Quantitative Research Definition: Data that can be measured, quantified. Basically Descriptive Statistics.
Read: Introduction to Quantitative Methods
Qualitative Research Definition: Data collected that is not numerical, hence cannot be quantified. It measures other characteristics through interviews, observation and focused groups among a few methods. It can also be termed as " Categorical Statistics ".
Read: Qualitative methods in public health
Mixed methods research. When quantitative and qualitative research methods are used.
Qualitative Research Methods:
Method | Overall Purpose | Advantages | Challenges |
---|---|---|---|
Surveys | |||
Interviews | |||
Observation | |||
Focus Groups | |||
Case Studies |
Source: https://managementhelp.org/evaluation/program-evaluation-guide.htm#anchor1585345
Kindlon Hall 5700 College Rd. Lisle, IL 60532 (630) 829-6050
Gillett Hall 225 E. Main St. Mesa, AZ 85201 (480) 878-7514
Know the Differences & Comparisons
There are many differences between primary and secondary data, which are discussed in this article. But the most important difference is that primary data is factual and original whereas secondary data is just the analysis and interpretation of the primary data. While primary data is collected with an aim for getting solution to the problem at hand, secondary data is collected for other purposes.
Comparison chart.
Basis for Comparison | Primary Data | Secondary Data |
---|---|---|
Meaning | Primary data refers to the first hand data gathered by the researcher himself. | Secondary data means data collected by someone else earlier. |
Data | Real time data | Past data |
Process | Very involved | Quick and easy |
Source | Surveys, observations, experiments, questionnaire, personal interview, etc. | Government publications, websites, books, journal articles, internal records etc. |
Cost effectiveness | Expensive | Economical |
Collection time | Long | Short |
Specific | Always specific to the researcher's needs. | May or may not be specific to the researcher's need. |
Available in | Crude form | Refined form |
Accuracy and Reliability | More | Relatively less |
Primary data is data originated for the first time by the researcher through direct efforts and experience, specifically for the purpose of addressing his research problem. Also known as the first hand or raw data. Primary data collection is quite expensive, as the research is conducted by the organisation or agency itself, which requires resources like investment and manpower. The data collection is under direct control and supervision of the investigator.
The data can be collected through various methods like surveys, observations, physical testing, mailed questionnaires, questionnaire filled and sent by enumerators, personal interviews, telephonic interviews, focus groups, case studies, etc.
Secondary data implies second-hand information which is already collected and recorded by any person other than the user for a purpose, not relating to the current research problem. It is the readily available form of data collected from various sources like censuses, government publications, internal records of the organisation, reports, books, journal articles, websites and so on.
Secondary data offer several advantages as it is easily available, saves time and cost of the researcher. But there are some disadvantages associated with this, as the data is gathered for the purposes other than the problem in mind, so the usefulness of the data may be limited in a number of ways like relevance and accuracy.
Moreover, the objective and the method adopted for acquiring data may not be suitable to the current situation. Therefore, before using secondary data, these factors should be kept in mind.
The fundamental differences between primary and secondary data are discussed in the following points:
As can be seen from the above discussion that primary data is an original and unique data, which is directly collected by the researcher from a source according to his requirements. As opposed to secondary data which is easily accessible but are not pure as they have undergone through many statistical treatments.
vimbainashe marume says
June 29, 2017 at 2:55 pm
Thank you for the information it is of great importance to us as Anderson students who have the privilege to use internet for our assignments
December 20, 2017 at 11:30 am
V.nice n easy way to describe.. Really helpful.. Thanks alot
allana says
October 19, 2018 at 4:49 pm
Thank you for this information it was very useful to use in class!
Lornah says
December 3, 2018 at 12:27 pm
very articulate and simple to understand. thanks alot for this information
February 8, 2019 at 7:22 am
What is the difference between independent and dependant variables in research?
Surbhi S says
September 26, 2019 at 2:14 pm
You can find the difference between independent and dependent variable here: https://keydifferences.com/difference-between-independent-and-dependent-variable.html
Moussa Ibrahim says
February 11, 2019 at 5:44 am
It’s really guided me. Thanks
Munazza majeed says
June 26, 2019 at 8:11 am
very simple,authentic and valuable data…………..its really help me alot thank you so much
Carolina Vazquez says
February 7, 2020 at 11:02 am
It is really helpful thank you for this information.
Salman Abuzar says
July 26, 2020 at 5:56 pm
Very well explained especially the illustration in the table makes it much easier to understand. Thank you very much for this useful information.
MURHULA KAPALATA Gloire says
November 13, 2020 at 5:01 pm
it’s really helpfull and very easier to understand
CALCULUS says
November 27, 2020 at 1:29 pm
Wow! This is so impressive, I have discovered a lot out of these😊
Tinenyasha says
February 10, 2021 at 4:42 pm
i really appreciate your materials ,helps me a lot in my study . very easy to understand.
Chinchan says
February 14, 2021 at 10:12 pm
Thank you so much for the information
December 14, 2021 at 5:06 pm
Thank you so much <3
January 29, 2022 at 10:45 pm
Thank you. The information is very clear and simple to understand.
Muhindo Ronald says
October 4, 2022 at 4:18 pm
Thanks, the information is readable and can be understood
Rkboss says
October 29, 2022 at 7:52 am
Thank you so much. It helps me in exam time. Thanks..🙏🙏😌
Your email address will not be published. Required fields are marked *
Save my name, email, and website in this browser for the next time I comment.
Home Market Research
As we continue exploring the exciting research world, we’ll come across two primary and secondary data approaches. This article will focus on primary research – what it is, how it’s done, and why it’s essential.
We’ll discuss the methods used to gather first-hand data and examples of how it’s applied in various fields. Get ready to discover how this research can be used to solve research problems , answer questions, and drive innovation.
Primary research is a methodology researchers use to collect data directly rather than depending on data collected from previously done research. Technically, they “own” the data. Primary research is solely carried out to address a certain problem, which requires in-depth analysis .
There are two forms of research:
Businesses or organizations can conduct primary research or employ a third party to conduct research. One major advantage of primary research is this type of research is “pinpointed.” Research only focuses on a specific issue or problem and on obtaining related solutions.
For example, a brand is about to launch a new mobile phone model and wants to research the looks and features they will soon introduce.
Organizations can select a qualified sample of respondents closely resembling the population and conduct primary research with them to know their opinions. Based on this research, the brand can now think of probable solutions to make necessary changes in the looks and features of the mobile phone.
In this technology-driven world, meaningful data is more valuable than gold. Organizations or businesses need highly validated data to make informed decisions. This is the very reason why many companies are proactive in gathering their own data so that the authenticity of data is maintained and they get first-hand data without any alterations.
Here are some of the primary research methods organizations or businesses use to collect data:
Conducting interviews is a qualitative research method to collect data and has been a popular method for ages. These interviews can be conducted in person (face-to-face) or over the telephone. Interviews are an open-ended method that involves dialogues or interaction between the interviewer (researcher) and the interviewee (respondent).
Conducting a face-to-face interview method is said to generate a better response from respondents as it is a more personal approach. However, the success of face-to-face interviews depends heavily on the researcher’s ability to ask questions and his/her experience related to conducting such interviews in the past. The types of questions that are used in this type of research are mostly open-ended questions . These questions help to gain in-depth insights into the opinions and perceptions of respondents.
Personal interviews usually last up to 30 minutes or even longer, depending on the subject of research. If a researcher is running short of time conducting telephonic interviews can also be helpful to collect data.
Once conducted with pen and paper, surveys have come a long way since then. Today, most researchers use online surveys to send to respondents to gather information from them. Online surveys are convenient and can be sent by email or can be filled out online. These can be accessed on handheld devices like smartphones, tablets, iPads, and similar devices.
Once a survey is deployed, a certain amount of stipulated time is given to respondents to answer survey questions and send them back to the researcher. In order to get maximum information from respondents, surveys should have a good mix of open-ended questions and close-ended questions . The survey should not be lengthy. Respondents lose interest and tend to leave it half-done.
It is a good practice to reward respondents for successfully filling out surveys for their time and efforts and valuable information. Most organizations or businesses usually give away gift cards from reputed brands that respondents can redeem later.
This popular research technique is used to collect data from a small group of people, usually restricted to 6-10. Focus group brings together people who are experts in the subject matter for which research is being conducted.
Focus group has a moderator who stimulates discussions among the members to get greater insights. Organizations and businesses can make use of this method, especially to identify niche markets to learn about a specific group of consumers.
In this primary research method, there is no direct interaction between the researcher and the person/consumer being observed. The researcher observes the reactions of a subject and makes notes.
Trained observers or cameras are used to record reactions. Observations are noted in a predetermined situation. For example, a bakery brand wants to know how people react to its new biscuits, observes notes on consumers’ first reactions, and evaluates collective data to draw inferences .
Primary and secondary research are two distinct approaches to gathering information, each with its own characteristics and advantages.
While primary research involves conducting surveys to gather firsthand data from potential customers, secondary market research is utilized to analyze existing industry reports and competitor data, providing valuable context and benchmarks for the survey findings.
Find out more details about the differences:
Primary research has several advantages over other research methods, making it an indispensable tool for anyone seeking to understand their target market, improve their products or services, and stay ahead of the competition. So let’s dive in and explore the many benefits of primary research.
While primary research is a powerful tool for gathering unique and firsthand data, it also has its limitations. As we explore the drawbacks, we’ll gain a deeper understanding of when primary research may not be the best option and how to work around its challenges.
Every research is conducted with a purpose. Primary research is conducted by organizations or businesses to stay informed of the ever-changing market conditions and consumer perception. Excellent customer satisfaction (CSAT) has become a key goal and objective of many organizations.
A customer-centric organization knows the importance of providing exceptional products and services to its customers to increase customer loyalty and decrease customer churn. Organizations collect data and analyze it by conducting primary research to draw highly evaluated results and conclusions. Using this information, organizations are able to make informed decisions based on real data-oriented insights.
QuestionPro is a comprehensive survey platform that can be used to conduct primary research. Users can create custom surveys and distribute them to their target audience , whether it be through email, social media, or a website.
QuestionPro also offers advanced features such as skip logic, branching, and data analysis tools, making collecting and analyzing data easier. With QuestionPro, you can gather valuable insights and make informed decisions based on the results of your primary research. Start today for free!
LEARN MORE FREE TRIAL
Jun 28, 2024
Jun 25, 2024
Jun 21, 2024
Jun 18, 2024
by Lee Steinbock , on October 25, 2022
Not only can you simply plug your search term into any web browser, but you will also get an almost innumerable number of results, many of which circularly source from one another. As such, how can you avoid bad data and ensure that you’re relying on the best information to make strategic decisions?
The experts here at Freedonia Custom Research (FCR) are here to help you navigate all of these data sources.
At the highest level, market research data can be split into primary and secondary data sources, although from a best practices perspective, secondary research should always be performed first.
Secondary data is publicly available or relatively inexpensive to obtain and can be used as the foundation for any analysis or business decision — so long as you can feel comfortable regarding the source, something FCR can assist with.
Sources of secondary data include, but are not limited to, the following:
As noted, there are often limitations to relying solely on secondary sources, especially if you are interested in a niche product or a new technology. In these cases, the information may be outdated or not accurately reflect the industry situation as a whole. You might be asking a question that no one has tried to answer before. So what should you do now? Primary research.
A primary resource is information that is collected specifically for your purposes, directly from people who are involved in the industry that is being examined. Methods of primary data collection will vary based on the goals of the research and the level of detail being sought.
Examples of primary data sources include:
Overwhelmed at how to put all of the pieces together? Here are a few ways that the FCR team can help, based on our long track record of conducting secondary and primary market research for corporations across a wide array of industries:
If you’d like to learn more about how Freedonia Custom Research can help you navigate a sea of data, please contact us at 440-684-9600 or request more information on our website .
If you need deeper market insights and actionable data to guide your strategic business decisions, you may want to consider a voice of market (VOM) study, which allows you to gather qualitative data directly from market participants. Click the button below to learn more and download the PDF describing " 8 Steps to a Successful Voice of Market Project ."
Our goal is to help you better understand your customer, market, and competition in order to help drive your business growth.
Posts by topic.
MarketResearch.com 6116 Executive Blvd Suite 550 Rockville, MD 20852 800.298.5699 (U.S.) +1.240.747.3093 (International) [email protected]
Subscribe to blog, connect with us.
When it comes to research methodology, primary data and secondary data are essential components of the process. What is primary data and secondary data in research methodology?
Primary data is information collected through direct observation or experimentation, while secondary data is existing knowledge obtained from sources such as books, reports, and surveys. Understanding how to collect both primary and secondary data can be a challenge for R&D teams looking for insights into their projects.
In this blog post, we will explore what exactly these two types of research entail, how they should be collected in order to get the best results possible, how to analyze your findings, and how to apply those results to your project.
By understanding more about what is primary data and secondary data in research methodology, you can ensure that any decisions made regarding an innovation project are well-informed ones!
Table of Contents
Types of primary data, advantages of primary data, disadvantages of primary data, how to collect primary and secondary data, methods for collecting primary and secondary data, challenges in collecting what is primary data and secondary data in research methodology, tips for collecting reliable primary and secondary data, analyzing primary and secondary research results, challenges in analyzing research results.
Primary data is information that has been collected directly from its original source. It is original and unique to the research project or study being conducted, as opposed to secondary data which has already been gathered and published by someone else.
Primary data can be collected through a variety of methods such as surveys, interviews, focus groups, observations, experiments, and more.
This type of data can be qualitative or quantitative in nature and provides insight into a particular issue or problem being studied. It is often used in research projects to gain an understanding of people’s opinions, behaviors, attitudes, and preferences on various topics.
The types of primary data depend on the method used for collecting it. Common types include survey responses (qualitative), interview transcripts (qualitative), observation notes (quantitative), and experiment results (quantitative).
Other examples include photographs taken during fieldwork trips or video recordings made during interviews with participants in a study.
Using primary data offers several advantages over relying solely on secondary sources when conducting research.
First off, it allows researchers to collect their own unique set of information that may not have been available before. This gives them greater control over what they are studying as well as how they interpret their findings.
Additionally, primary sources tend to provide more accurate results since there are fewer chances for errors due to human bias or misinterpretation.
Lastly, using primary sources also helps ensure that any potential ethical issues related to collecting personal information are addressed prior to the beginning of the project – something which isn’t always possible with secondary sources!
Despite all these benefits associated with using primary sources, there are some drawbacks too.
One major disadvantage is cost. Primary data collection can become quite expensive if done incorrectly!
Another downside relates to accuracy. Since much less time goes into verifying each data source, mistakes may occur more frequently — resulting in unreliable conclusions.
Key Takeaway: Primary data is a valuable source of information for research as it allows researchers to collect their own unique set of information that may not have been available before.
What is primary data and secondary data in research methodology?
Primary data can be gathered through surveys, interviews, focus groups, and experiments. It provides an accurate picture of the subject being studied since it has not been altered or influenced by other sources.
Secondary data is information that has already been collected and stored in a database. Examples of secondary data include census records, government statistics, published journal articles , and public opinion polls.
Secondary data can provide valuable insights into the topic being studied but may not always be up-to-date or reliable due to its age or source material.
There are several methods available for collecting primary and secondary data including surveys, interviews, focus groups, and experiments as well as online resources such as databases and archives.
Surveys are one of the most common methods used to collect primary data. They involve asking specific questions from a group of people who have agreed to participate in the survey process.
Interviews are another popular method used to gather primary information. They involve having an interviewer ask questions face-to-face with participants who have agreed to take part in the interview process.
Focus groups allow researchers to gain insight into specific topics by gathering together small groups of individuals who share similar interests or experiences so that their opinions can be discussed openly among each other during a moderated session.
Experiments are often used when conducting scientific research. They involve manipulating variables within controlled conditions while measuring results over time.
Online resources such as databases and archives offer access to large amounts of existing secondary information which can then be analyzed further if needed.
One challenge associated with collecting both primary and secondary data is obtaining accurate responses from participants.
Another issue could arise if there’s too much bias present within certain types of datasets (eg: political opinion polls) which makes it difficult for researchers to accurately interpret results.
Additionally, there might also exist some privacy concerns depending on the nature of personal details required while conducting research (eg: medical studies).
How to ensure reliable results when collecting both primary and secondary datasets?
First, make sure you have enough sample size.
Secondly, try to avoid using biased sources like political opinion polls.
Third, check all relevant privacy laws prior to starting any project involving the collection of personal details.
Lastly, double-check the accuracy and validity of all your findings before drawing final conclusions.
Key Takeaway: Collecting reliable primary and secondary data for research projects requires careful consideration of various factors. Researchers should ensure an adequate sample size, avoid biased sources, check relevant privacy laws, and double-check accuracy before drawing conclusions.
The first step in analyzing primary and secondary research results is to identify the key points from each study. This includes understanding what was studied, who participated in the study, how it was conducted, and any other relevant information about the study’s methodology.
Once this information has been gathered, it can be used to draw conclusions about the findings. Additionally, researchers should compare their own findings with those of other studies on similar topics to gain a more comprehensive understanding of their topic area.
Analyzing primary and secondary research results can be challenging due to sample size or methodology.
It is also difficult to determine which findings are reliable since some studies may have methodological flaws that could affect their accuracy or validity.
Additionally, interpreting qualitative data can be especially challenging since there is often no clear-cut answer when examining subjective responses from participants in a survey or interview setting.
Finally, researchers must take care not to make assumptions based on limited evidence as this could lead them astray from accurate interpretations of their results.
Primary data is collected through surveys, interviews, experiments, or observations while secondary data is obtained from existing sources such as books, journals, newspapers, and websites. Collecting both types of data requires careful planning and execution to ensure accuracy and reliability.
Analyzing the results of primary and secondary research can help identify trends in the industry that could be used to inform decisions or strategies for innovation teams.
Are you an R&D or innovation team looking for a solution to help centralize data sources and provide rapid time to insights? Look no further than Cypris . Our platform is designed specifically for teams like yours, providing easy access to primary and secondary data research so that your team can make the most informed decisions possible.
With our streamlined approach, there’s never been a better way to maximize efficiency in the pursuit of groundbreaking ideas!
Home » Secondary Data – Types, Methods and Examples
Table of Contents
Definition:
Secondary data refers to information that has been collected, processed, and published by someone else, rather than the researcher gathering the data firsthand. This can include data from sources such as government publications, academic journals, market research reports, and other existing datasets.
Types of secondary data are as follows:
Secondary Data Collection Methods are as follows:
Secondary data can come in various formats depending on the source from which it is obtained. Here are some common formats of secondary data:
Secondary data analysis involves the use of pre-existing data for research purposes. Here are some common methods of secondary data analysis:
Here are some steps to follow when gathering secondary data:
Here are some examples of secondary data from different fields:
The purpose of secondary data is to provide researchers with information that has already been collected by others for other purposes. Secondary data can be used to support research questions, test hypotheses, and answer research objectives. Some of the key purposes of secondary data are:
Secondary data can be useful in a variety of research contexts, and there are several situations in which it may be appropriate to use secondary data. Some common situations in which secondary data may be used include:
Secondary data have several characteristics that distinguish them from primary data. Here are some of the key characteristics of secondary data:
There are several advantages to using secondary data in research, including:
While there are many advantages to using secondary data in research, there are also some limitations that should be considered. Some of the main limitations of secondary data include:
Researcher, Academic Writer, Web developer
Last updated: April 23, 2024
Data contains raw facts or figures that a researcher captures, stores, manipulates or analyzes to discern some meaning or make a decision. Data is not important for its own sake but because it helps us find an answer to a research question . Researchers use two categories of data: primary and secondary data .
Hence, it’s important to know the definition, purpose, advantages, and drawbacks of primary and secondary data and understand the context in which we can use them.
In this tutorial, we’ll explain the difference between these two data types.
Primary data represents raw findings from first-hand fieldwork, questionnaires, interview transcripts, focus groups, observational studies, or experimental data. It’s unfiltered and unprocessed, so it’s in the form in which it was recorded.
Primary data is the foundational material from which researchers build theories, answer questions, and formulate hypotheses. So, gathering primary data is the first step of many research methodologies .
Let’s say a company is market-testing a mobile app. It invited several users from a test group to use the app so they could provide feedback on improving features or usability. For example, the company may want to find out things such as:
During the test sessions, participants complete the questionnaire, and the app records all the interactions with the user. So, we know the exact timesteps at which the users performed any action, such as entering data or clicking on a menu item. Additionally, we have their textual responses to the questions from our survey. In this example, the users’ textual responses we get from usability testing constitute our primary data.
Surveys are one of the most common and popular methods of collecting primary data. They are structured queries about people’s attitudes, experiences, or behavior.
Further, researchers can interview study participants to get data. Interviews may be in person, over the phone, or even online. Because of their interactive nature, interviews can provide more details than surveys, often revealing things that a survey can miss.
Another method is observational study. Observational studies collect data on events, interactions, or behaviors as they occur spontaneously in nature or society. For example, the researchers can conduct an observational usability study. They can track users’ activity through the app to note where they get stuck or confused. Observations bring researchers closer to understanding the inner life of social, cultural, or ecological systems. These observations enable the rhythms, deviations, and connections that quantitative methods may not reveal.
Finally, experimental designs allow researchers to systematically manipulate (or ‘test’) independent variables by random assignment. They observe the effects on dependent variables and model these effects in controlled conditions.
For example, when designing a mobile app, researchers might want to measure and test the usability of the app interface against an alternative one. They could randomly assign users to either use Design A or Design B and compare the results in terms of specific measures and indicators of usability. Examples include time to complete a task, error rate, and level of satisfaction. In so doing, they can isolate the effect of the interface design on the usability outcomes.
Secondary data refers to the data previously gathered, organized, and stored by another individual or organization. Secondary data can also be defined as data derived from primary data. For example, raw recordings of interviews represent the primary data, and the transcripts derived from them are the secondary data:
Secondary data can contain many items without a clear structure, as the data can come from various internal and external databases, published works, non-published documents, maps, photographs, videos, and so forth. So, a researcher first has to organize all the data into a coherent structure suitable for answering the specified research question .
Published books contain a substantial body of secondary data. They usually contain references to other books and articles with data that can be relevant to our research question.
In addition to published sources, researchers can look into unpublished sources, which allow them to obtain information that is not readily published. These sources can be found in government agencies, non-profits, or private research institutes and cover a wide range of highly focused topics.
Organizations also generate terabytes of internal data —financial data, customer data, corporate performance metrics, employee surveys, etc. Internal sources often contain private data that can reveal insights about organizational processes, market shifts, or consumer tastes.
External data sources are all data sources compiled in another institution or organization than ours. These include data produced by national and local government agencies, statistical bureaus, international organizations, research consortia, and others.
Let’s compare the two data types:
The researcher controls data collection, from method selection and interviewing to measurement scheme details | The researchers using the secondary data don’t have control over the questionnaire, interview protocol, etc. | |
This process is both time-consuming and resource-intensive | Although it is still more cost-effective than collecting primary data, it also requires an investment of time and effort | |
The protection of confidentiality and privacy arises from direct contact between the researcher and the human participants during the collection of sensitive or personal data | The researchers might have ethical dilemmas concerning issues of privacy and confidentiality, issues of ownership, intellectual property rights, etc. | |
Primary data collection can provide researchers with real-time data about the phenomenon under investigation | Researchers must consider whether any changes over time might influence the interpretation of the data |
While primary data offers researchers complete control over the type, volume, and style of data collected, collecting it from scratch may be costly.
On the other hand, secondary data, which is relatively inexpensive and easier to get, poses ethical and methodological issues that we need to consider. The researcher’s objectives and purposes will determine the choice of research method.
In this article, we compare primary and secondary data. The former helps in analysis with more precision and detail but demands more time and resources for collecting. In contrast, secondary data provides some advantages over primary data because researchers don’t have to gather them. This eliminates the costs of time and money needed to gather primary data. However, researchers have to be careful. They need to ensure that the secondary data they use are relevant to their work and that they have been collected properly and ethically .
Primary research is research conducted by you or your team that examines and collects information directly from the context of the design problem.
Simply put, primary research is research that is your own original work.
For example, if a researcher is interested in learning about the dietary habits of people in a particular region, he or she could administer a survey to residents of that region inquiring about what types of food they typically eat.
Here, the researcher would be performing primary research.
Contrary to primary research, secondary research is research that was originally conducted by someone else.
Using our example from above, if after doing some investigation the researcher learns that a similar study has already been performed, he or she could utilize the results and findings from that study to assist him with his overall goal.
Here the researcher would be performing secondary research.
Related: Why You Should Consider Secondary Data Analysis for Your Next Study
Use secondary research as a starting point for your research process. .
Imagine that you’ve been tasked with developing an exercise program for elderly people.
The goal of the program is to outline and schedule exercises and workouts in order to promote healthy lifestyles amongst senior citizens.
But there’s a catch — You don’t have any experience in exercise science or developing this kind of program.
The best place to start in order to kick off the project would be to leverage existing research.
You could review publicly available materials on exercise regimens optimized for the age of your target audience. This could involve reading published research reports, books, or articles.
Your findings from this secondary research could then help you define your own approach for how you plan to create the fitness plan for senior citizens. Additionally, starting with secondary research gives you an understanding of what's already been done, and it alerts you of where there may be gaps.
Continuing on with our example above, you may realize that after researching existing materials on senior citizens and exercising that you know very little about what will motivate elderly people to exercise.
If you find yourself in a similar situation, continue to identify resources to educate yourself on the matter at hand.
In this case, secondary research has already saved you some time. If you had opted to not perform secondary research, and instead had made an attempt to build the exercise program from scratch using gut instinct, you would have spent a considerable amount of time banging your head against a theoretical wall to no avail.
If after digging into the available secondary sources, you realize that you still don’t have the precise knowledge needed to develop an effective program, you might then decide that primary research is the only viable way for you to move forward.
Once you have a deep understanding of the problem at hand thanks to your secondary research, you can then plan your primary research efforts accordingly, so that you can fill in any gaps and obtain any information that was previously missing.
Both methods are most effective when they work together.
Surveys are one of the most commonly used ways in which original data not found through secondary research is collected.
This is because surveys are context-specific, meaning that the data collected from the survey comes directly from your exact target audience. Plus, there are essentially limitless ways to customize and tailor your survey to resonate with your target audience, which allows you to collect only the most pertinent data for your project.
To start building and administering powerful surveys today, start a trial with Alchemer!
See all blog posts >
This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful.
Strictly Necessary Cookie should be enabled at all times so that we can save your preferences for cookie settings.
If you disable this cookie, we will not be able to save your preferences. This means that every time you visit this website you will need to enable or disable cookies again.
This website uses Google Analytics to collect anonymous information such as the number of visitors to the site, and the most popular pages.
Keeping this cookie enabled helps us to improve our website.
Please enable Strictly Necessary Cookies first so that we can save your preferences!
By continuing to browse the site you are agreeing to our use of cookies and similar tracking technologies described in our privacy policy .
Teaching & learning.
As part of its broad-based teaching mission, the AHA develops and shares resources for educators and students. From regional teaching conferences and online programs to pathbreaking research projects, AHA initiatives foster a community grounded in our shared commitment to understanding the past. We support and convene people who share a love of history and historical thinking.
The AHA strives to ensure that every K–12 student has access to high quality history instruction. We create resources for the classroom, advise on state and federal policy, and advocate for the vital importance of history in public education.
Teaching and learning are at the foundation of the AHA’s mission to promote historical thinking in public life. What do students learn in undergraduate history courses? How and why are history majors so successful in a variety of careers?
Many historians will pursue graduate training at some stage in their career. To meet the needs of both students and graduate programs, the AHA creates resources, provides platforms, and convenes conversations about student success from application to completion.
History department chairs are on the front lines of the discipline, defending historians’ work and supporting their professional lives at all stages of their academic careers. The AHA strives to strengthen this work and provide resources and opportunities that make chairs’ work easier and valued. The AHA provides resources and hosts a variety of events and opportunities to benefit department chairs and build community, including webinars, sessions at the annual meeting, and an in-person workshop.
Essential, carefully researched resources by historians providing context for conversations about current events.
What do students learn in introductory history courses? How can historical thinking support student learning and success across the curriculum? Our regional conferences endeavor to strengthen the community of practice focused on introductory history courses, both in secondary and higher education.
June 10, 2024
June 9, 2024
Aha historical collections.
The AHA has made primary sources available for research purposes, along with AHA archival reports and documents.
Vetted Resources compiles in a central location materials and tools that have been professionally vetted by historians, offering instructors access to high-quality materials that meet professional standards
June 20, 2024
June 16, 2024
The history of racism and racist violence: monuments and museums, join the aha.
The AHA brings together historians from all specializations and all work contexts, embracing the breadth and variety of activity in history today.
Article sidebar.
© 2018 The authors.
The Ghana Journal of Development Studies is published twice a year (May & October) by the Faculty of Integrated Development Studies as a service to development related research.
No part of this publication may be reproduced, stored in a retrieval system or transmitted in any means; electronic, mechanical, photocopy, recording or otherwise, without the written authorisation of the publisher and copyright owner.
The content is licensed uder a CC-BY license.
Interrogating the effectiveness of statutory bodies and state enterprises committee on budget oversight in botswana: an exploratory study, thato queen lesole, christopher dick-sagoe, daniel odoom, lawrencia agyepong.
This study explored the effectiveness of the Statutory Bodies and Public Enterprises (SBPE) Committee on budget oversight in Botswana. The accountability theorygrounded this research. The study predominantly embraced a qualitative approachand an exploratory research design to interrogate the effectiveness of theCommittee’s oversight function. It used both primary and secondary data collection methods. In terms of primary data collection, interviews were conducted withkeystakeholders involved in the budget oversight function. Additionally, the studyconducted a documentary review of relevant government reports, budgets, andfinancial statements to supplement the information gathered frominterviews. Thematic analysis was conducted based on the data obtained. The study observedthat the SBPE Committee was perceived as ineffective in undertaking its oversight responsibility. Poor accountability manifested in various ways, including untimelyand inaccurate financial reporting. Also, inadequate technical expertise, funding, logistics, low autonomy, lack of enforcement capacity, and poor separation of power impeded the Committee’s ability to perform its oversight responsibility effectively. The research recommended constitutional reforms in Botswana that wouldempower parliament to follow through on its recommendations and emancipatethelegislative arm of government from executive control and manipulation.
AJOL is a Non Profit Organisation that cannot function without donations. AJOL and the millions of African and international researchers who rely on our free services are deeply grateful for your contribution. AJOL is annually audited and was also independently assessed in 2019 by E&Y.
Your donation is guaranteed to directly contribute to Africans sharing their research output with a global readership.
Background Despite restoration of epicardial blood flow in acute ST-elevation myocardial infarction (STEMI), inadequate microcirculatory perfusion is common and portends a poor prognosis. Intracoronary (IC) thrombolytic therapy can reduce microvascular thrombotic burden; however, contemporary studies have produced conflicting outcomes.
Objectives This meta-analysis aims to evaluate the efficacy and safety of adjunctive IC thrombolytic therapy at the time of primary percutaneous coronary intervention (PCI) among patients with STEMI.
Methods Comprehensive literature search of six electronic databases identified relevant randomised controlled trials. The primary outcome was major adverse cardiac events (MACE). The pooled risk ratio (RR) and weighted mean difference (WMD) with a 95% CI were calculated.
Results 12 studies with 1915 patients were included. IC thrombolysis was associated with a significantly lower incidence of MACE (RR=0.65, 95% CI 0.51 to 0.82, I 2 =0%, p<0.0004) and improved left ventricular ejection fraction (WMD=1.87; 95% CI 1.07 to 2.67; I 2 =25%; p<0.0001). Subgroup analysis demonstrated a significant reduction in MACE for trials using non-fibrin (RR=0.39, 95% CI 0.20 to 0.78, I 2 =0%, p=0.007) and moderately fibrin-specific thrombolytic agents (RR=0.62, 95% CI 0.47 to 0.83, I 2 =0%, p=0.001). No significant reduction was observed in studies using highly fibrin-specific thrombolytic agents (RR=1.10, 95% CI 0.62 to 1.96, I 2 =0%, p=0.75). Furthermore, there were no significant differences in mortality (RR=0.91; 95% CI 0.48 to 1.71; I 2 =0%; p=0.77) or bleeding events (major bleeding, RR=1.24; 95% CI 0.47 to 3.28; I 2 =0%; p=0.67; minor bleeding, RR=1.47; 95% CI 0.90 to 2.40; I 2 =0%; p=0.12).
Conclusion Adjunctive IC thrombolysis at the time of primary PCI in patients with STEMI improves clinical and myocardial perfusion parameters without an increased rate of bleeding. Further research is needed to optimise the selection of thrombolytic agents and treatment protocols.
All data relevant to the study are included in the article or uploaded as supplemental information.
This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ .
https://doi.org/10.1136/heartjnl-2024-324078
Request permissions.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
ST-elevation myocardial infarction (STEMI) is a significant cause of morbidity and mortality worldwide. Microvascular obstruction affects about half of patients with STEMI, leading to adverse outcomes. Previous studies on adjunctive intracoronary thrombolysis have shown inconsistent results.
This meta-analysis demonstrates that adjunctive intracoronary thrombolysis during primary percutaneous coronary intervention (PCI) significantly reduces major adverse cardiac events and improves left ventricular ejection fraction. Furthermore, it significantly improves myocardial perfusion parameters without increasing bleeding risk.
Adjunctive intracoronary thrombolysis in patients with STEMI undergoing primary PCI shows promise for clinical benefit. Future studies should identify high-risk patients for microcirculatory dysfunction to optimise treatment strategies and clinical outcomes.
Ischaemic heart disease remains a leading cause of morbidity and mortality worldwide. 1 2 ST-elevation myocardial infarction (STEMI) occurs due to coronary vessel occlusion causing transmural myocardial ischaemia and subsequent necrosis. 3 The cornerstone of contemporary management involves prompt reopening of the occluded coronary artery with percutaneous coronary intervention (PCI). 4 5 Despite restoring epicardial blood flow, roughly 50% of patients fail to achieve adequate microvascular perfusion. 6 This phenomenon, known as microvascular obstruction (MVO), is predictive of a poor cardiac prognosis driven by left ventricular remodelling and larger infarct size. 7–9
In patients with STEMI, MVO is characterised by distal embolisation of atherothrombotic debris and fibrin-rich microvascular thrombi. 10 A growing body of evidence supports the efficacy of adjunctive low-dose intracoronary (IC) thrombolysis in this population. Sezer et al performed the first randomised controlled trial (RCT), demonstrating an improvement in myocardial perfusion with low-dose IC streptokinase post-PCI. 11 Subsequent studies focused on newer fibrin-specific agents with a lower propensity for systemic bleeding. 12 Despite encouraging results, many studies were inadequately powered and yielded conflicting outcomes. This meta-analysis aims to evaluate the efficacy and safety of adjunctive IC thrombolytic therapy at the time of primary PCI in patients with STEMI.
The present study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. 13
Electronic searches were performed using PubMed, Ovid Medline, Cochrane Library, ProQuest, ACP Journal Club and Google Scholar from their dates of inception to January 2022. The search terms “STEMI” AND “intracoronary” AND (“thrombolysis” OR “tenecteplase” OR “alteplase” OR “prourokinase” OR “urokinase” OR “streptokinase”) were combined as both keywords and Medical Subject Headings terms, with filters for RCTs. This was supplemented by hand searching the bibliographies of review articles and all potentially relevant studies.
Two reviewers (RR and SV) independently screened the title and abstracts of articles identified in the search. Full-text publications were subsequently reviewed separately if either reviewer considered the manuscript as being potentially eligible. Any disagreements regarding final study inclusion were resolved by discussion and consensus with a third reviewer (CCYW).
Studies were included if they met following inclusion criteria: (1) RCT, (2) STEMI population, (3) IC thrombolysis given to treatment group with comparison with a control group (CG) receiving no thrombolytic therapy, (4) major adverse cardiovascular event (MACE) was an outcome reported.
All publications were limited to those involving human subjects and no restrictions were based on language. Reviews, meta-analyses, abstracts, case reports, conference presentations, editorials and expert opinions were excluded. When institutions published duplicate studies with accumulating numbers of patients or increased lengths of follow-up, only the most complete reports were included for assessment.
Two investigators (RR and SV) independently extracted data from text, tables and figures. Any discrepancies were resolved by discussion and consensus with a third reviewer (CCYW). For each of the included trials, the following data were extracted: publication year, number of patients, baseline characteristics of participants, treatment details (including specific agents administered), follow-up duration and endpoints.
Study quality and risk of bias were critically appraised using the updated Cochrane Collaboration Risk-of-Bias Tool V.2. 14 Five domains of bias were evaluated: (1) randomisation process, (2) deviations from study protocol, (3) missing outcome data, (4) outcome measurement and (5) selective reporting of results.
The predetermined primary endpoint was MACE, which represented a composite outcome as defined by each individual study. While the individual components of MACE were generally consistent across studies, minor discrepancies existed ( online supplemental table 1 ). Secondary outcomes included clinical endpoints (mortality, heart failure (HF), major and minor bleeding), myocardial perfusion endpoints (thrombolysis in myocardial infarction (TIMI) flow grade 3, TIMI myocardial perfusion grade (TMPG), corrected TIMI frame count (CTFC), ST-resolution (STR)) and echocardiographic parameters (left ventricular ejection fraction (LVEF)). Subgroup analysis for MACE was conducted based on fibrin specificity of the thrombolytic agent. This classification comprised non-fibrin-specific agents (streptokinase and urokinase), moderately fibrin-specific agents (prourokinase) and highly fibrin-specific agents (alteplase and tenectaplase). Clinical outcomes were assessed at the end of the follow-up period, which ranged from 1 to 12 months, while echocardiographic parameters were evaluated within a time frame of 1–6 months.
Statistical analysis.
The mean difference (MD) or relative risk (RR) was used as summary statistics and reported with 95% CIs. Meta-analyses were performed using random-effects models to take into account the anticipated clinical and methodological diversity between studies. The I 2 statistic was used to estimate the percentage of total variation across studies due to heterogeneity rather than chance, with values exceeding 50% indicative of considerable heterogeneity. For meta-analysis of continuous data, values presented as median and IQR were converted to mean and SD using the quantile method previously described by Wan et al . 15 For subgroup analyses, a standard test of heterogeneity was used to assess for significant difference between subgroups with p<0.05 considered statistically significant.
Meta-regression analyses were performed to explore potential heterogeneity with the following moderator variables individually assessed for significance: publication year, mean age, proportion of male participants, percentage of left anterior descending artery infarcts, proportion of smokers, as well as baseline prevalence of diabetes, hypertension and dyslipidaemia.
Publication bias was assessed for the primary endpoint of MACE using funnel plots comparing log of point estimates with their SE. Egger’s linear regression method and Begg’s rank correlation test were used to detect funnel plot asymmetry. 16 17 Statistical analysis was conducted with Review Manager V.5.3.5 (Cochrane Collaboration, Oxford, UK) and Comprehensive Meta-Analysis V.3.0 (Biostat, Englewood, New Jersey, USA). All p values were two sided, and values <0.05 were considered statistically significant.
A total of 245 unique records were identified through electronic searches using six online databases, from which 85 duplicates were removed. Of these, 120 were excluded based on title and abstract alone. After screening the full text of the remaining 40 articles, 12 studies 18–29 were found to meet the inclusion criteria, as summarised on the PRISMA flow chart in figure 1 .
Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow chart of literature search and study selection.
IC thrombolysis was examined in 12 studies (n=1030 received IC thrombolysis and 885 no IC thrombolysis). Included studies used non-fibrin-specific (streptokinase, urokinase), moderately fibrin-specific (prourokinase) and highly fibrin-specific thrombolytic (alteplase, tenecteplase) agents. The timing and delivery of IC thrombolytic therapy varied between studies. A complete summary of study characteristics and baseline participant characteristics is presented in tables 1 and 2 , respectively. Primary and secondary outcomes are summarised in online supplemental table 2 . According to the revised Cochrane tool, the overall risk of bias assessment for procedural measures was judged to be ‘low risk’ in two studies, ‘some concerns’ in eight studies and ‘high risk’ in two studies ( online supplemental figure 1 ).
Summary of studies investigating intracoronary thrombolysis for patients with STEMI
Summary of baseline patient characteristics in studies investigating intracoronary thrombolysis for patients with STEMI
All 12 RCTs reported the incidence of MACE. Compared with the CG, IC thrombolysis treatment significantly improved the occurrence of MACE at the end of follow-up (RR=0.65, 95% CI 0.51 to 0.82, I 2 =0%, p<0.0004; figure 2 ). Subgroup analysis demonstrated a significant reduction in MACE for trials using non-fibrin (RR=0.39, 95% CI 0.20 to 0.78, I 2 =0%, p=0.007) and moderately fibrin-specific thrombolysis (RR=0.62, 95% CI 0.47 to 0.83, I 2 =0%, p=0.001). MACE was observed at a similar rate in studies using highly fibrin-specific thrombolysis (RR=1.10, 95% CI 0.62 to 1.96, I 2 =0%, p=0.75). Test for subgroup difference was not significant (p=0.07). Furthermore, IC thrombolysis was associated with an improvement of LVEF (weighted MD (WMD)=1.87; 95% CI, 1.07 to 2.67; I 2 =25%; p<0.0001; online supplemental figure 2 ). There was a trend towards lower incidence of HF hospitalisation (RR=0.66; 95% CI 0.42 to 1.05; I 2 =0%; p=0.08; online supplemental figure 3 ), though not statistically significant. No significant differences were observed in mortality (RR=0.95; 95% CI 0.50 to 1.81; I 2 =0%; p=0.88; online supplemental figure 4 ), major bleeding (RR=1.24; 95% CI 0.47 to 3.28; I 2 =0%; p=0.67; online supplemental figure 5 ) and minor bleeding events (RR=1.47; 95% CI 0.90 to 2.40; I 2 =0%; p=0.12; online supplemental figure 6 ) between the two groups.
Forest plot displaying relative risk for major adverse cardiovascular events with intracoronary (IC) thrombolysis (stratified by fibrin-specific and non-fibrin-specific agents) or placebo in ST-elevation myocardial infarction. Squares and diamonds=risk ratios. Lines=95% CIs.
In patients with STEMI, IC thrombolysis significantly improved TIMI flow grade 3 (RR=1.09; 95% CI 1.02 to 1.15; I 2 =63%; p=0.006), TMPG (RR=1.38; 95% CI 1.13 to 1.68; I 2 =54%; p=0.001), complete STR (RR=1.20; 95% CI 1.10 to 1.31; I 2 =51%; p<0.0001) and CTFC (WMD=−4.58; 95% CI −6.23 to –2.72; I 2 =41%; p<0.0001) when compared with the CG ( figure 3 ).
Forest plots of myocardial perfusion outcomes with intracoronary (IC) thrombolysis or placebo in ST-elevation myocardial infarction. (A) Thrombolysis in myocardial infarction (TIMI) flow grade 3. (B) TIMI myocardial perfusion grade 3. (C) ST-segment resolution. (D) Corrected TIMI frame count. Squares and diamonds=risk ratios/weighted mean difference. Lines=95% CIs.
For primary endpoint of MACE, meta-regression analyses did not identify the following moderator variables as significant effect modifiers: publication year (p=0.97), proportion of male (p=0.23), prevalence of diabetes (p=0.44), proportion of smokers (p=0.68), prevalence of dyslipidaemia (p=0.44) and prevalence of hypertension (p=0.21).
Both Egger’s linear regression method (p=0.73) and Begg’s rank correlation test (p=0.63) suggested that publication bias was not an influencing factor when MACE was selected as the primary endpoint.
The present meta-analysis examined 12 RCTs that included 1915 patients with STEMI undergoing primary PCI. All trials evaluated the efficacy and safety of IC thrombolytic agents compared with a CG. The main findings were that patients administered IC thrombolysis had: (1) significantly lower incidence of MACE, (2) improvement in LVEF and (3) superior myocardial perfusion parameters (TIMI flow grade 3, TMPG, CTFC and complete STR). Notably, there were no significant differences observed in mortality and bleeding events in both groups.
Mortality rates following STEMI remain high, with 30-day mortality rates ranging from 5.4% to 14% and 1-year mortality rates ranging from 6.6% to 17.5%. 30 Despite the increased availability of primary PCI facilities and advancements in reperfusion strategies, there has been limited improvement in STEMI mortality rates. 31 Moreover, complications such as HF, arrhythmia, repeat revascularisation and reinfarction continue to be prevalent. 32–34 Despite restoring epicardial blood flow through PCI, MVO is evident in almost half of patients with STEMI. 6 It is characterised by distal embolisation of atherothrombotic debris, de novo microvascular thrombosis formation and plugging of circulating blood cells. 35 Furthermore, the upregulation of inflammatory mediators leads to intramyocardial haemorrhage and further microvascular necrosis. 36 37 These mechanistic pathways contribute to a larger infarct size, adverse myocardial remodelling and worse prognosis. 7 8 38
Thrombolytic therapy is an effective treatment for acute coronary thrombosis. 39 It inhibits red blood cell aggregation and dissolves thrombi to facilitate adequate microvascular perfusion. 40 41 Thrombolytic agents are commonly classified based on their affinity for fibrin. Streptokinase and urokinase lack fibrin specificity, indiscriminately activating both circulating and clot-bound plasminogen. Prourokinase has moderate fibrin specificity with a propensity for activation on fibrin surfaces, although systemic fibrinogen degradation has been observed. Alteplase and tenectaplase are highly fibrin specific, activating fibrin-bound plasminogen with minimal impact on circulating free plasminogen.
Utilisation of a facilitated PCI strategy with adjunctive intravenous thrombolysis improves coronary flow acutely, 42 however, causes paradoxical activation of thrombin, leading to increased bleeding. 43 44 As a result, clinicians considered the administration of IC thrombolytic therapy. Encouraging results from an open-chest animal model 45 led to the first randomised trial using adjunctive IC streptokinase in 41 patients with STEMI undergoing primary PCI. 11 In the IC streptokinase group, patients demonstrated improved coronary flow reserve, index of microcirculatory resistance (IMR) and CTFC 2 days after primary PCI. 11 Further RCTs with moderately fibrin-specific thrombolytic agents (prourokinase) demonstrated similar results with improved myocardial perfusion parameters. 19 20 22 23 26–28 Notably, the T-TIME Study, a large RCT of 440 patients comparing a highly fibrin-specific thrombolytic agent (alteplase) against placebo, reported different outcomes. At 3-month follow-up, there were no significant differences in rates of death or HF hospitalisation between groups. In addition, microvascular obstruction (% left ventricular mass) on cardiac magnetic resonance (CMR) between groups at 2–7 days did not differ. The ICE T-TIMI trial, which also used a highly fibrin-specific thrombolytic agent (tenecteplase), investigated its efficacy in 40 patients. This small study administered two fixed doses of 4 mg of IC tenecteplase and evaluated the primary endpoint of culprit lesion per cent diameter stenosis after the first bolus of tenecteplase or placebo. The results indicated no significant difference in the primary endpoint between the two groups.
In an initial meta-analysis of six RCTs investigating the use of IC thrombolysis in patients with STEMI compared with placebo, findings revealed a reduction in MVO but no impact on MACE. 46 Subsequent analyses, including studies with larger sample sizes or focusing on specific thrombolytic agents, have since been conducted with varied results. 47 48 Our meta-analysis, which is the largest to date, demonstrates that adjunctive IC thrombolysis in patients with STEMI improves both clinical and microcirculation outcomes. Although bleeding events did not significantly increase, it is plausible that a tradeoff may exist for reducing MACE. Notably, subgroup analysis for MACE demonstrated no significant benefit for highly fibrin-specific agents ( figure 2 ).
Intuitively, fibrin-specific thrombolytics are presumed to offer inherent advantages over their less fibrin-specific counterparts. In vivo studies have revealed that administration of alteplase in patients with STEMI induced shorter periods of thrombin and kallikrein activation, less reduction in fibrinogen, and a decrease in D-dimer and plasmin–antiplasmin complexes compared with streptokinase. 49 In this regard, tenecteplase demonstrates superior performance relative to alteplase with almost no paradoxical procoagulant effect due to reduced activation of thrombin and the kallikrein–factor XII system. 50
Nonetheless, other variables may diminish the significance of fibrin specificity. It has been argued that administration of IC alteplase, a short-acting thrombolytic with a half-life of 4–6 min, before flow optimisation with stenting may have contributed to the negative results seen in T-TIME. Although prourokinase has a similarly short half-life and was also given before stenting in multiple studies, it was associated with better results. 19 20 22 23 26–28 The therapeutic efficacy of prourokinase predominantly relies on its conversion to urokinase, a non-fibrin-specific direct plasminogen activator, potentially resulting in a prolonged duration of action. Furthermore, inducing a systemic fibrinolytic state with a non-selective agent may be paradoxically desirable in patients receiving adjunctive IC thrombolytics during primary PCI. This approach can potentially prevent further thrombus reaccumulation and embolisation to the microcirculation, especially in a highly thrombogenic environment. In contrast, fibrin-specific agents may heighten the risk of rethrombosis and reocclusion due to their limited impact on systemic fibrinogen depletion. Nevertheless, such varied outcomes across these studies could be attributed to the heterogeneous methodologies used.
Despite encouraging results, future studies targeting patients at the highest risk of MVO with appropriately powered sample sizes are required. The ongoing RESTORE-MI (Restoring Microcirculatory Perfusion in STEMI) trial ( NCT03998319 ) has a unique approach in which all study participants will undergo assessment of microvascular integrity after primary PCI prior to inclusion. Only patients with objective evidence of microvascular dysfunction (IMR value >32) following reperfusion will be randomised to treatment with IC tenecteplase or placebo. The primary endpoint measured will be cardiovascular mortality and rehospitalisation for HF at 24 months, in addition to infarct size on CMR at 6 months post-PCI. This study may potentially support a novel therapeutic approach towards treating MVO in patients with STEMI in the future.
Several key limitations should be considered when interpreting the findings of the present meta-analysis. First, several studies were subject to bias due to issues in randomisation and blinding, leading to an increased chance of type 1 (false-positive) error. In addition, the sample size of individual studies, except for the T-TIME trial, was relatively small. Second, inconsistencies in the duration of follow-up and the definition of clinical outcomes, such as MACE, were observed among the studies. Third, interventional protocols varied between RCTs. For example, IC thrombolytic therapy differed in agent, dosage, timing and route of administration. Initial studies used non-fibrin-specific agents, while contemporary studies moved towards newer fibrin-specific therapy. Besides Sezer et al , 25 all other studies administered IC thrombolysis therapy prior to stent implantation. 18–24 26–29 Within the latter group, some delivered before flow restoration, 19 21 29 though most did so after balloon dilation or thrombus aspiration. 18 20 22–24 26–28 Similarly, the methods of IC administration of the agents varied between non-selective delivery through guiding catheters 24 25 to selective delivery via IC catheters. 18–24 26–29 Furthermore, antiplatelet, anticoagulant and glycoprotein IIb/IIIa inhibitors (GPI) regimens also differed ( table 1 ). Finally, patient selection was diverse between studies. Though regression analysis did not detect any significant effect modifiers, total ischaemic time was omitted due to significant heterogeneity in reporting.
Impaired myocardial perfusion remains a clinical challenge in patients with STEMI. Despite its limitations, this meta-analysis favours the use of IC thrombolytic therapy during primary PCI. Overall, IC thrombolysis reduced the incidence of MACE and improved myocardial perfusion markers without increasing the risk of bleeding. Future clinical trials should be appropriately powered for clinical outcomes and focus on patients at high risk of microcirculatory dysfunction.
Patient consent for publication.
Not applicable.
Supplementary data.
This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.
X @RajanRehan23
Contributors RR—conceptualisation, methodology, data analysis, writing (original draft preparation), reviewing and editing the final manuscript. SV—methodology, data analysis. CCYW—conceptualisation, methodology, data analysis. FP—supervision, writing (reviewing and editing). JL—supervision, writing (reviewing and editing). AK—supervision, writing (reviewing and editing). AY—conceptualisation, methodology, writing (reviewing and editing). HDW—conceptualisation, methodology, writing (reviewing and editing). WF—conceptualisation, methodology, writing (reviewing and editing). MN—conceptualisation, methodology, supervision, writing (reviewing and editing), guarantor.
Funding This study is funded by the National Health and Medical Research Council (2022150).
Competing interests JL has received minor honoraria from Abbott Vascular, Boehringer Ingelheim and Bayer. AY has received minor honoraria and research support from Abbot Vascular and Philips Healthcare. WF has received research support from Abbott Vascular and Medtronic; and has minor stock options with HeartFlow. MN has received research support from Abbot Vascular. HDW has received grant support paid to the institution and fees for serving on Steering Committees of the ODYSSEY trial from Sanofi and Regeneron Pharmaceuticals, the ISCHEMIA and MINT Study from the National Institutes of Health, the STRENGTH trial from Omthera Pharmaceuticals, the HEART-FID Study from American Regent, the DAL-GENE Study from DalCor Pharma UK, the AEGIS-II Study from CSL Behring, the CLEAR OUTCOMES Study from Esperion Therapeutics, and the SOLIST-WHF and SCOREDS trials from Sanofi Aventis Australia. The remaining authors have nothing to disclose.
Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.
Provenance and peer review Not commissioned; externally peer reviewed.
Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.
IMAGES
VIDEO
COMMENTS
When doing secondary research, researchers use and analyze data from primary research sources. Secondary research is widely used in many fields of study and industries, such as legal research and market research. In the sciences, for instance, one of the most common methods of secondary research is a systematic review. ... Combining primary and ...
Primary research definition. When you conduct primary research, you're collecting data by doing your own surveys or observations. Secondary research definition: In secondary research, you're looking at existing data from other researchers, such as academic journals, government agencies or national statistics. Free Ebook: The Qualtrics ...
The purpose of primary data is to gather information directly from the source, without relying on secondary sources or pre-existing data. This data is collected through research methods such as surveys, interviews, experiments, and observations. Primary data is valuable because it is tailored to the specific research question or problem at hand ...
Navigating the Pros and Cons. Balance Your Research Needs: Consider starting with secondary research to gain a broad understanding of the subject matter, then delve into primary research for specific, targeted insights that are tailored to your precise needs. Resource Allocation: Evaluate your budget, time, and resource availability. Primary research can offer more specific and actionable data ...
Primary research is a research approach that involves gathering data directly while secondary research is a research approach that involves relying on already existing data when carrying out a systematic investigation. This means that in primary research, the researcher is directly involved in the data collection and categorization process.
Primary research is a research method that relies on direct data collection, rather than relying on data that's already been collected by someone else. In other words, primary research is any type of research that you undertake yourself, firsthand, while using data that has already been collected is called secondary research .
When to use secondary research. Secondary research is a very common research method, used in lieu of collecting your own primary data. It is often used in research designs or as a way to start your research process if you plan to conduct primary research later on.. Since it is often inexpensive or free to access, secondary research is a low-stakes way to determine if further primary research ...
It is a method of research that relies on data that is readily available, rather than gathering new data through primary research methods. Secondary research relies on reviewing and analyzing sources such as published studies, reports, articles, books, government databases, and online resources to extract relevant information for a specific ...
Secondary research involves gathering data that has already been collected by someone else. This type of research can be conducted through various sources, such as academic journals, books, government reports, and online databases. Secondary research is less time-consuming and less expensive than primary research, as the data has already been ...
Data sources. In primary research, your data is collected via surveys, interviews, focus groups, and observation. All sources of data are collected directly by the team conducting the research. Secondary research sources include database information, government websites, trade body statistics, textbooks, research journals, media stories, and ...
Sources of data: primary vs secondary data. To answer a research question, there are many potential sources of data. Two main categories are primary data and secondary data. Primary data is newly collected data; it can be gathered directly from people's responses (surveys), or from their biometrics (blood pressure, weight, blood tests, etc.).
Primary data and secondary data are both used in research and statistics. They can be used to carry out the same kind of research in these fields depending on data availability. This is because secondary data and primary data have the same content. The only difference is the method by which they are collected.
Introduction. Conducting research involves two types of data: primary data and secondary data. While secondary research deals with existing data, primary research collects new data. Ultimately, the most appropriate type of research depends on which method is best suited to your research question. While this article discusses the difference ...
Primary vs secondary research. Unlike secondary research, primary research involves creating data first-hand by directly working with interviewees, target users, or a target market. Primary research focuses on the method for carrying out research, asking questions, and collecting data using approaches such as:
Primary Data: Data that has been generated by the researcher himself/herself, surveys, interviews, experiments, specially designed for understanding and solving the research problem at hand. Secondary Data: Using existing data generated by large government Institutions, healthcare facilities etc. as part of organizational record keeping.The data is then extracted from more varied datafiles.
In research, there are different methods used to gather information, all of which fall into two categories, i.e. primary data, and secondary data. As the name suggests, primary data is one which is collected for the first time by the researcher while secondary data is the data already collected or produced by others.
Here are some of the primary research methods organizations or businesses use to collect data: 1. Interviews (telephonic or face-to-face) Conducting interviews is a qualitative research method to collect data and has been a popular method for ages. These interviews can be conducted in person (face-to-face) or over the telephone.
Surveys. Advantages — Surveys are a great way to collect significant amounts of representative quantitative data via primary research methods. Disadvantages — Whereas in-depth interviews are dynamic in nature, surveys are static, and don't allow for follow-up or further probing as to the "why" someone does something.
Primary data is collected through surveys, interviews, experiments, or observations while secondary data is obtained from existing sources such as books, journals, newspapers, and websites. Collecting both types of data requires careful planning and execution to ensure accuracy and reliability. Analyzing the results of primary and secondary ...
Types of secondary data are as follows: Published data: Published data refers to data that has been published in books, magazines, newspapers, and other print media. Examples include statistical reports, market research reports, and scholarly articles. Government data: Government data refers to data collected by government agencies and departments.
Learn the difference between primary and secondary data in research. ... The researcher's objectives and purposes will determine the choice of research method. 5. Conclusion. In this article, we compare primary and secondary data. The former helps in analysis with more precision and detail but demands more time and resources for collecting.
Using Primary Research and Secondary Research Together. Once you have a deep understanding of the problem at hand thanks to your secondary research, you can then plan your primary research efforts accordingly, so that you can fill in any gaps and obtain any information that was previously missing. Both methods are most effective when they work ...
Collecting useful secondary information often requires searching for reliable and relevant sources and mostly involves large amounts of reading. Secondary data involves research others have completed, so this form of research often does not require interaction with others. Primary data research involves gathering data yourself.
Primary market research is the process of gathering firsthand data directly from your target audience to gain valuable insights and make informed business decisions.
Resources for Educators & Students K-12 Education The AHA strives to ensure that every K-12 student has access to high quality history instruction. We create resources for the classroom, advise on state and federal policy, and advocate for the vital importance of history in public education. Learn More Undergraduate Education…
It used both primary and secondary data collection methods. In terms of primary data collection, interviews were conducted withkeystakeholders involved in the budget oversight function. Additionally, the studyconducted a documentary review of relevant government reports, budgets, andfinancial statements to supplement the information ...
1. Introduction. Dengue fever (DF), a mosquito-borne viral infection, is a major public health concern, with more than 390 million dengue cases estimated to occur every year [], particularly in tropical and subtropical areas [] of the globe.Transmitted by the bite of a female Aedes mosquito [3, 4], DF is caused by 4 antigenically distinct but related viruses, named DENV1 to DENV-4 serotypes.
Quantitative and qualitative data analysis methods were used to assess the extent and format of ASD-related articles as well as the discourse tone and thematic representation. Treatments were evaluated for their level of evidence through comparison with a combination of primary, secondary, and tertiary literature.
Primary and secondary outcomes are summarised in online supplemental table 2. According to the revised Cochrane tool, the overall risk of bias assessment for procedural measures was judged to be 'low risk' in two studies, 'some concerns' in eight studies and 'high risk' in two studies ( online supplemental figure 1 ).