disorders, intellectual disability, personality disorders, schizophrenia, and substance use disorders).
The solid lines represent the adjusted odds ratios, and the shaded areas represent the 95% CIs. In restricted cubic splines analysis, knots were placed at the 10th, 50th, and 90th percentiles of ADHD medication use.
eTable 1. International Classification of Diseases (ICD) Codes from the Swedish National Inpatient Register
eTable 2. Type of Cardiovascular Disease in Cases
eTable 3. Risk of CVD Associated With ADHD Medication Use Across Different Average Defined Daily Doses
eTable 4. Risk of CVD Associated With Cumulative Duration of Use of Different Types of ADHD Medications
eTable 5. Sensitivity Analyses of CVD Risk Associated With Cumulative Use of ADHD Medications, Based On Different Cohort, Exposure, and Outcome Definitions
eFigure. Risk of CVD Associated With Cumulative Use of ADHD Medications, Stratified by Sex
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Zhang L , Li L , Andell P, et al. Attention-Deficit/Hyperactivity Disorder Medications and Long-Term Risk of Cardiovascular Diseases. JAMA Psychiatry. 2024;81(2):178–187. doi:10.1001/jamapsychiatry.2023.4294
© 2024
Question Is long-term use of attention-deficit/hyperactivity disorder (ADHD) medication associated with an increased risk of cardiovascular disease (CVD)?
Findings In this case-control study of 278 027 individuals in Sweden aged 6 to 64 years who had an incident ADHD diagnosis or ADHD medication dispensation, longer cumulative duration of ADHD medication use was associated with an increased risk of CVD, particularly hypertension and arterial disease, compared with nonuse.
Meaning Findings of this study suggest that long-term exposure to ADHD medications was associated with an increased risk of CVD; therefore, the potential risks and benefits of long-term ADHD medication use should be carefully weighed.
Importance Use of attention-deficit/hyperactivity disorder (ADHD) medications has increased substantially over the past decades. However, the potential risk of cardiovascular disease (CVD) associated with long-term ADHD medication use remains unclear.
Objective To assess the association between long-term use of ADHD medication and the risk of CVD.
Design, Setting, and Participants This case-control study included individuals in Sweden aged 6 to 64 years who received an incident diagnosis of ADHD or ADHD medication dispensation between January 1, 2007, and December 31, 2020. Data on ADHD and CVD diagnoses and ADHD medication dispensation were obtained from the Swedish National Inpatient Register and the Swedish Prescribed Drug Register, respectively. Cases included individuals with ADHD and an incident CVD diagnosis (ischemic heart diseases, cerebrovascular diseases, hypertension, heart failure, arrhythmias, thromboembolic disease, arterial disease, and other forms of heart disease). Incidence density sampling was used to match cases with up to 5 controls without CVD based on age, sex, and calendar time. Cases and controls had the same duration of follow-up.
Exposure Cumulative duration of ADHD medication use up to 14 years.
Main Outcomes and Measures The primary outcome was incident CVD. The association between CVD and cumulative duration of ADHD medication use was measured using adjusted odds ratios (AORs) with 95% CIs.
Results Of 278 027 individuals with ADHD aged 6 to 64 years, 10 388 with CVD were identified (median [IQR] age, 34.6 [20.0-45.7] years; 6154 males [59.2%]) and matched with 51 672 control participants without CVD (median [IQR] age, 34.6 [19.8-45.6] years; 30 601 males [59.2%]). Median (IQR) follow-up time in both groups was 4.1 (1.9-6.8) years. Longer cumulative duration of ADHD medication use was associated with an increased risk of CVD compared with nonuse (0 to ≤1 year: AOR, 0.99 [95% CI, 0.93-1.06]; 1 to ≤2 years: AOR, 1.09 [95% CI, 1.01-1.18]; 2 to ≤3 years: AOR, 1.15 [95% CI, 1.05-1.25]; 3 to ≤5 years: AOR, 1.27 [95% CI, 1.17-1.39]; and >5 years: AOR, 1.23 [95% CI, 1.12-1.36]). Longer cumulative ADHD medication use was associated with an increased risk of hypertension (eg, 3 to ≤5 years: AOR, 1.72 [95% CI, 1.51-1.97] and >5 years: AOR, 1.80 [95% CI, 1.55-2.08]) and arterial disease (eg, 3 to ≤5 years: AOR, 1.65 [95% CI, 1.11-2.45] and >5 years: AOR, 1.49 [95% CI, 0.96-2.32]). Across the 14-year follow-up, each 1-year increase of ADHD medication use was associated with a 4% increased risk of CVD (AOR, 1.04 [95% CI, 1.03-1.05]), with a larger increase in risk in the first 3 years of cumulative use (AOR, 1.08 [95% CI, 1.04-1.11]) and stable risk over the remaining follow-up. Similar patterns were observed in children and youth (aged <25 years) and adults (aged ≥25 years).
Conclusions and Relevance This case-control study found that long-term exposure to ADHD medications was associated with an increased risk of CVDs, especially hypertension and arterial disease. These findings highlight the importance of carefully weighing potential benefits and risks when making treatment decisions about long-term ADHD medication use. Clinicians should regularly and consistently monitor cardiovascular signs and symptoms throughout the course of treatment.
Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric disorder characterized by developmentally inappropriate inattentiveness, impulsivity, and hyperactivity. 1 , 2 Pharmacological therapy, including both stimulants and nonstimulants, is recommended as the first-line treatment for ADHD in many countries. 1 , 3 The use of ADHD medication has increased greatly in both children and adults during the past decades. 4 Although the effectiveness of ADHD medications has been demonstrated in randomized clinical trials (RCTs) and other studies, 5 , 6 concerns remain regarding their potential cardiovascular safety. 7 Meta-analyses of RCTs have reported increases in heart rate and blood pressure associated with both stimulant and nonstimulant ADHD medications. 5 , 7 - 9
As RCTs typically evaluate short-term effects (average treatment duration of 75 days), 7 it remains uncertain whether and to what extent the increases in blood pressure and heart rate associated with ADHD medication lead to clinically significant cardiovascular disease (CVD) over time. Longitudinal observational studies 10 - 12 examining the association between ADHD medication use and serious cardiovascular outcomes have emerged in recent years, but the findings have been mixed. A meta-analysis 13 of observational studies found no statistically significant association between ADHD medication and risk of CVD. However, the possibility of a modest risk increase cannot be ruled out due to several methodological limitations in these studies, including confounding by indication, immortal time bias, and prevalent user bias. Additionally, most of these studies had an average follow-up time of no more than 2 years. 13 , 14 Thus, evidence regarding the long-term cardiovascular risk of ADHD medication use is still lacking.
Examining the long-term cardiovascular risk associated with ADHD medicine use is clinically important given that individuals with a diagnosis of ADHD, regardless of whether they receive treatment, face an elevated risk of CVD. 15 Additionally, a substantial proportion of young individuals with ADHD continues to have impairing symptoms in adulthood, 16 necessitating prolonged use of ADHD medication. Notably, studies have indicated a rising trend in the long-term use of ADHD medications, with approximately half of individuals using ADHD medication for over 5 years. 17 Furthermore, evidence is lacking regarding how cardiovascular risk may vary based on factors such as type of CVD, type of ADHD medication, age, and sex. 13 Therefore, there is a need for long-term follow-up studies to address these knowledge gaps and provide a more comprehensive understanding of the cardiovascular risks associated with ADHD medication use. This information is also crucial from a public health perspective, particularly due to the increasing number of individuals receiving ADHD medications worldwide. 4
This study aimed to assess the association between cumulative use of ADHD medication up to 14 years and the risk of CVD by using nationwide health registers in Sweden. We hypothesized that longer cumulative use of ADHD medication would be associated with increased CVD risk. In addition, we aimed to examine whether the associations differ across types of ADHD medication, types of CVD, sex, and age groups.
We used data from several Swedish nationwide registers linked through unique personal identification numbers. 18 Diagnoses were obtained from the National Inpatient Register, 19 which contains data on inpatient diagnoses since 1973 and outpatient diagnoses since 2001. Information on prescribed medications was retrieved from the Swedish Prescribed Drug Register, which contains all dispensed medications in Sweden since July 2005 and includes information on drug identity based on the Anatomical Therapeutic Chemical (ATC) classification, 20 dispensing dates, and free-text medication prescriptions. Socioeconomic factors were obtained from the Longitudinal Integrated Database for Health Insurance and Labour Market studies. 21 Information on death was retrieved from the Swedish Cause of Death Register, 22 which contains information on all deaths since 1952. The study was approved by the Swedish Ethical Review Authority. Informed patient consent is not required for register-based studies in Sweden. The study followed the Reporting of Studies Conducted Using Observational Routinely Collected Health Data–Pharmacoepidemiological Research ( RECORD-PE ) guideline. 23
We conducted a nested case-control study of all individuals residing in Sweden aged 6 to 64 years who received an incident diagnosis of ADHD or ADHD medication dispensation 15 between January 1, 2007, and December 31, 2020. The diagnosis of ADHD ( International Statistical Classification of Diseases and Related Health Problems, Tenth Revision [ ICD-10 ] code F90) was identified from the National Inpatient Register. Incident ADHD medication dispensation was identified from the Swedish Prescribed Drug Register and was defined as a dispensation after at least 18 months without any ADHD medication dispensation. 24 Baseline (ie, cohort entry) was defined as the date of incident ADHD diagnosis or ADHD medication dispensation, whichever came first. Individuals with ADHD medication prescriptions for indications other than ADHD 25 and individuals who emigrated, died, or had a history of CVD before baseline were excluded from the study. The cohort was followed until the case index date (ie, the date of CVD diagnosis), death, migration, or the study end date (December 31, 2020), whichever came first.
Within the study cohort, we identified cases as individuals with an incident diagnosis of any CVD (including ischemic heart diseases, cerebrovascular diseases, hypertension, heart failure, arrhythmias, thromboembolic disease, arterial disease, and other forms of heart disease; eTable 1 in Supplement 1 ) during follow-up. For each case, the date of their CVD diagnosis was assigned as the index date. Using incidence density sampling, 26 up to 5 controls without CVD were randomly selected for each case from the base cohort of individuals with ADHD. The matching criteria included age, sex, and calendar time, ensuring that cases and controls had the same duration of follow-up from baseline to index date. Controls were eligible for inclusion if they were alive, living in Sweden, and free of CVD at the time when their matched case received a diagnosis of CVD, with the index date set as the date of CVD diagnosis of the matched case ( Figure 1 ). Controls were derived from the same base cohort as the cases. Thus, a case with a later date of CVD diagnosis could potentially serve as a control for another case in the study. 26
The main exposure was cumulative duration of ADHD medication use, which included all ADHD medications approved in Sweden during the study period, including stimulants (methylphenidate [ATC code N06BA04], amphetamine [ATC code N06BA01], dexamphetamine [ATC code N06BA02], and lisdexamfetamine [ATC code N06BA12]) as well as nonstimulants (atomoxetine [ATC code N06BA09] and guanfacine [ATC code C02AC02]). Duration of ADHD medication use was derived from a validated algorithm that estimates treatment duration from free text in prescription records. 25 The cumulative duration of ADHD medication use was calculated by summing all days covered by ADHD medication between baseline and 3 months prior to the index date. The last 3 months before the index date were excluded to reduce reverse causation, as clinicians’ perception of potential cardiovascular risks may influence ADHD medication prescription. This time window was chosen because routine psychiatric practice in Sweden limits a prescription to a maximum 3 months at a time. 27 Individuals with follow-up of less than 3 months were excluded.
We conducted conditional logistic regression analyses to estimate odds ratios (ORs) for the associations between cumulative durations of ADHD medication use and incident CVD. Crude ORs were adjusted for all matching variables (age, sex, and calendar time) by design. Adjusted ORs (AORs) were additionally controlled for country of birth (Sweden vs other), highest educational level (primary or lower secondary, upper secondary, postsecondary or postgraduate, or unknown; individuals aged <16 years were included as a separate category), and diagnoses of somatic (type 2 diabetes, obesity, dyslipidemia, and sleep disorders) and psychiatric comorbidities (anxiety disorders, autism spectrum disorder, bipolar disorder, conduct disorder, depressive disorder, eating disorders, intellectual disability, personality disorders, schizophrenia, and substance use disorders; eTable 1 in Supplement 1 ) before baseline. The association between cumulative ADHD medication use and incident CVD was assessed using both continuous and categorical measures (no ADHD medication use, 0 to ≤1, 1 to ≤2, 2 to ≤3, 3 to ≤5, and >5 years). To capture potential nonlinear associations, we used restricted cubic splines to examine ADHD medication use as a continuous measure throughout follow-up. 28 The associations were examined in the full sample and stratified by age at baseline, that is, children or youth (<25 years old) and adults (≥25 years old). Furthermore, to evaluate the association with dosage of ADHD medication, we estimated the risk of CVD associated with each 1-year increase in use of ADHD medication across different dosage groups categorized by the average defined daily dose (DDD; for instance, 1 DDD of methylphenidate equals 30 mg) during follow-up. 29
In subgroup analyses, we examined the associations between ADHD medication use and specific CVDs, including arrhythmias, arterial disease, cerebrovascular disease, heart failure, hypertension, ischemic heart disease, and thromboembolic disease (eTable 1 in Supplement 1 ). Additionally, we investigated the associations with CVD risk for the most commonly prescribed ADHD medications in Sweden, ie, methylphenidate, lisdexamfetamine, and atomoxetine, while adjusting for other ADHD medication use. We also examined sex-specific associations.
To further examine the robustness of our findings, we conducted 4 sensitivity analyses. First, we restricted the sample to ever users of ADHD medication to reduce unmeasured confounding between ADHD medication users and nonusers. Second, we assessed ADHD medication exposure over the entire follow-up period without excluding the 3 months prior to the index date. Third, to capture fatal cardiovascular events, we additionally included death by CVD in the outcome definition. Finally, we constructed a conditional logistic regression model that adjusted for propensity scores of ADHD medication use. Data management was performed using SAS, version 9.4 (SAS Institute Inc) and all analyses were performed using R, version 4.2.3 (R Foundation for Statistical Computing).
The study cohort consisted of 278 027 individuals with ADHD aged 6 to 64 years. The incidence rate of CVD was 7.34 per 1000 person-years. After applying exclusion criteria and matching, the analysis included 10 388 cases (median [IQR] age at baseline, 34.6 (20.0-45.7) years; 6154 males [59.2%] and 4234 females [40.8%]) and 51 672 matched controls (median [IQR] age at baseline, 34.6 [19.8-45.6] years; 30 601 males [59.2%] and 21 071 females [40.8%]) ( Figure 1 and Table 1 ). Median (IQR) follow-up in both groups was 4.1 (1.9-6.8) years. Among the controls, 3363 had received a CVD diagnosis after their index dates. The most common types of CVD in cases were hypertension (4210 cases [40.5%]) and arrhythmias (1310 cases [12.6%]; eTable 2 in Supplement 1 ). Table 1 presents the sociodemographic information and somatic and psychiatric comorbidities in cases and controls. In general, cases had higher rates of somatic and psychiatric comorbidities and a lower level of educational attainment compared with controls.
A similar proportion of cases (83.9%) and controls (83.5%) used ADHD medication during follow-up, with methylphenidate being the most commonly dispensed type, followed by atomoxetine and lisdexamfetamine. Longer cumulative duration of ADHD medication use was associated with an increased risk of CVD compared with nonuse (0 to ≤1 year: AOR, 0.99 [95% CI, 0.93-1.06]; 1 to ≤2 years: AOR, 1.09 [95% CI, 1.01-1.18]; 2 to ≤3 years: AOR, 1.15 [95% CI, 1.05-1.25]; 3 to ≤5 years: AOR, 1.27 [95% CI, 1.17-1.39]; and >5 years: AOR, 1.23 [95% CI, 1.12-1.36]) ( Figure 2 ). The restricted cubic spline model suggested a nonlinear association, with the AORs increasing rapidly for the first 3 cumulative years of ADHD medication use and then becoming stable thereafter ( Figure 3 ). Throughout the entire follow-up, each 1-year increase in the use of ADHD medication was associated with a 4% increased risk of CVD (AOR, 1.04 [95% CI, 1.03-1.05]), and the corresponding increase for the first 3 years was 8% (AOR, 1.08 [95% CI, 1.04-1.11]). We observed similar results when examining children or youth and adults separately ( Figure 2 ). The restricted cubic spline model suggested a similar nonlinear association, with higher AORs in children or youth than in adults, but the 95% CIs largely overlapped ( Figure 3 ). Furthermore, similar associations were observed for females and males (eFigure in Supplement 1 ). The dosage analysis showed that the risk of CVD associated with each 1 year of ADHD medication use increased with higher average DDDs. The risk was found to be statistically significant only among individuals with a mean dose of at least 1.5 times the DDD (eTable 3 in Supplement 1 ). For example, among individuals with a mean DDD of 1.5 to 2 or less (eg, for methylphenidate, 45 to ≤60 mg), each 1-year increase in ADHD medication use was associated with a 4% increased risk of CVD (AOR, 1.04 [95% CI, 1.02-1.05]). Among individuals with a mean DDD >2 (eg, for methylphenidate >60 mg), each 1-year increase in ADHD medication use was associated with 5% increased risk of CVD (AOR, 1.05 [95% CI, 1.03-1.06]).
When examining the risk for specific CVDs, we found that long-term use of ADHD medication (compared with no use) was associated with an increased risk of hypertension (AOR, 1.72 [95% CI, 1.51-1.97] for 3 to ≤5 years; AOR, 1.80 [95% CI 1.55-2.08] for >5 years) ( Table 2 ), as well as arterial disease (AOR, 1.65 [95% CI, 1.11-2.45] for 3 to ≤5 years; AOR, 1.49 [95% CI 0.96-2.32] for >5 years). However, we did not observe any statistically significant increased risk for arrhythmias, heart failure, ischemic heart disease, thromboembolic disease, or cerebrovascular disease ( Table 2 ). Furthermore, long-term use of methylphenidate (compared with no use) was associated with an increased risk of CVD (AOR, 1.20 [95% CI, 1.10-1.31] for 3 to ≤5 years; AOR, 1.19 [95% CI, 1.08-1.31]) for >5 years; eTable 4 in Supplement 1 ). Compared with no use, lisdexamfetamine was also associated with an elevated risk of CVD (AOR, 1.23 [95% CI, 1.05-1.44] for 2 to ≤3 years; AOR, 1.17 [95% CI, 0.98-1.40] for >3 years), while the AOR for atomoxetine use was significant only for the first year of use (1.07 [95% CI 1.01-1.13]; eTable 4 in Supplement 1 ).
In sensitivity analyses, we observed a similar pattern of estimates when the analysis was restricted to ever users of ADHD medications. Significantly increased risk of CVD was found when comparing ADHD medication use for 1 year or less with use for 3 to 5 or less years (AOR, 1.28 (95% CI, 1.18-1.38) or for use for more than 5 years (AOR, 1.24 [95% CI, 1.13-1.36]) (eTable 5 in Supplement 1 ). When assessing ADHD medication use across the entire follow-up period, and compared with no use, the pattern of estimates was similar to the main analysis (3 to ≤5 years: AOR, 1.28 [95% CI, 1.18-1.39]; >5 years: AOR, 1.25 [95% CI, 1.14-1.37]) (eTable 5 in Supplement 1 ). The analysis that included cardiovascular death as a combined outcome also had results similar to the main analysis. Moreover, when adjusting for propensity scores of ADHD medication use, the findings remained consistent (eTable 5 in Supplement 1 ).
This large, nested case-control study found an increased risk of incident CVD associated with long-term ADHD medication use, and the risk increased with increasing duration of ADHD medication use. This association was statistically significant both for children and youth and for adults, as well as for females and males. The primary contributors to the association between long-term ADHD medication use and CVD risk was an increased risk of hypertension and arterial disease. Increased risk was also associated with stimulant medication use.
We found individuals with long-term ADHD medication use had an increased risk of incident CVD in a dose-response manner in the first 3 years of cumulative ADHD medication use. To our knowledge, few previous studies have investigated the association between long-term ADHD medication use and the risk of CVD with follow-up of more than 2 years. 13 The only 2 prior studies with long-term follow-up (median, 9.5 and 7.9 years 30 , 31 ) found an average 2-fold and 3-fold increased risk of CVD with ADHD medication use compared with nonuse during the study period, yet 1 of the studies 30 included only children, and participants in the other study 31 were not the general population of individuals with ADHD (including those with ADHD and long QT syndrome). Furthermore, both studies were subject to prevalent user bias. Results from the current study suggest that the CVD risk associated with ADHD medication use (23% increased risk for >5 years of ADHD medication use compared with nonuse) is lower than previously reported. 30 , 31 Furthermore, we observed that the increased risk stabilized after the first several years of medication use and persisted throughout the 14-year follow-up period.
The association between ADHD medication use and CVD was significant for hypertension and arterial disease, while no significant association was observed with other types of cardiovascular events. To our knowledge, only 1 previous study 12 has examined the association between ADHD medication use and clinically diagnosed hypertension, and it found an increased risk, although the increase was not statistically significant. Furthermore, increased blood pressure associated with ADHD medication use has been well documented. 7 , 9 One study 32 found that blood pressure was mainly elevated during the daytime, suggesting that the cardiovascular system may recover at night. However, the cross-sectional nature of that study cannot preclude a long-term risk of clinically diagnosed hypertension associated with ADHD medication use. We also identified an increased risk for arterial disease. To date, no previous study has explored the association between ADHD medication use and arterial disease. A few studies have reported that ADHD medication may be associated with changes in serum lipid profiles, but the results were not consistent. 33 , 34 Further research is needed on the potential implications of ADHD medications for individuals’ lipid profiles. We did not observe any association between ADHD medication use and the risk of arrhythmias. A recent systematic review of observational studies of ADHD medication use reported an elevated risk of arrhythmias, but the finding was not statistically significant. 13 A review of RCTs also found that the use of stimulants was associated with an average increase in heart rate of 5.7 beats/min, 9 but no evidence of prolonged QT interval or tachycardia was found based on electrocardiograms. 7 Additionally, it is worth noting that some individuals receiving ADHD medications might be prescribed antiarrhythmic β-blockers to alleviate palpitation symptoms, thus potentially attenuating an association between ADHD medications and arrhythmias. Nevertheless, the absence of an association between ADHD medication use and clinically diagnosed arrhythmias in the present study does not rule out an increased risk for mild arrhythmias or subclinical symptoms, as palpitations and sinus tachycardia are not routinely coded as arrhythmia diagnoses. Further research is necessary to replicate our findings.
Regarding types of ADHD medication, findings of the present study suggest that increasing cumulative durations of methylphenidate and lisdexamfetamine use were associated with incident CVD, while the associations for atomoxetine were statistically significant only for the first year of use. Previous RCTs have reported increased blood pressure and heart rate with methylphenidate, lisdexamfetamine, and atomoxetine, 5 , 35 , 36 but the mechanisms behind these adverse effects are still a topic of debate; there might be differences in cardiovascular adverse effects in stimulants vs nonstimulants. 37
We found that the association between cumulative duration of ADHD medication use and CVD was similar in females and males. Previous investigations exploring sex-specific association found higher point estimates in females, although the differences were not statistically significant. 13 Research has indicated that females diagnosed with ADHD may demonstrate different comorbidity patterns and potentially have different responses to stimulant medications compared with males. 38 - 40 Therefore, additional studies are needed to explore and better understand the potential sex-specific differences in cardiovascular responses to ADHD medications.
A strength of this study is that data on ADHD medication prescriptions and CVD diagnoses were recorded prospectively, so the results were not affected by recall bias. The findings should, however, be interpreted in the context of several limitations. First, our approach for identification of patients with CVD was based on recorded diagnoses and there could be under ascertainment of cardiovascular diagnoses in the registers used. This means that some controls may have had undiagnosed CVD that did not yet require medical care, which would tend to underestimate associations between ADHD medication use and CVD. Second, exposure misclassification may have occurred if patients did not take their medication as prescribed. This misclassification, if nondifferential, would tend to reduce ORs such that the estimates we observed were conservative. Third, while we accounted for a wide range of potential confounding variables, considering the observational nature of the study and the possibility of residual confounding, we could not prove causality. It is possible that the association observed might have been affected by time-varying confounders. For example, other psychotropic medications and lifestyle factors could have affected both ADHD medication use and the occurrence of cardiovascular events. 41 , 42 Confounding by ADHD severity is also a potential factor to consider, as individuals with more severe ADHD symptoms may have more comorbidities and a less healthy lifestyle, which could affect the risk of CVD. Fourth, the study did not examine the risk of CVD among individuals with preexisting CVD. Individuals with preexisting CVD represent a distinct clinical group that requires careful monitoring; thus, evaluating the risk among them necessitates a different study design that carefully considers the potential impact of prior knowledge and periodic monitoring. Finally, the results by type of ADHD medication and type of CVD need to be replicated by studies with larger sample sizes.
The results of this population-based case-control study with a longitudinal follow-up of 14 years suggested that long-term use of ADHD medication was associated with an increased risk of CVD, especially hypertension and arterial disease, and the risk was higher for stimulant medications. These findings highlight the importance of carefully weighing potential benefits and risks when making treatment decisions on long-term ADHD medication use. Clinicians should be vigilant in monitoring patients, particularly among those receiving higher doses, and consistently assess signs and symptoms of CVD throughout the course of treatment. Monitoring becomes even more crucial considering the increasing number of individuals engaging in long-term use of ADHD medication.
Accepted for Publication: August 29, 2023.
Published Online: November 22, 2023. doi:10.1001/jamapsychiatry.2023.4294
Open Access: This is an open access article distributed under the terms of the CC-BY License . © 2023 Zhang L et al. JAMA Psychiatry .
Corresponding Authors: Zheng Chang, PhD ( [email protected] ) and Le Zhang, PhD ( [email protected] ), Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, 171 65 Stockholm, Sweden.
Author Contributions: Dr Zhang and Prof Chang had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Zhang, Johnell, Larsson, Chang.
Acquisition, analysis, or interpretation of data: Zhang, Li, Andell, Garcia-Argibay, Quinn, D'Onofrio, Brikell, Kuja-Halkola, Lichtenstein, Johnell, Chang.
Drafting of the manuscript: Zhang.
Critical review of the manuscript for important intellectual content: All authors.
Statistical analysis: Zhang, Li.
Obtained funding: Larsson, Chang.
Administrative, technical, or material support: Garcia-Argibay, D'Onofrio, Kuja-Halkola, Lichtenstein, Chang.
Supervision: Andell, Lichtenstein, Johnell, Larsson, Chang.
Conflict of Interest Disclosures: Dr Larsson reported receiving grants from Takeda Pharmaceuticals and personal fees from Takeda Pharmaceuticals, Evolan, and Medici Medical Ltd outside the submitted work. No other disclosures were reported.
Funding/Support: This study was supported by grants from the Swedish Research Council for Health, Working Life, and Welfare (2019-01172 and 2022-01111) (Dr Chang) and the European Union’s Horizon 2020 research and innovation program under grant agreement 965381 (Dr Larsson).
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Data Sharing Statement: See Supplement 2 .
Watch CBS News
By Megan Cerullo
Edited By Anne Marie Lee
Updated on: June 25, 2024 / 9:06 AM EDT / CBS News
CDK Global is now calling the cyberattack that took down its software platform for its auto dealership clients "a ransom event."
In a note to clients Saturday, CDK for the first time acknowledged that the hackers that made its dealer management system, or DMS, unavailable to clients for days , are demanding a ransom to restore its systems.
"Thank you for your patience as we recover from the cyber ransom event that occurred on June 19th," CDK said in a memo to clients on Saturday, according to a copy of the email obtained by CBS MoneyWatch .
CDK added in the note that it has started restoring its systems and expects the process of bringing major applications back online "to take several days and not weeks."
In its memo, the company also warned car dealerships to be alert to phishing scams, or entities posing as CDK but who are in fact bad actors trying to obtain proprietary information like customers' passwords.
A CDK spokesperson told CBS MoneyWatch that it is providing customers "with alternate ways to conduct business" while its systems remain inoperative.
The cybercriminals behind the CDK attack are linked to a group called BlackSuit, Bloomberg reported on Monday, citing Allan Liska of computer security firm Recorded Future. In a June 21 story , the media outlet also said the hackers were demanding tens of millions of dollars and that CDK planned to pay the ransom.
Liska didn't immediately respond to a request for comment. CDK itself hasn't pointed to any group behind the attack on its system that has disrupted car dealerships across the U.S. since last week. Companies targeted in ransomware schemes are often reluctant to disclose information in the midst of negotiations with hackers on a payment.
"When you see an attack of this kind, it almost always ends up being a ransomware attack," Cliff Steinhauer, director of information security and engagement at the National Cybersecurity Alliance, told the Associated Press. "We see it time and time again unfortunately, [particularly in] the last couple of years. No industry and no organization or software company is immune."
The hack has left some car dealers unable to do business altogether, while others report using pen and paper, and even "sticky notes" to record transactions.
Tom Maoli, owner of Celebrity Motor Car Company, which operates five luxury car dealerships across New York and New Jersey, on Monday told CBS MoneyWatch his employees "are doing everything manually."
"We are trying to keep our customers happy and the biggest issue is the banking side of things, which is completely backed up. We can't fund deals," he said.
Asbury Automotive Group, a Fortune 500 company operating more than 150 new car dealerships across the U.S., in a statement on Monday said the attack has "adversely impacted" its operations and has hindered its ability to do business. Its Koons Automotive dealerships in Maryland and Virginia, however, which don't rely on CDK's software, have been able to operate without interruption, the company said.
Ransomware attacks are on the rise. In 2023, more than 2,200 entities, including U.S. hospitals, schools and governments were directly impacted by ransomware, according to Emisoft , an anti-malware software company. Additionally, thousands of private sector companies were targeted. Some experts believe that the only way to stop such attacks is to ban the payment of ransoms, which Emisoft said would lead bad actors to "quickly pivot and move from high impact encryption-based attacks to other less disruptive forms of cybercrime."
Earlier this year, the U.S. Department of State offered $10 million in exchange for the identities of leaders of the Hive ransomware gang, which since 2021 has been responsible for attacks on more than 1,500 institutions in over 80 countries, resulting in the theft of more than $100 million.
Megan Cerullo is a New York-based reporter for CBS MoneyWatch covering small business, workplace, health care, consumer spending and personal finance topics. She regularly appears on CBS News 24/7 to discuss her reporting.
FILE - A flag supporting LGBTQ+ rights decorates a desk on the Democratic side of the Kansas House of Representatives during a debate, March 28, 2023, at the Statehouse in Topeka, Kan. The U.S. Supreme Court agreed Monday to consider whether a Tennessee ban on gender-affirming care for minors is constitutional. (AP Photo/John Hanna, File)
The U.S. Supreme Court said Monday that it will hear arguments on the constitutionality of state bans on gender-affirming care for transgender minors.
The issue has emerged as a big one in the past few years. While transgender people have gained more visibility and acceptance in many respects, half the states have pushed back with laws banning certain health care services for transgender kids.
Things to know about the issue:
Gender-affirming care includes a range of medical and mental health services to support a person’s gender identity, including when it’s different from the sex they were assigned at birth.
The services are offered to treat gender dysphoria, the unease a person may have because their assigned gender and gender identity don’t match. The condition has been linked to depression and suicidal thoughts.
Gender-affirming care encompasses counseling and treatment with medications that block puberty, and hormone therapy to produce physical changes. Those for transgender men cause periods to stop, increase facial and body hair, and deepen voices, among others. The hormones used by transgender women can have effects such as slowing growth of body and facial hair and increasing breast growth.
Gender-affirming care can also include surgery, including operations to transform genitals and chests. These surgeries are rarely offered to minors .
Over the past three years, 26 Republican-controlled states have passed laws restricting gender-affirming care for minors. Most of the laws ban puberty blockers, hormone treatment and surgery for those under 18. Some include provisions that allow those already receiving treatment to continue.
The laws also make exceptions for gender-affirming treatments that are not part of a gender transition, such as medications to stop breast growth in boys and excessive facial hair in girls.
One of the laws — in Arkansas — was nixed by a federal court and is not being enforced.
Meanwhile, at least 14 Democratic-controlled states have adopted laws intended to protect access to gender-affirming care.
The gender-affirming care legislation is a major part of a broader set of laws and policies that has emerged in Republican-controlled states that rein in rights of transgender people. Other policies, adopted in the name of protecting women and girls, bar transgender people from school bathrooms and sports competitions that align with their gender.
Most of the bans have faced court challenges, and most are not very far along in the legal pipeline yet.
The law in Arkansas is the only one to have been struck down entirely, but the state has asked a federal appeals court to reverse that ruling.
The 6th U.S. Circuit Court of Appeals, one step below the Supreme Court, last year ruled that Kentucky and Tennessee can continue to enforce their bans amid legal challenges. The high court has agreed to hear the Tennessee case in the term that starts later this year.
The U.S. Supreme Court in April ruled that Idaho can enforce its ban while litigation over it proceeds. A lower court had put it on hold.
Every major U.S. medical group, including the American Academy of Pediatrics and the American Medical Association, has opposed the bans and said that gender-affirming treatments can be medically necessary and are supported by evidence.
But around the world, medical experts and government health officials are not in lockstep. Some European countries in recent years have warned about overdiagnosis of gender dysphoria.
In England, the state-funded National Health Service commissioned a review of gender identity services for children and adolescents, appointing retired pediatrician Dr. Hilary Cass to lead the effort. The final version of the Cass Review , published in April, found “no good evidence on the long-term outcomes of interventions to manage gender-related distress.”
England’s health service stopped prescribing puberty blockers to children with gender dysphoria outside of a research setting, following recommendations from Cass’ interim report.
The World Professional Association for Transgender Health and its U.S. affiliate issued a statement in May saying they’re deeply concerned about the process, content and consequences of the review, saying it “deprives young trans and gender diverse people of the high-quality care they deserve and causes immense distress and harm to both young patients and their families.”
Research/Study Research/Study
Special Programs Abortion Rights & Reproductive Health
Written by Sophie Lawton , Jacina Hollins-Borges & John Knefel
Published 06/24/24 1:30 PM EDT
At least 22 partner organizations of Project 2025, a coalition of over 100 conservative groups looking to staff the next potential administration of former President Donald Trump, have publicly criticized in vitro fertilization, according to a Media Matters review.
Project 2025 is organized by conservative think tank The Heritage Foundation, and has laid out a radical plan for governance during a second Trump term. The initiative's wide-ranging policy proposals are laid out in its “ Mandate for Leadership ,” a staunchly anti-choice document. Although the Mandate itself doesn’t mention IVF, Heritage has published several pieces opposing the procedure and celebrated a ruling by the Alabama Supreme Court that extended de facto personhood rights to frozen embryos, severely curtailing access to IVF. After abrupt political backlash , Alabama’s governor passed a law protecting IVF providers from legal liability, which some Project 2025 partner organizations have criticized for rendering the original “fetal personhood” ruling moot.
The organizations and individuals associated with Project 2025 who oppose IVF have raised various objections, none of which are scientifically or medically sound. Some opponents, for example, have elided the difference between the legal definition of “viable” — like that used by Louisiana, which has the most restrictive anti-IVF laws in the country — and the medical definition. Louisiana allows IVF but prohibits the destruction of embryos, forcing fertility clinics to ship them to other states for storage. These organizations will often point out that despite this law, Louisiana has more babies born through IVF than Alabama, though they fail to mention that both states have some of the lowest rates of IVF births in the country.
Similarly, some partner organizations have suggested following European countries' leads in regulating IVF, several of them naming Italy as a suitable example. Italy once had laws classifying embryos as living people and severely regulating IVF procedures; all of them were repealed after IVF became more difficult to access and less likely to succeed.
Other Project 2025 associates have argued that IVF is a form of eugenics or that it will lead to cloning or extreme forms of genetic modification and experimentation. Still others have baselessly claimed that IVF is underregulated, ignoring the multiple federal and state guidelines and licensing requirements that providers must meet.
For the full report on Project 2025's attack on reproductive rights, click here .
The heritage foundation, alabama policy institute, alliance defending freedom, the american conservative, american family association, american principles project, americans united for life, amac action, california family council, concerned women for america, discovery institute, eagle forum, ethics and public policy center, family policy alliance, family research council, independent women’s forum, dr. james dobson family institute, liberty university, media research center, mississippi center for public policy, students for life of america, susan b. anthony pro-life america, turning point usa.
The Heritage Foundation's Emma Waters has written extensively against assisted reproductive technologies, particularly IVF and surrogacy. Her opposition draws on unsubstantiated concerns about possible harms to children who lack access to both biological parents and on biblical teaching about proper procreation. [Media Matters, 3/1/24 , 4/2/24 ]
In a March article titled “Why the IVF Industry Must Be Regulated,” Waters laid out policy recommendations that would impose heavy medical restrictions on IVF and make the procedure more difficult for couples to access and harder for facilities to perform. [Media Matters, 3/19/24 ]
In an article describing her biblical reasoning for not supporting IVF, Waters argued that it is important for Protestants specifically to “take a firm and authoritative stance on reproductive technology” because “Protestants necessarily hold a central place in America’s political and institutional life.” [The Heritage Foundation, 1/24/24 ]
Waters celebrated the Alabama Supreme Court ruling on IVF, calling it “an unqualified victory” and claiming “parents should be grateful that their embryos will receive greater protection.” In another piece on the ruling, Waters suggested states adopt stricter laws around IVF procedures, like those that exist in some European countries. [The Heritage Foundation, 2/27/24 , 2/28/24 ]
In a 2023 article, Waters complained about a California bill that would allow single parents or same-sex couples to access IVF through their health care service plans, stating, “No amount of technology or health insurance coverage can alter God’s created order.” She also claimed that allowing more widespread use of IVF procedures would create a “human trafficking market.” [The Heritage Foundation, 6/20/23 ]
Waters repeated her complaints about LGBTQ couples using IVF and other assisted reproductive technologies in another article titled “Radical ‘Right to Build Families Act’ Would Unleash IVF and Commercial Surrogacy.” In the article, Waters claimed that “the pro-abortion and the LGBTQ coalitions” are pushing assisted reproductive technologies, writing that both coalitions “have been quite hostile to the rights of children and the unborn.” [The Heritage Foundation, 1/13/23 ]
In an interview with the Family Policy Alliance, Alabama Policy Institute president and CEO Stephanie Smith claimed, “The Alabama Supreme Court ruled — correctly, in our opinion — that those embryos were children and should be treated as children under our wrongful death statutes.” Referencing Louisiana’s strict IVF laws, she went on to suggest new parameters that would make the treatment more difficult to receive. [YouTube, 2/29/24, 2/29/24 ]
API released a joint statement with Susan B. Anthony Pro-Life America criticizing Alabama’s stop-gap measure to protect providers of IVF from criminal charges. The statement said, “It is unacceptable the Alabama Legislature has advanced a bill that falls short of pro-life expectations and fails to respect the dignity of human life.” [The New York Times, 2/28/24 ]
In an article titled, “In IVF case, Alabama Supreme Court protects life from conception,” Alliance Defending Freedom senior counsel Denise Burke claimed the Alabama ruling was “a victory for life and the rights of parents.” Burke argued, “Cases like this one demonstrate that being pro-life entails more than just protecting unborn children from abortion.” [Alliance Defending Freedom, 3/18/24 ]
In a statement, Burke called the Alabama ruling “a tremendous victory” for “unborn children created through assisted reproductive technology.” [The New York Times, 2/22/24 ]
An article in the American Conservative by contributor Carmel Richardson claimed IVF is helping the “LGBT movement” distort the meaning of family. Richardson wrote, “To limit the baby-making industry is to give hard answers to those who would like a chicken in every pot and a baby in every lesbian, gay, bisexual, and transgender arm.” Richardson later disparaged IVF for allowing even a “transgender pedophile” to have a child. [The American Conservative, 3/1/24 ]
Contributor Christopher Brunet argued in a piece titled, “A personal IVF story” that he “should be allowed to condemn IVF” because “while one may born as the result of a rape, for example, it does not mean that they can’t condemn rape.” Brunet called IVF “the hope and despair of professional women in middle management” and “propaganda against nature, persuading a generation of collegiate women that they're not losing fertility every day after they turn 20.” Brunet also admonished Republicans for caving to pressure to support IVF, writing, “Just as there is now no going back on IVF, there is also no going back on gay marriage, civil rights, demographic replacement.” [The American Conservative, 2/28/24 ]
Them Before Us President Katy Faust published a story in The American Conservative titled “Alabama sets the stage for a Supreme Court fight over IVF,” in which she praised the Alabama ruling and claimed Louisiana has similar guidelines about embryos. Faust claimed these laws “protect children from their rampant destruction at the hands of #BigFertility” and called on conservatives to “not only challenge the baby-taking industry, but the baby-making industry.” [The American Conservative, 2/24/24 ]
In a call to action against Mississippi’s “anti-life” bill HB 1688, American Family Association claimed the bill would grant an “unrestricted right to destroy unborn children” through procedures such as IVF. The organization called it a “very bad amendment” and asked readers to contact their local lawmakers about the bill. HB 1688 would protect the right to assisted reproductive procedures in Mississippi. [American Family Association, 3/8/24 ; Mississippi Today, 3/7/24 ]
In a second call to action against Mississippi’s HB 1688, AFA Vice President Walker Wildmon stated that the bill “creates an unrestricted right to destroy unborn children as part of very broadly defined ‘treatments or procedures.’” [American Family Association, 3/11/24 ]
On his podcast At The Core , Wildmon claimed, “The ruling in Alabama had to do with wasting embryos, or dumping embryos or discarding” and went on to state “eyes are being opened to how much of a disregard as a culture we’ve had for babies with this IVF discussion.” [American Family Radio, At The Core , 2/28/24 ]
In a Facebook live panel hosted by AFA about the Alabama IVF ruling, Wildmon claimed, “An embryo is a baby,” and stated, “IVF is not being threatened here.” [Facebook, American Family Association Action, 3/1/24 ]
American Principles Project President Terry Schilling tweeted about IVF: “If America isn’t careful, we could actually create a government backed institution of buying and selling human beings. Which, I thought, we decided long ago was wrong.” American Principles Project previously tweeted a statement by Schilling where he told Republicans to “come up with reasonable policy” and that “they should come up with what they actually believe and support and stand for.” [Twitter/X, 3/7/24 , 2/27/24 ]
In a February statement posted to its website, Americans United for Life praised Sen. Cindy Hyde-Smith (R-MS) for blocking legislation that would protect the right to reproductive treatments. The statement claimed that “embryonic children are typically treated as property rather than persons” and that there is a “near-total lack of patient health and safety regulations and meaningful regulatory oversight” in the IVF industry. [Americans United for Life, 2/28/24 ]
Chief legal counsel for AUL Steve Aden spoke with The Washington Post, criticizing Trump’s statement about IVF treatments and stating that “the ethical approach to IVF is to ensure that human lives are not wantonly created and destroyed in the process.” The Post also highlights the “model legislation to limit the number of embryos created per IVF cycle” that AUL previously drafted. [The Washington Post, 2/24/24 ]
In 2022, Aden compared IVF treatments to “eugenics,” telling The Guardian he considers “most” kinds of IVF “untenable in a culture that respects all human life.” [The Guardian, 5/12/22 ]
In a piece on the Association of Mature American Citizens Action website, author John Moor suggested giving the Alabama Supreme Court credit for “having the courage” to make the ruling limiting IVF. He went on to compare a “preborn child” to people who “fall under a government protected characteristic,” claiming the government protects individuals from discrimination “based on age, mental capacity and appearance like skin color” and therefore should protect embryos as well. [AMAC Action, 3/18/24 ]
On Instagram, the California Family Council claimed, “By the numbers the IVF Industry is responsible for the loss of more embryonic life every year than the abortion industry.” [Instagram, 3/6/24 ]
In a statement on its website, the CFC claimed there are “grave moral concerns inherent to IVF,” and, “We cannot ignore the plight of our embryonic brothers and sisters.” The statement heavily doubled down on the idea that embryos are humans and advocated for the adoption of laws like those regulating IVF in Louisiana and countries like Germany, Italy, France, Poland, New Zealand, and Australia. [California Family Council, 3/8/24 ]
In 2023, CFC attacked a California bill it claimed “would require employers to provide insurance plans that cover all nonexperimental fertility treatments, including … for a surrogate hired by any couple or single person.” The CFC statement criticized the bill for expanding fertility treatments to include LGBTQ families, stating, “Children have the natural right to their biological father and mother, and they suffer tremendously in every area of life when this right is infringed upon.” [California Family Council, 6/19/23 ]
Valerie Bynog, a legislative strategist for Concerned Women for America Legislative Action Committee, wrote in a blog on the organization’s website, “An embryo … is a living being.” Bynog criticized the American IVF industry for not having laws like “many European countries” that have “common sense regulations” around IVF. [Concerned Women for America, 2/29/24 ]
Discovery Institute Chair and Senior Fellow Wesley J. Smith wrote in 2017 that IVF is lacking the “moralistic restriction” of only being used by infertile married couples, and referred to the treatment as “positive eugenics.” [Discovery Institute, 10/27/17 ]
Smith previously wrote in 2013 that IVF opens the door for “polyamorous threesomes or lesbian couples” to have children and claimed it must be stopped. He also claimed, “We already know that children born via IVF have poorer health outcomes than children conceived naturally,” and compared IVF treatments to cloning animals. [Discovery Institute, 9/26/13 ]
In a statement on its website, Eagle Forum claimed, “Other states and countries are performing IVF in ethical ways,” referencing Louisiana and European countries, and claimed Louisiana’s IVF regulations “clearly haven’t deterred fertility clinics.” The statement attacked Sen. Tammy Duckworth’s (D-IL) Access to Family Building Act, saying it expands reproductive protections too widely to include “not only IVF, but cloning, gene editing, experimentation on embryos, commercial surrogacy, ‘designer babies’, and more,” and that it removes “religious conscience protections” around IVF. [Eagle Forum, 2/29/24 ]
Appearing as a guest on a Facebook live panel hosted by the American Family Association, Eagle Forum executive director Becky Gerritson claimed the Alabama ruling “did not stop IVF, it did not regulate IVF” and told the panel that Eagle Forum is “promoting and pushing” more regulation of the IVF industry. [Facebook, American Family Association Action, 3/1/24 ]
The Ethics and Public Policy Center published a piece on its website by fellow Patrick Brown in which he claimed that Republicans are making “a mistake” by criticizing the Alabama ruling and called for Republicans to refuse “broad progressive legislation that would make access to IVF an ‘individual right.’” Brown pushed back on calls for IVF to be an individual right, claiming that it has “weakened” the “family as an institution,” and suggested policy that would cover IVF for only “legally married couples using their own sperm and egg.” He also called the Alabama ruling a “modest” case against IVF. [Ethics and Public Policy Center, 3/2/24 ]
EPPC President Ryan Anderson published a piece titled, “The truth about Alabama’s ruling on IVF” wherein he claimed that “the media … falsely claimed IVF was about to be banned— and Republicans fell for the claim.” Anderson’s whole piece referred to IVF embryos as “frozen embryonic children” and called IVF “morally and emotionally fraught.” [Ethics and Public Policy Center, 2/28/24 ]
EPPC fellow Andrew Walker criticized Christians and pro-life Americans for not having a stronger stance against IVF. He called IVF “morally problematic” for taking sexual intercourse out of conception, breaking a “holy and inviolable seal,” and for creating embryos that won’t be used, claiming, “In Christian language, these embryos are our neighbors.” [Ethics and Public Policy Center, 2/28/24 ]
EPPC fellow Aaron Kheriaty wrote a piece for Newsweek titled “After Alabama ruling, it's time for a serious look at the ethics of the IVF industry,” in which he claimed that “there is no morally just solution” for modern IVF treatments. [Newsweek, 2/29/24 ]
In a Family Policy Alliance podcast, Director of Public Policy Joseph Kohm stated, “Each of those fertilized embryos that are frozen is a unique human life,” before praising the Alabama Supreme Court for addressing the issue of IVF. [YouTube, 2/29/24 ]
Family Research Council President Tony Perkins told The Associated Press that the Alabama Supreme Court’s decision was “a beautiful defense of life.” [The Associated Press, 2/23/24 ]
On X, Perkins asserted that Sen. Tammy Duckworth’s (D-IL) bill protecting reproductive services was “an overreach designed to advance the Democrats’ radical, Frankensteinian agenda.” He also claimed the bill would legalize “creation of animal-human hybrids (‘chimeras’)” and “trafficking and destruction of human embryos.” In a later post, Perkins pushed for more “IVF safeguards.” [Twitter/X, 2/28/24 , 2/28/24 ]
On his podcast, Washington Watch, Perkins claimed Duckworth’s bill “raises numerous moral and bioethical issues that go far beyond ensuring the IVF issue” and again claimed it would allow the creation of human-animal hybrids. [YouTube, Washington Watch, 2/28/24 ]
On the Independent Women’s Forum’s She Thinks Podcast, Natural Womanhood editor Grace Emily Stark argued that “all across the board people, even medical professionals, have this really inflated idea of how successful IVF is that does not match reality.” [Independent Women’s Forum, She Thinks Podcast , 2/17/23 ]
On the High Noon podcast, IWF senior fellow Emily Jashinsky argued, “The pro-life movement should lead with the reality that there is a way for IVF to be done ethically where you’re not discarding embryos.” Later, host Inez Stepman asked: “Do we really want to live in a world where we’re eugenically selecting babies, where we are commodifying the act of pregnancy?” [Independent Women’s Forum, High Noon , 2/28/24 ]
IWF cross-posted an article originally written for Fox News by IWF visiting fellow Emma Waters, warning that “AI will fuel disturbing ‘build-a-child’ industry.” Waters claimed: “Seventy-five percent of IVF clinics in the U.S. offer genetic testing. This allows parents to create multiple embryos and select the one that matches their preferred sex and eye, hair, and skin color.” She added: “They can also gauge if a child will develop certain health problems. In one controversial case, deaf parents tried to create a child who would inherit their deafness. Of course, clinics destroy the unwanted embryos.” [Independent Women’s Forum, 8/4/23 ]
In a Q&A post on the Dobson Digital Library, James Dobson declared that he is “strongly opposed to the practice of creating fertilized eggs from ‘donors’ outside the immediate family (this would include the donation of sperm or eggs from a brother or sister of the husband and wife wishing to conceive),” because such activity would be to “play God.” Dobson added that IVF is “less problematic” if “all the fertilized eggs are inserted into the uterus (i.e., no ova are wasted or disposed of after fertilization.” He also argued that implanting an already existing frozen embryo is akin to “adoption.” [Dobson Digital Library, accessed 4/2/24 ]
Liberty University posted a summary of a law school panel discussion on reproductive rights after the Dobbs decision, highlighting comments from The Justice Foundation’s Allan Parker on “how to advance that victory [Dobbs] by abolishing in vitro fertilization to protect frozen eggs that have already been fertilized, which he explained is an expansion of the idea that life begins at conception.” Parker said: “I think we need more scholarly research and more public education (on this topic) before the Supreme Court is willing to accept the argument that the right to life under the constitution protects life from the moment of conception.” He added, “It takes time to change culture. But we need to do the historical research, get the education about it to where the judges, based on the appropriate case with the appropriate evidence, will be comfortable making that judicial determination.” [Liberty University, 2/14/24 ]
Media Research Center’s Tierin-Rose Mandelburg responded to the Alabama Supreme Court decision in a blog post, writing, “This is a good thing. Regardless of whether a child is conceived naturally or by artificial implantation, that child has value and has sanctity and deserves to be treated as such. Throwing embryos away should be considered murder, as, now in Alabama, it is.” Mandelburg’s blog began with the line, “Sweet Home Alabama just got even sweeter for babies.” [NewsBusters, 2/19/24 ]
Media Research Center’s Jorge Bonilla argued that the mainstream media’s response to Alabama’s ruling was disingenuous and simply a cover to advocate for abortion rights, writing, “The panic point for the media is the Court’s grant of personhood to human embryos.” “Such a finding, were it to be upheld by the United States Supreme Court, drives a dagger into efforts to codify Roe,” he continued. He later added: “Personhood, even if not uttered out loud, is the whole ball game and the media know it. It’s hard to imagine the liberal media caring too much about IVF except that these stories enable advocacy for a Roe restoration. Personhood gets in the way of that.” [NewsBusters, 2/23/24 ]
Similar to the Heritage Foundation, the Mississippi Center for Public Policy argued more than a decade ago in support of a proposed “personhood amendment” to the state’s constitution, claiming it was “unlikely” to “be used to justify a ban on in vitro fertilization (IVF).” MCPP added: “IVF procedures can be performed without destroying human embryos, and therefore would still be permissible under Initiative 26. As is currently being done in many cases, any excess embryos not implanted in the womb could be frozen and implanted later or adopted out to other parents.” [Mississippi Center for Public Policy, 11/3/11 ]
Students for Life of America argued that a “consistent, intellectually-honest stance holds that human life begins at conception/fertilization,” and views discarding embryos as “a human rights violation,” claiming that the current process of IVF encourages “targeted killing” based on “undesirable traits” and “leads to eugenics.” [Students for Life of America, 1/27/22 , 4/21/22 , 2/23/24 ]
In a blog post, Students for Life of America prepared supporters to discuss IVF by raising the argument that “more die from IVF than abortion.” [Students for Life America, 2/23/24 ]
Susan B. Anthony Pro-Life America has advocated against federal bills drafted to protect IVF after the Alabama ruling. SBA Pro-Life America argued against Rep. Nancy Mace’s (R-SC) non-binding resolution that states “strong support” for IVF, arguing that it “leaves no room for reasonable laws like the one in Louisiana that for decades has protected human embryos while also allowing IVF.” The organization also heavily criticized Sen. Tammy Duckworth’s (D-IL) bill, saying it “would even codify a right to human cloning and genetic engineering of human embryos.” [Susan B. Anthony Pro-Life America, 2/28/24 , POLITICO, 2/27/24 ]
Turning Point USA’s Alex Clark, who frequently criticizes fertility care and birth control, has written about her changing stance on IVF, concluding in 2022 that IVF is not “really any different than an early abortion.” [Turning Point USA, 8/11/22 , 8/29/22 ; Media Matters, 6/11/23 , 2/14/23 ]
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Now, upon delving into the history of preventive detention, it is known that Article 22 was inserted upon the removal of the phrase 'due process' from Article 21. Hence this shift greatly affected the context of Article 22 and posed direct questions on the rights and restrictions provided by the article. While in the case of A.K.Roy v.
Article 22 of the Constitution of India deals with protection in cases of arrest and detention. It comes under the realm of the fundamental rights as provided by the Constitution. Until the case of Maneka Gandhi , [1] this was considered as the sole protection against laws that deprived someone of their right to life and personal liberty.
Article 22 : protection against preventive detention laws in the Constitution ... Article 22 is an incomplete as a code. In the case of Maneka Gandhi v. Union of India (1978), ... Consequently, this provision in our Constitution necessitates an effective and in-depth study and survey of the root cause, as well as the drafting of an appropriate ...
Article 22 has two parts—the first part deals with the cases of ordinary law and the second part deals with the cases of preventive detention law. Two Types of Detentions: Preventive detention is when a person is held in police custody only on the basis of a suspicion that they would conduct a criminal act or cause harm to society.
Protection under Preventive Detention. Article 22 (1) gives the following rights to an individual who is arrested or detained under an ordinary law: Right to know the reason (s) for one's arrest: A person in custody has a right to be told of the reason (s) for one's arrest at the moment of arrest. so that he can prepare for the trial, make ...
Article 22, Constitution of India 1950. (1) No person who is arrested shall be detained in custody without being informed, as soon as may be, of the grounds for such arrest nor shall he be denied the right to consult, and to be defended by, a legal practitioner of his choice. (2) Every person who is arrested and detained in custody shall be ...
For all Judicial Services Exams visit here https://bit.ly/JudiciarybyStudyIQJudiciary (Pre + Mains)https://bit.ly/JudiciaryPreMainsStudyIQ Judicial Services ...
Article 22 of the Indian constitution guarantees every person of the country six fundamental rights, one of which is the right to freedom. A country with such a large population like India has a high crime rate. Article 22 assures that each arrested individual facing a trial has competent legal representation.
Article 22 (1) gives an arrested person the right to consult or be defended by a legal practitioner or a lawyer of his own choice with the objective to represent himself before the court. Prior to Maneka Gandhi's case the view was that the court was not bound to provide the help of a lawyer unless a request was made.
This is the leading case that bolsters Clause 1of Article 22, wherein the two-judge divisional bench (Justice K. Singh and Justice A. S. Anand) clutched two major guidelines: a) Any person who has an active interest in the welfare of the arrestee has the right to be informed about the arrest and the subsequent place of custodial detention.
In the TransNEOS study, among patients who received neoadjuvant letrozole, the incidence of disease progression was low if the score on the 21-gene recurrence-score assay was below 31 (<1% among ...
Harshit Sharma, Preventive Detention: An Evil Of Article 22 , Journal on contemporary issues of law, VOL.3 ISSUE 11 (2017) Written By: Amrita Talwar, BBA LLB (1st Year) - University School of Law and Legal Studies, Guru Gobind Singh Indraprastha University, Dwarka. Email: [email protected], Ph no: 704275252.
Clauses (1) and (2) of Article 22 guarantee four rights on a person who is arrested for any offence under an ordinary law-. The right to be informed 'as soon as may be' of ground of arrest'. The right to consult and to be represented by a lawyer of his own choice. The right to be produced before a magistrate within 24 hours.
Punitive detention is to punish a person for an offence committed by him after trial and conviction in a court. Preventive detention, on the other hand, means detention of a person without trial and conviction by a court. Article 22 has two parts— the first part deals with the cases of ordinary law and the second part deals with the cases of ...
can introduce very effective treatment paradigms. Preparing the manuscript for a case report may be the first exposure to scientific writing for a budding clinician/researcher. This manuscript describes the steps of writing a case report and essential considerations when publishing these articles. Individual components of a case report and the "dos and don'ts" while preparing these ...
Purpose of case study methodology. Case study methodology is often used to develop an in-depth, holistic understanding of a specific phenomenon within a specified context. 11 It focuses on studying one or multiple cases over time and uses an in-depth analysis of multiple information sources. 16,17 It is ideal for situations including, but not limited to, exploring under-researched and real ...
Article 22 in The Constitution Of India 1949 22. Protection against arrest and detention in certain cases (1) No person who is arrested shall be detained in custody without being informed. as soon as…
In this way, a single clause of Article 22 can lead to the dismantling of the golden trilogy, i.e., the rights granted to an individual under Article 14,19 and 21 of the Indian constitution. The authorities can even deny the grounds of an arrest taking an excuse as the fact being against the public order as per clause 5 of Article 22.
P. PRAVEENKUMARYADAV31. This document summarizes Article 22 of the Indian Constitution regarding the rights of arrested persons. It discusses that Article 22 guarantees certain fundamental rights to arrested persons, including the right to be informed of arrest grounds, consult a lawyer, be produced before a magistrate within 24 hours, and not ...
Article 22 (1) - Any person who is in custody has to be informed as to why he has been arrested. Further, he cannot be denied the right to consult an advocate. Article 22 (2) - The arrested individual should be produced before a judicial magistrate within 24 hours of his arrest. People arrested under preventive detention law. Further Reading:
Fifty four percent of raw case users came from outside the U.S.. The Yale School of Management (SOM) case study directory pages received over 160K page views from 177 countries with approximately a third originating in India followed by the U.S. and the Philippines. Twenty-six of the cases in the list are raw cases.
Article 20 (2) establishes the principle of double jeopardy, safeguarding against multiple prosecutions or penalties for the same offense; and. Article 20 (3) ensures the right against self-incrimination, empowering individuals to abstain from providing potentially self-damaging testimony. Collectively, these principles fortify a just legal ...
These studies often seek to collate and correlate Breuer's flattened write-up of the case with historical reality, trying to reconstruct both Anna O.'s illness and her medical treatment.
22 The finding showed that although students valued courses that leveraged learning technologies, were well-designed and included defined objectives, the interpersonal ... case study research was appropriate, since this study focused on the exploration of a real-life phenomenon bounded by time and place. The study examined the experiences of a
In this study, a MAGIC population of 1021 lines was developed from four Xian and four Geng varieties from 5 subgroups of rice. A total of 44,000 genes showed functional polymorphisms among eight parents, including frameshift variations or premature stop codon variations, which provides the potential to map almost all genes of the MAGIC population.
To our knowledge, few previous studies have investigated the association between long-term ADHD medication use and the risk of CVD with follow-up of more than 2 years. 13 The only 2 prior studies with long-term follow-up (median, 9.5 and 7.9 years 30,31) found an average 2-fold and 3-fold increased risk of CVD with ADHD medication use compared ...
CDK Global is now calling the cyberattack that took down its software platform for its auto dealership clients "a ransom event." In a note to clients Saturday, CDK for the first time acknowledged ...
The U.S. Supreme Court said Monday that it will hear arguments on the constitutionality of state bans on gender-affirming care for transgender minors.. The issue has emerged as a big one in the past few years. While transgender people have gained more visibility and acceptance in many respects, half the states have pushed back with laws banning certain health care services for transgender kids.
In an article titled, "In IVF case, Alabama Supreme Court protects life from conception," Alliance Defending Freedom senior counsel Denise Burke claimed the Alabama ruling was "a victory for ...
Article I, §8, of the Constitution affords Congress power ... Case Studies of Mass Tort Limited Fund Class Action Settlements & Bankruptcy Reorganizations 6 (2000) ("bankruptcy reorganizations ... 6 App. in No. 22-110 etc. (CA2), at 1695. B Under the reorganization plan, victims' and creditors' claims .